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The map label for this gene is fadB [H]

Identifier: 189353682

GI number: 189353682

Start: 1944298

End: 1945263

Strand: Reverse

Name: fadB [H]

Synonym: BMULJ_04927

Alternate gene names: 189353682

Gene position: 1945263-1944298 (Counterclockwise)

Preceding gene: 189353683

Following gene: 189353681

Centisome position: 78.65

GC content: 67.91

Gene sequence:

>966_bases
ATGGCAGTGATAACCGACATCAAGACGTTCGCCGCCATCGGCACCGGCGTGATCGGCAGCGGATGGATCGCCCGCGCGCT
CGCGCACGGTCTCGACGTGGTGGTATGGGATCCCGCGCCGGGCGCGGAAGCGCGGCTGCGCGCGAACGTCGCGAACGCGT
GGCCCGCGCTCGAACGCGTCGGTCTTGCAGCGGGCGCCGATCCCGCGCGGCTGCGTTTCGAGTCGACGATCGAAGCCTGC
GTCGCCGACGCCGACTTCATCCAGGAAAGCGCGCCCGAGCGCGAAGCGCTGAAGCTCGAACTGCACGAGCAGATCAGCCG
CGCGGCGAAGCCCGACGCGATCATCGCATCGTCGACGTCGGGGCTGCTGCCGACCGATTTCTATGCGCGCGCGACGCATC
CGGAGCGCTGCGTGGTCGGCCATCCGTTCAATCCCGTGTATCTGCTGCCGCTCGTCGAAGTGCTCGGCGGCGCGCGCACG
TCGCCCGAAGCGGTCGAGGCCGCGATGGCGATCTATCGGAAGCTCGGCATGCGGCCGCTGCACGTCCGCAAGGAAGTGCC
GGGCTTCATCGCGGACCGGCTGCTCGAAGCGCTGTGGCGCGAGGCGCTGCATCTCGTCAACGAAGGCGTCGCGACGACCG
GCGAAATCGACGACGCGATCCGCTTCGGTGCAGGCATCCGCTGGTCGTTCATGGGGACGTTCCTGACCTACACGCTGGCC
GGCGGCGACGCGGGCATGCGACACTTCATGCAGCAGTTCGGCCCCGCGCTCGAACTGCCGTGGACGAAGCTCGTCGCGCC
GACGCTGACCGACGAACTGATCGATCGTGTCGTCGACGGCACGAGCGAGCAGCAGGGCAAGCGCAGCATCAAGGAACTCG
AACGCTATCGCGACGAGTGCATTACCGAGGTGCTGAAGGCGATCGCCGCGGTGAAGGCGCGGCATGGGATGCGATTCGAG
GACTGA

Upstream 100 bases:

>100_bases
GCCGAATTTGCGTGAGTGCGCCGAACGACCGATATGACATGGCGGCGCGCACGATGCGCGCGCGCCGTCCGATTTCTCTC
GAATTGAAGGATGCGTTGAC

Downstream 100 bases:

>100_bases
ACGAACATGACCGGCGATACCCCGCTGACGCTCTACCGCGACGTCGTGCGGCCCGAGTGGGTCGACTACAACGGCCATTT
GCGCGACGCGTTCTATCTGC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MAVITDIKTFAAIGTGVIGSGWIARALAHGLDVVVWDPAPGAEARLRANVANAWPALERVGLAAGADPARLRFESTIEAC
VADADFIQESAPEREALKLELHEQISRAAKPDAIIASSTSGLLPTDFYARATHPERCVVGHPFNPVYLLPLVEVLGGART
SPEAVEAAMAIYRKLGMRPLHVRKEVPGFIADRLLEALWREALHLVNEGVATTGEIDDAIRFGAGIRWSFMGTFLTYTLA
GGDAGMRHFMQQFGPALELPWTKLVAPTLTDELIDRVVDGTSEQQGKRSIKELERYRDECITEVLKAIAAVKARHGMRFE
D

Sequences:

>Translated_321_residues
MAVITDIKTFAAIGTGVIGSGWIARALAHGLDVVVWDPAPGAEARLRANVANAWPALERVGLAAGADPARLRFESTIEAC
VADADFIQESAPEREALKLELHEQISRAAKPDAIIASSTSGLLPTDFYARATHPERCVVGHPFNPVYLLPLVEVLGGART
SPEAVEAAMAIYRKLGMRPLHVRKEVPGFIADRLLEALWREALHLVNEGVATTGEIDDAIRFGAGIRWSFMGTFLTYTLA
GGDAGMRHFMQQFGPALELPWTKLVAPTLTDELIDRVVDGTSEQQGKRSIKELERYRDECITEVLKAIAAVKARHGMRFE
D
>Mature_320_residues
AVITDIKTFAAIGTGVIGSGWIARALAHGLDVVVWDPAPGAEARLRANVANAWPALERVGLAAGADPARLRFESTIEACV
ADADFIQESAPEREALKLELHEQISRAAKPDAIIASSTSGLLPTDFYARATHPERCVVGHPFNPVYLLPLVEVLGGARTS
PEAVEAAMAIYRKLGMRPLHVRKEVPGFIADRLLEALWREALHLVNEGVATTGEIDDAIRFGAGIRWSFMGTFLTYTLAG
GDAGMRHFMQQFGPALELPWTKLVAPTLTDELIDRVVDGTSEQQGKRSIKELERYRDECITEVLKAIAAVKARHGMRFED

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=317, Percent_Identity=29.6529968454259, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI296179429, Length=228, Percent_Identity=29.3859649122807, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI296179427, Length=245, Percent_Identity=27.3469387755102, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI20127408, Length=214, Percent_Identity=25.7009345794392, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787661, Length=259, Percent_Identity=30.1158301158301, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788682, Length=143, Percent_Identity=32.8671328671329, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790281, Length=125, Percent_Identity=28, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI193203623, Length=264, Percent_Identity=30.6818181818182, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI115533614, Length=265, Percent_Identity=30.5660377358491, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17549919, Length=236, Percent_Identity=30.9322033898305, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17553560, Length=232, Percent_Identity=30.1724137931034, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17563036, Length=230, Percent_Identity=26.9565217391304, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25144276, Length=207, Percent_Identity=27.536231884058, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17508953, Length=207, Percent_Identity=27.536231884058, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17508951, Length=207, Percent_Identity=27.536231884058, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17558304, Length=228, Percent_Identity=27.6315789473684, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45549573, Length=298, Percent_Identity=28.5234899328859, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI20129993, Length=247, Percent_Identity=29.1497975708502, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI19921000, Length=207, Percent_Identity=27.536231884058, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583077, Length=207, Percent_Identity=27.536231884058, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583079, Length=207, Percent_Identity=27.536231884058, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 34958; Mature: 34827

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVITDIKTFAAIGTGVIGSGWIARALAHGLDVVVWDPAPGAEARLRANVANAWPALERV
CCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
GLAAGADPARLRFESTIEACVADADFIQESAPEREALKLELHEQISRAAKPDAIIASSTS
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCC
GLLPTDFYARATHPERCVVGHPFNPVYLLPLVEVLGGARTSPEAVEAAMAIYRKLGMRPL
CCCCCCHHHHCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCH
HVRKEVPGFIADRLLEALWREALHLVNEGVATTGEIDDAIRFGAGIRWSFMGTFLTYTLA
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCC
GGDAGMRHFMQQFGPALELPWTKLVAPTLTDELIDRVVDGTSEQQGKRSIKELERYRDEC
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ITEVLKAIAAVKARHGMRFED
HHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AVITDIKTFAAIGTGVIGSGWIARALAHGLDVVVWDPAPGAEARLRANVANAWPALERV
CCHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
GLAAGADPARLRFESTIEACVADADFIQESAPEREALKLELHEQISRAAKPDAIIASSTS
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCC
GLLPTDFYARATHPERCVVGHPFNPVYLLPLVEVLGGARTSPEAVEAAMAIYRKLGMRPL
CCCCCCHHHHCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCH
HVRKEVPGFIADRLLEALWREALHLVNEGVATTGEIDDAIRFGAGIRWSFMGTFLTYTLA
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCC
GGDAGMRHFMQQFGPALELPWTKLVAPTLTDELIDRVVDGTSEQQGKRSIKELERYRDEC
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ITEVLKAIAAVKARHGMRFED
HHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]