Definition Pyrococcus furiosus DSM 3638, complete genome.
Accession NC_003413
Length 1,908,256

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The map label for this gene is ydfG [C]

Identifier: 18976446

GI number: 18976446

Start: 79562

End: 80317

Strand: Direct

Name: ydfG [C]

Synonym: PF0074

Alternate gene names: 18976446

Gene position: 79562-80317 (Clockwise)

Preceding gene: 18976443

Following gene: 18976447

Centisome position: 4.17

GC content: 43.65

Gene sequence:

>756_bases
ATGTCCAAAAATTATAAAAAACATCAAGCTTATATTGCTGGGAGGGATAAAATGAAGGTTGCCGTAATTACTGGGGCATC
CCGTGGAATCGGGGAAGCTATAGCAAAGGCCCTTGCTGAAGATGGATATTCCCTTGCCTTAGGGGCTAGAAGTGTTGATA
GGTTAGAGAAGATTGCCAAGGAACTCAGCGAAAAACATGGGGTGGAGGTATTTTACGACTACCTCGATGTATCAAAACCA
GAAAGCGTTGAAGAGTTTGCAAGGAAAACGCTAGCTCACTTTGGAGATGTGGACGTTGTTGTGGCCAATGCGGGGCTTGG
TTACTTTGGTAGGCTTGAAGAGCTTACAGAAGAGCAGTTCCACGAAATGATTGAAGTAAACCTTTTGGGAGTTTGGAGAA
CAATAAAAGCTTTCTTAAACTCCTTAAAGCGGACTGGAGGAGTGGCTATTGTTGTTACTTCAGATGTTTCTGCAAGGCTA
CTTCCATACGGTGGAGGTTATGTGGCAACTAAATGGGCTGCAAGAGCATTGGTAAGGACCTTCCAGATTGAGAATCCAGA
TGTGAGGTTCTTCGAGCTAAGACCTGGAGCAGTAGATACATATTTTGGAGGGAGCAAAGCTGGGAAGCCAAAGGAGCAAG
GGTATTTAAAACCTGAGGAAGTTGCTGAGGCAGTAAAATACCTCCTAAGACTTCCAAAGGATGTTAGGGTTGAGGAATTA
ATGTTGCGCTCAATTTATCAAAAACCTGAGTATTGA

Upstream 100 bases:

>100_bases
TTGATATTGTGATTTATAATATTTCCCATGCAATTATAAATGTGGGAAGATAGATATATGTTTAAACTTGCTTTTTGAGG
AGGCTCAATTCTCTTCATAA

Downstream 100 bases:

>100_bases
GGTGGTGTGCATGTTTGAGATATCAATTTATCTTCCCACAGAAATAGTTTTTGGTCCTGGGAAGCTTGAAATGCTTCCTA
AACTAGTGAAGAAGCATGGG

Product: alcohol dehydrogenase, short chain

Products: NA

Alternate protein names: ORFA [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MSKNYKKHQAYIAGRDKMKVAVITGASRGIGEAIAKALAEDGYSLALGARSVDRLEKIAKELSEKHGVEVFYDYLDVSKP
ESVEEFARKTLAHFGDVDVVVANAGLGYFGRLEELTEEQFHEMIEVNLLGVWRTIKAFLNSLKRTGGVAIVVTSDVSARL
LPYGGGYVATKWAARALVRTFQIENPDVRFFELRPGAVDTYFGGSKAGKPKEQGYLKPEEVAEAVKYLLRLPKDVRVEEL
MLRSIYQKPEY

Sequences:

>Translated_251_residues
MSKNYKKHQAYIAGRDKMKVAVITGASRGIGEAIAKALAEDGYSLALGARSVDRLEKIAKELSEKHGVEVFYDYLDVSKP
ESVEEFARKTLAHFGDVDVVVANAGLGYFGRLEELTEEQFHEMIEVNLLGVWRTIKAFLNSLKRTGGVAIVVTSDVSARL
LPYGGGYVATKWAARALVRTFQIENPDVRFFELRPGAVDTYFGGSKAGKPKEQGYLKPEEVAEAVKYLLRLPKDVRVEEL
MLRSIYQKPEY
>Mature_250_residues
SKNYKKHQAYIAGRDKMKVAVITGASRGIGEAIAKALAEDGYSLALGARSVDRLEKIAKELSEKHGVEVFYDYLDVSKPE
SVEEFARKTLAHFGDVDVVVANAGLGYFGRLEELTEEQFHEMIEVNLLGVWRTIKAFLNSLKRTGGVAIVVTSDVSARLL
PYGGGYVATKWAARALVRTFQIENPDVRFFELRPGAVDTYFGGSKAGKPKEQGYLKPEEVAEAVKYLLRLPKDVRVEELM
LRSIYQKPEY

Specific function: Unknown

COG id: COG4221

COG function: function code R; Short-chain alcohol dehydrogenase of unknown specificity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI109715829, Length=251, Percent_Identity=30.2788844621514, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI223718074, Length=249, Percent_Identity=31.7269076305221, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI32483357, Length=195, Percent_Identity=29.7435897435897, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI19923817, Length=253, Percent_Identity=27.6679841897233, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI20149619, Length=241, Percent_Identity=28.6307053941909, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI7706318, Length=188, Percent_Identity=29.7872340425532, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI4503817, Length=220, Percent_Identity=30.4545454545455, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI5031737, Length=187, Percent_Identity=29.4117647058824, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI33667109, Length=187, Percent_Identity=29.4117647058824, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI7657478, Length=192, Percent_Identity=30.2083333333333, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI142976729, Length=232, Percent_Identity=28.448275862069, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI126723191, Length=187, Percent_Identity=27.807486631016, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI40254992, Length=229, Percent_Identity=29.2576419213974, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI146231950, Length=145, Percent_Identity=32.4137931034483, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787820, Length=246, Percent_Identity=28.4552845528455, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082100, Length=230, Percent_Identity=30.8695652173913, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1787335, Length=159, Percent_Identity=36.4779874213836, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI2367175, Length=230, Percent_Identity=29.1304347826087, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786701, Length=235, Percent_Identity=25.531914893617, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082160, Length=112, Percent_Identity=32.1428571428571, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787526, Length=216, Percent_Identity=23.6111111111111, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI2367365, Length=228, Percent_Identity=28.5087719298246, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71997402, Length=229, Percent_Identity=30.5676855895196, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17570069, Length=192, Percent_Identity=29.6875, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=242, Percent_Identity=28.5123966942149, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=191, Percent_Identity=28.2722513089005, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=186, Percent_Identity=26.8817204301075, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=243, Percent_Identity=27.9835390946502, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=170, Percent_Identity=25.8823529411765, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=190, Percent_Identity=27.3684210526316, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=195, Percent_Identity=30.2564102564103, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=246, Percent_Identity=28.4552845528455, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115534660, Length=192, Percent_Identity=32.2916666666667, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=193, Percent_Identity=30.5699481865285, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322226, Length=184, Percent_Identity=29.3478260869565, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323882, Length=226, Percent_Identity=27.8761061946903, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322067, Length=169, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI116007236, Length=240, Percent_Identity=32.5, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24641232, Length=245, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281364494, Length=246, Percent_Identity=30.8943089430894, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI23397609, Length=188, Percent_Identity=36.7021276595745, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24641388, Length=243, Percent_Identity=31.2757201646091, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24663911, Length=244, Percent_Identity=30.7377049180328, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28571387, Length=243, Percent_Identity=25.9259259259259, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357041, Length=222, Percent_Identity=28.3783783783784, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21358495, Length=247, Percent_Identity=27.1255060728745, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644339, Length=186, Percent_Identity=30.6451612903226, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24648944, Length=238, Percent_Identity=28.1512605042017, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24643142, Length=225, Percent_Identity=31.1111111111111, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI116007238, Length=177, Percent_Identity=32.7683615819209, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI116007234, Length=240, Percent_Identity=29.1666666666667, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28571526, Length=222, Percent_Identity=28.8288288288288, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24648693, Length=243, Percent_Identity=27.9835390946502, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21355889, Length=243, Percent_Identity=27.9835390946502, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21356301, Length=223, Percent_Identity=28.2511210762332, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640492, Length=189, Percent_Identity=29.6296296296296, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24580925, Length=207, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355319, Length=191, Percent_Identity=29.3193717277487, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24584752, Length=160, Percent_Identity=30, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24649181, Length=167, Percent_Identity=29.940119760479, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 1300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 27984; Mature: 27853

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MSKNYKKHQAYIAGRDKMKVAVITGASRGIGEAIAKALAEDGYSLALGARSVDRLEKIAK
CCCCCHHHHHEEECCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEECHHHHHHHHHHHH
ELSEKHGVEVFYDYLDVSKPESVEEFARKTLAHFGDVDVVVANAGLGYFGRLEELTEEQF
HHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
HEMIEVNLLGVWRTIKAFLNSLKRTGGVAIVVTSDVSARLLPYGGGYVATKWAARALVRT
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHH
FQIENPDVRFFELRPGAVDTYFGGSKAGKPKEQGYLKPEEVAEAVKYLLRLPKDVRVEEL
HCCCCCCEEEEEECCCCEECCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHCCCCCCHHHH
MLRSIYQKPEY
HHHHHHCCCCC
>Mature Secondary Structure 
SKNYKKHQAYIAGRDKMKVAVITGASRGIGEAIAKALAEDGYSLALGARSVDRLEKIAK
CCCCHHHHHEEECCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEECHHHHHHHHHHHH
ELSEKHGVEVFYDYLDVSKPESVEEFARKTLAHFGDVDVVVANAGLGYFGRLEELTEEQF
HHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
HEMIEVNLLGVWRTIKAFLNSLKRTGGVAIVVTSDVSARLLPYGGGYVATKWAARALVRT
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHH
FQIENPDVRFFELRPGAVDTYFGGSKAGKPKEQGYLKPEEVAEAVKYLLRLPKDVRVEEL
HCCCCCCEEEEEECCCCEECCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHCCCCCCHHHH
MLRSIYQKPEY
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1905979; 11679669 [H]