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The map label for this gene is cynR [H]

Identifier: 189353894

GI number: 189353894

Start: 2201969

End: 2202940

Strand: Reverse

Name: cynR [H]

Synonym: BMULJ_05146

Alternate gene names: 189353894

Gene position: 2202940-2201969 (Counterclockwise)

Preceding gene: 189353899

Following gene: 189353892

Centisome position: 89.07

GC content: 68.21

Gene sequence:

>972_bases
ATGCGCGAACTGAACCAGCGCCGCCTGCGCTACTTTCATGAAGTCCTGACCCATGGCTCGATCCGCGGCGCGGCCGACAG
CATCAATACCGCGCCGTCCGTGATCACGCGGCAGATCCGCCTGCTCGAGGAGGAAATCGGCGTCGTGCTGTTCGAGCGCC
AGGCGCGCGGCGTGCGACCGACCGAGGCCGCCGCGCATCTGCTCGAATACTGGCGCGGTTGCCGTTCGCAGCAGGAACTG
TTCGAGGAGCGGCTGCAGGCGCTGCAGCGGCTTCAGTCCGGCCAGGTGCGGATCGTGACCAGCGAAGGCTATGTCGACGT
GCTGATGGACGAGGTGCTGACCGACTTCTGCATGCGCTATCCGAAACTCGACGTGATCGTCGACGTGCTGCCGGTCAACA
ACGTGCTGCAGGAGGTGGCCGAGAGCCGCGCGCATATCGGGCTCGCGTACAACCCGCCCGCGCATCCGGAGATCCGCTAT
CTCGCGACCTCGTCGCAGCCGGTGGTGGCGCTCGTCCACGCGGCCCATCCGCTTGCGGTGCGCGGCGGCCCGGTCCGCGC
GCACGAGCTCGGCGAGTATCCGCTCGCGCTGATGCCGCCGGCCTTCGGTCTCGGTCAGGTGGCGCAGATGCTCGCCTATA
CGGAGAACCTGCCGATCCGCCCGACGCTGACGACCAATTCGCTCGCGGTGCTGCGGCATTTCGTCAAGCGCCATCGAGGC
ATCACGCTGATCGGCGCGTTCGCGGCTTATCGCGAACTGGACAGCGGCGAGCTCGTCGCGCTGCCGATCGAGCATCCGTT
GTTCGATTCCGCGAAGGCGCGCCTGCTGGTGAAGACGGGGCGGCCGCTCGGTGTGGCGGCCGACACGCTGCTGAATTGCC
TGCTGAGCGACATGAAGATGTTCGCGGCGGCGAATGGCGGCGGCCGGACCAGGGACGCCGCGCGGAAGCGGGCGGTCAGG
CGCGCGCGGTAG

Upstream 100 bases:

>100_bases
GATGGCTGCATCGTCGGAGAGACGAAAAAGCAGAGCAAGAGCAACTTCCGTGCACTAATGTTGCTCCACGGGCAACACGT
GACGACACACCGGAATCCCC

Downstream 100 bases:

>100_bases
CGCGTGCTGCGGTTACGCCGCGTCGCCGTCGGCACGCAGCGCCCGCACCAGCTCGTTCGCGGCCTTGCCGAGCCCCGTAT
GCTTCGGCCGCCGCAGATAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MRELNQRRLRYFHEVLTHGSIRGAADSINTAPSVITRQIRLLEEEIGVVLFERQARGVRPTEAAAHLLEYWRGCRSQQEL
FEERLQALQRLQSGQVRIVTSEGYVDVLMDEVLTDFCMRYPKLDVIVDVLPVNNVLQEVAESRAHIGLAYNPPAHPEIRY
LATSSQPVVALVHAAHPLAVRGGPVRAHELGEYPLALMPPAFGLGQVAQMLAYTENLPIRPTLTTNSLAVLRHFVKRHRG
ITLIGAFAAYRELDSGELVALPIEHPLFDSAKARLLVKTGRPLGVAADTLLNCLLSDMKMFAAANGGGRTRDAARKRAVR
RAR

Sequences:

>Translated_323_residues
MRELNQRRLRYFHEVLTHGSIRGAADSINTAPSVITRQIRLLEEEIGVVLFERQARGVRPTEAAAHLLEYWRGCRSQQEL
FEERLQALQRLQSGQVRIVTSEGYVDVLMDEVLTDFCMRYPKLDVIVDVLPVNNVLQEVAESRAHIGLAYNPPAHPEIRY
LATSSQPVVALVHAAHPLAVRGGPVRAHELGEYPLALMPPAFGLGQVAQMLAYTENLPIRPTLTTNSLAVLRHFVKRHRG
ITLIGAFAAYRELDSGELVALPIEHPLFDSAKARLLVKTGRPLGVAADTLLNCLLSDMKMFAAANGGGRTRDAARKRAVR
RAR
>Mature_323_residues
MRELNQRRLRYFHEVLTHGSIRGAADSINTAPSVITRQIRLLEEEIGVVLFERQARGVRPTEAAAHLLEYWRGCRSQQEL
FEERLQALQRLQSGQVRIVTSEGYVDVLMDEVLTDFCMRYPKLDVIVDVLPVNNVLQEVAESRAHIGLAYNPPAHPEIRY
LATSSQPVVALVHAAHPLAVRGGPVRAHELGEYPLALMPPAFGLGQVAQMLAYTENLPIRPTLTTNSLAVLRHFVKRHRG
ITLIGAFAAYRELDSGELVALPIEHPLFDSAKARLLVKTGRPLGVAADTLLNCLLSDMKMFAAANGGGRTRDAARKRAVR
RAR

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=311, Percent_Identity=26.3665594855305, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1787949, Length=271, Percent_Identity=22.8782287822878, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1790399, Length=266, Percent_Identity=24.812030075188, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35908; Mature: 35908

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS50931 HTH_LYSR ; PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRELNQRRLRYFHEVLTHGSIRGAADSINTAPSVITRQIRLLEEEIGVVLFERQARGVRP
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCH
TEAAAHLLEYWRGCRSQQELFEERLQALQRLQSGQVRIVTSEGYVDVLMDEVLTDFCMRY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHC
PKLDVIVDVLPVNNVLQEVAESRAHIGLAYNPPAHPEIRYLATSSQPVVALVHAAHPLAV
CCHHHEEEECCHHHHHHHHHHHHHCEEEEECCCCCCCEEEEECCCCCCEEEEECCCCEEE
RGGPVRAHELGEYPLALMPPAFGLGQVAQMLAYTENLPIRPTLTTNSLAVLRHFVKRHRG
CCCCCCHHHCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCC
ITLIGAFAAYRELDSGELVALPIEHPLFDSAKARLLVKTGRPLGVAADTLLNCLLSDMKM
EEEEEHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
FAAANGGGRTRDAARKRAVRRAR
HHHCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MRELNQRRLRYFHEVLTHGSIRGAADSINTAPSVITRQIRLLEEEIGVVLFERQARGVRP
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCH
TEAAAHLLEYWRGCRSQQELFEERLQALQRLQSGQVRIVTSEGYVDVLMDEVLTDFCMRY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHC
PKLDVIVDVLPVNNVLQEVAESRAHIGLAYNPPAHPEIRYLATSSQPVVALVHAAHPLAV
CCHHHEEEECCHHHHHHHHHHHHHCEEEEECCCCCCCEEEEECCCCCCEEEEECCCCEEE
RGGPVRAHELGEYPLALMPPAFGLGQVAQMLAYTENLPIRPTLTTNSLAVLRHFVKRHRG
CCCCCCHHHCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCC
ITLIGAFAAYRELDSGELVALPIEHPLFDSAKARLLVKTGRPLGVAADTLLNCLLSDMKM
EEEEEHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
FAAANGGGRTRDAARKRAVRRAR
HHHCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]