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The map label for this gene is ahcY [H]

Identifier: 189423427

GI number: 189423427

Start: 324888

End: 326282

Strand: Reverse

Name: ahcY [H]

Synonym: Glov_0356

Alternate gene names: 189423427

Gene position: 326282-324888 (Counterclockwise)

Preceding gene: 189423428

Following gene: 189423426

Centisome position: 8.33

GC content: 59.07

Gene sequence:

>1395_bases
ATGGGAACTGATTACATCGTGGCTGACCTTGGCCTGGCAGACTGGGGCCGTAAAGAGATTAAAATAGCCGAGACCGAGAT
GCCCGGCCTGATGGCGATCCGTGAGGAGTATGCCGCCTCTCAGCCGCTGAAGGGAGCCCGCATTACCGGTTCGCTGCATA
TGACCATCCAGACCGCGGTGCTGATTGAGACCCTGACCGCCCTGGGTGCCCAGGTCCGCTGGGCCTCCTGCAACATTTTT
TCCACCCAGGATCATGCTGCTGCTGCCATTGCAGCATCAGGCGTGCCGGTCTTTGCCGTCAAGGGTGAATCCCTGACCGA
TTACTGGGACTACACCCACAAGATCTTTGAATGGGCTGACGGCGGTTTTTCCAACATGATCCTGGATGATGGCGGCGATG
CCACCCTGCTGCTGCACCTGGGCAGCAAGGCTGAAAAGGATCTTAGCGTCCTGAACAACCCCGGCTCTGAGGAAGAGACG
ATCCTGTTTGCCGCCATCAAGGCCAAACTGGCGGTTGATCCAACCTGGTACTCGGTCCGTCTGGCCCAGATCAAGGGTGT
CACCGAAGAGACCACCACCGGCGTGCACCGTCTGTATCAGATGCATGAACGTGGCGAGCTGGCCTTCCCGGCCATCAACG
TCAATGACTCGGTCACCAAATCCAAGTTCGACAACCTCTACGGCTGCCGCGAATCGCTGGTGGACGGCATCAAGCGGGCC
ACCGACGTGATGGTGGCCGGCAAGGTTGCTCTGGTCTGCGGCTACGGTGATGTGGGCAAAGGCTCGGCCCAGGCCCTGCG
CGCCCTGTCCGCCCAGGTCTGGGTCACCGAGATTGACCCGATCTGCGCCCTGCAGGCTGCCATGGAAGGCTACCGCGTGG
TAACCATGGAGTATGCTGCCGACAAGGCCGACATCTTCGTGACCTGCACCGGCAACTACCATGTCATTACCCATGAGCAC
CTGCTGAAAATGAAGGATCAGGCCATTGTCTGCAACATCGGTCACTTTGACAACGAGATCGAGGTTGCTGCCCTGGAACA
GTACCAGTGGGAAGAGATCAAGCCCCAGGTGGATCATATCATCCTGCCTTCCGGCAACCGGATCATCCTGCTGGCCAAGG
GACGCCTGGTGAACCTGGGCTGCGCCACCGGCCACCCCAGCTACGTCATGTCATCATCCTTTGCCAACCAGACCATCGCC
CAGATTGAGATCTTCTGCAACCCGGGCAAATACCCGACCGGCGTCTATGTACTGCCCAAGCATCTGGATGAAAAGGTGGC
CCGGCTGCAGCTGAAGAAGCTGAACGCCCAGCTGTCCGTGTTGACCAAGGAGCAGGCTGACTACATCGGCGTGCCGGTGG
AAGGCCCCTACAAGGCCGAGCATTACCGTTACTAA

Upstream 100 bases:

>100_bases
CGGATTTCGGCACGGTTGCCATTGCACAGATTCCGCCGCTGCAGGGACAGGAAGCGGTGCTGCTGATACAGGCGTACACA
ACAACCAAAGGAGAATGAAC

Downstream 100 bases:

>100_bases
GACATGACCCGGCGGGTAGCCCGGCAACAGCTGCCCGCCTTTCTCAAACGTGGAAGATGCTTCTCAGGTACAAGCCCATG
ACCATCGCATCCAACCTGAA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MGTDYIVADLGLADWGRKEIKIAETEMPGLMAIREEYAASQPLKGARITGSLHMTIQTAVLIETLTALGAQVRWASCNIF
STQDHAAAAIAASGVPVFAVKGESLTDYWDYTHKIFEWADGGFSNMILDDGGDATLLLHLGSKAEKDLSVLNNPGSEEET
ILFAAIKAKLAVDPTWYSVRLAQIKGVTEETTTGVHRLYQMHERGELAFPAINVNDSVTKSKFDNLYGCRESLVDGIKRA
TDVMVAGKVALVCGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTCTGNYHVITHEH
LLKMKDQAIVCNIGHFDNEIEVAALEQYQWEEIKPQVDHIILPSGNRIILLAKGRLVNLGCATGHPSYVMSSSFANQTIA
QIEIFCNPGKYPTGVYVLPKHLDEKVARLQLKKLNAQLSVLTKEQADYIGVPVEGPYKAEHYRY

Sequences:

>Translated_464_residues
MGTDYIVADLGLADWGRKEIKIAETEMPGLMAIREEYAASQPLKGARITGSLHMTIQTAVLIETLTALGAQVRWASCNIF
STQDHAAAAIAASGVPVFAVKGESLTDYWDYTHKIFEWADGGFSNMILDDGGDATLLLHLGSKAEKDLSVLNNPGSEEET
ILFAAIKAKLAVDPTWYSVRLAQIKGVTEETTTGVHRLYQMHERGELAFPAINVNDSVTKSKFDNLYGCRESLVDGIKRA
TDVMVAGKVALVCGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTCTGNYHVITHEH
LLKMKDQAIVCNIGHFDNEIEVAALEQYQWEEIKPQVDHIILPSGNRIILLAKGRLVNLGCATGHPSYVMSSSFANQTIA
QIEIFCNPGKYPTGVYVLPKHLDEKVARLQLKKLNAQLSVLTKEQADYIGVPVEGPYKAEHYRY
>Mature_463_residues
GTDYIVADLGLADWGRKEIKIAETEMPGLMAIREEYAASQPLKGARITGSLHMTIQTAVLIETLTALGAQVRWASCNIFS
TQDHAAAAIAASGVPVFAVKGESLTDYWDYTHKIFEWADGGFSNMILDDGGDATLLLHLGSKAEKDLSVLNNPGSEEETI
LFAAIKAKLAVDPTWYSVRLAQIKGVTEETTTGVHRLYQMHERGELAFPAINVNDSVTKSKFDNLYGCRESLVDGIKRAT
DVMVAGKVALVCGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTCTGNYHVITHEHL
LKMKDQAIVCNIGHFDNEIEVAALEQYQWEEIKPQVDHIILPSGNRIILLAKGRLVNLGCATGHPSYVMSSSFANQTIAQ
IEIFCNPGKYPTGVYVLPKHLDEKVARLQLKKLNAQLSVLTKEQADYIGVPVEGPYKAEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=59.7402597402597, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=59.3181818181818, Blast_Score=496, Evalue=1e-140,
Organism=Homo sapiens, GI24308043, Length=465, Percent_Identity=49.247311827957, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI298286489, Length=465, Percent_Identity=49.247311827957, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI195539337, Length=465, Percent_Identity=49.247311827957, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI195539349, Length=465, Percent_Identity=49.247311827957, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI21361647, Length=465, Percent_Identity=47.9569892473118, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=59.7849462365591, Blast_Score=525, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6320882, Length=478, Percent_Identity=58.1589958158996, Blast_Score=509, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=60.1731601731602, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24656245, Length=466, Percent_Identity=49.1416309012876, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45553387, Length=465, Percent_Identity=47.3118279569892, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI45553385, Length=464, Percent_Identity=47.198275862069, Blast_Score=421, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 50827; Mature: 50695

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTDYIVADLGLADWGRKEIKIAETEMPGLMAIREEYAASQPLKGARITGSLHMTIQTAV
CCCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEEEEEEEHHHH
LIETLTALGAQVRWASCNIFSTQDHAAAAIAASGVPVFAVKGESLTDYWDYTHKIFEWAD
HHHHHHHHCCEEEEEEEEEECCCCCHHEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCC
GGFSNMILDDGGDATLLLHLGSKAEKDLSVLNNPGSEEETILFAAIKAKLAVDPTWYSVR
CCCCEEEEECCCCEEEEEEECCCCCCHHHHHCCCCCCCCEEEEEEEEEEEEECCCEEEEE
LAQIKGVTEETTTGVHRLYQMHERGELAFPAINVNDSVTKSKFDNLYGCRESLVDGIKRA
EEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
TDVMVAGKVALVCGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVVTMEYAA
HHEEEECCEEEEECCCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHCCEEEEEEEECC
DKADIFVTCTGNYHVITHEHLLKMKDQAIVCNIGHFDNEIEVAALEQYQWEEIKPQVDHI
CCCCEEEEECCCEEEEEHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCHHHCCCCCCEE
ILPSGNRIILLAKGRLVNLGCATGHPSYVMSSSFANQTIAQIEIFCNPGKYPTGVYVLPK
EECCCCEEEEEECCCEEEEEECCCCCCHHEECHHCCCEEEEEEEEECCCCCCCEEEEECH
HLDEKVARLQLKKLNAQLSVLTKEQADYIGVPVEGPYKAEHYRY
HHHHHHHHHHHHHHCCEEEEEEECCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GTDYIVADLGLADWGRKEIKIAETEMPGLMAIREEYAASQPLKGARITGSLHMTIQTAV
CCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEEEEEEEHHHH
LIETLTALGAQVRWASCNIFSTQDHAAAAIAASGVPVFAVKGESLTDYWDYTHKIFEWAD
HHHHHHHHCCEEEEEEEEEECCCCCHHEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCC
GGFSNMILDDGGDATLLLHLGSKAEKDLSVLNNPGSEEETILFAAIKAKLAVDPTWYSVR
CCCCEEEEECCCCEEEEEEECCCCCCHHHHHCCCCCCCCEEEEEEEEEEEEECCCEEEEE
LAQIKGVTEETTTGVHRLYQMHERGELAFPAINVNDSVTKSKFDNLYGCRESLVDGIKRA
EEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
TDVMVAGKVALVCGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVVTMEYAA
HHEEEECCEEEEECCCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHCCEEEEEEEECC
DKADIFVTCTGNYHVITHEHLLKMKDQAIVCNIGHFDNEIEVAALEQYQWEEIKPQVDHI
CCCCEEEEECCCEEEEEHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCHHHCCCCCCEE
ILPSGNRIILLAKGRLVNLGCATGHPSYVMSSSFANQTIAQIEIFCNPGKYPTGVYVLPK
EECCCCEEEEEECCCEEEEEECCCCCCHHEECHHCCCEEEEEEEEECCCCCCCEEEEECH
HLDEKVARLQLKKLNAQLSVLTKEQADYIGVPVEGPYKAEHYRY
HHHHHHHHHHHHHHCCEEEEEEECCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA