Click here to switch to the map view.

The map label for this gene is glcD [H]

Identifier: 189423535

GI number: 189423535

Start: 434858

End: 436258

Strand: Reverse

Name: glcD [H]

Synonym: Glov_0464

Alternate gene names: 189423535

Gene position: 436258-434858 (Counterclockwise)

Preceding gene: 189423536

Following gene: 189423534

Centisome position: 11.14

GC content: 57.1

Gene sequence:

>1401_bases
ATGCTGGCCCTGTCCATTATCGAAGAACTCCGTGCCATTGTCGGCCCTGAAAATCTTGCCACTGAAAAGCAGGACCTGAT
CTGCTACGGCTACGATGCCACCCAGATGGAGTTTCTTCCCGCTGCCGTGGTGCATCCGGCCAATGCGGAAGAGACGGCAG
CGGTCCTGCGCCTGGCCAATCAACGTACATTTCCGGTTTTTCCCCGTGGTGCCGGCAGCGGCTTTACCGGCGGCGCCCTG
CCCAAGGCCGGCGGCGTGGTACTGGTGACCACCCGAATGAACAGGATCCTGCGGATTGACACCGAAAACCTGATTGCCGA
GGTGGAACCGGGAGTAGTGACCGAGGATTTCCAGAAGGCAGTAGAAAAGTTGGGGCTGTTCTATCCACCCGATCCGGCCT
CGTTGAAATTTTCCACCCTGGGTGGCAATGTCGCTGAAAATGCCGGTGGCCCCCGCTGTGTCAAATATGGCGTTACCAAA
GATTTTGTGATGGGGCTGGAGCTGGTACTCCCGACGGGCGAGATCATCCGTACCGGCACCGAGACCTACAAGGCGGTGGT
GGGCTACGACCTGACCCGCCTGTTGTGCGGCAGTGAAGGCACCCTGGGAGTCATCACCAAAATCATCTTCAAACTGCTGC
CGTTGCCCGAAGCAAAGAAAACCATGCTGACCATCTTTGATTCCATTGATGGCGCTGCCCGGGCGGTCTCCACCATCATC
GGCGCCAAGATCATCCCCACCACCCTTGAATTTATGGACTATGCCACCCTGCAGTGTGTTGAAAAGCGCTTTAACCTGGG
GATTCCGCCGGAAGGACGGGCCGTACTGCTGATTGAGGTGGATGGCGACAGGGAGCTGATCGAAAAGCAGGCTGCCCGCA
TCCATGACCTGATCAAGCCGCTGGGACTGGTACAGTTCCGGGCGGCCAAGGATGATGCCGAATCTGAGGCACTCTGGAAG
GTACGGCGGCTGGTCTCACCTTCACTGCGGGATGTCAATCCCCACAAGTTCAACGAGGATATTGTGGTGCCACGCAGCAA
GGTACCGGTGGTGATCCGACAGATTGAAAAGATCCAGCAGAAATACGACATCCCGATCGTCAACTTCGGCCATGCCGGCG
ACGGCAATATCCATGTCAATGTGATGATCAACAAAGAGATTCCGGGCCAGGAGGAAAAGGCCCATGAGGCGATCAAGGAG
ATCTTCCAGGCTGCCCTGGACCTGAACGGCACCATGTCGGGCGAGCATGGCGTGGGATTGGCCAAACAACCCTTTATCGA
GATGGAACTGACCCCGGCCCAGATCAGGGTCATGCAGGGAATCAAACTGGCGCTGGACCCCAACAACATTCTGAATCCGG
GGAAAATATTCCCCTGGAAGGACACTCCCCATGCAGCATGA

Upstream 100 bases:

>100_bases
GCTGTTCCAGCCCAAGGCAACCCGTTTCCCTTGCTTTTGGATTGCTGAATCGGGTAAGTTTTATCTTTTTAACTACGGTT
GATACGAGGTACCTATACAA

Downstream 100 bases:

>100_bases
TGATCAGAAAGAACTGCAGGAAGCCTCACTGGTCGGAAGGATTTTCTCACTGGAAGTCGCCTTGTTCTTAATGGGTGTAG
CCTCACTGATTTATGGTTTG

Product: FAD linked oxidase

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MLALSIIEELRAIVGPENLATEKQDLICYGYDATQMEFLPAAVVHPANAEETAAVLRLANQRTFPVFPRGAGSGFTGGAL
PKAGGVVLVTTRMNRILRIDTENLIAEVEPGVVTEDFQKAVEKLGLFYPPDPASLKFSTLGGNVAENAGGPRCVKYGVTK
DFVMGLELVLPTGEIIRTGTETYKAVVGYDLTRLLCGSEGTLGVITKIIFKLLPLPEAKKTMLTIFDSIDGAARAVSTII
GAKIIPTTLEFMDYATLQCVEKRFNLGIPPEGRAVLLIEVDGDRELIEKQAARIHDLIKPLGLVQFRAAKDDAESEALWK
VRRLVSPSLRDVNPHKFNEDIVVPRSKVPVVIRQIEKIQQKYDIPIVNFGHAGDGNIHVNVMINKEIPGQEEKAHEAIKE
IFQAALDLNGTMSGEHGVGLAKQPFIEMELTPAQIRVMQGIKLALDPNNILNPGKIFPWKDTPHAA

Sequences:

>Translated_466_residues
MLALSIIEELRAIVGPENLATEKQDLICYGYDATQMEFLPAAVVHPANAEETAAVLRLANQRTFPVFPRGAGSGFTGGAL
PKAGGVVLVTTRMNRILRIDTENLIAEVEPGVVTEDFQKAVEKLGLFYPPDPASLKFSTLGGNVAENAGGPRCVKYGVTK
DFVMGLELVLPTGEIIRTGTETYKAVVGYDLTRLLCGSEGTLGVITKIIFKLLPLPEAKKTMLTIFDSIDGAARAVSTII
GAKIIPTTLEFMDYATLQCVEKRFNLGIPPEGRAVLLIEVDGDRELIEKQAARIHDLIKPLGLVQFRAAKDDAESEALWK
VRRLVSPSLRDVNPHKFNEDIVVPRSKVPVVIRQIEKIQQKYDIPIVNFGHAGDGNIHVNVMINKEIPGQEEKAHEAIKE
IFQAALDLNGTMSGEHGVGLAKQPFIEMELTPAQIRVMQGIKLALDPNNILNPGKIFPWKDTPHAA
>Mature_466_residues
MLALSIIEELRAIVGPENLATEKQDLICYGYDATQMEFLPAAVVHPANAEETAAVLRLANQRTFPVFPRGAGSGFTGGAL
PKAGGVVLVTTRMNRILRIDTENLIAEVEPGVVTEDFQKAVEKLGLFYPPDPASLKFSTLGGNVAENAGGPRCVKYGVTK
DFVMGLELVLPTGEIIRTGTETYKAVVGYDLTRLLCGSEGTLGVITKIIFKLLPLPEAKKTMLTIFDSIDGAARAVSTII
GAKIIPTTLEFMDYATLQCVEKRFNLGIPPEGRAVLLIEVDGDRELIEKQAARIHDLIKPLGLVQFRAAKDDAESEALWK
VRRLVSPSLRDVNPHKFNEDIVVPRSKVPVVIRQIEKIQQKYDIPIVNFGHAGDGNIHVNVMINKEIPGQEEKAHEAIKE
IFQAALDLNGTMSGEHGVGLAKQPFIEMELTPAQIRVMQGIKLALDPNNILNPGKIFPWKDTPHAA

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=464, Percent_Identity=30.3879310344828, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI37595754, Length=487, Percent_Identity=29.1581108829569, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI119964728, Length=425, Percent_Identity=31.0588235294118, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI4501993, Length=461, Percent_Identity=24.295010845987, Blast_Score=129, Evalue=7e-30,
Organism=Escherichia coli, GI1789351, Length=456, Percent_Identity=36.1842105263158, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1787977, Length=534, Percent_Identity=26.9662921348315, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI48994907, Length=496, Percent_Identity=25.6048387096774, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI48994914, Length=133, Percent_Identity=36.8421052631579, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71992373, Length=462, Percent_Identity=31.1688311688312, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71992381, Length=462, Percent_Identity=30.0865800865801, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI71992392, Length=384, Percent_Identity=30.9895833333333, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17534361, Length=446, Percent_Identity=27.3542600896861, Blast_Score=178, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17556096, Length=469, Percent_Identity=24.3070362473348, Blast_Score=119, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320027, Length=474, Percent_Identity=28.6919831223629, Blast_Score=206, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6320023, Length=458, Percent_Identity=28.1659388646288, Blast_Score=179, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6320764, Length=466, Percent_Identity=28.5407725321888, Blast_Score=168, Evalue=1e-42,
Organism=Drosophila melanogaster, GI18921117, Length=424, Percent_Identity=30.6603773584906, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24639277, Length=424, Percent_Identity=30.6603773584906, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24639275, Length=424, Percent_Identity=30.6603773584906, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24653753, Length=469, Percent_Identity=24.5202558635394, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 50832; Mature: 50832

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALSIIEELRAIVGPENLATEKQDLICYGYDATQMEFLPAAVVHPANAEETAAVLRLAN
CHHHHHHHHHHHHHCCCHHCCCCCCEEEECCCCCHHHHCCHHHCCCCCCHHHHHHHHHHC
QRTFPVFPRGAGSGFTGGALPKAGGVVLVTTRMNRILRIDTENLIAEVEPGVVTEDFQKA
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECHHHHHHHCCCCCCCHHHHHH
VEKLGLFYPPDPASLKFSTLGGNVAENAGGPRCVKYGVTKDFVMGLELVLPTGEIIRTGT
HHHCCCCCCCCCCCEEEEECCCCHHHCCCCCEEEEECCCHHHHHCCCEEECCCHHHHCCH
ETYKAVVGYDLTRLLCGSEGTLGVITKIIFKLLPLPEAKKTMLTIFDSIDGAARAVSTII
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHH
GAKIIPTTLEFMDYATLQCVEKRFNLGIPPEGRAVLLIEVDGDRELIEKQAARIHDLIKP
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHH
LGLVQFRAAKDDAESEALWKVRRLVSPSLRDVNPHKFNEDIVVPRSKVPVVIRQIEKIQQ
HHHEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHH
KYDIPIVNFGHAGDGNIHVNVMINKEIPGQEEKAHEAIKEIFQAALDLNGTMSGEHGVGL
HHCCCEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AKQPFIEMELTPAQIRVMQGIKLALDPNNILNPGKIFPWKDTPHAA
CCCCCEEEECCHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLALSIIEELRAIVGPENLATEKQDLICYGYDATQMEFLPAAVVHPANAEETAAVLRLAN
CHHHHHHHHHHHHHCCCHHCCCCCCEEEECCCCCHHHHCCHHHCCCCCCHHHHHHHHHHC
QRTFPVFPRGAGSGFTGGALPKAGGVVLVTTRMNRILRIDTENLIAEVEPGVVTEDFQKA
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECHHHHHHHCCCCCCCHHHHHH
VEKLGLFYPPDPASLKFSTLGGNVAENAGGPRCVKYGVTKDFVMGLELVLPTGEIIRTGT
HHHCCCCCCCCCCCEEEEECCCCHHHCCCCCEEEEECCCHHHHHCCCEEECCCHHHHCCH
ETYKAVVGYDLTRLLCGSEGTLGVITKIIFKLLPLPEAKKTMLTIFDSIDGAARAVSTII
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHH
GAKIIPTTLEFMDYATLQCVEKRFNLGIPPEGRAVLLIEVDGDRELIEKQAARIHDLIKP
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHH
LGLVQFRAAKDDAESEALWKVRRLVSPSLRDVNPHKFNEDIVVPRSKVPVVIRQIEKIQQ
HHHEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHH
KYDIPIVNFGHAGDGNIHVNVMINKEIPGQEEKAHEAIKEIFQAALDLNGTMSGEHGVGL
HHCCCEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AKQPFIEMELTPAQIRVMQGIKLALDPNNILNPGKIFPWKDTPHAA
CCCCCEEEECCHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]