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The map label for this gene is treA [H]

Identifier: 189353540

GI number: 189353540

Start: 1777112

End: 1778839

Strand: Reverse

Name: treA [H]

Synonym: BMULJ_04784

Alternate gene names: 189353540

Gene position: 1778839-1777112 (Counterclockwise)

Preceding gene: 189353543

Following gene: 189353538

Centisome position: 71.93

GC content: 69.16

Gene sequence:

>1728_bases
ATGACGTCACGTCGTGCCGAATCGATCGTATCCGCCGCACCGACCGCATCGCATTGCGCGGCGGCCGCGCCCGCCGCGCC
CGCCGCCCCGCGCGTTCGCTGGGCCGCCGCGCTGGCGGTCGCCTATCTGGCCGTGGCCGGCTGCGCCGCGCAGGCGGACA
GCGCCAACCACGCCGCAACCCAGTTGGCCGCGTCGTCCGCGGCGACGGTGCCGAATGCGACGGCGGCCACGCTGCTGCCG
CCGCCGAGCCAGCTGTACGGCGACCTGTTCGTCGCGGTGCAGACGGCCCAGCTCTATCCGGACCAGAAGACTTTCGTCGA
TGCGACGCCCGACACCGATCCCGCGACGATCATGCAGTTGTATCAGCAACAGAAATCGCAGCCGGGCTTCTCGCTGAAGG
CCTTCGTCGACCAGCACTTCACGCCGCCGGCGCAAGGCGGCGTGACGCCGCCGCCGAACCAGACGCTGCGTGAGCACATC
GACTGGCTGTGGCCGCAGCTCACGCGCACGACGCCGACGGCGCCGCCGTACAGCTCGCTGATCCCGATGCCGAAACCGTA
CGTGGTGCCGGGCGGCCGTTTCCGCGAAGGCTATTACTGGGACACCTATTTCACGATGCTCGGGCTGCAGGTGTCGGGCC
GCGAGGATCTCGTCGACGACATGCTCGACAACTTCGCGCATCTGATCGATACGGTCGGGCACATCCCGAACGGCAACCGC
ACGTACTACGCGAGCCGCTCGCAGCCGCCGTTCTTCGCGTACATGGTGACGCTCGCCGCGCAGGCCGAGGGCGACAAGGT
CTATCAGAAATACCTGCCGGCGCTGCGCAAGGAATATGCGTACTGGATGCAGGGCGAATCGACGACGCCGCGCGGGCAGG
CCGCACGCCACGTCGTGGCGATGCCGGACGGCGCGGTGCTGAACCGCTACTGGGACGCGAGCGACACGCCGCGCGACGAG
TCGTATCTGGAAGACGTGACGACGGCGAAGGCGGCGTCGGGCCGTGCCGCGAACGACGTGTACCGCGACCTGCGGGCGGG
CGCGGAGAGCGGCTGGGATTACAGCTCGCGCTGGCTCGGCGACGGCAAGACGCTCGCGACGATCCGCACGACGTCGATCG
TGCCGGTCGACCTGAACAGCCTGATGTTCCATCTCGAACGGACGATCGTGAAGGGCTGCACGGTCACGCACGACGTCGGA
TGCGTGATCGACTTCTCGGGCCGCGCGGCGCGGCGCGCGCTCGCGATCAATCGCTGGCTGTGGAATCGCGGCGGCTATTA
CGGCGACTACGACTGGCAACTGCGCAAGCCGCGCGACGGCGTGACGGCGGCCGCGCTGTATCCGCTGTTCGCGGGCGTCG
CGTGGCCCGAGCGCGCGAAGGCGACGGCGCGCGAAGTGCGCAAGACGCTGCTGCAGCCCGGCGGTCTCGCGACGACGACC
GAGACGACCGGCCAGCAATGGGATGCGCCGAACGGCTGGGCGCCGCTGCAGTGGATCGCGATCGAAGGGTTGCGCCGCTA
CGGCGAGCCGGCGCTCGCGAAGGACATCGGCACGCGTTTCCTGGCCGACGTGAAGCATGTCTACGCGACCGAGGGCAAGC
TCGTCGAGAAATACGTCGTCGAAGGGGCCGGGCAGGGCGGCGGGGGCGGCGGCGAATATCCGCTGCAGGACGGCTTCGGC
TGGACCAACGGCGTCACGCTGAAGCTGCTCCAAATGTATGGCGAGTGA

Upstream 100 bases:

>100_bases
CTTCAACATCACGACGCGCATCGCTCGACGGCCATCGAGATGGGCGCGCACGCGACGAGACCATGCCGATCCACTCACCA
TCGAAAGGAGGGGACACGCC

Downstream 100 bases:

>100_bases
GGCGCGCGCGGCCGCCGTGCGGCGGCCGTGCCGTTGCTTTCGCGCATCGCGCGCGGCGCGCCGCCGATACCGGCTGAAAG
GTTTCGGCGCGCGTTTTCGC

Product: alpha,alpha-trehalase

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MTSRRAESIVSAAPTASHCAAAAPAAPAAPRVRWAAALAVAYLAVAGCAAQADSANHAATQLAASSAATVPNATAATLLP
PPSQLYGDLFVAVQTAQLYPDQKTFVDATPDTDPATIMQLYQQQKSQPGFSLKAFVDQHFTPPAQGGVTPPPNQTLREHI
DWLWPQLTRTTPTAPPYSSLIPMPKPYVVPGGRFREGYYWDTYFTMLGLQVSGREDLVDDMLDNFAHLIDTVGHIPNGNR
TYYASRSQPPFFAYMVTLAAQAEGDKVYQKYLPALRKEYAYWMQGESTTPRGQAARHVVAMPDGAVLNRYWDASDTPRDE
SYLEDVTTAKAASGRAANDVYRDLRAGAESGWDYSSRWLGDGKTLATIRTTSIVPVDLNSLMFHLERTIVKGCTVTHDVG
CVIDFSGRAARRALAINRWLWNRGGYYGDYDWQLRKPRDGVTAAALYPLFAGVAWPERAKATAREVRKTLLQPGGLATTT
ETTGQQWDAPNGWAPLQWIAIEGLRRYGEPALAKDIGTRFLADVKHVYATEGKLVEKYVVEGAGQGGGGGGEYPLQDGFG
WTNGVTLKLLQMYGE

Sequences:

>Translated_575_residues
MTSRRAESIVSAAPTASHCAAAAPAAPAAPRVRWAAALAVAYLAVAGCAAQADSANHAATQLAASSAATVPNATAATLLP
PPSQLYGDLFVAVQTAQLYPDQKTFVDATPDTDPATIMQLYQQQKSQPGFSLKAFVDQHFTPPAQGGVTPPPNQTLREHI
DWLWPQLTRTTPTAPPYSSLIPMPKPYVVPGGRFREGYYWDTYFTMLGLQVSGREDLVDDMLDNFAHLIDTVGHIPNGNR
TYYASRSQPPFFAYMVTLAAQAEGDKVYQKYLPALRKEYAYWMQGESTTPRGQAARHVVAMPDGAVLNRYWDASDTPRDE
SYLEDVTTAKAASGRAANDVYRDLRAGAESGWDYSSRWLGDGKTLATIRTTSIVPVDLNSLMFHLERTIVKGCTVTHDVG
CVIDFSGRAARRALAINRWLWNRGGYYGDYDWQLRKPRDGVTAAALYPLFAGVAWPERAKATAREVRKTLLQPGGLATTT
ETTGQQWDAPNGWAPLQWIAIEGLRRYGEPALAKDIGTRFLADVKHVYATEGKLVEKYVVEGAGQGGGGGGEYPLQDGFG
WTNGVTLKLLQMYGE
>Mature_574_residues
TSRRAESIVSAAPTASHCAAAAPAAPAAPRVRWAAALAVAYLAVAGCAAQADSANHAATQLAASSAATVPNATAATLLPP
PSQLYGDLFVAVQTAQLYPDQKTFVDATPDTDPATIMQLYQQQKSQPGFSLKAFVDQHFTPPAQGGVTPPPNQTLREHID
WLWPQLTRTTPTAPPYSSLIPMPKPYVVPGGRFREGYYWDTYFTMLGLQVSGREDLVDDMLDNFAHLIDTVGHIPNGNRT
YYASRSQPPFFAYMVTLAAQAEGDKVYQKYLPALRKEYAYWMQGESTTPRGQAARHVVAMPDGAVLNRYWDASDTPRDES
YLEDVTTAKAASGRAANDVYRDLRAGAESGWDYSSRWLGDGKTLATIRTTSIVPVDLNSLMFHLERTIVKGCTVTHDVGC
VIDFSGRAARRALAINRWLWNRGGYYGDYDWQLRKPRDGVTAAALYPLFAGVAWPERAKATAREVRKTLLQPGGLATTTE
TTGQQWDAPNGWAPLQWIAIEGLRRYGEPALAKDIGTRFLADVKHVYATEGKLVEKYVVEGAGQGGGGGGEYPLQDGFGW
TNGVTLKLLQMYGE

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=543, Percent_Identity=35.3591160220994, Blast_Score=259, Evalue=3e-69,
Organism=Escherichia coli, GI1787447, Length=494, Percent_Identity=56.2753036437247, Blast_Score=560, Evalue=1e-161,
Organism=Escherichia coli, GI1789936, Length=497, Percent_Identity=51.5090543259557, Blast_Score=505, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17542196, Length=531, Percent_Identity=32.015065913371, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI25148109, Length=535, Percent_Identity=31.588785046729, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17565078, Length=517, Percent_Identity=33.6557059961315, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI25141398, Length=543, Percent_Identity=31.3075506445672, Blast_Score=222, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI71987755, Length=423, Percent_Identity=30.0236406619385, Blast_Score=190, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319473, Length=431, Percent_Identity=30.6264501160093, Blast_Score=139, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6320204, Length=429, Percent_Identity=28.4382284382284, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24656680, Length=535, Percent_Identity=34.2056074766355, Blast_Score=256, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24656675, Length=535, Percent_Identity=34.2056074766355, Blast_Score=256, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24656661, Length=535, Percent_Identity=34.2056074766355, Blast_Score=255, Evalue=5e-68,
Organism=Drosophila melanogaster, GI17933716, Length=535, Percent_Identity=34.2056074766355, Blast_Score=255, Evalue=5e-68,
Organism=Drosophila melanogaster, GI24656670, Length=535, Percent_Identity=34.2056074766355, Blast_Score=255, Evalue=5e-68,
Organism=Drosophila melanogaster, GI24656685, Length=510, Percent_Identity=33.3333333333333, Blast_Score=238, Evalue=7e-63,
Organism=Drosophila melanogaster, GI22024178, Length=534, Percent_Identity=29.9625468164794, Blast_Score=212, Evalue=6e-55,
Organism=Drosophila melanogaster, GI45551104, Length=374, Percent_Identity=31.283422459893, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI28573474, Length=297, Percent_Identity=27.6094276094276, Blast_Score=115, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 62665; Mature: 62534

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00927 TREHALASE_1 ; PS00928 TREHALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRRAESIVSAAPTASHCAAAAPAAPAAPRVRWAAALAVAYLAVAGCAAQADSANHAAT
CCCHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
QLAASSAATVPNATAATLLPPPSQLYGDLFVAVQTAQLYPDQKTFVDATPDTDPATIMQL
HHHHHCCCCCCCCCEEEECCCHHHHHHHHHHEEEHHHHCCCCCEEEECCCCCCHHHHHHH
YQQQKSQPGFSLKAFVDQHFTPPAQGGVTPPPNQTLREHIDWLWPQLTRTTPTAPPYSSL
HHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHC
IPMPKPYVVPGGRFREGYYWDTYFTMLGLQVSGREDLVDDMLDNFAHLIDTVGHIPNGNR
CCCCCCEECCCCCCCCCEEEHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCCE
TYYASRSQPPFFAYMVTLAAQAEGDKVYQKYLPALRKEYAYWMQGESTTPRGQAARHVVA
EEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCEEEE
MPDGAVLNRYWDASDTPRDESYLEDVTTAKAASGRAANDVYRDLRAGAESGWDYSSRWLG
CCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
DGKTLATIRTTSIVPVDLNSLMFHLERTIVKGCTVTHDVGCVIDFSGRAARRALAINRWL
CCCEEEEEEECEEEEECHHHHHHHHHHHHHHCCCEEECCCEEEECCCHHHHHHHHHHHHH
WNRGGYYGDYDWQLRKPRDGVTAAALYPLFAGVAWPERAKATAREVRKTLLQPGGLATTT
HHCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEECC
ETTGQQWDAPNGWAPLQWIAIEGLRRYGEPALAKDIGTRFLADVKHVYATEGKLVEKYVV
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EGAGQGGGGGGEYPLQDGFGWTNGVTLKLLQMYGE
HCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TSRRAESIVSAAPTASHCAAAAPAAPAAPRVRWAAALAVAYLAVAGCAAQADSANHAAT
CCHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
QLAASSAATVPNATAATLLPPPSQLYGDLFVAVQTAQLYPDQKTFVDATPDTDPATIMQL
HHHHHCCCCCCCCCEEEECCCHHHHHHHHHHEEEHHHHCCCCCEEEECCCCCCHHHHHHH
YQQQKSQPGFSLKAFVDQHFTPPAQGGVTPPPNQTLREHIDWLWPQLTRTTPTAPPYSSL
HHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHC
IPMPKPYVVPGGRFREGYYWDTYFTMLGLQVSGREDLVDDMLDNFAHLIDTVGHIPNGNR
CCCCCCEECCCCCCCCCEEEHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCCE
TYYASRSQPPFFAYMVTLAAQAEGDKVYQKYLPALRKEYAYWMQGESTTPRGQAARHVVA
EEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCEEEE
MPDGAVLNRYWDASDTPRDESYLEDVTTAKAASGRAANDVYRDLRAGAESGWDYSSRWLG
CCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
DGKTLATIRTTSIVPVDLNSLMFHLERTIVKGCTVTHDVGCVIDFSGRAARRALAINRWL
CCCEEEEEEECEEEEECHHHHHHHHHHHHHHCCCEEECCCEEEECCCHHHHHHHHHHHHH
WNRGGYYGDYDWQLRKPRDGVTAAALYPLFAGVAWPERAKATAREVRKTLLQPGGLATTT
HHCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEECC
ETTGQQWDAPNGWAPLQWIAIEGLRRYGEPALAKDIGTRFLADVKHVYATEGKLVEKYVV
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EGAGQGGGGGGEYPLQDGFGWTNGVTLKLLQMYGE
HCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]