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The map label for this gene is rmlA1 [H]

Identifier: 189423549

GI number: 189423549

Start: 453627

End: 454508

Strand: Reverse

Name: rmlA1 [H]

Synonym: Glov_0478

Alternate gene names: 189423549

Gene position: 454508-453627 (Counterclockwise)

Preceding gene: 189423550

Following gene: 189423548

Centisome position: 11.6

GC content: 55.78

Gene sequence:

>882_bases
ATGAACCGAAAAGGCATTATCCTGGCTGGCGGAGCCGGCACCCGTCTGCATCCGGCAACCCTGGCCGTATCGAAACAGCT
GCTGCCGGTCTACGACAAGCCAATGATCTACTATCCGCTCAGCACCCTGATGCTGGCCGGAATCCGCGAAATACTTATCA
TCTCAACACCGCAGGACACCCCCCGTTTTGAACAATTGCTGGGCGACGGAAGTCAGTGGGGGCTTGAACTGCAGTACGCC
GTACAACCAAGTCCCGATGGTCTGGCCCAGGCCTTCATCATCGGCGAGCAGTTTATCGGGACGAGTCCTTCTGCGCTGGT
TCTGGGTGATAACATCTTCTACGGCCATGACTTTCATCAACTGTTGGGCAATGCCATGCAGCGCGAAACCGGGGCATCAG
TCTTTGCCTACCATGTCAATGACCCCGAACGCTACGGTGTCGTTGCCTTTGACGCTGGCGGTAAAGCCATCAGTCTTGAG
GAAAAGCCGCAGCAACCGAAATCAAACTACGCGGTTACCGGGCTTTACTTCTACGACAACAGTGTGGTGGAGCGGGCTCG
AGACCTGAAGCCGTCACCCCGTGGAGAGCTTGAGATTACCGACCTTAACCGGCTCTACCTTGAGGAAGAAAAACTGTCGG
TTGAGATCATGGGCCGCGGCTATGCCTGGCTGGATACCGGTACCCACGAGAGTCTGCTGGAGGCGGGTCAGTTTATTGCT
ACCCTGGAAAACCGCCAGGGCCTCAAGGTCGCCTGTCCGGAAGAGATTGCCTGGCGCCAAGACTGGATCACAGCTCAACA
GCTTGAAAAGCTGGCTCTACCGCTTGCCAAAAACGGCTATGGCCAATACCTGATGCGGCTTTTGAAGGATCAGATACTGT
AG

Upstream 100 bases:

>100_bases
GCCTGCCACCTCGCTGGAGGACGGTATTGCACGCTTTGTTGCATGGTTCCGCTCGTACTACAGCCATCCCGCATAAATCG
CATTGAAAGGAAGAAACAGC

Downstream 100 bases:

>100_bases
CTGTTACCATCACTGCTGGAGATTTGGTATAGCCGGTAAAGGCACCACAACCGGACAGCGGGACTCAGTAACCCAAATCA
AGAACCGGATACCTCATTTG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MNRKGIILAGGAGTRLHPATLAVSKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQDTPRFEQLLGDGSQWGLELQYA
VQPSPDGLAQAFIIGEQFIGTSPSALVLGDNIFYGHDFHQLLGNAMQRETGASVFAYHVNDPERYGVVAFDAGGKAISLE
EKPQQPKSNYAVTGLYFYDNSVVERARDLKPSPRGELEITDLNRLYLEEEKLSVEIMGRGYAWLDTGTHESLLEAGQFIA
TLENRQGLKVACPEEIAWRQDWITAQQLEKLALPLAKNGYGQYLMRLLKDQIL

Sequences:

>Translated_293_residues
MNRKGIILAGGAGTRLHPATLAVSKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQDTPRFEQLLGDGSQWGLELQYA
VQPSPDGLAQAFIIGEQFIGTSPSALVLGDNIFYGHDFHQLLGNAMQRETGASVFAYHVNDPERYGVVAFDAGGKAISLE
EKPQQPKSNYAVTGLYFYDNSVVERARDLKPSPRGELEITDLNRLYLEEEKLSVEIMGRGYAWLDTGTHESLLEAGQFIA
TLENRQGLKVACPEEIAWRQDWITAQQLEKLALPLAKNGYGQYLMRLLKDQIL
>Mature_293_residues
MNRKGIILAGGAGTRLHPATLAVSKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQDTPRFEQLLGDGSQWGLELQYA
VQPSPDGLAQAFIIGEQFIGTSPSALVLGDNIFYGHDFHQLLGNAMQRETGASVFAYHVNDPERYGVVAFDAGGKAISLE
EKPQQPKSNYAVTGLYFYDNSVVERARDLKPSPRGELEITDLNRLYLEEEKLSVEIMGRGYAWLDTGTHESLLEAGQFIA
TLENRQGLKVACPEEIAWRQDWITAQQLEKLALPLAKNGYGQYLMRLLKDQIL

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=246, Percent_Identity=23.9837398373984, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI11761621, Length=246, Percent_Identity=23.9837398373984, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=76.7361111111111, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=66.4335664335664, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1787488, Length=294, Percent_Identity=27.2108843537415, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788355, Length=238, Percent_Identity=28.9915966386555, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=190, Percent_Identity=26.3157894736842, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=258, Percent_Identity=26.3565891472868, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355443, Length=249, Percent_Identity=25.7028112449799, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24644084, Length=249, Percent_Identity=25.7028112449799, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32601; Mature: 32601

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRKGIILAGGAGTRLHPATLAVSKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQDT
CCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFEQLLGDGSQWGLELQYAVQPSPDGLAQAFIIGEQFIGTSPSALVLGDNIFYGHDFHQ
HHHHHHHCCCCCCCEEEEEEECCCCCHHHHHEEEHHHHCCCCCCEEEEECCEEECCHHHH
LLGNAMQRETGASVFAYHVNDPERYGVVAFDAGGKAISLEEKPQQPKSNYAVTGLYFYDN
HHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCEEECCCCCCCCCCCEEEEEEEEECC
SVVERARDLKPSPRGELEITDLNRLYLEEEKLSVEIMGRGYAWLDTGTHESLLEAGQFIA
HHHHHHHCCCCCCCCCEEEEECCEEEEECCCEEEEEEECCEEEEECCCHHHHHHHHHHEE
TLENRQGLKVACPEEIAWRQDWITAQQLEKLALPLAKNGYGQYLMRLLKDQIL
ECCCCCCCEEECCHHHHHHHHHHCHHHHHHHHCCHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNRKGIILAGGAGTRLHPATLAVSKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQDT
CCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFEQLLGDGSQWGLELQYAVQPSPDGLAQAFIIGEQFIGTSPSALVLGDNIFYGHDFHQ
HHHHHHHCCCCCCCEEEEEEECCCCCHHHHHEEEHHHHCCCCCCEEEEECCEEECCHHHH
LLGNAMQRETGASVFAYHVNDPERYGVVAFDAGGKAISLEEKPQQPKSNYAVTGLYFYDN
HHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCEEECCCCCCCCCCCEEEEEEEEECC
SVVERARDLKPSPRGELEITDLNRLYLEEEKLSVEIMGRGYAWLDTGTHESLLEAGQFIA
HHHHHHHCCCCCCCCCEEEEECCEEEEECCCEEEEEEECCEEEEECCCHHHHHHHHHHEE
TLENRQGLKVACPEEIAWRQDWITAQQLEKLALPLAKNGYGQYLMRLLKDQIL
ECCCCCCCEEECCHHHHHHHHHHCHHHHHHHHCCHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]