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The map label for this gene is degS [H]

Identifier: 189354085

GI number: 189354085

Start: 2429028

End: 2430407

Strand: Direct

Name: degS [H]

Synonym: BMULJ_05338

Alternate gene names: 189354085

Gene position: 2429028-2430407 (Clockwise)

Preceding gene: 189354084

Following gene: 189354086

Centisome position: 98.22

GC content: 70.43

Gene sequence:

>1380_bases
ATGAAGCTCAAGGCCAAGATTTTCCTGCTGGCGATCGTGCCGTTCCTGCTCGCGATCGCCGGAATCGGTTTCGGCGTGCG
CCAGCAGGCGACGTCGCTCGCGCGCACGCAGCATGCGACGATCCAGGCCGCGTATCTGTCGAGCAAGGAAGTCGAGCTGA
AGCACTACGTCGAGCTCGCGACGAGCGCGATCATGCCGCTGTACGACGCGGCCGGCCGCAACGGGCGCGACGACGCGATG
CTGCGCACGCAGGCGCTCGCGATGCTGCAGAAGATGGATTTCGGCCCGGACGGCTATTTCTTCGTGTACGACCTGCACGG
CAACGCGCTGATGCATCCGCGCGAGCCCGAGCGCGTCGGCCATAACTTCTGGACCATGCGCGACCCGCAGGGCGCGCTGA
CGATCCAGCAGCTGATCGGCGCCGCCTCGCGCGGCGGCGGCTTCGTGCGCTACGTCTGGCAGCGGCCGTCGACCGGCAAG
CCGGCGCCGAAGCTCGGCTACGTGGTCGCGCTCGAACGCTGGGGCTGGATGGTAGGCACCGGCATCTATCTCGACGACGT
CGACACCGCACTGCAGCGGATCGACGCCCGCGCTTCCGCGAACATCGAGCGCACGATGAGCTGGCTGACCGCGATCGCGC
TCACCGGCGCCGCGGCGATCGCCGTCTGCGCGCTGGTGCTGAACGTCAGCGAGTCGCGCAGCGCCGATGCGAAGCTCAAG
CAGCTCGCGCAGCGCGTCGTCGAATCGCAGGAGCAGGAGCGCGCGCGGCTGTCGCGCGAGCTGCACGACGGGATCAGTCA
GATGATGGTGTCCGCGAAGCTGATGCTCGAATCGGCGCTCGCGCGCTTCGAGCGCGGCACGGTGCGCGTGCCGGAAGCCG
AGCGCGCGCTCGCGTCCGGCGTCGTGCGGCTCGGCGACACGCTGCGCGAGGTGCGCCGCATCTCGCACGCGCTGCGCCCG
GCGATGCTCGACGATCTCGGCCTCGCGGCGGCGCTCGATCAGCTGATCCGCGAATTCGGCGCGCAAAGCGGCATCGACAT
CGGCTACACGCAGGTCGCGCACAGCGGCGCGCGGCCGCTGCCCGCAGCCGTGAACACCGCGCTGTTCCGGATCGCGCAGG
AAGCGCTCAGCAACATCGTGCATCATGCGCACGCGTCGCGCGCGGCCGTCACGCTCGACGTCGGCGCGCAGTCGGTCACG
CTGACGATCGCCGACAACGGCTGCGGCTTCGACGCCGTGCGCTCGCAGGCCGACGAGCGCCGCGGCATCGGGCTGCGCAA
CATGCGCGAGCGCCTCGACGCGCTCGGCGGCACGCTGACGATCACGTCGCAGGTCGGCCACACCGTCGTGGCCGCGCGCG
TGCCGCTACGCGACGCGTGA

Upstream 100 bases:

>100_bases
CCGCGCGCGCAAAATCGTCGACAATACCGGCTCGCTCCGCCGGCCGCGCGCCGGCGGCAAGCGTGCCGGCCGGCGCCGGC
GCGCGTCCGTCCGCGTCACC

Downstream 100 bases:

>100_bases
CGCCTTACCTCAGGAGACCCTTCGCATATGAGCGCCCCCGACACCGCCCGACCCGCCGCCCGGCTGCTGCTCGTCGACGA
TCATCCGCTCGTGCGCGACG

Product: two-component system sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKLKAKIFLLAIVPFLLAIAGIGFGVRQQATSLARTQHATIQAAYLSSKEVELKHYVELATSAIMPLYDAAGRNGRDDAM
LRTQALAMLQKMDFGPDGYFFVYDLHGNALMHPREPERVGHNFWTMRDPQGALTIQQLIGAASRGGGFVRYVWQRPSTGK
PAPKLGYVVALERWGWMVGTGIYLDDVDTALQRIDARASANIERTMSWLTAIALTGAAAIAVCALVLNVSESRSADAKLK
QLAQRVVESQEQERARLSRELHDGISQMMVSAKLMLESALARFERGTVRVPEAERALASGVVRLGDTLREVRRISHALRP
AMLDDLGLAAALDQLIREFGAQSGIDIGYTQVAHSGARPLPAAVNTALFRIAQEALSNIVHHAHASRAAVTLDVGAQSVT
LTIADNGCGFDAVRSQADERRGIGLRNMRERLDALGGTLTITSQVGHTVVAARVPLRDA

Sequences:

>Translated_459_residues
MKLKAKIFLLAIVPFLLAIAGIGFGVRQQATSLARTQHATIQAAYLSSKEVELKHYVELATSAIMPLYDAAGRNGRDDAM
LRTQALAMLQKMDFGPDGYFFVYDLHGNALMHPREPERVGHNFWTMRDPQGALTIQQLIGAASRGGGFVRYVWQRPSTGK
PAPKLGYVVALERWGWMVGTGIYLDDVDTALQRIDARASANIERTMSWLTAIALTGAAAIAVCALVLNVSESRSADAKLK
QLAQRVVESQEQERARLSRELHDGISQMMVSAKLMLESALARFERGTVRVPEAERALASGVVRLGDTLREVRRISHALRP
AMLDDLGLAAALDQLIREFGAQSGIDIGYTQVAHSGARPLPAAVNTALFRIAQEALSNIVHHAHASRAAVTLDVGAQSVT
LTIADNGCGFDAVRSQADERRGIGLRNMRERLDALGGTLTITSQVGHTVVAARVPLRDA
>Mature_459_residues
MKLKAKIFLLAIVPFLLAIAGIGFGVRQQATSLARTQHATIQAAYLSSKEVELKHYVELATSAIMPLYDAAGRNGRDDAM
LRTQALAMLQKMDFGPDGYFFVYDLHGNALMHPREPERVGHNFWTMRDPQGALTIQQLIGAASRGGGFVRYVWQRPSTGK
PAPKLGYVVALERWGWMVGTGIYLDDVDTALQRIDARASANIERTMSWLTAIALTGAAAIAVCALVLNVSESRSADAKLK
QLAQRVVESQEQERARLSRELHDGISQMMVSAKLMLESALARFERGTVRVPEAERALASGVVRLGDTLREVRRISHALRP
AMLDDLGLAAALDQLIREFGAQSGIDIGYTQVAHSGARPLPAAVNTALFRIAQEALSNIVHHAHASRAAVTLDVGAQSVT
LTIADNGCGFDAVRSQADERRGIGLRNMRERLDALGGTLTITSQVGHTVVAARVPLRDA

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4564

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=232, Percent_Identity=36.2068965517241, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787474, Length=209, Percent_Identity=30.1435406698565, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788812, Length=204, Percent_Identity=31.3725490196078, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49786; Mature: 49786

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKAKIFLLAIVPFLLAIAGIGFGVRQQATSLARTQHATIQAAYLSSKEVELKHYVELA
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEHHCCCCHHHHHHHHHH
TSAIMPLYDAAGRNGRDDAMLRTQALAMLQKMDFGPDGYFFVYDLHGNALMHPREPERVG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEECCCCCHHHHC
HNFWTMRDPQGALTIQQLIGAASRGGGFVRYVWQRPSTGKPAPKLGYVVALERWGWMVGT
CCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCHHEEEEHHCCCCCCC
GIYLDDVDTALQRIDARASANIERTMSWLTAIALTGAAAIAVCALVLNVSESRSADAKLK
CEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
QLAQRVVESQEQERARLSRELHDGISQMMVSAKLMLESALARFERGTVRVPEAERALASG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHH
VVRLGDTLREVRRISHALRPAMLDDLGLAAALDQLIREFGAQSGIDIGYTQVAHSGARPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCC
PAAVNTALFRIAQEALSNIVHHAHASRAAVTLDVGAQSVTLTIADNGCGFDAVRSQADER
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHH
RGIGLRNMRERLDALGGTLTITSQVGHTVVAARVPLRDA
CCCCHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCC
>Mature Secondary Structure
MKLKAKIFLLAIVPFLLAIAGIGFGVRQQATSLARTQHATIQAAYLSSKEVELKHYVELA
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEHHCCCCHHHHHHHHHH
TSAIMPLYDAAGRNGRDDAMLRTQALAMLQKMDFGPDGYFFVYDLHGNALMHPREPERVG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEECCCCCHHHHC
HNFWTMRDPQGALTIQQLIGAASRGGGFVRYVWQRPSTGKPAPKLGYVVALERWGWMVGT
CCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCHHEEEEHHCCCCCCC
GIYLDDVDTALQRIDARASANIERTMSWLTAIALTGAAAIAVCALVLNVSESRSADAKLK
CEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
QLAQRVVESQEQERARLSRELHDGISQMMVSAKLMLESALARFERGTVRVPEAERALASG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHH
VVRLGDTLREVRRISHALRPAMLDDLGLAAALDQLIREFGAQSGIDIGYTQVAHSGARPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCC
PAAVNTALFRIAQEALSNIVHHAHASRAAVTLDVGAQSVTLTIADNGCGFDAVRSQADER
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHH
RGIGLRNMRERLDALGGTLTITSQVGHTVVAARVPLRDA
CCCCHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]