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The map label for this gene is gabT [H]

Identifier: 189353910

GI number: 189353910

Start: 2221472

End: 2222761

Strand: Direct

Name: gabT [H]

Synonym: BMULJ_05162

Alternate gene names: 189353910

Gene position: 2221472-2222761 (Clockwise)

Preceding gene: 189353908

Following gene: 189353911

Centisome position: 89.82

GC content: 67.52

Gene sequence:

>1290_bases
ATGACCGTGAAGAATGCCGACCTGCTGGCCCGCAAGAACGCCGCGACCCCGCGCGGCGTCGGAGTGATGTGCGACTTCTA
CGCCGCCCGCGCCGAGAACGCGGAGCTGTGGGACGTCGAAGGCCGCCGTTTCATCGATTTCGCCGCGGGCATCGCGGTGC
TGAACACGGGCCATCGTCATCCGAAGATCGTCAAGGCGATCGCGGAGCAGCTGGAGCTCTTCACGCACACCGCCTACCAG
ATCGTCCCGTACGCGTCGTACGTCGAGCTGGCCGAAAAGATCAACGAACGCGCGCCGGGCGACTTCCCGAAAAAGACGGC
GTTCTTCACGACCGGTGCCGAAGCCGTCGAAAACGCGATCAAGATCGCACGCGCGGCAACGGGCCGTCCGGGCGTGATCG
CGTTCTCGGGCGGCTTCCACGGCCGCACGATGATGGGCATGGCGCTGACCGGCAAGGTCGCCCCGTACAAGCTGAACTTC
GGTCCGTTCCCGGGCGACGTGTTCCACGCACCATACCCGAACGCCGTGCACGGCGTGACGACCGCCGACTCGATCAAGGC
GATCGAGATGCTGTTCAAGGCCGACATCGATCCGAAGCGCGTCGCCGCGATCATCTTCGAACCGGTCCAGGGCGAAGGCG
GCTTCAACCCGGCGCCGGCCGAGTTCGTCCGCGCGCTGCGCAAGATCTGTAACGAGCACGGCATCCTGCTGATCGCCGAC
GAAGTGCAGACGGGCTTCGCGCGTACCGGCAAGCTGTTCGCGATGCAGCACTACGACGTGCTGGCCGACCTGATCACGAT
GGCGAAGAGCCTCGCGGGCGGCATGCCGCTGTCGGGCGTCGTCGGCCGTGCGGACGTGATGGACGCGGCCGCCCCGGGCG
GCCTCGGCGGCACGTACGCGGGCAACCCGCTCGCGGTCGCGTCGGCGCACGCGGTGCTCGAGATCATCGACGAAGAAAAG
CTGTGCGAGCGCGCGACGCAGCTCGGCGACACGCTGAAGGCGAAGCTGAACGCGCTGCAGGCCGAGGTGCCGCAGATCGC
CGACGTGCGCGGCCCGGGTGCGATGATTGCGGTCGAGTTCATGAAGCCGGGCACCGGCGAGCCGGACGCCGAATTCACGA
AGCGCGTGCAGGCGCGTGCGCTCGAGCGCGGGCTGCTGCTGCTCGTCTGCGGCGTGTACTCGAACGTCGTGCGCTTCCTG
TTCCCGCTGACGATCCCGCAAGCCGTGTTCGACGAAGCGCTCGCGATCCTCGAGGAAGTGCTGAAGGAAACGGTCGGCGT
GCCGGCCTGA

Upstream 100 bases:

>100_bases
TTGAAATGGCTCTGATTGCCAGAGCCAAATGTGATTATAGTCGCGACCATGGGTTGCCGATGCGCCCGCCTCTCACCTCA
CCGGACAGAACATCAAGGAG

Downstream 100 bases:

>100_bases
GTTCCCGTCAACCGAATGCGCCGCCGCCGTCGTGAAGACGGCGGCGGCCGTTTCATCTTCACAGCAGGTACCGGAATGAG
CACTGTTCAAGAAACCCTGG

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTVKNADLLARKNAATPRGVGVMCDFYAARAENAELWDVEGRRFIDFAAGIAVLNTGHRHPKIVKAIAEQLELFTHTAYQ
IVPYASYVELAEKINERAPGDFPKKTAFFTTGAEAVENAIKIARAATGRPGVIAFSGGFHGRTMMGMALTGKVAPYKLNF
GPFPGDVFHAPYPNAVHGVTTADSIKAIEMLFKADIDPKRVAAIIFEPVQGEGGFNPAPAEFVRALRKICNEHGILLIAD
EVQTGFARTGKLFAMQHYDVLADLITMAKSLAGGMPLSGVVGRADVMDAAAPGGLGGTYAGNPLAVASAHAVLEIIDEEK
LCERATQLGDTLKAKLNALQAEVPQIADVRGPGAMIAVEFMKPGTGEPDAEFTKRVQARALERGLLLLVCGVYSNVVRFL
FPLTIPQAVFDEALAILEEVLKETVGVPA

Sequences:

>Translated_429_residues
MTVKNADLLARKNAATPRGVGVMCDFYAARAENAELWDVEGRRFIDFAAGIAVLNTGHRHPKIVKAIAEQLELFTHTAYQ
IVPYASYVELAEKINERAPGDFPKKTAFFTTGAEAVENAIKIARAATGRPGVIAFSGGFHGRTMMGMALTGKVAPYKLNF
GPFPGDVFHAPYPNAVHGVTTADSIKAIEMLFKADIDPKRVAAIIFEPVQGEGGFNPAPAEFVRALRKICNEHGILLIAD
EVQTGFARTGKLFAMQHYDVLADLITMAKSLAGGMPLSGVVGRADVMDAAAPGGLGGTYAGNPLAVASAHAVLEIIDEEK
LCERATQLGDTLKAKLNALQAEVPQIADVRGPGAMIAVEFMKPGTGEPDAEFTKRVQARALERGLLLLVCGVYSNVVRFL
FPLTIPQAVFDEALAILEEVLKETVGVPA
>Mature_428_residues
TVKNADLLARKNAATPRGVGVMCDFYAARAENAELWDVEGRRFIDFAAGIAVLNTGHRHPKIVKAIAEQLELFTHTAYQI
VPYASYVELAEKINERAPGDFPKKTAFFTTGAEAVENAIKIARAATGRPGVIAFSGGFHGRTMMGMALTGKVAPYKLNFG
PFPGDVFHAPYPNAVHGVTTADSIKAIEMLFKADIDPKRVAAIIFEPVQGEGGFNPAPAEFVRALRKICNEHGILLIADE
VQTGFARTGKLFAMQHYDVLADLITMAKSLAGGMPLSGVVGRADVMDAAAPGGLGGTYAGNPLAVASAHAVLEIIDEEKL
CERATQLGDTLKAKLNALQAEVPQIADVRGPGAMIAVEFMKPGTGEPDAEFTKRVQARALERGLLLLVCGVYSNVVRFLF
PLTIPQAVFDEALAILEEVLKETVGVPA

Specific function: Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=408, Percent_Identity=33.3333333333333, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI13994255, Length=419, Percent_Identity=30.3102625298329, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI37574042, Length=423, Percent_Identity=28.8416075650118, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI284507298, Length=324, Percent_Identity=33.641975308642, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI24119277, Length=414, Percent_Identity=27.0531400966184, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI226442709, Length=396, Percent_Identity=29.2929292929293, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI226442705, Length=442, Percent_Identity=27.8280542986425, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI188536080, Length=425, Percent_Identity=28.9411764705882, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI38679950, Length=425, Percent_Identity=28.9411764705882, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI38679946, Length=425, Percent_Identity=28.9411764705882, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=70.0712589073634, Blast_Score=589, Evalue=1e-169,
Organism=Escherichia coli, GI1789016, Length=421, Percent_Identity=53.9192399049881, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1788044, Length=390, Percent_Identity=36.1538461538462, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1789759, Length=408, Percent_Identity=33.3333333333333, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI145693181, Length=382, Percent_Identity=34.8167539267016, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1786349, Length=345, Percent_Identity=32.7536231884058, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1786991, Length=349, Percent_Identity=33.5243553008596, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25144271, Length=404, Percent_Identity=33.4158415841584, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI32564660, Length=429, Percent_Identity=32.6340326340326, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71992977, Length=423, Percent_Identity=30.4964539007092, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI25144274, Length=289, Percent_Identity=34.2560553633218, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=430, Percent_Identity=27.906976744186, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI71981843, Length=160, Percent_Identity=31.25, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=351, Percent_Identity=37.3219373219373, Blast_Score=212, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6324432, Length=411, Percent_Identity=32.360097323601, Blast_Score=202, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6321456, Length=372, Percent_Identity=29.0322580645161, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6324386, Length=323, Percent_Identity=26.3157894736842, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21357415, Length=407, Percent_Identity=33.1695331695332, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI161085790, Length=448, Percent_Identity=29.9107142857143, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI28574759, Length=451, Percent_Identity=29.7117516629712, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI21356575, Length=414, Percent_Identity=30.4347826086957, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI281366494, Length=362, Percent_Identity=28.7292817679558, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24667139, Length=362, Percent_Identity=28.7292817679558, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24667143, Length=362, Percent_Identity=28.7292817679558, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19 [H]

Molecular weight: Translated: 45769; Mature: 45638

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00600 AA_TRANSFER_CLASS_3 ; PS00636 DNAJ_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKNADLLARKNAATPRGVGVMCDFYAARAENAELWDVEGRRFIDFAAGIAVLNTGHRH
CCCCCCHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCC
PKIVKAIAEQLELFTHTAYQIVPYASYVELAEKINERAPGDFPKKTAFFTTGAEAVENAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHH
KIARAATGRPGVIAFSGGFHGRTMMGMALTGKVAPYKLNFGPFPGDVFHAPYPNAVHGVT
HHHHHCCCCCCEEEEECCCCCCEEECEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCC
TADSIKAIEMLFKADIDPKRVAAIIFEPVQGEGGFNPAPAEFVRALRKICNEHGILLIAD
CHHHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEC
EVQTGFARTGKLFAMQHYDVLADLITMAKSLAGGMPLSGVVGRADVMDAAAPGGLGGTYA
CHHHCHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCC
GNPLAVASAHAVLEIIDEEKLCERATQLGDTLKAKLNALQAEVPQIADVRGPGAMIAVEF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEE
MKPGTGEPDAEFTKRVQARALERGLLLLVCGVYSNVVRFLFPLTIPQAVFDEALAILEEV
ECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LKETVGVPA
HHHHCCCCC
>Mature Secondary Structure 
TVKNADLLARKNAATPRGVGVMCDFYAARAENAELWDVEGRRFIDFAAGIAVLNTGHRH
CCCCCHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCC
PKIVKAIAEQLELFTHTAYQIVPYASYVELAEKINERAPGDFPKKTAFFTTGAEAVENAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHH
KIARAATGRPGVIAFSGGFHGRTMMGMALTGKVAPYKLNFGPFPGDVFHAPYPNAVHGVT
HHHHHCCCCCCEEEEECCCCCCEEECEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCC
TADSIKAIEMLFKADIDPKRVAAIIFEPVQGEGGFNPAPAEFVRALRKICNEHGILLIAD
CHHHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEC
EVQTGFARTGKLFAMQHYDVLADLITMAKSLAGGMPLSGVVGRADVMDAAAPGGLGGTYA
CHHHCHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCC
GNPLAVASAHAVLEIIDEEKLCERATQLGDTLKAKLNALQAEVPQIADVRGPGAMIAVEF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEE
MKPGTGEPDAEFTKRVQARALERGLLLLVCGVYSNVVRFLFPLTIPQAVFDEALAILEEV
ECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LKETVGVPA
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]