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The map label for this gene is shc [H]

Identifier: 189354095

GI number: 189354095

Start: 2454434

End: 2456407

Strand: Reverse

Name: shc [H]

Synonym: BMULJ_05349

Alternate gene names: 189354095

Gene position: 2456407-2454434 (Counterclockwise)

Preceding gene: 189354096

Following gene: 189354094

Centisome position: 99.32

GC content: 67.53

Gene sequence:

>1974_bases
ATGAACGATCTCACCGATATGGCTACCCTGTCGGCCGGCACCGTGCCGGCCGAGCTCGATGCGGCCGTCGCACGCGCGAC
CGACGCGCTGCTCGCCGCGCAGAACGCGGACGGGCACTGGGTCTACGAACTCGAAGCCGATTCGACGATTCCCGCCGAAT
ACGTGCTGCTCGTCCACTATCTCGGCGAGACGCCGAACCTCGAGCTCGAACAGAAGATCGGCCGCTATCTGCGCCGGATC
CAGCAGGCCGACGGCGGCTGGCCGCTGTTTACCGACGGCGCACCGAACATCAGCGCGAGCGTGAAGGCGTACTTCGCGCT
GAAGGTGATCGGCGACGACGAAAACGCCGAGCACATGCAGCGCGCGCGTCGCGCGATCCACGCGATGGGCGGCGCCGAGA
TGTCGAACGTGTTCACGCGGATTCAGCTCGCGTTGTACGGCGCGATTCCGTGGCGCGCGGTGCCGATGATGCCGGTCGAG
ATCATGCTGCTGCCGCAGTGGTTCCCGTTCCATCTGTCGAAGGTGTCGTACTGGGCGCGCACGGTGATCGTGCCGCTGCT
CGTGCTGAATGCGAAGCGACCGCTTGCGAAGAATCCGCGCGGCGTCCGCATCGACGAACTGTTCATCGATCCGCCCGTCA
ACGCGGGCCTGCTGCCGCGCCAGGGTCACCAGAGCGCCGGCTGGTTCGCGTTCTTCCGTGCGGTCGATCACGTGCTGCGC
GCGGTCGACGGGCTGTTTCCGGCTTATACGCGCGAGCGCGCGATTCGTCAGGCCGTCGCGTTCGTCGACGAGCGGCTGAA
CGGCGAGGACGGCCTCGGCGCGATCTATCCGGCGATGGCCAACGCGGTGATGATGTACGACGTGCTCGGCTACGCGGAAG
ATCATCCGAATCGCGCGATCGCGCGCAAGTCGATCGAGAAGCTGCTCGTCGTGCACGAAGACGAAGCGTATTGCCAGCCG
TGTCTGTCGCCCGTCTGGGATACCTCGCTCGCCGCGCATGCGCTGCTCGAGACGCGCGATCCGCGCGCCGAGCAGGCGGC
CGTGCGCGGCCTCGACTGGCTGCGTCCGCTGCAGATCCTCGACGTGCGCGGCGACTGGATCTCGCGCCGTCCGCACGTGC
GTCCCGGCGGCTGGGCGTTCCAGTACGCGAACCCGCACTACCCCGACGTCGACGATACGGCCGTCGTCGCGATGGCGATG
GATCGCGCGCAAAAGCTGAACCAGTCCGACACGTATCGCGAGTCGATCGCGCGTGCGCGCGAGTGGGTCGTCGGCATGCA
GAGCAGCGACGGCGGCTGGGGCGCGTTCGAGCCGGAAAACACGCAGTACTACCTGAACAACATCCCGTTCTCCGATCACG
GCGCGCTGCTCGATCCGCCGACGGCCGACGTGTCGGGCCGCTGTCTGTCGATGCTGTCGCAGCTCGGCGAAACCGCGCTG
AACAGCGACGCGGCGCGCCGCGCGCTCGACTACATGCTGAAGGAGCAGGAGCCGGACGGCAGCTGGTACGGCCGCTGGGG
GATGAACTACGTGTACGGCACGTGGACGGCGCTGTGCGCGCTGAATGCGGCTGGCCTCGGGCCCGACGACGCGCGCGTGA
AGCGCGCGGCGCAATGGCTGCTGTCGATCCAGAACAAGGACGGCGGCTGGGGCGAGGACGGCGACAGCTACAAGCTGAAC
TACCGCGGCTACGAGCCCGCACCGAGCACGGCATCGCAGACGGCCTGGGCGCTGCTCGGCCTGATGGCGGCCGGCGAGGT
GAACAACCCGGCGGTCAAGCGCGGGATCGACTATCTGATCGCCGAACAGAAGGAGCACGGCCTGTGGGACGAAGCGCGCT
TCACTGCGACCGGCTTCCCGCGCGTGTTCTATCTGCGCTATCACGGCTATCGCAAGTTCTTCCCGCTGTGGGCGCTGGCG
CGCTACCGCAACCTGAAGCGCGACAACACGACGCGCGTCACGGTCGGGATCTGA

Upstream 100 bases:

>100_bases
GCGACTGGATTGCCACCGGCTTGCCCGCCACGATCGAGGGCGCGATCCGTTCCGGCCAGCAGGCCGCGGACGCGCTCCAG
ACACAATAAGAGAGGGACCG

Downstream 100 bases:

>100_bases
CGCGGATGGCATCGCAGCAGAGCGGCGGGCTGCCCGTCATCGCGGTGACGGGCATGGCGTTCGAGGCGCGCATCGCGCGC
GGCGACGGCGTCGAGGCCGT

Product: squalene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MNDLTDMATLSAGTVPAELDAAVARATDALLAAQNADGHWVYELEADSTIPAEYVLLVHYLGETPNLELEQKIGRYLRRI
QQADGGWPLFTDGAPNISASVKAYFALKVIGDDENAEHMQRARRAIHAMGGAEMSNVFTRIQLALYGAIPWRAVPMMPVE
IMLLPQWFPFHLSKVSYWARTVIVPLLVLNAKRPLAKNPRGVRIDELFIDPPVNAGLLPRQGHQSAGWFAFFRAVDHVLR
AVDGLFPAYTRERAIRQAVAFVDERLNGEDGLGAIYPAMANAVMMYDVLGYAEDHPNRAIARKSIEKLLVVHEDEAYCQP
CLSPVWDTSLAAHALLETRDPRAEQAAVRGLDWLRPLQILDVRGDWISRRPHVRPGGWAFQYANPHYPDVDDTAVVAMAM
DRAQKLNQSDTYRESIARAREWVVGMQSSDGGWGAFEPENTQYYLNNIPFSDHGALLDPPTADVSGRCLSMLSQLGETAL
NSDAARRALDYMLKEQEPDGSWYGRWGMNYVYGTWTALCALNAAGLGPDDARVKRAAQWLLSIQNKDGGWGEDGDSYKLN
YRGYEPAPSTASQTAWALLGLMAAGEVNNPAVKRGIDYLIAEQKEHGLWDEARFTATGFPRVFYLRYHGYRKFFPLWALA
RYRNLKRDNTTRVTVGI

Sequences:

>Translated_657_residues
MNDLTDMATLSAGTVPAELDAAVARATDALLAAQNADGHWVYELEADSTIPAEYVLLVHYLGETPNLELEQKIGRYLRRI
QQADGGWPLFTDGAPNISASVKAYFALKVIGDDENAEHMQRARRAIHAMGGAEMSNVFTRIQLALYGAIPWRAVPMMPVE
IMLLPQWFPFHLSKVSYWARTVIVPLLVLNAKRPLAKNPRGVRIDELFIDPPVNAGLLPRQGHQSAGWFAFFRAVDHVLR
AVDGLFPAYTRERAIRQAVAFVDERLNGEDGLGAIYPAMANAVMMYDVLGYAEDHPNRAIARKSIEKLLVVHEDEAYCQP
CLSPVWDTSLAAHALLETRDPRAEQAAVRGLDWLRPLQILDVRGDWISRRPHVRPGGWAFQYANPHYPDVDDTAVVAMAM
DRAQKLNQSDTYRESIARAREWVVGMQSSDGGWGAFEPENTQYYLNNIPFSDHGALLDPPTADVSGRCLSMLSQLGETAL
NSDAARRALDYMLKEQEPDGSWYGRWGMNYVYGTWTALCALNAAGLGPDDARVKRAAQWLLSIQNKDGGWGEDGDSYKLN
YRGYEPAPSTASQTAWALLGLMAAGEVNNPAVKRGIDYLIAEQKEHGLWDEARFTATGFPRVFYLRYHGYRKFFPLWALA
RYRNLKRDNTTRVTVGI
>Mature_657_residues
MNDLTDMATLSAGTVPAELDAAVARATDALLAAQNADGHWVYELEADSTIPAEYVLLVHYLGETPNLELEQKIGRYLRRI
QQADGGWPLFTDGAPNISASVKAYFALKVIGDDENAEHMQRARRAIHAMGGAEMSNVFTRIQLALYGAIPWRAVPMMPVE
IMLLPQWFPFHLSKVSYWARTVIVPLLVLNAKRPLAKNPRGVRIDELFIDPPVNAGLLPRQGHQSAGWFAFFRAVDHVLR
AVDGLFPAYTRERAIRQAVAFVDERLNGEDGLGAIYPAMANAVMMYDVLGYAEDHPNRAIARKSIEKLLVVHEDEAYCQP
CLSPVWDTSLAAHALLETRDPRAEQAAVRGLDWLRPLQILDVRGDWISRRPHVRPGGWAFQYANPHYPDVDDTAVVAMAM
DRAQKLNQSDTYRESIARAREWVVGMQSSDGGWGAFEPENTQYYLNNIPFSDHGALLDPPTADVSGRCLSMLSQLGETAL
NSDAARRALDYMLKEQEPDGSWYGRWGMNYVYGTWTALCALNAAGLGPDDARVKRAAQWLLSIQNKDGGWGEDGDSYKLN
YRGYEPAPSTASQTAWALLGLMAAGEVNNPAVKRGIDYLIAEQKEHGLWDEARFTATGFPRVFYLRYHGYRKFFPLWALA
RYRNLKRDNTTRVTVGI

Specific function: Catalyzes the cyclization of squalene into hopene. Probably part of an operon y4aABCD involved in the synthesis of an isoprenoid compound [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=646, Percent_Identity=26.3157894736842, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI47933397, Length=646, Percent_Identity=26.3157894736842, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI224177558, Length=646, Percent_Identity=26.3157894736842, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI224177556, Length=646, Percent_Identity=25.5417956656347, Blast_Score=171, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321863, Length=166, Percent_Identity=36.7469879518072, Blast_Score=101, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 73426; Mature: 73426

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS01074 TERPENE_SYNTHASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLTDMATLSAGTVPAELDAAVARATDALLAAQNADGHWVYELEADSTIPAEYVLLVHY
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCHHHHHHHHH
LGETPNLELEQKIGRYLRRIQQADGGWPLFTDGAPNISASVKAYFALKVIGDDENAEHMQ
HCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCEEEEEEEEEECCCCCHHHHH
RARRAIHAMGGAEMSNVFTRIQLALYGAIPWRAVPMMPVEIMLLPQWFPFHLSKVSYWAR
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
TVIVPLLVLNAKRPLAKNPRGVRIDELFIDPPVNAGLLPRQGHQSAGWFAFFRAVDHVLR
HHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AVDGLFPAYTRERAIRQAVAFVDERLNGEDGLGAIYPAMANAVMMYDVLGYAEDHPNRAI
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
ARKSIEKLLVVHEDEAYCQPCLSPVWDTSLAAHALLETRDPRAEQAAVRGLDWLRPLQIL
HHHHHHHHEEEECCHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEE
DVRGDWISRRPHVRPGGWAFQYANPHYPDVDDTAVVAMAMDRAQKLNQSDTYRESIARAR
EECCCHHCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
EWVVGMQSSDGGWGAFEPENTQYYLNNIPFSDHGALLDPPTADVSGRCLSMLSQLGETAL
HHHEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
NSDAARRALDYMLKEQEPDGSWYGRWGMNYVYGTWTALCALNAAGLGPDDARVKRAAQWL
CHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LSIQNKDGGWGEDGDSYKLNYRGYEPAPSTASQTAWALLGLMAAGEVNNPAVKRGIDYLI
HHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCHHHHH
AEQKEHGLWDEARFTATGFPRVFYLRYHGYRKFFPLWALARYRNLKRDNTTRVTVGI
HCCHHCCCCCCCCEEECCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEEC
>Mature Secondary Structure
MNDLTDMATLSAGTVPAELDAAVARATDALLAAQNADGHWVYELEADSTIPAEYVLLVHY
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCHHHHHHHHH
LGETPNLELEQKIGRYLRRIQQADGGWPLFTDGAPNISASVKAYFALKVIGDDENAEHMQ
HCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCEEEEEEEEEECCCCCHHHHH
RARRAIHAMGGAEMSNVFTRIQLALYGAIPWRAVPMMPVEIMLLPQWFPFHLSKVSYWAR
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
TVIVPLLVLNAKRPLAKNPRGVRIDELFIDPPVNAGLLPRQGHQSAGWFAFFRAVDHVLR
HHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AVDGLFPAYTRERAIRQAVAFVDERLNGEDGLGAIYPAMANAVMMYDVLGYAEDHPNRAI
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
ARKSIEKLLVVHEDEAYCQPCLSPVWDTSLAAHALLETRDPRAEQAAVRGLDWLRPLQIL
HHHHHHHHEEEECCHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEE
DVRGDWISRRPHVRPGGWAFQYANPHYPDVDDTAVVAMAMDRAQKLNQSDTYRESIARAR
EECCCHHCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
EWVVGMQSSDGGWGAFEPENTQYYLNNIPFSDHGALLDPPTADVSGRCLSMLSQLGETAL
HHHEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
NSDAARRALDYMLKEQEPDGSWYGRWGMNYVYGTWTALCALNAAGLGPDDARVKRAAQWL
CHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LSIQNKDGGWGEDGDSYKLNYRGYEPAPSTASQTAWALLGLMAAGEVNNPAVKRGIDYLI
HHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCHHHHH
AEQKEHGLWDEARFTATGFPRVFYLRYHGYRKFFPLWALARYRNLKRDNTTRVTVGI
HCCHHCCCCCCCCEEECCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]