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The map label for this gene is lexA1 [H]

Identifier: 189424297

GI number: 189424297

Start: 1277307

End: 1277936

Strand: Reverse

Name: lexA1 [H]

Synonym: Glov_1232

Alternate gene names: 189424297

Gene position: 1277936-1277307 (Counterclockwise)

Preceding gene: 189424299

Following gene: 189424296

Centisome position: 32.62

GC content: 57.94

Gene sequence:

>630_bases
ATGAATACCTATGAAGGCAAACCCCGACAAGAACTGACTCAGCGCCAGAAGCAGGTGCTGCAGTTCATTACGTCATACAC
GGATGACAACGGCTTTCCGCCCAGCCAGCGCGAGATCGCCCGTCACCTGAATGTCTCGGGCACACTGCCGGTCATGAAGC
ATCTCGGGGCATTGGAGCGCAAAGGGTACATCAAGCGGGAGAGTGTCAACCGGGGCATCGCTCTGGTGCGGCCGGCCAAC
CGTTCAGTATCTCTGCCGGTGGTCGGTGTCGTGCGTGCAGGGCACCTTGCCCCTGCGATTGAAGATATTCAGGGGCACTT
CGCGGTGGATCCGATGGCGGTCAAAGGAGATGACTGCTTCTTTCTGCGGGTAAGTGGCGATTCCATGATCAATGCAGGCA
TCCTGGACGGCGATCTGGCAATGGTGCGGCCGCAGCAGACTGCCGGCAACAAAGATACCGTGGTTGCCATGATTGATGGT
GAGGTGACGCTGAAATGGTTCTACCGGGAACGGGACCACATCCGGCTGCAACCGGCAAACCCGAACATGGAACCGATCAT
TATCCGTCCGGAGGATGGCGAACTGAGCATAGTCGGCAAGGTAATCGGCGTGTACCGCCGGATGAACTGA

Upstream 100 bases:

>100_bases
CAGCCCGTTTCCGGCTCTTCTCAACAATCCCGGCGGCTTGCCCATCGCGTACAGCTCATTTTGGTATTGACATCCGTATA
AAATCATATATGGTAGTCAT

Downstream 100 bases:

>100_bases
CCCAAGAAACCAACAAACCTTTCAGGAGCGTGAACAATGGAACCGATCGTCTTATTTGGGGTAGTGATACTTGTTTTTGG
ATTATGGCTGGAGTTTGAAC

Product: transcriptional repressor, LexA family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MNTYEGKPRQELTQRQKQVLQFITSYTDDNGFPPSQREIARHLNVSGTLPVMKHLGALERKGYIKRESVNRGIALVRPAN
RSVSLPVVGVVRAGHLAPAIEDIQGHFAVDPMAVKGDDCFFLRVSGDSMINAGILDGDLAMVRPQQTAGNKDTVVAMIDG
EVTLKWFYRERDHIRLQPANPNMEPIIIRPEDGELSIVGKVIGVYRRMN

Sequences:

>Translated_209_residues
MNTYEGKPRQELTQRQKQVLQFITSYTDDNGFPPSQREIARHLNVSGTLPVMKHLGALERKGYIKRESVNRGIALVRPAN
RSVSLPVVGVVRAGHLAPAIEDIQGHFAVDPMAVKGDDCFFLRVSGDSMINAGILDGDLAMVRPQQTAGNKDTVVAMIDG
EVTLKWFYRERDHIRLQPANPNMEPIIIRPEDGELSIVGKVIGVYRRMN
>Mature_209_residues
MNTYEGKPRQELTQRQKQVLQFITSYTDDNGFPPSQREIARHLNVSGTLPVMKHLGALERKGYIKRESVNRGIALVRPAN
RSVSLPVVGVVRAGHLAPAIEDIQGHFAVDPMAVKGDDCFFLRVSGDSMINAGILDGDLAMVRPQQTAGNKDTVVAMIDG
EVTLKWFYRERDHIRLQPANPNMEPIIIRPEDGELSIVGKVIGVYRRMN

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=196, Percent_Identity=39.2857142857143, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1787431, Length=138, Percent_Identity=34.0579710144928, Blast_Score=71, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23300; Mature: 23300

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTYEGKPRQELTQRQKQVLQFITSYTDDNGFPPSQREIARHLNVSGTLPVMKHLGALER
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHCCHHHH
KGYIKRESVNRGIALVRPANRSVSLPVVGVVRAGHLAPAIEDIQGHFAVDPMAVKGDDCF
CCCEEECCCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHCCCEEECCEEECCCCEE
FLRVSGDSMINAGILDGDLAMVRPQQTAGNKDTVVAMIDGEVTLKWFYRERDHIRLQPAN
EEEECCCCEEECCEECCCEEEECCCCCCCCCCEEEEEECCCEEEEEEEECCCEEEEECCC
PNMEPIIIRPEDGELSIVGKVIGVYRRMN
CCCCEEEEECCCCCEEEHHHHHHHHHCCC
>Mature Secondary Structure
MNTYEGKPRQELTQRQKQVLQFITSYTDDNGFPPSQREIARHLNVSGTLPVMKHLGALER
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHCCHHHH
KGYIKRESVNRGIALVRPANRSVSLPVVGVVRAGHLAPAIEDIQGHFAVDPMAVKGDDCF
CCCEEECCCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHCCCEEECCEEECCCCEE
FLRVSGDSMINAGILDGDLAMVRPQQTAGNKDTVVAMIDGEVTLKWFYRERDHIRLQPAN
EEEECCCCEEECCEECCCEEEECCCCCCCCCCEEEEEECCCEEEEEEEECCCEEEEECCC
PNMEPIIIRPEDGELSIVGKVIGVYRRMN
CCCCEEEEECCCCCEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA