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The map label for this gene is ptxR [H]

Identifier: 189353955

GI number: 189353955

Start: 2270919

End: 2271902

Strand: Reverse

Name: ptxR [H]

Synonym: BMULJ_05208

Alternate gene names: 189353955

Gene position: 2271902-2270919 (Counterclockwise)

Preceding gene: 189353958

Following gene: 189353951

Centisome position: 91.86

GC content: 69.92

Gene sequence:

>984_bases
ATGACCAAAAAATCCCATGACTCCCGTGATCCACAAGGCGGTTCGCGCATTCCGACGGTGCCCGTGGACAGCGCCGGCTA
TCGTTTCGAGCTGATGGAGACGTTCGTACGCATAGTCGAGGCCGGCAGCCTGTCGGCCGCCGCGGCGCAGATGCATACGA
CGCAGCCGACGGTCAGCCGCAGGCTGCAGGCGCTCGAGCGCTCGCTCGGCGTGCGGCTGCTGCAGCGGACCACGCATGCG
ATGCGGCTGACCGTCGACGGCGAGCGCTGCTTCAAACGCGCGAAGGATCTGCTCGCGAGCTGGGCCGCGTTCGAAGCCGA
TCTGCGCGGCGCGCAGGAGGAGCCCGACGGCCTGCTGCGCGTCGCCGTGCCGCATGCGTTCGGCCAGGAGCGCTTCGTCG
AGCCGCTCGCGCGATTTTTGCGCGACTATCCGCGCGTGTCGGTCGAATGGCTGCTGCAGGACGACGTGCGCGATTTCGTC
GGCAGCGGCATCGACTGCGCGATCCAGGTCGGCGAACCGACCGATCCGGGCGTGGTCGCGATCCGGCTGACGAACGTGCC
GCGCTTCGTCGCAGCGGCGCCGTCGGTGCTCGGCGGTGCCGACGTGCCGCGCGATCCCGACGCGCTCGCCGCGCTGCCGT
GGCTCGCGCTGAGCACGTACTACCGCACCGAGTTGACGCTCACGCATGCGACGACCGGCGACACGCGCCGGATCCGGATT
CGCCCGCGCATGACCACCGCGAATCTGTACGCGCTGCGCAGCGCGGCGCTGCTCGGCCTCGGCGCGTGCGTCGGTTCGTC
GTGGATGCTCGCCGGCGACCTTGCGCGCGGCGAACTCGTGCATCTCGCGCCCGAGTGGCACGCGGCGCCGTTGCCCGTTT
ATCTGATCTATCCGCACGCGCAGTTCTATCCGTCGCGGCTCGTGCGGTTCGCCGCGATGATGCGCGAAGCGGTGCCGCGT
CTCGTCGAAGGGCGCGACCCGTGA

Upstream 100 bases:

>100_bases
TGGGCGTCCTCAGTGGTGGAAACACGATGGACGCGAGTGTGACCGCGCGGCACGCGCGACGGTAGTAGCGCGCCGCGCAG
ACTTGTTATACGTTTCACGT

Downstream 100 bases:

>100_bases
TGCGGCGGCCGGCGCCGCCGGCGCTCAGCGTCGGCGAATGCCTTCGGGCAGCGCGCTGATGCGCCGCACTTCCGGCGAGT
CGAGCCATGCGCGCGACGCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTKKSHDSRDPQGGSRIPTVPVDSAGYRFELMETFVRIVEAGSLSAAAAQMHTTQPTVSRRLQALERSLGVRLLQRTTHA
MRLTVDGERCFKRAKDLLASWAAFEADLRGAQEEPDGLLRVAVPHAFGQERFVEPLARFLRDYPRVSVEWLLQDDVRDFV
GSGIDCAIQVGEPTDPGVVAIRLTNVPRFVAAAPSVLGGADVPRDPDALAALPWLALSTYYRTELTLTHATTGDTRRIRI
RPRMTTANLYALRSAALLGLGACVGSSWMLAGDLARGELVHLAPEWHAAPLPVYLIYPHAQFYPSRLVRFAAMMREAVPR
LVEGRDP

Sequences:

>Translated_327_residues
MTKKSHDSRDPQGGSRIPTVPVDSAGYRFELMETFVRIVEAGSLSAAAAQMHTTQPTVSRRLQALERSLGVRLLQRTTHA
MRLTVDGERCFKRAKDLLASWAAFEADLRGAQEEPDGLLRVAVPHAFGQERFVEPLARFLRDYPRVSVEWLLQDDVRDFV
GSGIDCAIQVGEPTDPGVVAIRLTNVPRFVAAAPSVLGGADVPRDPDALAALPWLALSTYYRTELTLTHATTGDTRRIRI
RPRMTTANLYALRSAALLGLGACVGSSWMLAGDLARGELVHLAPEWHAAPLPVYLIYPHAQFYPSRLVRFAAMMREAVPR
LVEGRDP
>Mature_326_residues
TKKSHDSRDPQGGSRIPTVPVDSAGYRFELMETFVRIVEAGSLSAAAAQMHTTQPTVSRRLQALERSLGVRLLQRTTHAM
RLTVDGERCFKRAKDLLASWAAFEADLRGAQEEPDGLLRVAVPHAFGQERFVEPLARFLRDYPRVSVEWLLQDDVRDFVG
SGIDCAIQVGEPTDPGVVAIRLTNVPRFVAAAPSVLGGADVPRDPDALAALPWLALSTYYRTELTLTHATTGDTRRIRIR
PRMTTANLYALRSAALLGLGACVGSSWMLAGDLARGELVHLAPEWHAAPLPVYLIYPHAQFYPSRLVRFAAMMREAVPRL
VEGRDP

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=281, Percent_Identity=29.1814946619217, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1786401, Length=293, Percent_Identity=29.6928327645051, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789440, Length=266, Percent_Identity=26.3157894736842, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI145693193, Length=294, Percent_Identity=27.2108843537415, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87081978, Length=266, Percent_Identity=24.4360902255639, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1787589, Length=270, Percent_Identity=23.3333333333333, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789204, Length=134, Percent_Identity=32.8358208955224, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1787128, Length=177, Percent_Identity=23.728813559322, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 36059; Mature: 35928

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKSHDSRDPQGGSRIPTVPVDSAGYRFELMETFVRIVEAGSLSAAAAQMHTTQPTVSR
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHH
RLQALERSLGVRLLQRTTHAMRLTVDGERCFKRAKDLLASWAAFEADLRGAQEEPDGLLR
HHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
VAVPHAFGQERFVEPLARFLRDYPRVSVEWLLQDDVRDFVGSGIDCAIQVGEPTDPGVVA
EECCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEE
IRLTNVPRFVAAAPSVLGGADVPRDPDALAALPWLALSTYYRTELTLTHATTGDTRRIRI
EEECCCCHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEEEECCCCCEEEEE
RPRMTTANLYALRSAALLGLGACVGSSWMLAGDLARGELVHLAPEWHAAPLPVYLIYPHA
EECCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEECCCCCCCCCEEEEECCCH
QFYPSRLVRFAAMMREAVPRLVEGRDP
HHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TKKSHDSRDPQGGSRIPTVPVDSAGYRFELMETFVRIVEAGSLSAAAAQMHTTQPTVSR
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHH
RLQALERSLGVRLLQRTTHAMRLTVDGERCFKRAKDLLASWAAFEADLRGAQEEPDGLLR
HHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
VAVPHAFGQERFVEPLARFLRDYPRVSVEWLLQDDVRDFVGSGIDCAIQVGEPTDPGVVA
EECCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEE
IRLTNVPRFVAAAPSVLGGADVPRDPDALAALPWLALSTYYRTELTLTHATTGDTRRIRI
EEECCCCHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEEEECCCCCEEEEE
RPRMTTANLYALRSAALLGLGACVGSSWMLAGDLARGELVHLAPEWHAAPLPVYLIYPHA
EECCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEECCCCCCCCCEEEEECCCH
QFYPSRLVRFAAMMREAVPRLVEGRDP
HHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]