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The map label for this gene is adiC [H]

Identifier: 189353571

GI number: 189353571

Start: 1821258

End: 1822787

Strand: Direct

Name: adiC [H]

Synonym: BMULJ_04815

Alternate gene names: 189353571

Gene position: 1821258-1822787 (Clockwise)

Preceding gene: 189353566

Following gene: 189353572

Centisome position: 73.64

GC content: 67.84

Gene sequence:

>1530_bases
ATGTCGGATGCCAGCTCGTCCTCCTCACAACCCTCCACATCGTCCGCCGCAGCCGCGCCGAAGATCGGCGTGATTCCCGC
GACGCTGATGGTCGCCGGCAACATGATGGGCTCCGGCGTCTTCATGCTGCCCGCGAACCTCGCCGCCACCGGCGGCATCG
CAGTCTTCGGCTGGCTGATCACCGTCGTCGGCGCGGTGTCGCTCGCGCTGGTGTTCGCGAAGCTCGCCGCGATCGACCCG
GCCGCCGGCGGCCCGTACGCGTATGCGCGCAAGGCGTTCGGGCCGTACATGGGCTACCAGACCAACCTGATCTACTGGCT
CGCGAACGTGCTCGGCAACGTCGGCCTTGCCGTCGCAGGCCTCGGCTATCTGACGCACTTCTTCCCGATGCTGCGCGATC
CGCTCGTGTTCGCGCTCGCGCAGATCTTCGTGATCTGGCTGTTCACGTACGCGAACATCCTCGGGCCGAACGTCGTCGGC
CGCGTGCAGTCGGTCACGACGATCTTCGCGCTGGTGCCGATCCTCGCGATGGCCGTGTTCGGCTGGTTCTGGTTCAGCAA
GGACGTCTATCTCGCCGGCTGGAACGTGTCGGGCACCGGCAGCTTCCGCGCGATCGGCGCGACGCTGAACTTCACGCTGT
GGGCGTTCATCGGCGTCGAGAGCGCGTCGGTATCGGCCGGCGTCGTCGAGAATCCTGCGCGCAACGTGCCGATCGCGACC
GTCGGCGGCGTCGTGCTCGCGGCGGTCTGCTACGTGCTGAGCTCGACCGTGATCATGGGGATGATCCCGAACAAGGCGCT
GCTCGCGTCGAGCGCGCCGTTCGCCGATGCCGCGCGCCTCGCGCTCGGCGACACCGCCGCGAATGCGGTCGCGCTCTGCG
CGGCGCTCGGCTGTCTCGGCTCGCTCGCGGGCTGGACGCTGCTGGTCGGCCAGACCGCGAAGGCCGCCGCCGACGACGGC
TTGTTCGCCAGCGTGTTCGCGCGCGTCAATTCGAAGAACGTGCCGTCGGCCGGCCTCGCGATCGTCGCGACGATCATGTC
GGTGCAGGTGCTCGCGACGATGTCGCCAAGCGCCAGCGAGCAGTTCGGCAAGATCGCGTCGATCGCCGTGATCATGACGC
TGCTGCCGTACATCTATTCGTGCATCGCGATCAAGGTGCTCGGCTACGGCAAGATGCCTTCGCACCAGTTCACGTTCTAT
ACGATCGTCGGCCTGATCGGCGCGGTCTACGCGCTGTGGGCGATGGTCGGCTCCGACGGCCAGCAGACGCGCTGGTCGCT
GATCTTCGTCGTCGCGACGATCGTGTTCTACGAGCTGTCGATCAACCGTCAGCGCGAGATCGAGGAAACCCACGTGCATC
CGGGCGGCCGCTCGCCGCGCTGGGTGCGCTATCTCGCGCTCGCCGTCACGATCGCCGCGCTTGCCGCGACCTTCTGGATC
TCCGTCGGCCGTCACCGCGCCGACATCCTTCACGCGCGCTCGCCGGCCGTTGCTGCGGGCGCCCCTGCAACCCAGCACAC
GGGGGAATGA

Upstream 100 bases:

>100_bases
CCATCCAGACGTTCAATAAAACGACGATCCGCGCCGGAATCGTCGATCGGGCGCCGGCCTCGCCACCTCAACCGCATCAC
GCCTTCTCAAGGAGCCTTGC

Downstream 100 bases:

>100_bases
CACATGACCGCTTCCTTGACCCAACCGGCGTTCCGCCGCCTCGGCATGAAGGCGCTGCTGGTGCAGCACGACATCGACGC
ACGCACGGCCACCGCACGCG

Product: arginine:agmatin antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MSDASSSSSQPSTSSAAAAPKIGVIPATLMVAGNMMGSGVFMLPANLAATGGIAVFGWLITVVGAVSLALVFAKLAAIDP
AAGGPYAYARKAFGPYMGYQTNLIYWLANVLGNVGLAVAGLGYLTHFFPMLRDPLVFALAQIFVIWLFTYANILGPNVVG
RVQSVTTIFALVPILAMAVFGWFWFSKDVYLAGWNVSGTGSFRAIGATLNFTLWAFIGVESASVSAGVVENPARNVPIAT
VGGVVLAAVCYVLSSTVIMGMIPNKALLASSAPFADAARLALGDTAANAVALCAALGCLGSLAGWTLLVGQTAKAAADDG
LFASVFARVNSKNVPSAGLAIVATIMSVQVLATMSPSASEQFGKIASIAVIMTLLPYIYSCIAIKVLGYGKMPSHQFTFY
TIVGLIGAVYALWAMVGSDGQQTRWSLIFVVATIVFYELSINRQREIEETHVHPGGRSPRWVRYLALAVTIAALAATFWI
SVGRHRADILHARSPAVAAGAPATQHTGE

Sequences:

>Translated_509_residues
MSDASSSSSQPSTSSAAAAPKIGVIPATLMVAGNMMGSGVFMLPANLAATGGIAVFGWLITVVGAVSLALVFAKLAAIDP
AAGGPYAYARKAFGPYMGYQTNLIYWLANVLGNVGLAVAGLGYLTHFFPMLRDPLVFALAQIFVIWLFTYANILGPNVVG
RVQSVTTIFALVPILAMAVFGWFWFSKDVYLAGWNVSGTGSFRAIGATLNFTLWAFIGVESASVSAGVVENPARNVPIAT
VGGVVLAAVCYVLSSTVIMGMIPNKALLASSAPFADAARLALGDTAANAVALCAALGCLGSLAGWTLLVGQTAKAAADDG
LFASVFARVNSKNVPSAGLAIVATIMSVQVLATMSPSASEQFGKIASIAVIMTLLPYIYSCIAIKVLGYGKMPSHQFTFY
TIVGLIGAVYALWAMVGSDGQQTRWSLIFVVATIVFYELSINRQREIEETHVHPGGRSPRWVRYLALAVTIAALAATFWI
SVGRHRADILHARSPAVAAGAPATQHTGE
>Mature_508_residues
SDASSSSSQPSTSSAAAAPKIGVIPATLMVAGNMMGSGVFMLPANLAATGGIAVFGWLITVVGAVSLALVFAKLAAIDPA
AGGPYAYARKAFGPYMGYQTNLIYWLANVLGNVGLAVAGLGYLTHFFPMLRDPLVFALAQIFVIWLFTYANILGPNVVGR
VQSVTTIFALVPILAMAVFGWFWFSKDVYLAGWNVSGTGSFRAIGATLNFTLWAFIGVESASVSAGVVENPARNVPIATV
GGVVLAAVCYVLSSTVIMGMIPNKALLASSAPFADAARLALGDTAANAVALCAALGCLGSLAGWTLLVGQTAKAAADDGL
FASVFARVNSKNVPSAGLAIVATIMSVQVLATMSPSASEQFGKIASIAVIMTLLPYIYSCIAIKVLGYGKMPSHQFTFYT
IVGLIGAVYALWAMVGSDGQQTRWSLIFVVATIVFYELSINRQREIEETHVHPGGRSPRWVRYLALAVTIAALAATFWIS
VGRHRADILHARSPAVAAGAPATQHTGE

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI187423910, Length=354, Percent_Identity=25.1412429378531, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI7657591, Length=354, Percent_Identity=25.1412429378531, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI2367353, Length=433, Percent_Identity=57.2748267898383, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI1790575, Length=441, Percent_Identity=39.9092970521542, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1786908, Length=438, Percent_Identity=34.703196347032, Blast_Score=278, Evalue=7e-76,
Organism=Escherichia coli, GI1787890, Length=449, Percent_Identity=26.9487750556793, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI87082250, Length=331, Percent_Identity=28.7009063444109, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786302, Length=358, Percent_Identity=23.7430167597765, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786789, Length=403, Percent_Identity=23.5732009925558, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1790653, Length=323, Percent_Identity=22.2910216718266, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=354, Percent_Identity=27.1186440677966, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540018, Length=318, Percent_Identity=26.4150943396226, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71982608, Length=408, Percent_Identity=24.0196078431373, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982612, Length=408, Percent_Identity=24.0196078431373, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321492, Length=370, Percent_Identity=22.1621621621622, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641993, Length=348, Percent_Identity=24.7126436781609, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24641995, Length=348, Percent_Identity=24.7126436781609, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53029; Mature: 52898

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDASSSSSQPSTSSAAAAPKIGVIPATLMVAGNMMGSGVFMLPANLAATGGIAVFGWLI
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHCCCEEEECCCHHHCCHHHHHHHHH
TVVGAVSLALVFAKLAAIDPAAGGPYAYARKAFGPYMGYQTNLIYWLANVLGNVGLAVAG
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHH
LGYLTHFFPMLRDPLVFALAQIFVIWLFTYANILGPNVVGRVQSVTTIFALVPILAMAVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GWFWFSKDVYLAGWNVSGTGSFRAIGATLNFTLWAFIGVESASVSAGVVENPARNVPIAT
HHHHHCCCEEEEECCCCCCCCCEEECHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCHHH
VGGVVLAAVCYVLSSTVIMGMIPNKALLASSAPFADAARLALGDTAANAVALCAALGCLG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHH
SLAGWTLLVGQTAKAAADDGLFASVFARVNSKNVPSAGLAIVATIMSVQVLATMSPSASE
HHHHHHHEECCCHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
QFGKIASIAVIMTLLPYIYSCIAIKVLGYGKMPSHQFTFYTIVGLIGAVYALWAMVGSDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
QQTRWSLIFVVATIVFYELSINRQREIEETHVHPGGRSPRWVRYLALAVTIAALAATFWI
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SVGRHRADILHARSPAVAAGAPATQHTGE
HHCCHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDASSSSSQPSTSSAAAAPKIGVIPATLMVAGNMMGSGVFMLPANLAATGGIAVFGWLI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHCCCEEEECCCHHHCCHHHHHHHHH
TVVGAVSLALVFAKLAAIDPAAGGPYAYARKAFGPYMGYQTNLIYWLANVLGNVGLAVAG
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHH
LGYLTHFFPMLRDPLVFALAQIFVIWLFTYANILGPNVVGRVQSVTTIFALVPILAMAVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GWFWFSKDVYLAGWNVSGTGSFRAIGATLNFTLWAFIGVESASVSAGVVENPARNVPIAT
HHHHHCCCEEEEECCCCCCCCCEEECHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCHHH
VGGVVLAAVCYVLSSTVIMGMIPNKALLASSAPFADAARLALGDTAANAVALCAALGCLG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHH
SLAGWTLLVGQTAKAAADDGLFASVFARVNSKNVPSAGLAIVATIMSVQVLATMSPSASE
HHHHHHHEECCCHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
QFGKIASIAVIMTLLPYIYSCIAIKVLGYGKMPSHQFTFYTIVGLIGAVYALWAMVGSDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
QQTRWSLIFVVATIVFYELSINRQREIEETHVHPGGRSPRWVRYLALAVTIAALAATFWI
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SVGRHRADILHARSPAVAAGAPATQHTGE
HHCCHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]