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The map label for this gene is phoP [H]

Identifier: 189423443

GI number: 189423443

Start: 348422

End: 349444

Strand: Reverse

Name: phoP [H]

Synonym: Glov_0372

Alternate gene names: 189423443

Gene position: 349444-348422 (Counterclockwise)

Preceding gene: 189423444

Following gene: 189423435

Centisome position: 8.92

GC content: 56.01

Gene sequence:

>1023_bases
ATGACAAAACAGCTGGGCGACATACTGGTTGATACGGAGCTGATCAGCAGAAAGACGCTGGAACGGGCACTGGAACGCCA
AAAGGCAACTGCCAAGCGCCTGGGGCAGGTTCTGGAGGAGATGGGGGTTATTACCGAGGCAGAGCTGATGGAGGCACTGG
TCAGCCAGCACAGCCCCTTTGCCGACATCAACCAGAAAAAGCAGTTGGGCGACATCCTGGTGAGGGCCAAACTGATCAGC
GAAAAGACCCTGGAACGGGCACTGGAGCGCCAGCACACTGAAGGGAAAAAGCTTGGTGAAGTGTTGGAGGAGATGGGGGT
CATCACTGAACTTGAGCTGGTAGAGGCGCTGGGACGCCAGTTCGGCTTCAAGACCGTCACAGACTTCAGCAACCGTACCT
ATCCGGCCGAGACAATCAACCTGCTACCCACTGAGTTTGTCATGAAACGGCTCGTGTTTCCGTTGAAGCACAAGGATATG
ATGCTGGCAGTGGCCATAACCGATCCTTTTGACGGCGAGACCACCGACATGATTGCCCGCATCACCGGACTGCAGGTAGT
GCCGGTAATTGCCACCCGTAAGGAAATACTGGAGGCGATCGCCCGCCATTATCTGAATGCACCGGTAAACCCGGATGCCG
GCAACACGATTCTGGTGGTGGAGGATTCTCCCACGGTTGCCACCGTTGTGCAGGCAGCCCTGGTAAAAGAAGGGTACAAC
GTCATTATCTGCAAAGACGGTATTGAGGCGCTCAAGACCACCCTGACCCATCGCCCTCAACTGGTGATTACCGATGCCCA
GATGCCCAAACTGGATGGACATGGTCTGCTGCGGGCAATCAAGGCCAATCCGATTACCGCGGCGATTCCGGTGATCATGC
TGACCGGCCGGGCCTCCACCGATGAAGAGCAGAAGGCGCTTGACGCCGGCTTCTTTGACTTCATCCCCAAACCGGTCCAG
CCGCTACGGGTGGTGTCTCGGGTCAAGCGTGCCCTGGAGCTATCAAAGAAGATAAAAAATTAA

Upstream 100 bases:

>100_bases
TGCAGCTGTCCAAGCATCCCCTGACTGATGCCGGTATCAAAAAATTCCTGGAAGACTGGGAAAAAGTGCCGAAGTAGTTT
GTGCACTACGTGGAGGTCGT

Downstream 100 bases:

>100_bases
CGCCGCCGCTTCTGGCCCCGCCTGAATTCCCAGGGAGGCTGAGGGTTCGTATCCCGCCAGAGTCCCCGGTGTTGGCGCCG
AGCCTGTTCTTCCAAAGCGA

Product: response regulator receiver protein

Products: NADP; 2 glutathione [C]

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MTKQLGDILVDTELISRKTLERALERQKATAKRLGQVLEEMGVITEAELMEALVSQHSPFADINQKKQLGDILVRAKLIS
EKTLERALERQHTEGKKLGEVLEEMGVITELELVEALGRQFGFKTVTDFSNRTYPAETINLLPTEFVMKRLVFPLKHKDM
MLAVAITDPFDGETTDMIARITGLQVVPVIATRKEILEAIARHYLNAPVNPDAGNTILVVEDSPTVATVVQAALVKEGYN
VIICKDGIEALKTTLTHRPQLVITDAQMPKLDGHGLLRAIKANPITAAIPVIMLTGRASTDEEQKALDAGFFDFIPKPVQ
PLRVVSRVKRALELSKKIKN

Sequences:

>Translated_340_residues
MTKQLGDILVDTELISRKTLERALERQKATAKRLGQVLEEMGVITEAELMEALVSQHSPFADINQKKQLGDILVRAKLIS
EKTLERALERQHTEGKKLGEVLEEMGVITELELVEALGRQFGFKTVTDFSNRTYPAETINLLPTEFVMKRLVFPLKHKDM
MLAVAITDPFDGETTDMIARITGLQVVPVIATRKEILEAIARHYLNAPVNPDAGNTILVVEDSPTVATVVQAALVKEGYN
VIICKDGIEALKTTLTHRPQLVITDAQMPKLDGHGLLRAIKANPITAAIPVIMLTGRASTDEEQKALDAGFFDFIPKPVQ
PLRVVSRVKRALELSKKIKN
>Mature_339_residues
TKQLGDILVDTELISRKTLERALERQKATAKRLGQVLEEMGVITEAELMEALVSQHSPFADINQKKQLGDILVRAKLISE
KTLERALERQHTEGKKLGEVLEEMGVITELELVEALGRQFGFKTVTDFSNRTYPAETINLLPTEFVMKRLVFPLKHKDMM
LAVAITDPFDGETTDMIARITGLQVVPVIATRKEILEAIARHYLNAPVNPDAGNTILVVEDSPTVATVVQAALVKEGYNV
IICKDGIEALKTTLTHRPQLVITDAQMPKLDGHGLLRAIKANPITAAIPVIMLTGRASTDEEQKALDAGFFDFIPKPVQP
LRVVSRVKRALELSKKIKN

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG3437

COG function: function code KT; Response regulator containing a CheY-like receiver domain and an HD-GYP domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790299, Length=117, Percent_Identity=31.6239316239316, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790437, Length=123, Percent_Identity=34.9593495934959, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1786599, Length=113, Percent_Identity=30.9734513274336, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788905, Length=119, Percent_Identity=31.9327731092437, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI145693157, Length=103, Percent_Identity=33.0097087378641, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 37669; Mature: 37537

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQLGDILVDTELISRKTLERALERQKATAKRLGQVLEEMGVITEAELMEALVSQHSPF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
ADINQKKQLGDILVRAKLISEKTLERALERQHTEGKKLGEVLEEMGVITELELVEALGRQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
FGFKTVTDFSNRTYPAETINLLPTEFVMKRLVFPLKHKDMMLAVAITDPFDGETTDMIAR
CCCCHHHHCCCCCCCHHHHHCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHH
ITGLQVVPVIATRKEILEAIARHYLNAPVNPDAGNTILVVEDSPTVATVVQAALVKEGYN
HHCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCE
VIICKDGIEALKTTLTHRPQLVITDAQMPKLDGHGLLRAIKANPITAAIPVIMLTGRAST
EEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHCCCCHHHHHHHEEECCCCC
DEEQKALDAGFFDFIPKPVQPLRVVSRVKRALELSKKIKN
CHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKQLGDILVDTELISRKTLERALERQKATAKRLGQVLEEMGVITEAELMEALVSQHSPF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
ADINQKKQLGDILVRAKLISEKTLERALERQHTEGKKLGEVLEEMGVITELELVEALGRQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
FGFKTVTDFSNRTYPAETINLLPTEFVMKRLVFPLKHKDMMLAVAITDPFDGETTDMIAR
CCCCHHHHCCCCCCCHHHHHCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHH
ITGLQVVPVIATRKEILEAIARHYLNAPVNPDAGNTILVVEDSPTVATVVQAALVKEGYN
HHCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCE
VIICKDGIEALKTTLTHRPQLVITDAQMPKLDGHGLLRAIKANPITAAIPVIMLTGRAST
EEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHCCCCHHHHHHHEEECCCCC
DEEQKALDAGFFDFIPKPVQPLRVVSRVKRALELSKKIKN
CHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH2; oxidized glutathione [C]

Specific reaction: NADPH2 + oxidized glutathione = NADP + 2 glutathione [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]