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The map label for this gene is ftsI [H]

Identifier: 189353814

GI number: 189353814

Start: 2109061

End: 2111280

Strand: Direct

Name: ftsI [H]

Synonym: BMULJ_05061

Alternate gene names: 189353814

Gene position: 2109061-2111280 (Clockwise)

Preceding gene: 189353813

Following gene: 189353817

Centisome position: 85.28

GC content: 71.35

Gene sequence:

>2220_bases
GTGTCGTTCCTTCGCCTCGCACTGGCGCGCTGCCGCGCGCGCGTCGCGCCGTTCGCCGCCGGCTGCGCGGCCCGCCTGCG
CGCCGCGCTGCGCAGCGCCGCACACGCGCTTCGCCATCCGACGCGCCGCGGCATCGCGCTGACGCTCGCCGCGATACCGA
CGCTCGCGGTGCTGGTGCTGCTCGCGTTCGTGCCGTTCACGCCGAGCATCGGCGACATCCGCAAGGCACGCATCGAGCGG
CCCGCGCGCGTGCTGTCGGCCGACGGCAAGCTGATCGCCGAGTTCCGGCCGGTCAATCGCGAATGGGTGCCGTTGAAGCT
GATTTCGCCGCACACCGTCGACGCATTGATCGCGACCGAGGATCGCCGCTTCTACGCGCACCACGGCATCGACTGGCGCC
GCACGCTCGCGGCCGCATTGCATACGTTCGGCGGCGAGCGCCAGGGCGGCTCGACGATCACGCAGCAGCTCGCGCGCAAT
CTCTATCCGGACGAAGTCGGCCGCGCGCCGACGCTCACGCGCAAGCTGAAGGAGCTCGTCACCGCGTTCAAGATCGAGAT
GGTGTACAGCAAGGCCGAGATTCTCGAGACCTATCTGAACACGGTGCCGTTCCTCTACAACGCGTACGGCGTCGAGATGG
CCGCGCGGACCTACTTCGGCAAATCGGCGGACCAGCTCGACGTCGTCGAAAGCGCGACGCTCGTCGGGATGCTGAAGGGC
AACAGCTACTACAACCCGGTGCTGAATCCCGAGCGCGCATTGCAGCGTCGCAACGTCGTGCTCGAGCAGATGGCGAAGGC
CGGCATGCTGTCGGCGAGCGAACTCGCGCGGCTGCAGCGCCGGCCGCTGCGCGTCGACTTCGAACGGCAGACGGCCGAGC
CGGGCCTCGCGCCGCATTTCGCGGTGCAGGTGCGCAAATGGCTGATCGCGTGGGCCGACAGCCACGACTACGATCTGTAT
TCGGACGGCCTCGTGATCCGCACGACGCTCGACGCGCGACTGCAGCAGATGGCCACGCGCGCGCTCGTCCAGCAGACCGA
CCGTTTGCAGGCCGTCGCCGACGCCGCCTGGCGCGGCCCGTCCGGCTGCGGGCTGCGCAACGCGCTGTTCCGCGGCTTCA
TGCGGCAGACGCCCGATTACCGCGACGCGCGCGACGCGGGGCTCACCGATGCGGCAGCGCTGACGCAGCTCGGCGCGAAC
CGCGCGTTCGTGCGCGCGCTATGCGAGCGCAAGACACAGGTGCAGGCCGGCTTCGTCGCGATCGATCCGCGCAACGGCGC
GATCCGCGCGTGGGTCGGCAGCCCCGATTTCGGCGACGAGCCGTTCGACCACGTCGAGCAGGCGCGGCGCCAGCCGGGCT
CGACGTTCAAGCCGTTCGTCTACGGCGCCGCGTTCGCGGACGGCGCGCGGCCGAGCGACACGTTCGTCGATCGCGACGTC
GCGATTCCGCTCGGCGATCGCAGCGTGTGGCGCCCCACCGACGCGGAGCCGCCGACCGGTGCGCCGATGACGCTGCGCGA
TGCGCTCGCGCTGTCGCGCAACCGGATCACCGCCCAGCTGATGCAGCGCGAAGGCGCGGCGAAGGTCGTGCGGCTCGCGC
GCGCGATGGGTGTGCGCGACAGCCCGCTCGAGGCGGTGCCGTCGCTCGCGCTCGGCACGAGCCCCGTCACGCTGAAGGAG
ATGGTGTCCGCGTACGCGACGATCGCGAACCGCGGCGTCTATGTCGCGCCGCAGGCGATCACGCAGATCGAGGATCGCAA
CGGCAAGGTGCTTGCGCGCTTCGCCGACGCGCCGCCGCAACGCGCGCTGCCGGCCAACGCGGCGCTCACGCTCGTCGACG
TGATGCGCGACGTCGTCGACCGCGGCACGGGCGCCGACATCCGCACGCGCTACGGGATTCGCGGCGACGTGGCCGGCAAG
ACCGGTACGACGCAGGACAACGCGGACGGCTGGTTCATCCTGATGCATCCGCAACTCGTCGCGGGCGCCTGGGTCGGCTT
CGACGACGGCAGCGTGACGCTGCGCAGCGACTACTGGGGCGCGGGCGCGCACAGTGCGCTGCCGATCGTCGGCGCGTTCT
ATGTCGACGCGCTGCGCGCACGCGCGATCGATCCGCACGCGCAGCTCTCGCCCGACTTCCGCCCGCGCGCCGCGCCGGCA
CCCGCGCCGAAGCGGCGCGCGCATCCGGGCCTGTTCGACTGGCTGCGACTGTTCCGCTAG

Upstream 100 bases:

>100_bases
CTGTAAATCTTGCAAGCGAAACGCCGCTTGCGCCGCATTCGCCGCGCGCGCGTTTGCTAGCATCGCGGCTTTTTCCGCCC
CGCCCGCCGTGAATCGCTTC

Downstream 100 bases:

>100_bases
CGCGTCAGTCCGCCGTATCGCCGCCCTTCGGCAGCTTCGACCACGCGCCGCGGCCGGGCAGCGGCGACCATGCGGGGCGC
GTCTTGCGCGCGCTGTCGAT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 739; Mature: 738

Protein sequence:

>739_residues
MSFLRLALARCRARVAPFAAGCAARLRAALRSAAHALRHPTRRGIALTLAAIPTLAVLVLLAFVPFTPSIGDIRKARIER
PARVLSADGKLIAEFRPVNREWVPLKLISPHTVDALIATEDRRFYAHHGIDWRRTLAAALHTFGGERQGGSTITQQLARN
LYPDEVGRAPTLTRKLKELVTAFKIEMVYSKAEILETYLNTVPFLYNAYGVEMAARTYFGKSADQLDVVESATLVGMLKG
NSYYNPVLNPERALQRRNVVLEQMAKAGMLSASELARLQRRPLRVDFERQTAEPGLAPHFAVQVRKWLIAWADSHDYDLY
SDGLVIRTTLDARLQQMATRALVQQTDRLQAVADAAWRGPSGCGLRNALFRGFMRQTPDYRDARDAGLTDAAALTQLGAN
RAFVRALCERKTQVQAGFVAIDPRNGAIRAWVGSPDFGDEPFDHVEQARRQPGSTFKPFVYGAAFADGARPSDTFVDRDV
AIPLGDRSVWRPTDAEPPTGAPMTLRDALALSRNRITAQLMQREGAAKVVRLARAMGVRDSPLEAVPSLALGTSPVTLKE
MVSAYATIANRGVYVAPQAITQIEDRNGKVLARFADAPPQRALPANAALTLVDVMRDVVDRGTGADIRTRYGIRGDVAGK
TGTTQDNADGWFILMHPQLVAGAWVGFDDGSVTLRSDYWGAGAHSALPIVGAFYVDALRARAIDPHAQLSPDFRPRAAPA
PAPKRRAHPGLFDWLRLFR

Sequences:

>Translated_739_residues
MSFLRLALARCRARVAPFAAGCAARLRAALRSAAHALRHPTRRGIALTLAAIPTLAVLVLLAFVPFTPSIGDIRKARIER
PARVLSADGKLIAEFRPVNREWVPLKLISPHTVDALIATEDRRFYAHHGIDWRRTLAAALHTFGGERQGGSTITQQLARN
LYPDEVGRAPTLTRKLKELVTAFKIEMVYSKAEILETYLNTVPFLYNAYGVEMAARTYFGKSADQLDVVESATLVGMLKG
NSYYNPVLNPERALQRRNVVLEQMAKAGMLSASELARLQRRPLRVDFERQTAEPGLAPHFAVQVRKWLIAWADSHDYDLY
SDGLVIRTTLDARLQQMATRALVQQTDRLQAVADAAWRGPSGCGLRNALFRGFMRQTPDYRDARDAGLTDAAALTQLGAN
RAFVRALCERKTQVQAGFVAIDPRNGAIRAWVGSPDFGDEPFDHVEQARRQPGSTFKPFVYGAAFADGARPSDTFVDRDV
AIPLGDRSVWRPTDAEPPTGAPMTLRDALALSRNRITAQLMQREGAAKVVRLARAMGVRDSPLEAVPSLALGTSPVTLKE
MVSAYATIANRGVYVAPQAITQIEDRNGKVLARFADAPPQRALPANAALTLVDVMRDVVDRGTGADIRTRYGIRGDVAGK
TGTTQDNADGWFILMHPQLVAGAWVGFDDGSVTLRSDYWGAGAHSALPIVGAFYVDALRARAIDPHAQLSPDFRPRAAPA
PAPKRRAHPGLFDWLRLFR
>Mature_738_residues
SFLRLALARCRARVAPFAAGCAARLRAALRSAAHALRHPTRRGIALTLAAIPTLAVLVLLAFVPFTPSIGDIRKARIERP
ARVLSADGKLIAEFRPVNREWVPLKLISPHTVDALIATEDRRFYAHHGIDWRRTLAAALHTFGGERQGGSTITQQLARNL
YPDEVGRAPTLTRKLKELVTAFKIEMVYSKAEILETYLNTVPFLYNAYGVEMAARTYFGKSADQLDVVESATLVGMLKGN
SYYNPVLNPERALQRRNVVLEQMAKAGMLSASELARLQRRPLRVDFERQTAEPGLAPHFAVQVRKWLIAWADSHDYDLYS
DGLVIRTTLDARLQQMATRALVQQTDRLQAVADAAWRGPSGCGLRNALFRGFMRQTPDYRDARDAGLTDAAALTQLGANR
AFVRALCERKTQVQAGFVAIDPRNGAIRAWVGSPDFGDEPFDHVEQARRQPGSTFKPFVYGAAFADGARPSDTFVDRDVA
IPLGDRSVWRPTDAEPPTGAPMTLRDALALSRNRITAQLMQREGAAKVVRLARAMGVRDSPLEAVPSLALGTSPVTLKEM
VSAYATIANRGVYVAPQAITQIEDRNGKVLARFADAPPQRALPANAALTLVDVMRDVVDRGTGADIRTRYGIRGDVAGKT
GTTQDNADGWFILMHPQLVAGAWVGFDDGSVTLRSDYWGAGAHSALPIVGAFYVDALRARAIDPHAQLSPDFRPRAAPAP
APKRRAHPGLFDWLRLFR

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=600, Percent_Identity=31.5, Blast_Score=251, Evalue=9e-68,
Organism=Escherichia coli, GI1788867, Length=643, Percent_Identity=27.9937791601866, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1786343, Length=266, Percent_Identity=35.7142857142857, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI1789601, Length=182, Percent_Identity=37.3626373626374, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.- [C]

Molecular weight: Translated: 81108; Mature: 80977

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLRLALARCRARVAPFAAGCAARLRAALRSAAHALRHPTRRGIALTLAAIPTLAVLVL
CHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHH
LAFVPFTPSIGDIRKARIERPARVLSADGKLIAEFRPVNREWVPLKLISPHTVDALIATE
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCEEEEEECC
DRRFYAHHGIDWRRTLAAALHTFGGERQGGSTITQQLARNLYPDEVGRAPTLTRKLKELV
CCEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHCCCCCHHHHHHHHHH
TAFKIEMVYSKAEILETYLNTVPFLYNAYGVEMAARTYFGKSADQLDVVESATLVGMLKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEEEEC
NSYYNPVLNPERALQRRNVVLEQMAKAGMLSASELARLQRRPLRVDFERQTAEPGLAPHF
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEHHHHCCCCCCCHHH
AVQVRKWLIAWADSHDYDLYSDGLVIRTTLDARLQQMATRALVQQTDRLQAVADAAWRGP
HHHHHHHHHHCCCCCCCCEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SGCGLRNALFRGFMRQTPDYRDARDAGLTDAAALTQLGANRAFVRALCERKTQVQAGFVA
CCCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEE
IDPRNGAIRAWVGSPDFGDEPFDHVEQARRQPGSTFKPFVYGAAFADGARPSDTFVDRDV
EECCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCHHEEHHHCCCCCCCCCCCCCCE
AIPLGDRSVWRPTDAEPPTGAPMTLRDALALSRNRITAQLMQREGAAKVVRLARAMGVRD
EEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
SPLEAVPSLALGTSPVTLKEMVSAYATIANRGVYVAPQAITQIEDRNGKVLARFADAPPQ
CCHHHHCHHHCCCCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHCCCCCEEEEECCCCCC
RALPANAALTLVDVMRDVVDRGTGADIRTRYGIRGDVAGKTGTTQDNADGWFILMHPQLV
CCCCCCHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCCEEEEEECCHHH
AGAWVGFDDGSVTLRSDYWGAGAHSALPIVGAFYVDALRARAIDPHAQLSPDFRPRAAPA
HHEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PAPKRRAHPGLFDWLRLFR
CCCCCCCCCCHHHHHHHHC
>Mature Secondary Structure 
SFLRLALARCRARVAPFAAGCAARLRAALRSAAHALRHPTRRGIALTLAAIPTLAVLVL
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHH
LAFVPFTPSIGDIRKARIERPARVLSADGKLIAEFRPVNREWVPLKLISPHTVDALIATE
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCEEEEEECC
DRRFYAHHGIDWRRTLAAALHTFGGERQGGSTITQQLARNLYPDEVGRAPTLTRKLKELV
CCEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHCCCCCHHHHHHHHHH
TAFKIEMVYSKAEILETYLNTVPFLYNAYGVEMAARTYFGKSADQLDVVESATLVGMLKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEEEEC
NSYYNPVLNPERALQRRNVVLEQMAKAGMLSASELARLQRRPLRVDFERQTAEPGLAPHF
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEHHHHCCCCCCCHHH
AVQVRKWLIAWADSHDYDLYSDGLVIRTTLDARLQQMATRALVQQTDRLQAVADAAWRGP
HHHHHHHHHHCCCCCCCCEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SGCGLRNALFRGFMRQTPDYRDARDAGLTDAAALTQLGANRAFVRALCERKTQVQAGFVA
CCCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEE
IDPRNGAIRAWVGSPDFGDEPFDHVEQARRQPGSTFKPFVYGAAFADGARPSDTFVDRDV
EECCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCHHEEHHHCCCCCCCCCCCCCCE
AIPLGDRSVWRPTDAEPPTGAPMTLRDALALSRNRITAQLMQREGAAKVVRLARAMGVRD
EEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
SPLEAVPSLALGTSPVTLKEMVSAYATIANRGVYVAPQAITQIEDRNGKVLARFADAPPQ
CCHHHHCHHHCCCCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHCCCCCEEEEECCCCCC
RALPANAALTLVDVMRDVVDRGTGADIRTRYGIRGDVAGKTGTTQDNADGWFILMHPQLV
CCCCCCHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCCEEEEEECCHHH
AGAWVGFDDGSVTLRSDYWGAGAHSALPIVGAFYVDALRARAIDPHAQLSPDFRPRAAPA
HHEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PAPKRRAHPGLFDWLRLFR
CCCCCCCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA