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The map label for this gene is hisG

Identifier: 189424184

GI number: 189424184

Start: 1174095

End: 1174970

Strand: Reverse

Name: hisG

Synonym: Glov_1119

Alternate gene names: 189424184

Gene position: 1174970-1174095 (Counterclockwise)

Preceding gene: 189424185

Following gene: 189424178

Centisome position: 29.99

GC content: 58.22

Gene sequence:

>876_bases
ATGAGCACCGTACTACGTTTCGGTATCCCTAAAGGAAGTCTGGAAGAGGCCACGGTCGATCTGTTCAAACAGGCCGGCTG
GCAGATCGGCATCTCTTCCCGCAGCTACTTCCCCACCGTTGATGACGGCGAGATGAAATGCCACCTGATCCGGCCGCAGG
AGATGGGCAAATATGTGGAGCGCGGCACCATTGATGTAGGAATTGCAGGCCGTGACTGGATTCGTGAAAACGACTCCGAT
GTGGTGGAAGTCTGCGAGATGGTCTACTCAAAAGTCTCCCGCCGCCCGGTGCGCTGGGTGCTGGTGGTGGCTCAGGACTC
ACCGGTTCAGGGACCGGAAGACCTGCAGGGTGCCACCATCTCCACTGAGCTGGTGGAGTTTACCAAGCGCTACTTCAAGG
AGCGCAACATCCAGGTCAATGTCGAATTTTCCTGGGGCGCCACCGAAGCCAAAGTGGTTGACGGCCTCTGTGATGCCATT
GTTGAGGTCACCGAGACCGGCTCCACAATCCGGGCCAATAACCTGCGGATCGTCTGTGACCTGATGGAATCGGTGCCGGT
CATGGTGGCCAACAAGGCCGCCTGGGAAGACCCCTGGAAACGGGCCAAGATTGAGCAGATTGCAACCCTGCTCAATTCCG
CCCTGCGGGCCGAGGGGATGGTCGGCCTGAAACTGAATGCCCCGGCTGAAAAGGTTGAAGCGATCACCGGCATCCTGCCT
AGCCAGAAGGCGCCCACCGTTGCCCACCTCTACAAATCAGACTGGGTTTCGATTGAGAGCATCCTGCCTGAAAAAGAGGT
GCGCCGGATCGTACCGGAACTGCTGCGCCTGGGGGCCGAGGGGATCATTGAATACCCGTTGAGCAAGATCATCTGA

Upstream 100 bases:

>100_bases
GCCACACCGGCAACCGCAGCTGTTTCTATGTCAAGTGGGAGGATGGTCAGTGGGTCGAGCATTCCAACCCGCTCTTCAAC
CCCGAGGAGGTTTACAAGAA

Downstream 100 bases:

>100_bases
TACCCTGTGAAACAATCAAGCCCACATCATGCCCTCCCCGAAGCCATGATGTGGGCTTTTTAGCCATTATGGCCGGATAA
CGGTGAGTTTCAGATAGTAG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSTVLRFGIPKGSLEEATVDLFKQAGWQIGISSRSYFPTVDDGEMKCHLIRPQEMGKYVERGTIDVGIAGRDWIRENDSD
VVEVCEMVYSKVSRRPVRWVLVVAQDSPVQGPEDLQGATISTELVEFTKRYFKERNIQVNVEFSWGATEAKVVDGLCDAI
VEVTETGSTIRANNLRIVCDLMESVPVMVANKAAWEDPWKRAKIEQIATLLNSALRAEGMVGLKLNAPAEKVEAITGILP
SQKAPTVAHLYKSDWVSIESILPEKEVRRIVPELLRLGAEGIIEYPLSKII

Sequences:

>Translated_291_residues
MSTVLRFGIPKGSLEEATVDLFKQAGWQIGISSRSYFPTVDDGEMKCHLIRPQEMGKYVERGTIDVGIAGRDWIRENDSD
VVEVCEMVYSKVSRRPVRWVLVVAQDSPVQGPEDLQGATISTELVEFTKRYFKERNIQVNVEFSWGATEAKVVDGLCDAI
VEVTETGSTIRANNLRIVCDLMESVPVMVANKAAWEDPWKRAKIEQIATLLNSALRAEGMVGLKLNAPAEKVEAITGILP
SQKAPTVAHLYKSDWVSIESILPEKEVRRIVPELLRLGAEGIIEYPLSKII
>Mature_290_residues
STVLRFGIPKGSLEEATVDLFKQAGWQIGISSRSYFPTVDDGEMKCHLIRPQEMGKYVERGTIDVGIAGRDWIRENDSDV
VEVCEMVYSKVSRRPVRWVLVVAQDSPVQGPEDLQGATISTELVEFTKRYFKERNIQVNVEFSWGATEAKVVDGLCDAIV
EVTETGSTIRANNLRIVCDLMESVPVMVANKAAWEDPWKRAKIEQIATLLNSALRAEGMVGLKLNAPAEKVEAITGILPS
QKAPTVAHLYKSDWVSIESILPEKEVRRIVPELLRLGAEGIIEYPLSKII

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=296, Percent_Identity=23.3108108108108, Blast_Score=82, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320896, Length=291, Percent_Identity=25.4295532646048, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_GEOLS (B3E6L6)

Other databases:

- EMBL:   CP001089
- RefSeq:   YP_001951361.1
- ProteinModelPortal:   B3E6L6
- SMR:   B3E6L6
- GeneID:   6367657
- GenomeReviews:   CP001089_GR
- KEGG:   glo:Glov_1119
- HOGENOM:   HBG391868
- OMA:   SWGATEA
- ProtClustDB:   PRK00489
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 32414; Mature: 32283

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVLRFGIPKGSLEEATVDLFKQAGWQIGISSRSYFPTVDDGEMKCHLIRPQEMGKYVE
CCCCEECCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEEECHHHHHHHHH
RGTIDVGIAGRDWIRENDSDVVEVCEMVYSKVSRRPVRWVLVVAQDSPVQGPEDLQGATI
CCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHCCCCCH
STELVEFTKRYFKERNIQVNVEFSWGATEAKVVDGLCDAIVEVTETGSTIRANNLRIVCD
HHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEECCEEEEEE
LMESVPVMVANKAAWEDPWKRAKIEQIATLLNSALRAEGMVGLKLNAPAEKVEAITGILP
HHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCC
SQKAPTVAHLYKSDWVSIESILPEKEVRRIVPELLRLGAEGIIEYPLSKII
CCCCCHHHHHHHHCCEEHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHCC
>Mature Secondary Structure 
STVLRFGIPKGSLEEATVDLFKQAGWQIGISSRSYFPTVDDGEMKCHLIRPQEMGKYVE
CCCEECCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEEECHHHHHHHHH
RGTIDVGIAGRDWIRENDSDVVEVCEMVYSKVSRRPVRWVLVVAQDSPVQGPEDLQGATI
CCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHCCCCCH
STELVEFTKRYFKERNIQVNVEFSWGATEAKVVDGLCDAIVEVTETGSTIRANNLRIVCD
HHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEECCEEEEEE
LMESVPVMVANKAAWEDPWKRAKIEQIATLLNSALRAEGMVGLKLNAPAEKVEAITGILP
HHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCC
SQKAPTVAHLYKSDWVSIESILPEKEVRRIVPELLRLGAEGIIEYPLSKII
CCCCCHHHHHHHHCCEEHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA