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The map label for this gene is pmrA [H]

Identifier: 189423946

GI number: 189423946

Start: 905896

End: 907083

Strand: Reverse

Name: pmrA [H]

Synonym: Glov_0879

Alternate gene names: 189423946

Gene position: 907083-905896 (Counterclockwise)

Preceding gene: 189423947

Following gene: 189423941

Centisome position: 23.15

GC content: 62.12

Gene sequence:

>1188_bases
ATGAACGGGCAGCACCGGAATCTGTTCAGGGTGTTGTTTCTGATCAATTTCCTGATCTCGCTGGGGTTCGGTGTCAGCGA
CGCCTTTTTTCCGCTCTACTGCCAGAGCATCGGAGCCCGAGGGCTGCTGCTGGGGGTGGCGGTTGGCGGCTATGCGCTGT
CAAAGATCATCTTCAGCCCGATCATGGGATCGCTGGCAGACCGCTTTGGGCGGCGGCAGCTGGTTATCACCAGCCTGCTG
GTCTACCTGCTGGTCTCCTGCAGTTACCTGGTAACCGAAAACCTGGTGGTGGTGGTCTCTCTGCGCCTGCTGCAAGGGGC
CGGTTGCGCCATGTTCCGGCCGGTGGTGCAGACACTGATTGCCGATCATGCCAGCAGCAGGCAGTGGGGCAAGGCGATGG
GCAGCTTTGATATCTCCTTCTACGCCGCGCTCAGCAGCGGCCCGCTGATCGGCGGGATCATCATGGACCAGGCAGGCTTT
CACGGCCTGTTCGGCGTCCTGATTATCTGCAGCATGGCCGCATTGGGGCTGGCCCTTGCTGCGATCCCGCGACAGCTGCA
ACCGCCCCGCATAGCGCAGGAAGTCTCCGCTCAACCTGGCATCAGGAACATCTGCCGTCAGGGCGGCACGCTGCAGGGGC
TGCTGCTGTTCATCTTCGGCAGGGCCTGCGGCATCACGGCCTGCGGAACGTTTCTGCCGATCCTGCTTTCATCAAAACTG
GGGATGAGCGGGGTACAGGTGGGAATCATCATGGCCTCGGCCACCCTGATCATGACGTTGCTGCTGCGCCCGGCAGGCCG
GATTGCCGACCGGGTGCCCCGCAGGATGCTGGTGATCTGCGGCGGCACGGTGGTGCCATTACTTTACATGCTGCTGCCCG
TTGCAGCCGACTTCATGCAGATGCTCGGTGTGACGCTGGGGATCGGCGCATTCAGCGCCCTCTCGCAGCCGGCCACCAGC
GCCTTGCTGGCTGAGGAGGGACAGCGGCTGGGAATGGGAACCTCGATCGGCACCTTCCATGCCTTCTTAAACCTGGGATT
TGTGGCGGGACCGCTGCTGGGGTCACTGCTGCAGAGTTCGGCAGGACTGCAAGGGGTATTTATCGCCATCGGCCTGATCG
GACTCTGTTCCGTGGCCGGTTTCATCCTGAACAAACCGGTACGGAAACTGACGGTGGCACAGGCCTGA

Upstream 100 bases:

>100_bases
TGCTCAGCCTGCATATCGACAAGCACGACCAGATGCTTGAGCAGTACCTGATCTCCGGCGTTCAGCCGTATCAATGCCAG
CAGTACCAGGAGCTGTACAG

Downstream 100 bases:

>100_bases
AGGCCTGCTGCGCAAGACTTCACACCGGCAAATAATCTCTCGGGCAGACCTTCTTCAGGACTGGTCTGCTATCAGCTGCC
TGGCCAATGCCAGCTCTTCA

Product: major facilitator superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MNGQHRNLFRVLFLINFLISLGFGVSDAFFPLYCQSIGARGLLLGVAVGGYALSKIIFSPIMGSLADRFGRRQLVITSLL
VYLLVSCSYLVTENLVVVVSLRLLQGAGCAMFRPVVQTLIADHASSRQWGKAMGSFDISFYAALSSGPLIGGIIMDQAGF
HGLFGVLIICSMAALGLALAAIPRQLQPPRIAQEVSAQPGIRNICRQGGTLQGLLLFIFGRACGITACGTFLPILLSSKL
GMSGVQVGIIMASATLIMTLLLRPAGRIADRVPRRMLVICGGTVVPLLYMLLPVAADFMQMLGVTLGIGAFSALSQPATS
ALLAEEGQRLGMGTSIGTFHAFLNLGFVAGPLLGSLLQSSAGLQGVFIAIGLIGLCSVAGFILNKPVRKLTVAQA

Sequences:

>Translated_395_residues
MNGQHRNLFRVLFLINFLISLGFGVSDAFFPLYCQSIGARGLLLGVAVGGYALSKIIFSPIMGSLADRFGRRQLVITSLL
VYLLVSCSYLVTENLVVVVSLRLLQGAGCAMFRPVVQTLIADHASSRQWGKAMGSFDISFYAALSSGPLIGGIIMDQAGF
HGLFGVLIICSMAALGLALAAIPRQLQPPRIAQEVSAQPGIRNICRQGGTLQGLLLFIFGRACGITACGTFLPILLSSKL
GMSGVQVGIIMASATLIMTLLLRPAGRIADRVPRRMLVICGGTVVPLLYMLLPVAADFMQMLGVTLGIGAFSALSQPATS
ALLAEEGQRLGMGTSIGTFHAFLNLGFVAGPLLGSLLQSSAGLQGVFIAIGLIGLCSVAGFILNKPVRKLTVAQA
>Mature_395_residues
MNGQHRNLFRVLFLINFLISLGFGVSDAFFPLYCQSIGARGLLLGVAVGGYALSKIIFSPIMGSLADRFGRRQLVITSLL
VYLLVSCSYLVTENLVVVVSLRLLQGAGCAMFRPVVQTLIADHASSRQWGKAMGSFDISFYAALSSGPLIGGIIMDQAGF
HGLFGVLIICSMAALGLALAAIPRQLQPPRIAQEVSAQPGIRNICRQGGTLQGLLLFIFGRACGITACGTFLPILLSSKL
GMSGVQVGIIMASATLIMTLLLRPAGRIADRVPRRMLVICGGTVVPLLYMLLPVAADFMQMLGVTLGIGAFSALSQPATS
ALLAEEGQRLGMGTSIGTFHAFLNLGFVAGPLLGSLLQSSAGLQGVFIAIGLIGLCSVAGFILNKPVRKLTVAQA

Specific function: Efflux pump for various substrates [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI87081738, Length=348, Percent_Identity=25.8620689655172, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1787291, Length=387, Percent_Identity=24.2894056847545, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1; PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 41445; Mature: 41445

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGQHRNLFRVLFLINFLISLGFGVSDAFFPLYCQSIGARGLLLGVAVGGYALSKIIFSP
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IMGSLADRFGRRQLVITSLLVYLLVSCSYLVTENLVVVVSLRLLQGAGCAMFRPVVQTLI
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ADHASSRQWGKAMGSFDISFYAALSSGPLIGGIIMDQAGFHGLFGVLIICSMAALGLALA
HHCCCCHHHHHHHCCCCHHHEEECCCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AIPRQLQPPRIAQEVSAQPGIRNICRQGGTLQGLLLFIFGRACGITACGTFLPILLSSKL
HHHHCCCCCHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCC
GMSGVQVGIIMASATLIMTLLLRPAGRIADRVPRRMLVICGGTVVPLLYMLLPVAADFMQ
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHEEEEECCHHHHHHHHHHHHHHHHHH
MLGVTLGIGAFSALSQPATSALLAEEGQRLGMGTSIGTFHAFLNLGFVAGPLLGSLLQSS
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
AGLQGVFIAIGLIGLCSVAGFILNKPVRKLTVAQA
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
>Mature Secondary Structure
MNGQHRNLFRVLFLINFLISLGFGVSDAFFPLYCQSIGARGLLLGVAVGGYALSKIIFSP
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IMGSLADRFGRRQLVITSLLVYLLVSCSYLVTENLVVVVSLRLLQGAGCAMFRPVVQTLI
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ADHASSRQWGKAMGSFDISFYAALSSGPLIGGIIMDQAGFHGLFGVLIICSMAALGLALA
HHCCCCHHHHHHHCCCCHHHEEECCCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AIPRQLQPPRIAQEVSAQPGIRNICRQGGTLQGLLLFIFGRACGITACGTFLPILLSSKL
HHHHCCCCCHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCC
GMSGVQVGIIMASATLIMTLLLRPAGRIADRVPRRMLVICGGTVVPLLYMLLPVAADFMQ
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHEEEEECCHHHHHHHHHHHHHHHHHH
MLGVTLGIGAFSALSQPATSALLAEEGQRLGMGTSIGTFHAFLNLGFVAGPLLGSLLQSS
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
AGLQGVFIAIGLIGLCSVAGFILNKPVRKLTVAQA
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9869592; 11463916 [H]