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The map label for this gene is hpsA [H]

Identifier: 18976592

GI number: 18976592

Start: 235489

End: 236793

Strand: Direct

Name: hpsA [H]

Synonym: PF0220

Alternate gene names: 18976592

Gene position: 235489-236793 (Clockwise)

Preceding gene: 18976590

Following gene: 18976593

Centisome position: 12.34

GC content: 41.23

Gene sequence:

>1305_bases
ATGGCAAGTCCAGTAGATGGCTACTATCAAATTCTTTGGTCCAGTAAATTTTTCTCTTTATTTTCATATTTATCCCCCTC
TGATAATACTACAAATATAAAAACTTTAAAAGAGCACCCTCTAAAACAAAAACGGGTGTGTGTTATGATACTCCAAGTTG
CACTTGATTTAACAGACATTGAGCAGGCTATTTCTATAGCAGAGAAAGCTGCACGTGGTGGCGCTCACTGGTTAGAAGTC
GGGACTCCCTTAATTAAGAAAGAAGGAATGCGTGCGGTAGAACTAATGAAAAGGAGATTCCCAGACAGGAAAATTGTAGC
AGATCTAAAGACCATGGATACTGGAGCCCTAGAAGTTGAGATGGCGGCGAGGCATGGTGCTGATGTAGTTTCAATTCTTG
GAGTTGCAGATGATAAAACAATAAAAGACGCCTTAGCTGTTGCAAGAAAATATGGTATAAAAGTAATGGTAGACTTAATC
GGAGTGAAAGACAAAGTAAAGAGAGCAAAGGAACTCGAAGAGATGGGGGTTCATTATATTCTCGTTCACACGGGAATAGA
TGAGCAGGCCCAGGGAAAGAGCCCACTTGAGGATTTAGAAAAAGTGGTCAAAGCTGTTAAGATTCCAGTGGCCGTGGCTG
GTGGGTTAAATCTCGAGACAATTCCGAAGGTAATAGAGCTAGGGGCCACAATAATAGTAGTTGGAAGTGCAATTACAAAG
GCTAAGGATCCAGAAGAGGTTACTAGGAAAATTATAGATCTATTCTGGGATGAATACATGAGGACAATAAAAAAGGCCAT
GAAAGATATAACTGAACACATAAACGAAGTTGCAGATAAGCTAAAATTGGAAGAGGTTAGGGGATTAGTTGATGCAATGA
TAGGTGCAAATAAGATCTTTATCTATGGAGCTGGAAGAAGTGGCCTTGTAGGCAAAGCCTTTGCAATGAGACTGATGCAC
CTCGACTTCAACGTCTATGTAGTTGGAGAAACAATAACGCCTGCATTTGAAGAAGGAGACCTGTTGATTGCTATTAGTGG
TTCAGGTGAAACTAAGACTATCGTAGATGCCGCTGAGATTGCTAAGCAGCAAGGAGGAAAGGTAGTGGCAATAACATCTT
ATAGGGACTCAACACTTGGAAAATTGGCCGATGTCGTAGTTGAGATCCCAGGAAGAACTAAGACTGATGTTCCAACAGAT
TACATAGCTCGTCAAATGCTCACCCAATACAAGTGGACTGCTCCAATGGGAACTCTATTTGAGGACTCTACCATGGTATT
TCTCGATGGCGTAATAGCTTGCTAA

Upstream 100 bases:

>100_bases
TGATTGAAATCAAAGATCATCCCTTGCTCGTTAATATCCCCATAAATCTCAATTTCAATCCTGTAGGTATGCCCATGAAT
TCTCTTGCACTTGCTTTCAT

Downstream 100 bases:

>100_bases
TGGCCACATTCCAAAAGACGGAGAAAGATATGAAAAGGAAGCACGCTACTCTCGAGTAGTTTCCTATTCCCAATTTTCCC
CATTTTACTGGAGGTGGGAC

Product: hexulose-6-phosphate synthase (d-arabino 3-hexulose 6-phosphate formaldehyde lyase)

Products: NA

Alternate protein names: HPS; D-arabino-3-hexulose-6-phosphate formaldehyde lyase [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MASPVDGYYQILWSSKFFSLFSYLSPSDNTTNIKTLKEHPLKQKRVCVMILQVALDLTDIEQAISIAEKAARGGAHWLEV
GTPLIKKEGMRAVELMKRRFPDRKIVADLKTMDTGALEVEMAARHGADVVSILGVADDKTIKDALAVARKYGIKVMVDLI
GVKDKVKRAKELEEMGVHYILVHTGIDEQAQGKSPLEDLEKVVKAVKIPVAVAGGLNLETIPKVIELGATIIVVGSAITK
AKDPEEVTRKIIDLFWDEYMRTIKKAMKDITEHINEVADKLKLEEVRGLVDAMIGANKIFIYGAGRSGLVGKAFAMRLMH
LDFNVYVVGETITPAFEEGDLLIAISGSGETKTIVDAAEIAKQQGGKVVAITSYRDSTLGKLADVVVEIPGRTKTDVPTD
YIARQMLTQYKWTAPMGTLFEDSTMVFLDGVIAC

Sequences:

>Translated_434_residues
MASPVDGYYQILWSSKFFSLFSYLSPSDNTTNIKTLKEHPLKQKRVCVMILQVALDLTDIEQAISIAEKAARGGAHWLEV
GTPLIKKEGMRAVELMKRRFPDRKIVADLKTMDTGALEVEMAARHGADVVSILGVADDKTIKDALAVARKYGIKVMVDLI
GVKDKVKRAKELEEMGVHYILVHTGIDEQAQGKSPLEDLEKVVKAVKIPVAVAGGLNLETIPKVIELGATIIVVGSAITK
AKDPEEVTRKIIDLFWDEYMRTIKKAMKDITEHINEVADKLKLEEVRGLVDAMIGANKIFIYGAGRSGLVGKAFAMRLMH
LDFNVYVVGETITPAFEEGDLLIAISGSGETKTIVDAAEIAKQQGGKVVAITSYRDSTLGKLADVVVEIPGRTKTDVPTD
YIARQMLTQYKWTAPMGTLFEDSTMVFLDGVIAC
>Mature_433_residues
ASPVDGYYQILWSSKFFSLFSYLSPSDNTTNIKTLKEHPLKQKRVCVMILQVALDLTDIEQAISIAEKAARGGAHWLEVG
TPLIKKEGMRAVELMKRRFPDRKIVADLKTMDTGALEVEMAARHGADVVSILGVADDKTIKDALAVARKYGIKVMVDLIG
VKDKVKRAKELEEMGVHYILVHTGIDEQAQGKSPLEDLEKVVKAVKIPVAVAGGLNLETIPKVIELGATIIVVGSAITKA
KDPEEVTRKIIDLFWDEYMRTIKKAMKDITEHINEVADKLKLEEVRGLVDAMIGANKIFIYGAGRSGLVGKAFAMRLMHL
DFNVYVVGETITPAFEEGDLLIAISGSGETKTIVDAAEIAKQQGGKVVAITSYRDSTLGKLADVVVEIPGRTKTDVPTDY
IARQMLTQYKWTAPMGTLFEDSTMVFLDGVIAC

Specific function: Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate [H]

COG id: COG0269

COG function: function code G; 3-hexulose-6-phosphate synthase and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPS/KGPDC family. HPS subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790640, Length=209, Percent_Identity=31.1004784688995, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790006, Length=216, Percent_Identity=27.3148148148148, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788767, Length=102, Percent_Identity=41.1764705882353, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR017120
- InterPro:   IPR001754
- InterPro:   IPR011060
- InterPro:   IPR005493 [H]

Pfam domain/function: PF03737 Methyltransf_6; PF00215 OMPdecase [H]

EC number: =4.1.2.43 [H]

Molecular weight: Translated: 47595; Mature: 47464

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPVDGYYQILWSSKFFSLFSYLSPSDNTTNIKTLKEHPLKQKRVCVMILQVALDLTDI
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHH
EQAISIAEKAARGGAHWLEVGTPLIKKEGMRAVELMKRRFPDRKIVADLKTMDTGALEVE
HHHHHHHHHHHCCCCHHHHHCCCHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEE
MAARHGADVVSILGVADDKTIKDALAVARKYGIKVMVDLIGVKDKVKRAKELEEMGVHYI
EHHHCCCCHHHHEECCCCHHHHHHHHHHHHCCCEEEHHHHCCHHHHHHHHHHHHCCCEEE
LVHTGIDEQAQGKSPLEDLEKVVKAVKIPVAVAGGLNLETIPKVIELGATIIVVGSAITK
EEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCEEEEEECHHHC
AKDPEEVTRKIIDLFWDEYMRTIKKAMKDITEHINEVADKLKLEEVRGLVDAMIGANKIF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
IYGAGRSGLVGKAFAMRLMHLDFNVYVVGETITPAFEEGDLLIAISGSGETKTIVDAAEI
EEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHH
AKQQGGKVVAITSYRDSTLGKLADVVVEIPGRTKTDVPTDYIARQMLTQYKWTAPMGTLF
HHHCCCCEEEEECCCCHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHH
EDSTMVFLDGVIAC
CCCEEEEECHHHCC
>Mature Secondary Structure 
ASPVDGYYQILWSSKFFSLFSYLSPSDNTTNIKTLKEHPLKQKRVCVMILQVALDLTDI
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHH
EQAISIAEKAARGGAHWLEVGTPLIKKEGMRAVELMKRRFPDRKIVADLKTMDTGALEVE
HHHHHHHHHHHCCCCHHHHHCCCHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEE
MAARHGADVVSILGVADDKTIKDALAVARKYGIKVMVDLIGVKDKVKRAKELEEMGVHYI
EHHHCCCCHHHHEECCCCHHHHHHHHHHHHCCCEEEHHHHCCHHHHHHHHHHHHCCCEEE
LVHTGIDEQAQGKSPLEDLEKVVKAVKIPVAVAGGLNLETIPKVIELGATIIVVGSAITK
EEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCEEEEEECHHHC
AKDPEEVTRKIIDLFWDEYMRTIKKAMKDITEHINEVADKLKLEEVRGLVDAMIGANKIF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
IYGAGRSGLVGKAFAMRLMHLDFNVYVVGETITPAFEEGDLLIAISGSGETKTIVDAAEI
EEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHH
AKQQGGKVVAITSYRDSTLGKLADVVVEIPGRTKTDVPTDYIARQMLTQYKWTAPMGTLF
HHHCCCCEEEEECCCCHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHH
EDSTMVFLDGVIAC
CCCEEEEECHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA