Click here to switch to the map view.

The map label for this gene is ribBA [H]

Identifier: 189423948

GI number: 189423948

Start: 907542

End: 908741

Strand: Reverse

Name: ribBA [H]

Synonym: Glov_0881

Alternate gene names: 189423948

Gene position: 908741-907542 (Counterclockwise)

Preceding gene: 189423949

Following gene: 189423947

Centisome position: 23.2

GC content: 61.08

Gene sequence:

>1200_bases
ATGGCACGATCCTCCATAGAACAGGCGATCAGGGATATCCGCAACGGCAGGATGGTTATTCTGGTTGACGATGAAGATCG
GGAAAACGAAGGCGATCTGACCATGGCAGCCGAGCATGTCACCCCGGAGGCGATCAATTTCATGGCCAAGTATGGCCGCG
GCCTGATCTGCCTGACCCTGACCGAAGAGCGCTGTGACCAGCTTGAGCTGCCGCCCATGGTTTCAGAGAACAACTCACCA
TTCCAGACCGCCTTTACGGTTTCCATTGAGGCCCGCCATGGAGTGACCACCGGCATCTCGGCAGCAGACCGGGCCCAGAC
CATCCTGACCGCGATTGCCGACAATACCGGGCCGGAGGATCTCTCCCGCCCCGGCCATATCTTTCCGCTGCGTGCACGGG
CCGGCGGGGTGCTGGTACGCACCGGCCAGACTGAAGGTTCGGTGGATCTGGCCCGTCTGGCCGGGCTGAAACCGGCCGGG
GTAATCTGCGAGATCATGAACGAGGACGGCAGCATGGCCCGCATGCCGCAGTTGAGGGAGTTTGCCCTGCGGCACGGCAT
CCGGATCTGCTCGGTGGCCGATCTGGTGGCCTACCGGCTGAAGCATGAATCACTGGTGCGACCGGTGGCGGAGGCAAAGC
TGCCCACCTGGGCCGGCAAATTCCGCGTGGTTGCCTTTGAGAATGATATTGACGGCCTGGAGCATATCGCCCTGGTCAAG
GGAGAGATCAGGCCGGACGAGCCGGTGCTGGTCAGGGTGCATTCGGAGTGTCTGACCAGTGACGTATTCGGCAGCATCCG
CTGTGACTGCGGCGGACAGCTCAGCCGGGCCATGGACCGCATTGAACAGGAAGGCGCAGGCATCCTGTTGTACATGCGGC
AGGAAGGCAGGGGGATCGGCCTGATCAACAAGCTCAAGGCCTATGAACTGCAGGATCAGGGCTGCGATACCGTTGAGGCC
AACGAGGCGCTGGGATTCAAGGCCGATCTGCGGGATTACGGCATTGGCGCCCAGATGCTCAGGGCGCTGGGAGCCAGAAA
GATCCGCCTGATGACCAACAACCCCAAGAAGATGATCGGACTGGAGGGGTATGGCCTGAATATTGTTGAGCGGGTACCGA
TCGAGATGAAGGCGTTAAGCACCAACATGCGCTACCTGCAGACCAAGCGCGACAAGCTCGGGCACCTGCTGGCTGCCTGA

Upstream 100 bases:

>100_bases
GAGCATCCTCCTTAGGTGGTGCAATGGGGGGAGAGCGATCTCCCCCAATTTTTCAGCAGACACCAGTTCTCTTCAGTCAC
AGGCAAAGGAGTACAGAGCG

Downstream 100 bases:

>100_bases
GCAAGAGGAGAACAGATCATGTCTTCTTACAGCCCACTCAATACCTTCGGTTATGTTGCAACACAGCATCTCATGCCGTA
TGACAGCCGGCAGGCCAGGT

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MARSSIEQAIRDIRNGRMVILVDDEDRENEGDLTMAAEHVTPEAINFMAKYGRGLICLTLTEERCDQLELPPMVSENNSP
FQTAFTVSIEARHGVTTGISAADRAQTILTAIADNTGPEDLSRPGHIFPLRARAGGVLVRTGQTEGSVDLARLAGLKPAG
VICEIMNEDGSMARMPQLREFALRHGIRICSVADLVAYRLKHESLVRPVAEAKLPTWAGKFRVVAFENDIDGLEHIALVK
GEIRPDEPVLVRVHSECLTSDVFGSIRCDCGGQLSRAMDRIEQEGAGILLYMRQEGRGIGLINKLKAYELQDQGCDTVEA
NEALGFKADLRDYGIGAQMLRALGARKIRLMTNNPKKMIGLEGYGLNIVERVPIEMKALSTNMRYLQTKRDKLGHLLAA

Sequences:

>Translated_399_residues
MARSSIEQAIRDIRNGRMVILVDDEDRENEGDLTMAAEHVTPEAINFMAKYGRGLICLTLTEERCDQLELPPMVSENNSP
FQTAFTVSIEARHGVTTGISAADRAQTILTAIADNTGPEDLSRPGHIFPLRARAGGVLVRTGQTEGSVDLARLAGLKPAG
VICEIMNEDGSMARMPQLREFALRHGIRICSVADLVAYRLKHESLVRPVAEAKLPTWAGKFRVVAFENDIDGLEHIALVK
GEIRPDEPVLVRVHSECLTSDVFGSIRCDCGGQLSRAMDRIEQEGAGILLYMRQEGRGIGLINKLKAYELQDQGCDTVEA
NEALGFKADLRDYGIGAQMLRALGARKIRLMTNNPKKMIGLEGYGLNIVERVPIEMKALSTNMRYLQTKRDKLGHLLAA
>Mature_398_residues
ARSSIEQAIRDIRNGRMVILVDDEDRENEGDLTMAAEHVTPEAINFMAKYGRGLICLTLTEERCDQLELPPMVSENNSPF
QTAFTVSIEARHGVTTGISAADRAQTILTAIADNTGPEDLSRPGHIFPLRARAGGVLVRTGQTEGSVDLARLAGLKPAGV
ICEIMNEDGSMARMPQLREFALRHGIRICSVADLVAYRLKHESLVRPVAEAKLPTWAGKFRVVAFENDIDGLEHIALVKG
EIRPDEPVLVRVHSECLTSDVFGSIRCDCGGQLSRAMDRIEQEGAGILLYMRQEGRGIGLINKLKAYELQDQGCDTVEAN
EALGFKADLRDYGIGAQMLRALGARKIRLMTNNPKKMIGLEGYGLNIVERVPIEMKALSTNMRYLQTKRDKLGHLLAA

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=198, Percent_Identity=55.0505050505051, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1787533, Length=192, Percent_Identity=57.2916666666667, Blast_Score=216, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=39.8058252427184, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=42.6900584795322, Blast_Score=122, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 43890; Mature: 43759

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARSSIEQAIRDIRNGRMVILVDDEDRENEGDLTMAAEHVTPEAINFMAKYGRGLICLTL
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEHHCCHHHHHHHHHHCCCEEEEEE
TEERCDQLELPPMVSENNSPFQTAFTVSIEARHGVTTGISAADRAQTILTAIADNTGPED
CHHHCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHH
LSRPGHIFPLRARAGGVLVRTGQTEGSVDLARLAGLKPAGVICEIMNEDGSMARMPQLRE
HCCCCCEEEEEECCCEEEEEECCCCCCCHHHHHCCCCCCCEEEEEECCCCCCHHCHHHHH
FALRHGIRICSVADLVAYRLKHESLVRPVAEAKLPTWAGKFRVVAFENDIDGLEHIALVK
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHEEEEEE
GEIRPDEPVLVRVHSECLTSDVFGSIRCDCGGQLSRAMDRIEQEGAGILLYMRQEGRGIG
CCCCCCCCEEEEECHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCC
LINKLKAYELQDQGCDTVEANEALGFKADLRDYGIGAQMLRALGARKIRLMTNNPKKMIG
HHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHCCCCEEEEEECCCCCEEE
LEGYGLNIVERVPIEMKALSTNMRYLQTKRDKLGHLLAA
ECCCCCCEEEECCEEEEHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARSSIEQAIRDIRNGRMVILVDDEDRENEGDLTMAAEHVTPEAINFMAKYGRGLICLTL
CHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEHHCCHHHHHHHHHHCCCEEEEEE
TEERCDQLELPPMVSENNSPFQTAFTVSIEARHGVTTGISAADRAQTILTAIADNTGPED
CHHHCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHH
LSRPGHIFPLRARAGGVLVRTGQTEGSVDLARLAGLKPAGVICEIMNEDGSMARMPQLRE
HCCCCCEEEEEECCCEEEEEECCCCCCCHHHHHCCCCCCCEEEEEECCCCCCHHCHHHHH
FALRHGIRICSVADLVAYRLKHESLVRPVAEAKLPTWAGKFRVVAFENDIDGLEHIALVK
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHEEEEEE
GEIRPDEPVLVRVHSECLTSDVFGSIRCDCGGQLSRAMDRIEQEGAGILLYMRQEGRGIG
CCCCCCCCEEEEECHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCC
LINKLKAYELQDQGCDTVEANEALGFKADLRDYGIGAQMLRALGARKIRLMTNNPKKMIG
HHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHCCCCEEEEEECCCCCEEE
LEGYGLNIVERVPIEMKALSTNMRYLQTKRDKLGHLLAA
ECCCCCCEEEECCEEEEHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]