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The map label for this gene is ytpA [H]

Identifier: 18976852

GI number: 18976852

Start: 496589

End: 497362

Strand: Direct

Name: ytpA [H]

Synonym: PF0480

Alternate gene names: 18976852

Gene position: 496589-497362 (Clockwise)

Preceding gene: 18976849

Following gene: 18976858

Centisome position: 26.02

GC content: 40.83

Gene sequence:

>774_bases
ATGACCCAGGTATACAAAGCAAAATTTGGAACTCCAAACAGAGGATGGGTTATAATAGTTCACGGATTAGGAGAGCACAG
TGGAAGGTACTCAAAACTGGTAAGCATGCTTGTAAATGAAGGATATGCAGTCTATACATTTGACTGGCCAGGTCATGGAA
AGAGCCCAGGAAAAAGAGGTCATACAAGCGTTGAAGAAGCAATGGAAATAATAGACTTTATCATAGAGGAGATAAACGAT
AAACCTTTTCTCTTTGGCCACAGCCTCGGAGGATTAACAGTGATAAGATATGCAGAAACAAGGCCAGAAAAGATTAGAGG
AGTTATTGCCTCCTCCCCAGCTCTGGCTAAGAGCCCAAAAACACCCTCTTTTATGGTTGCACTTGCAAAAATTCTTGGAG
TCTTGCTTCCAAGCTTAACACTCTCCAATGGAATAGATCCCAATCTTCTCTCAAGAAATCCAGATGCTGTAAAAAGATAC
ATAGAAGATCCCCTGGTTCATGACAGAATTTCTGCCAAACTGGGAAGGAGCATATTCAAGAACATGGATCTTGCTCACAG
AGAAGCCCACAAAATTAAAGTTCCAGTTCTACTCTTAGTTGGGACTGGGGATGTTATAACTCCTCCAGAAGGAGCTAGAA
AGTTATACGGGGAAATCAAAGTGGAAGATAAGGAAATTGTAGAGTTCGAAGGTGCATACCATGAGATATTTGAAGATCCA
GAATGGGGAGAAGAGTTTCATAAAAAGATAGTTGAGTGGATAAAGAAGCATTGA

Upstream 100 bases:

>100_bases
CTATAATTAACGAAAGGTGTTGTAGGAGTTGTATATGTACTAAGCTAAGTTGACATAAAAAAGAGGAAAAAGATAAATCC
TTTAATTCCTATTTATCTAT

Downstream 100 bases:

>100_bases
GAGGGGAAGTCAGGCGACTGTTTATTCATCACTAGCTCAGCACTCGGCAAACTCATCATCCCCTCCTGCAACACCTTGTT
TTTGTTTTTTATAACATTTA

Product: lysophospholipase

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MTQVYKAKFGTPNRGWVIIVHGLGEHSGRYSKLVSMLVNEGYAVYTFDWPGHGKSPGKRGHTSVEEAMEIIDFIIEEIND
KPFLFGHSLGGLTVIRYAETRPEKIRGVIASSPALAKSPKTPSFMVALAKILGVLLPSLTLSNGIDPNLLSRNPDAVKRY
IEDPLVHDRISAKLGRSIFKNMDLAHREAHKIKVPVLLLVGTGDVITPPEGARKLYGEIKVEDKEIVEFEGAYHEIFEDP
EWGEEFHKKIVEWIKKH

Sequences:

>Translated_257_residues
MTQVYKAKFGTPNRGWVIIVHGLGEHSGRYSKLVSMLVNEGYAVYTFDWPGHGKSPGKRGHTSVEEAMEIIDFIIEEIND
KPFLFGHSLGGLTVIRYAETRPEKIRGVIASSPALAKSPKTPSFMVALAKILGVLLPSLTLSNGIDPNLLSRNPDAVKRY
IEDPLVHDRISAKLGRSIFKNMDLAHREAHKIKVPVLLLVGTGDVITPPEGARKLYGEIKVEDKEIVEFEGAYHEIFEDP
EWGEEFHKKIVEWIKKH
>Mature_256_residues
TQVYKAKFGTPNRGWVIIVHGLGEHSGRYSKLVSMLVNEGYAVYTFDWPGHGKSPGKRGHTSVEEAMEIIDFIIEEINDK
PFLFGHSLGGLTVIRYAETRPEKIRGVIASSPALAKSPKTPSFMVALAKILGVLLPSLTLSNGIDPNLLSRNPDAVKRYI
EDPLVHDRISAKLGRSIFKNMDLAHREAHKIKVPVLLLVGTGDVITPPEGARKLYGEIKVEDKEIVEFEGAYHEIFEDPE
WGEEFHKKIVEWIKKH

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=256, Percent_Identity=33.984375, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI6005786, Length=256, Percent_Identity=33.984375, Blast_Score=131, Evalue=6e-31,
Organism=Escherichia coli, GI1787678, Length=243, Percent_Identity=24.2798353909465, Blast_Score=73, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322756, Length=272, Percent_Identity=28.3088235294118, Blast_Score=89, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 28773; Mature: 28641

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVYKAKFGTPNRGWVIIVHGLGEHSGRYSKLVSMLVNEGYAVYTFDWPGHGKSPGKRG
CCCEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
HTSVEEAMEIIDFIIEEINDKPFLFGHSLGGLTVIRYAETRPEKIRGVIASSPALAKSPK
CCCHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCC
TPSFMVALAKILGVLLPSLTLSNGIDPNLLSRNPDAVKRYIEDPLVHDRISAKLGRSIFK
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
NMDLAHREAHKIKVPVLLLVGTGDVITPPEGARKLYGEIKVEDKEIVEFEGAYHEIFEDP
CCCHHHHHHHEEEEEEEEEECCCCCCCCCHHHHHHHHHEEECCHHHHHHCCHHHHHHCCC
EWGEEFHKKIVEWIKKH
CHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQVYKAKFGTPNRGWVIIVHGLGEHSGRYSKLVSMLVNEGYAVYTFDWPGHGKSPGKRG
CCEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
HTSVEEAMEIIDFIIEEINDKPFLFGHSLGGLTVIRYAETRPEKIRGVIASSPALAKSPK
CCCHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCC
TPSFMVALAKILGVLLPSLTLSNGIDPNLLSRNPDAVKRYIEDPLVHDRISAKLGRSIFK
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
NMDLAHREAHKIKVPVLLLVGTGDVITPPEGARKLYGEIKVEDKEIVEFEGAYHEIFEDP
CCCHHHHHHHEEEEEEEEEECCCCCCCCCHHHHHHHHHEEECCHHHHHHCCHHHHHHCCC
EWGEEFHKKIVEWIKKH
CHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]