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The map label for this gene is gltA [H]

Identifier: 189424443

GI number: 189424443

Start: 1415066

End: 1416388

Strand: Reverse

Name: gltA [H]

Synonym: Glov_1379

Alternate gene names: 189424443

Gene position: 1416388-1415066 (Counterclockwise)

Preceding gene: 189424444

Following gene: 189424439

Centisome position: 36.15

GC content: 54.95

Gene sequence:

>1323_bases
ATGGCTCTGAAGGAAACTCTGAAGCAGAAAATCGAAGAGCATCGTCCCCGCACCACCCGTCTGGTAAAAGAATTCGGCAA
GGTGAAGATTGATGAAGTAACCATCGATCAGTGCATCGGCGGCGCCCGCGACATCCGCAGCCTGGTAACCGACATTTCCT
ACCTGGATCCCCAGGAAGGCATCCGCTTCCGTGGCAAGACTATTCCTGAGACCTTTGCTGCCCTTCCTAAGGCACCCGGC
TCAAACTACCCCACTGTTGAGTCTTTCTGGTATATGCTGCTTACCGGCGATGTCCCGACCGAGGCACAGGTAGCAGAAGT
TGTTGCCGAATGGAAGACCCGCCAGGAAGTTCCTCAGTACGTTTTTGATGTACTTCGCGCTCTGCCCCGTGACAGCCATC
CAATGGTCATGCTTTCCGTTGCGATGCTGACCCTCCAGAAGGACTCCAAGTTTGCCGGCTTCTACAACTCCGGTAAATTC
AACAAGATGACAGCTTGGGAGTATGTGTACGAAGACGCCAGCGATATCGTTGCCCGTATCCCGATTATTGCTGCCTTCAT
CTACAACCTGAAGTACCGTGGTGACAAGCAGATCGCTATCGATCCGAGCCTGGATATGGGTGCCAACTTTGCCCACATGA
TCGGCCAGAAAGAGGAGTACAAGGACGTTGCACGTATGTACTTCATCCTGCACTCCGACCATGAGTCCGGCAACGTATCT
GCACACACCACCCATCTGGTGCACTCCGCCCTGTCTGACCCATATTACGCATACTCCGCAGGCCTGAACGGTCTGGCCGG
CCCGCTGCACGGCCTGGCCAACCAGGAAGTTCTGGACTGGACCCTGAAGTTCCAGGAGAAGTACTGCAAGGATGTAGAGC
CTACTGAAGAACTGATCAAAGCTGCTCTGTGGGATACCCTCAACGCTGGTCAGGTTATCCCTGGCTATGGCCACGCTGTT
CTGCGCAAGACCGACCCACGCTACACTTCACAGCGTGAGTTCTGCCTCAACACCCCGGGCCTTAAAGACTACCCGCTGTT
CAAAGTTATCGCCAAGATCTTTGAAGTTGCTCCTGGCGTTCTGACTGAGCACGGCAAGACCAAGAACCCTTGGCCGAACG
TTGACGCACAGTCCGGCGTTATCCAGATGTACTACGGTCTGACCGAGTATGACTTCTACACCGTACTGTTCGGTGTAGGC
CGCGCACTGGGCTGCATGGCCAACATCACTTGGGACCGCGGTCTGGGCTACGCCCTTGAGCGTCCCAAGTCTGTTACCAC
TGCAATGCTTGAGAAATGGGCTGAGGCTGGCGGCCGTAACTAA

Upstream 100 bases:

>100_bases
TGTTATAACAGCCAAAATTTTTGTATACAGTATATTCAAAACGTTTATTGTATTGTGCAATTAACTAGTTGCACCATTAT
CCCGAAAGGAGAAGTACACA

Downstream 100 bases:

>100_bases
TACCGCCCGCTGGTGCTGTAAAACAAAAGGGGATGCGCTATCGCATCCCCTTTTTATGTTCATATCTCGCAACCAACGTT
CAGATTTATTTCCCGCTAAA

Product: type I citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MALKETLKQKIEEHRPRTTRLVKEFGKVKIDEVTIDQCIGGARDIRSLVTDISYLDPQEGIRFRGKTIPETFAALPKAPG
SNYPTVESFWYMLLTGDVPTEAQVAEVVAEWKTRQEVPQYVFDVLRALPRDSHPMVMLSVAMLTLQKDSKFAGFYNSGKF
NKMTAWEYVYEDASDIVARIPIIAAFIYNLKYRGDKQIAIDPSLDMGANFAHMIGQKEEYKDVARMYFILHSDHESGNVS
AHTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLDWTLKFQEKYCKDVEPTEELIKAALWDTLNAGQVIPGYGHAV
LRKTDPRYTSQREFCLNTPGLKDYPLFKVIAKIFEVAPGVLTEHGKTKNPWPNVDAQSGVIQMYYGLTEYDFYTVLFGVG
RALGCMANITWDRGLGYALERPKSVTTAMLEKWAEAGGRN

Sequences:

>Translated_440_residues
MALKETLKQKIEEHRPRTTRLVKEFGKVKIDEVTIDQCIGGARDIRSLVTDISYLDPQEGIRFRGKTIPETFAALPKAPG
SNYPTVESFWYMLLTGDVPTEAQVAEVVAEWKTRQEVPQYVFDVLRALPRDSHPMVMLSVAMLTLQKDSKFAGFYNSGKF
NKMTAWEYVYEDASDIVARIPIIAAFIYNLKYRGDKQIAIDPSLDMGANFAHMIGQKEEYKDVARMYFILHSDHESGNVS
AHTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLDWTLKFQEKYCKDVEPTEELIKAALWDTLNAGQVIPGYGHAV
LRKTDPRYTSQREFCLNTPGLKDYPLFKVIAKIFEVAPGVLTEHGKTKNPWPNVDAQSGVIQMYYGLTEYDFYTVLFGVG
RALGCMANITWDRGLGYALERPKSVTTAMLEKWAEAGGRN
>Mature_439_residues
ALKETLKQKIEEHRPRTTRLVKEFGKVKIDEVTIDQCIGGARDIRSLVTDISYLDPQEGIRFRGKTIPETFAALPKAPGS
NYPTVESFWYMLLTGDVPTEAQVAEVVAEWKTRQEVPQYVFDVLRALPRDSHPMVMLSVAMLTLQKDSKFAGFYNSGKFN
KMTAWEYVYEDASDIVARIPIIAAFIYNLKYRGDKQIAIDPSLDMGANFAHMIGQKEEYKDVARMYFILHSDHESGNVSA
HTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLDWTLKFQEKYCKDVEPTEELIKAALWDTLNAGQVIPGYGHAVL
RKTDPRYTSQREFCLNTPGLKDYPLFKVIAKIFEVAPGVLTEHGKTKNPWPNVDAQSGVIQMYYGLTEYDFYTVLFGVGR
ALGCMANITWDRGLGYALERPKSVTTAMLEKWAEAGGRN

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=436, Percent_Identity=48.8532110091743, Blast_Score=438, Evalue=1e-123,
Organism=Escherichia coli, GI1786939, Length=403, Percent_Identity=28.287841191067, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786527, Length=334, Percent_Identity=25.1497005988024, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17555174, Length=441, Percent_Identity=49.6598639455782, Blast_Score=438, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6324328, Length=439, Percent_Identity=52.1640091116173, Blast_Score=463, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319850, Length=437, Percent_Identity=51.0297482837529, Blast_Score=450, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6325257, Length=461, Percent_Identity=39.4793926247288, Blast_Score=329, Evalue=5e-91,
Organism=Drosophila melanogaster, GI24640124, Length=436, Percent_Identity=51.3761467889908, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24640126, Length=436, Percent_Identity=51.3761467889908, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI21356863, Length=435, Percent_Identity=41.8390804597701, Blast_Score=347, Evalue=6e-96,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 49533; Mature: 49402

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKETLKQKIEEHRPRTTRLVKEFGKVKIDEVTIDQCIGGARDIRSLVTDISYLDPQEG
CCHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEEEHHHHCCCHHHHHHHHHHHHHCCHHHC
IRFRGKTIPETFAALPKAPGSNYPTVESFWYMLLTGDVPTEAQVAEVVAEWKTRQEVPQY
CEECCCCCHHHHHHCCCCCCCCCCCHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VFDVLRALPRDSHPMVMLSVAMLTLQKDSKFAGFYNSGKFNKMTAWEYVYEDASDIVARI
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
PIIAAFIYNLKYRGDKQIAIDPSLDMGANFAHMIGQKEEYKDVARMYFILHSDHESGNVS
HHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC
AHTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLDWTLKFQEKYCKDVEPTEELIK
HHHHHHHHHHHCCCCEEHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
AALWDTLNAGQVIPGYGHAVLRKTDPRYTSQREFCLNTPGLKDYPLFKVIAKIFEVAPGV
HHHHHCCCCCCCCCCCCCHHEECCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCH
LTEHGKTKNPWPNVDAQSGVIQMYYGLTEYDFYTVLFGVGRALGCMANITWDRGLGYALE
HHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHC
RPKSVTTAMLEKWAEAGGRN
CCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALKETLKQKIEEHRPRTTRLVKEFGKVKIDEVTIDQCIGGARDIRSLVTDISYLDPQEG
CHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEEEHHHHCCCHHHHHHHHHHHHHCCHHHC
IRFRGKTIPETFAALPKAPGSNYPTVESFWYMLLTGDVPTEAQVAEVVAEWKTRQEVPQY
CEECCCCCHHHHHHCCCCCCCCCCCHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VFDVLRALPRDSHPMVMLSVAMLTLQKDSKFAGFYNSGKFNKMTAWEYVYEDASDIVARI
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
PIIAAFIYNLKYRGDKQIAIDPSLDMGANFAHMIGQKEEYKDVARMYFILHSDHESGNVS
HHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC
AHTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLDWTLKFQEKYCKDVEPTEELIK
HHHHHHHHHHHCCCCEEHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
AALWDTLNAGQVIPGYGHAVLRKTDPRYTSQREFCLNTPGLKDYPLFKVIAKIFEVAPGV
HHHHHCCCCCCCCCCCCCHHEECCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCH
LTEHGKTKNPWPNVDAQSGVIQMYYGLTEYDFYTVLFGVGRALGCMANITWDRGLGYALE
HHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHC
RPKSVTTAMLEKWAEAGGRN
CCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]