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The map label for this gene is betA [H]

Identifier: 189353736

GI number: 189353736

Start: 2006544

End: 2008244

Strand: Direct

Name: betA [H]

Synonym: BMULJ_04981

Alternate gene names: 189353736

Gene position: 2006544-2008244 (Clockwise)

Preceding gene: 189353735

Following gene: 189353737

Centisome position: 81.13

GC content: 67.02

Gene sequence:

>1701_bases
ATGACGACACGCGAATACGACTACATCATCTGCGGCGCGGGCTCCGCGGGCAACGTGCTCGCGACGCGCCTGACGGAAGA
TCCGAATGTGACGGTGCTGCTGCTCGAAGCAGGCGGCCCCGACTACCGCTTCGACTTCCGCACGCAGATGCCGGCGGCCC
TCGCCTATCCGCTGCAGGGCCGCCGCTACAACTGGGCGTACGAGACCGATCCCGAGCCGCACATGGACAACCGCCGGATG
GAATGCGGGCGCGGCAAGGGGCTCGGCGGCTCGTCGCTGATCAACGGGATGTGCTACATCCGCGGCAACGCGCTCGACTA
CGACAACTGGGCGACGCACCAGGGCCTCGAGAACTGGACGTATCTCGACTGCCTGCCGTACTTCAAGAAGGCCGAGACGC
GCGACATCGGGCCGAACGACTATCACGGCGGCGACGGCCCCGTGTCGGTGACGACGAGCAAGCCGGGCGTGAACCCGCTG
TTCGAGGCGATGGTCGAGGCCGGCGTGCAAGCCGGCTATCCGCGCACGGAGGATCTGAACGGCTATCAGCAGGAAGGCTT
CGGCCCGATGGATCGCACGGTCACGCCGAAGGGCCGCCGCGCGAGCACCGCGCGCGGCTACCTCGATCAGGCGAAGACGC
GGCCGAATCTCGAGATCGTCACGCACGCGCTCGCCGATCGCATCCTGTTCGACGGCAAGCGCGCATCGGGCGTCACGTAT
CTGCGCGGCAACGAGCGCGCGACCGCGCACGCGCGCCGGGAAGTGCTCGTGTGCAGCGGTGCGATCGCGTCGCCGCAGCT
GCTGCAGCGCTCGGGCGTCGGCCCCGGCGCTTGGCTGAAGGAACTCGACATTCCGATCGTGCTCGATCTGCCGGGCGTCG
GCCAGAACCTGCAGGACCATCTGGAGATGTACATCCAGTACGAATGCAAGGAGCCGGTGTCGCTCTATCCCGCGCTGAAG
TGGTGGAACCAGCCGAAGATCGGTCTCGAATGGATGCTGAACGGCACCGGCCTCGGCGCGAGCAATCACTTCGAGGCGGG
CGGCTTCATCCGCACGCGCGACGACGATCCCTGGCCGAACATCCAGTATCACTTCCTGCCCGTTGCGATCAACTACAACG
GCTCGAACGCGATCGAGATGCACGGCTTCCAGGCGCACGTCGGTTCGATGCGTTCTCCGAGCCGCGGCCGCGTGAAGCTG
CGCTCGCGCGATCCGAACGCGCATCCGAGCATCCTGTTCAACTACATGGCCGAAGCGCTCGACTGGCGCGAATTCCGCGA
CGCGATCCGCGCGACGCGCGAGATCATGCGGCAGCCGGCGCTCGACCGCTATCGCGGCCGCGAGCTGAATCCGGGCGCCG
ACCTGAAGAGCGACAAGGAGCTCGACGCGTTCGTGCGCGCCCGCGCCGAAACCGCGTTCCATCCGTCGTGCTCGTGCAAG
ATGGGCTACGACGACATGGCGGTGGTCGACAACGAAGGGCGCGTGCACGGGCTCGAGGGGCTGCGCGTCGTCGATGCGTC
GATCATGCCGATCATCACGACCGGCAACCTGAACGCGCCGACGATCATGATCGCCGAGAAGATCGCCGACAAGATCCGCG
GCCGCAAGCCGCTCGAGCGCGCGAACGTGCCGTACTTCGTCGCGAACGGCGCACCGGCGCGCAACGTCGCGAAGGCCGTG
CGTCAGCCGGAAACGGTTTGA

Upstream 100 bases:

>100_bases
GGCATCACGACGCTCGAACACTACACTCGGATCAAGTCGGTGCAGGTCGAGTTGGGCCGCTACAACCCGGTATTTTGAGT
CCTCAAGGAGTTCAACCGTC

Downstream 100 bases:

>100_bases
GTCGGCGGACGCGCATCGCAGCTTGCGGTGCGCGTCCCGTTGTTCGCTTCCCGCGCTTCCTACACTTCGCGCACTTCCCG
CGCTTTCCACGCTTCCGCCG

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MTTREYDYIICGAGSAGNVLATRLTEDPNVTVLLLEAGGPDYRFDFRTQMPAALAYPLQGRRYNWAYETDPEPHMDNRRM
ECGRGKGLGGSSLINGMCYIRGNALDYDNWATHQGLENWTYLDCLPYFKKAETRDIGPNDYHGGDGPVSVTTSKPGVNPL
FEAMVEAGVQAGYPRTEDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQAKTRPNLEIVTHALADRILFDGKRASGVTY
LRGNERATAHARREVLVCSGAIASPQLLQRSGVGPGAWLKELDIPIVLDLPGVGQNLQDHLEMYIQYECKEPVSLYPALK
WWNQPKIGLEWMLNGTGLGASNHFEAGGFIRTRDDDPWPNIQYHFLPVAINYNGSNAIEMHGFQAHVGSMRSPSRGRVKL
RSRDPNAHPSILFNYMAEALDWREFRDAIRATREIMRQPALDRYRGRELNPGADLKSDKELDAFVRARAETAFHPSCSCK
MGYDDMAVVDNEGRVHGLEGLRVVDASIMPIITTGNLNAPTIMIAEKIADKIRGRKPLERANVPYFVANGAPARNVAKAV
RQPETV

Sequences:

>Translated_566_residues
MTTREYDYIICGAGSAGNVLATRLTEDPNVTVLLLEAGGPDYRFDFRTQMPAALAYPLQGRRYNWAYETDPEPHMDNRRM
ECGRGKGLGGSSLINGMCYIRGNALDYDNWATHQGLENWTYLDCLPYFKKAETRDIGPNDYHGGDGPVSVTTSKPGVNPL
FEAMVEAGVQAGYPRTEDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQAKTRPNLEIVTHALADRILFDGKRASGVTY
LRGNERATAHARREVLVCSGAIASPQLLQRSGVGPGAWLKELDIPIVLDLPGVGQNLQDHLEMYIQYECKEPVSLYPALK
WWNQPKIGLEWMLNGTGLGASNHFEAGGFIRTRDDDPWPNIQYHFLPVAINYNGSNAIEMHGFQAHVGSMRSPSRGRVKL
RSRDPNAHPSILFNYMAEALDWREFRDAIRATREIMRQPALDRYRGRELNPGADLKSDKELDAFVRARAETAFHPSCSCK
MGYDDMAVVDNEGRVHGLEGLRVVDASIMPIITTGNLNAPTIMIAEKIADKIRGRKPLERANVPYFVANGAPARNVAKAV
RQPETV
>Mature_565_residues
TTREYDYIICGAGSAGNVLATRLTEDPNVTVLLLEAGGPDYRFDFRTQMPAALAYPLQGRRYNWAYETDPEPHMDNRRME
CGRGKGLGGSSLINGMCYIRGNALDYDNWATHQGLENWTYLDCLPYFKKAETRDIGPNDYHGGDGPVSVTTSKPGVNPLF
EAMVEAGVQAGYPRTEDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQAKTRPNLEIVTHALADRILFDGKRASGVTYL
RGNERATAHARREVLVCSGAIASPQLLQRSGVGPGAWLKELDIPIVLDLPGVGQNLQDHLEMYIQYECKEPVSLYPALKW
WNQPKIGLEWMLNGTGLGASNHFEAGGFIRTRDDDPWPNIQYHFLPVAINYNGSNAIEMHGFQAHVGSMRSPSRGRVKLR
SRDPNAHPSILFNYMAEALDWREFRDAIRATREIMRQPALDRYRGRELNPGADLKSDKELDAFVRARAETAFHPSCSCKM
GYDDMAVVDNEGRVHGLEGLRVVDASIMPIITTGNLNAPTIMIAEKIADKIRGRKPLERANVPYFVANGAPARNVAKAVR
QPETV

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=549, Percent_Identity=50.8196721311475, Blast_Score=530, Evalue=1e-150,
Organism=Escherichia coli, GI1786503, Length=554, Percent_Identity=78.3393501805054, Blast_Score=924, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=551, Percent_Identity=48.0943738656987, Blast_Score=497, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24642048, Length=569, Percent_Identity=36.5553602811951, Blast_Score=315, Evalue=6e-86,
Organism=Drosophila melanogaster, GI45549471, Length=581, Percent_Identity=36.3166953528399, Blast_Score=315, Evalue=8e-86,
Organism=Drosophila melanogaster, GI45551458, Length=580, Percent_Identity=36.3793103448276, Blast_Score=314, Evalue=9e-86,
Organism=Drosophila melanogaster, GI24642042, Length=571, Percent_Identity=36.6024518388792, Blast_Score=298, Evalue=8e-81,
Organism=Drosophila melanogaster, GI24642059, Length=570, Percent_Identity=36.140350877193, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24642055, Length=580, Percent_Identity=36.0344827586207, Blast_Score=282, Evalue=4e-76,
Organism=Drosophila melanogaster, GI24642051, Length=575, Percent_Identity=32.5217391304348, Blast_Score=261, Evalue=6e-70,
Organism=Drosophila melanogaster, GI24642039, Length=571, Percent_Identity=35.9019264448336, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI18859995, Length=573, Percent_Identity=35.4275741710297, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI17137792, Length=555, Percent_Identity=34.5945945945946, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24642035, Length=573, Percent_Identity=32.8097731239092, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24650267, Length=577, Percent_Identity=33.1022530329289, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24642037, Length=574, Percent_Identity=32.9268292682927, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI18859993, Length=576, Percent_Identity=34.0277777777778, Blast_Score=226, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24645930, Length=577, Percent_Identity=27.0363951473137, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24642057, Length=588, Percent_Identity=28.2312925170068, Blast_Score=133, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 62959; Mature: 62828

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTREYDYIICGAGSAGNVLATRLTEDPNVTVLLLEAGGPDYRFDFRTQMPAALAYPLQG
CCCCCCCEEEECCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEECCCCCHHEECCCCC
RRYNWAYETDPEPHMDNRRMECGRGKGLGGSSLINGMCYIRGNALDYDNWATHQGLENWT
CEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCCCCHHHCCCCCCE
YLDCLPYFKKAETRDIGPNDYHGGDGPVSVTTSKPGVNPLFEAMVEAGVQAGYPRTEDLN
EEHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCC
GYQQEGFGPMDRTVTPKGRRASTARGYLDQAKTRPNLEIVTHALADRILFDGKRASGVTY
CHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
LRGNERATAHARREVLVCSGAIASPQLLQRSGVGPGAWLKELDIPIVLDLPGVGQNLQDH
EECCCCHHHHHHCEEEEECCCCCCHHHHHHCCCCCCHHHHHCCCCEEEECCCCCCCHHHH
LEMYIQYECKEPVSLYPALKWWNQPKIGLEWMLNGTGLGASNHFEAGGFIRTRDDDPWPN
HHEEEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCC
IQYHFLPVAINYNGSNAIEMHGFQAHVGSMRSPSRGRVKLRSRDPNAHPSILFNYMAEAL
CEEEEEEEEEEECCCCEEEECCHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
DWREFRDAIRATREIMRQPALDRYRGRELNPGADLKSDKELDAFVRARAETAFHPSCSCK
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEE
MGYDDMAVVDNEGRVHGLEGLRVVDASIMPIITTGNLNAPTIMIAEKIADKIRGRKPLER
CCCCCEEEECCCCCEECCCCEEEECCCEEEEEEECCCCCCEEHHHHHHHHHHCCCCCHHH
ANVPYFVANGAPARNVAKAVRQPETV
CCCCEEEECCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
TTREYDYIICGAGSAGNVLATRLTEDPNVTVLLLEAGGPDYRFDFRTQMPAALAYPLQG
CCCCCCEEEECCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEECCCCCHHEECCCCC
RRYNWAYETDPEPHMDNRRMECGRGKGLGGSSLINGMCYIRGNALDYDNWATHQGLENWT
CEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCCCCHHHCCCCCCE
YLDCLPYFKKAETRDIGPNDYHGGDGPVSVTTSKPGVNPLFEAMVEAGVQAGYPRTEDLN
EEHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCC
GYQQEGFGPMDRTVTPKGRRASTARGYLDQAKTRPNLEIVTHALADRILFDGKRASGVTY
CHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
LRGNERATAHARREVLVCSGAIASPQLLQRSGVGPGAWLKELDIPIVLDLPGVGQNLQDH
EECCCCHHHHHHCEEEEECCCCCCHHHHHHCCCCCCHHHHHCCCCEEEECCCCCCCHHHH
LEMYIQYECKEPVSLYPALKWWNQPKIGLEWMLNGTGLGASNHFEAGGFIRTRDDDPWPN
HHEEEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCC
IQYHFLPVAINYNGSNAIEMHGFQAHVGSMRSPSRGRVKLRSRDPNAHPSILFNYMAEAL
CEEEEEEEEEEECCCCEEEECCHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
DWREFRDAIRATREIMRQPALDRYRGRELNPGADLKSDKELDAFVRARAETAFHPSCSCK
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEE
MGYDDMAVVDNEGRVHGLEGLRVVDASIMPIITTGNLNAPTIMIAEKIADKIRGRKPLER
CCCCCEEEECCCCCEECCCCEEEECCCEEEEEEECCCCCCEEHHHHHHHHHHCCCCCHHH
ANVPYFVANGAPARNVAKAVRQPETV
CCCCEEEECCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA