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The map label for this gene is ribBA [H]

Identifier: 189424354

GI number: 189424354

Start: 1337405

End: 1338607

Strand: Reverse

Name: ribBA [H]

Synonym: Glov_1289

Alternate gene names: 189424354

Gene position: 1338607-1337405 (Counterclockwise)

Preceding gene: 189424355

Following gene: 189424353

Centisome position: 34.17

GC content: 60.6

Gene sequence:

>1203_bases
ATGGTGCCATGTAGCAATATTAGGGCAGCAATAAAGGATATCCGCAACGGCAGAATGGTTATTCTGGTTGATGATGAAGA
TCGGGAGAACGAAGGCGATCTGACCATGGCAGCCGAGCATGTCACCCCGGAGGCGATCAATTTCATGGCCAAGTATGGCC
GCGGCCTGATCTGCCTGACCCTGACCGAAGAGCGCTGTGACCAGCTTGAGCTGCCGCCCATGGTTTCAGAGAACAACTCA
CCATTCCAGACCGCCTTTACGGTTTCCATTGAGGCCCGCCATGGAGTGACCACCGGCATCTCGGCAGCAGACCGGGCCCA
GACCATCCTGACCGCGATTGCCGACAATACCGGGCCGGAGGATCTCTCCCGCCCCGGCCATATCTTTCCGCTGCGTGCAC
GGGCCGGCGGGGTGCTGGTACGCACCGGCCAGACTGAAGGTTCGGTGGATCTGGCCCGTCTGGCCGGGCTGAAACCGGCC
GGGGTAATCTGCGAGATCATGAACGAGGACGGCAGCATGGCCCGCATGCCGCAGTTGAGGGAGTTTGCCCTGCGGCACGG
CATCCGGATCTGCTCGGTGGCCGATCTGGTGGCCTACCGGCTGAAGCATGAATCACTGGTGCGACCGGTGGCGGAGGCAA
AGCTGCCCACCTGGGCCGGCAAATTCCGCGTGGTTGCCTTTGAGAATGATATTGACGGCCTGGAGCATATCGCCCTGGTC
AAGGGAGAGATCAGGCCGGACGAGCCGGTGCTGGTCAGGGTGCATTCGGAGTGTCTGACCAGTGACGTATTCGGCAGCAT
CCGCTGTGACTGCGGCGGACAGCTCAGCCGGGCCATGGACCGCATTGAACAGGAAGGCGCAGGCATCCTGTTGTACATGC
GGCAGGAAGGCAGGGGGATCGGCCTGATCAACAAGCTCAAGGCCTATGAACTGCAGGATCAGGGCTGCGATACCGTTGAG
GCCAACGAGGCGCTGGGATTCAAGGCCGATCTGCGGGATTACGGCATTGGCGCCCAGATGCTCAGGGCGCTGGGAGCCAG
AAAGATCCGCCTGATGACCAACAACCCCAAGAAGATGATCGGACTGGAGGGGTATGGCCTGAATATTGTTGAGCGGGTAC
CGATCGAGATGAAGGCGTTAAGCACCAACATGCGCTACCTGCAGACCAAGCGCGACAAGCTCGGGCACCTGCTGGCTGCC
TGA

Upstream 100 bases:

>100_bases
CCGGAGTAATAACCCCTTAACTAGATAGCGTCTTTGGCCAAGGCAATTAACTTACTGTGCAGTAGAGCATTCATTAAATT
CGGGCAAAGGAACAATATTC

Downstream 100 bases:

>100_bases
GCAAGAGGAGAACAGATCATGTCTTCTTACAGCCCACTCAATACCTTCGGTTATGTTGCAACACAGCATCTCATGCCGTA
TGACAGCCGGCAGGCCAGGT

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MVPCSNIRAAIKDIRNGRMVILVDDEDRENEGDLTMAAEHVTPEAINFMAKYGRGLICLTLTEERCDQLELPPMVSENNS
PFQTAFTVSIEARHGVTTGISAADRAQTILTAIADNTGPEDLSRPGHIFPLRARAGGVLVRTGQTEGSVDLARLAGLKPA
GVICEIMNEDGSMARMPQLREFALRHGIRICSVADLVAYRLKHESLVRPVAEAKLPTWAGKFRVVAFENDIDGLEHIALV
KGEIRPDEPVLVRVHSECLTSDVFGSIRCDCGGQLSRAMDRIEQEGAGILLYMRQEGRGIGLINKLKAYELQDQGCDTVE
ANEALGFKADLRDYGIGAQMLRALGARKIRLMTNNPKKMIGLEGYGLNIVERVPIEMKALSTNMRYLQTKRDKLGHLLAA

Sequences:

>Translated_400_residues
MVPCSNIRAAIKDIRNGRMVILVDDEDRENEGDLTMAAEHVTPEAINFMAKYGRGLICLTLTEERCDQLELPPMVSENNS
PFQTAFTVSIEARHGVTTGISAADRAQTILTAIADNTGPEDLSRPGHIFPLRARAGGVLVRTGQTEGSVDLARLAGLKPA
GVICEIMNEDGSMARMPQLREFALRHGIRICSVADLVAYRLKHESLVRPVAEAKLPTWAGKFRVVAFENDIDGLEHIALV
KGEIRPDEPVLVRVHSECLTSDVFGSIRCDCGGQLSRAMDRIEQEGAGILLYMRQEGRGIGLINKLKAYELQDQGCDTVE
ANEALGFKADLRDYGIGAQMLRALGARKIRLMTNNPKKMIGLEGYGLNIVERVPIEMKALSTNMRYLQTKRDKLGHLLAA
>Mature_400_residues
MVPCSNIRAAIKDIRNGRMVILVDDEDRENEGDLTMAAEHVTPEAINFMAKYGRGLICLTLTEERCDQLELPPMVSENNS
PFQTAFTVSIEARHGVTTGISAADRAQTILTAIADNTGPEDLSRPGHIFPLRARAGGVLVRTGQTEGSVDLARLAGLKPA
GVICEIMNEDGSMARMPQLREFALRHGIRICSVADLVAYRLKHESLVRPVAEAKLPTWAGKFRVVAFENDIDGLEHIALV
KGEIRPDEPVLVRVHSECLTSDVFGSIRCDCGGQLSRAMDRIEQEGAGILLYMRQEGRGIGLINKLKAYELQDQGCDTVE
ANEALGFKADLRDYGIGAQMLRALGARKIRLMTNNPKKMIGLEGYGLNIVERVPIEMKALSTNMRYLQTKRDKLGHLLAA

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=203, Percent_Identity=53.6945812807882, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI1787533, Length=192, Percent_Identity=57.2916666666667, Blast_Score=216, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=39.7058823529412, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=42.6900584795322, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 43931; Mature: 43931

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPCSNIRAAIKDIRNGRMVILVDDEDRENEGDLTMAAEHVTPEAINFMAKYGRGLICLT
CCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEHHCCHHHHHHHHHHCCCEEEEE
LTEERCDQLELPPMVSENNSPFQTAFTVSIEARHGVTTGISAADRAQTILTAIADNTGPE
ECHHHCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHH
DLSRPGHIFPLRARAGGVLVRTGQTEGSVDLARLAGLKPAGVICEIMNEDGSMARMPQLR
HHCCCCCEEEEEECCCEEEEEECCCCCCCHHHHHCCCCCCCEEEEEECCCCCCHHCHHHH
EFALRHGIRICSVADLVAYRLKHESLVRPVAEAKLPTWAGKFRVVAFENDIDGLEHIALV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHEEEEE
KGEIRPDEPVLVRVHSECLTSDVFGSIRCDCGGQLSRAMDRIEQEGAGILLYMRQEGRGI
ECCCCCCCCEEEEECHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCC
GLINKLKAYELQDQGCDTVEANEALGFKADLRDYGIGAQMLRALGARKIRLMTNNPKKMI
CHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHCCCCEEEEEECCCCCEE
GLEGYGLNIVERVPIEMKALSTNMRYLQTKRDKLGHLLAA
EECCCCCCEEEECCEEEEHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVPCSNIRAAIKDIRNGRMVILVDDEDRENEGDLTMAAEHVTPEAINFMAKYGRGLICLT
CCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEHHCCHHHHHHHHHHCCCEEEEE
LTEERCDQLELPPMVSENNSPFQTAFTVSIEARHGVTTGISAADRAQTILTAIADNTGPE
ECHHHCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHH
DLSRPGHIFPLRARAGGVLVRTGQTEGSVDLARLAGLKPAGVICEIMNEDGSMARMPQLR
HHCCCCCEEEEEECCCEEEEEECCCCCCCHHHHHCCCCCCCEEEEEECCCCCCHHCHHHH
EFALRHGIRICSVADLVAYRLKHESLVRPVAEAKLPTWAGKFRVVAFENDIDGLEHIALV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHEEEEE
KGEIRPDEPVLVRVHSECLTSDVFGSIRCDCGGQLSRAMDRIEQEGAGILLYMRQEGRGI
ECCCCCCCCEEEEECHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCC
GLINKLKAYELQDQGCDTVEANEALGFKADLRDYGIGAQMLRALGARKIRLMTNNPKKMI
CHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHCCCCEEEEEECCCCCEE
GLEGYGLNIVERVPIEMKALSTNMRYLQTKRDKLGHLLAA
EECCCCCCEEEECCEEEEHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]