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The map label for this gene is mmsB [H]

Identifier: 189353614

GI number: 189353614

Start: 1871316

End: 1872215

Strand: Reverse

Name: mmsB [H]

Synonym: BMULJ_04858

Alternate gene names: 189353614

Gene position: 1872215-1871316 (Counterclockwise)

Preceding gene: 189353615

Following gene: 189353613

Centisome position: 75.7

GC content: 69.67

Gene sequence:

>900_bases
ATGAAGATCGGTTTTATCGGCCTCGGCCACATGGGCGCGCCGATGGCGCTGAACCTGCTGAAGGCCGGCCACGACGTGCG
CGCGTTCGACCTGAGCGCCGATGCGCTGCGCGCGCTGCAGGACGCCGGCGCGCAAGTGGCGACGTCGCCGCGCGACGCGG
CCGGCGGCGCCGCATTCGTGATCACGATGCTGCCCGCCGCGCCGCACGTGCGTTCGGTGTTGACCGGCGAGCACGGCGTG
CTGGCCGGCCTCGAGTCCGGCGCGACCGTGATCGATTCGAGCACGATCGATCCGGCGAGCGCGCAGGCGTTCGGCGCGCT
GGTGCGCGAGCACGGCGGCGCATTCGTCGATGCGCCGGTGTCGGGCGGCACGGGCGGCGCGGCGGCCGGCACGCTGACGT
TCATGGTCGGCGGCAGCGATGCCGATTTCGAGCGCGTGAAACCCGTGCTCGCGGGCATGGGCAAGAACATCGTCCATTGC
GGCGCGACCGGCATGGGGCAGGTCGCGAAAGTCTGCAACAACCTCGTGCTCGGCATCTCGATGGCGGCCGTGTCGGAGGC
GATGGCGCTCGGCGTCGCGCTCGGCATCGATCCGAAGGTGCTCGCCGGCATCATCAACACGTCGACCGGCCGCTGCTGGA
GTTCCGACACGTACAACCCGTATCCGGGCGTGATCGAGACCGCGCCGTCGTCGCGCGGCTATACGGGCGGGTTCGGCACG
GACCTGATGCTGAAGGATCTCGGCCTCGCGAACGATGCCGCAAAGCAGGCGCGTCAGCCCGTCTATCTCGGCGCGCTCGC
GCAGCAGCTGTACCAGACGATGAGCAGCCGCGGCGACGGCCAGCTCGATTTCTCGGCGGTGATCCGCCTGTATCAACCGG
CAACGAAGAAGGACGCGTGA

Upstream 100 bases:

>100_bases
GTCAACACGACGATCCGGCTGCATTGAGCGCGCACACGCGACGAAACGATAGACGGGCGCCGTTGCGCGAGCCGCGGCGC
CCGACGACGGGAGACAAACG

Downstream 100 bases:

>100_bases
TGATCGAACTCGACTATGTCGACGACGGCGCGATCGCGTGCGCGACGCTGAAGCGTCCGCCCGCGAACGCGTTTACCGCC
GACGGGCTGCGGCAACTGCA

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKIGFIGLGHMGAPMALNLLKAGHDVRAFDLSADALRALQDAGAQVATSPRDAAGGAAFVITMLPAAPHVRSVLTGEHGV
LAGLESGATVIDSSTIDPASAQAFGALVREHGGAFVDAPVSGGTGGAAAGTLTFMVGGSDADFERVKPVLAGMGKNIVHC
GATGMGQVAKVCNNLVLGISMAAVSEAMALGVALGIDPKVLAGIINTSTGRCWSSDTYNPYPGVIETAPSSRGYTGGFGT
DLMLKDLGLANDAAKQARQPVYLGALAQQLYQTMSSRGDGQLDFSAVIRLYQPATKKDA

Sequences:

>Translated_299_residues
MKIGFIGLGHMGAPMALNLLKAGHDVRAFDLSADALRALQDAGAQVATSPRDAAGGAAFVITMLPAAPHVRSVLTGEHGV
LAGLESGATVIDSSTIDPASAQAFGALVREHGGAFVDAPVSGGTGGAAAGTLTFMVGGSDADFERVKPVLAGMGKNIVHC
GATGMGQVAKVCNNLVLGISMAAVSEAMALGVALGIDPKVLAGIINTSTGRCWSSDTYNPYPGVIETAPSSRGYTGGFGT
DLMLKDLGLANDAAKQARQPVYLGALAQQLYQTMSSRGDGQLDFSAVIRLYQPATKKDA
>Mature_299_residues
MKIGFIGLGHMGAPMALNLLKAGHDVRAFDLSADALRALQDAGAQVATSPRDAAGGAAFVITMLPAAPHVRSVLTGEHGV
LAGLESGATVIDSSTIDPASAQAFGALVREHGGAFVDAPVSGGTGGAAAGTLTFMVGGSDADFERVKPVLAGMGKNIVHC
GATGMGQVAKVCNNLVLGISMAAVSEAMALGVALGIDPKVLAGIINTSTGRCWSSDTYNPYPGVIETAPSSRGYTGGFGT
DLMLKDLGLANDAAKQARQPVYLGALAQQLYQTMSSRGDGQLDFSAVIRLYQPATKKDA

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=290, Percent_Identity=51.0344827586207, Blast_Score=314, Evalue=6e-86,
Organism=Homo sapiens, GI40556376, Length=294, Percent_Identity=26.8707482993197, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1790315, Length=289, Percent_Identity=39.1003460207612, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1786719, Length=300, Percent_Identity=38, Blast_Score=175, Evalue=3e-45,
Organism=Escherichia coli, GI145693186, Length=296, Percent_Identity=35.1351351351351, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1789092, Length=297, Percent_Identity=34.3434343434343, Blast_Score=127, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17557316, Length=302, Percent_Identity=49.0066225165563, Blast_Score=273, Evalue=8e-74,
Organism=Drosophila melanogaster, GI24655230, Length=291, Percent_Identity=48.7972508591065, Blast_Score=274, Evalue=4e-74,
Organism=Drosophila melanogaster, GI19922568, Length=291, Percent_Identity=48.7972508591065, Blast_Score=274, Evalue=4e-74,
Organism=Drosophila melanogaster, GI28574115, Length=296, Percent_Identity=23.3108108108108, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30260; Mature: 30260

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFIGLGHMGAPMALNLLKAGHDVRAFDLSADALRALQDAGAQVATSPRDAAGGAAFV
CEEEEEECCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCEEECCCCCCCCCEEEE
ITMLPAAPHVRSVLTGEHGVLAGLESGATVIDSSTIDPASAQAFGALVREHGGAFVDAPV
EEECCCCHHHHHHHCCCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHCCCEEEECCC
SGGTGGAAAGTLTFMVGGSDADFERVKPVLAGMGKNIVHCGATGMGQVAKVCNNLVLGIS
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHH
MAAVSEAMALGVALGIDPKVLAGIINTSTGRCWSSDTYNPYPGVIETAPSSRGYTGGFGT
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCC
DLMLKDLGLANDAAKQARQPVYLGALAQQLYQTMSSRGDGQLDFSAVIRLYQPATKKDA
HHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKIGFIGLGHMGAPMALNLLKAGHDVRAFDLSADALRALQDAGAQVATSPRDAAGGAAFV
CEEEEEECCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCEEECCCCCCCCCEEEE
ITMLPAAPHVRSVLTGEHGVLAGLESGATVIDSSTIDPASAQAFGALVREHGGAFVDAPV
EEECCCCHHHHHHHCCCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHCCCEEEECCC
SGGTGGAAAGTLTFMVGGSDADFERVKPVLAGMGKNIVHCGATGMGQVAKVCNNLVLGIS
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHH
MAAVSEAMALGVALGIDPKVLAGIINTSTGRCWSSDTYNPYPGVIETAPSSRGYTGGFGT
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCC
DLMLKDLGLANDAAKQARQPVYLGALAQQLYQTMSSRGDGQLDFSAVIRLYQPATKKDA
HHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]