BacMap

Definition	Burkholderia multivorans ATCC 17616 chromosome 2, complete genome.
Accession	NC_010805
Length	2,473,162

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The map label for this gene is cbr [H]

Identifier: 189353486

GI number: 189353486

Start: 1703424

End: 1704170

Strand: Reverse

Name: cbr [H]

Synonym: BMULJ_04730

Alternate gene names: 189353486

Gene position: 1704170-1703424 (Counterclockwise)

Preceding gene: 189353487

Following gene: 189353478

Centisome position: 68.91

GC content: 71.08

Gene sequence:

>747_bases
ATGAACATGCAATTCGACTTCAGCGGTGCGCGCGTGCTCGTCACCGGCGCATCGAGCGGGATCGGCCGCGCCTGTGCCGT
CGCACTCGCGCAAGCGGGCGCGCAGGTCGTCGCGGCTGCGCGCGACATGGCGGCGCTCGAGACGCTCGCCGGCGAAACGG
GCTGCGACACGGTGCGCCTCGACGTCGGCGGCGACGAGCAGGCGATCGATGCCGTGCTCGCGCGGTACGCCGCATTCGAC
GGGCTCGTGAACTGCGCGGGCGTCGCCTCGCTCGAATCGGCGCTCGACGTCGGCGCGGCGAGCTTCGATCGCGTGATGAC
CGTCAATGCGCGCGGCGCCGCGCTCGTCGCCCGCGCCGTCGCGCGCGGGATGATCGAACGGGGCGGCGCGCGCGGCGGCA
GCATCGTCAACGTGTCGAGTCAGGCCGCGCTCGTCGGGCTGCCCGCGCATCTGAGCTACTGCGCGTCGAAGGCTGCGATG
GATGCGATCACGCGCGTGCTCTGCATCGAGCTCGGCCCGCACGGGATCCGCGTGAACAGCGTGAACCCGACCGTCACGCT
GACGCCGATGGCGCAGTTCGCCTGGAGCGATCCGGCGAAAAGCGCGCCGATGCTCGCGGCGATTCCGCTCGGGCGGTTTG
CGCAGCCCGATGAAGTCGTCGCGCCGGTGCTGTTTCTGTTGAGCGGCGCGGCGTCGATGATCAGTGGCGTATCGCTCGCG
ATCGACGGCGGCTATACGGCGCGGTAG

Upstream 100 bases:

>100_bases
CCGATCCCGCGCGCGCGGCCGCGTATGCGGCGCGCTTTGCGCTCTACACGGCGCTGTACCCCGCGCTCAAGCCGATCATG
CACGCGCTGCAATCCGGATC

Downstream 100 bases:

>100_bases
CGGCGCTCGCGCGTGACGTTTCATCACGTCGCGTCACGTCGCGGCGCGCGTGTTCGTGCGGCGCTGCCGCATCGGTGCAC
GCGCATGCCCGCACAACCGT

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MNMQFDFSGARVLVTGASSGIGRACAVALAQAGAQVVAAARDMAALETLAGETGCDTVRLDVGGDEQAIDAVLARYAAFD
GLVNCAGVASLESALDVGAASFDRVMTVNARGAALVARAVARGMIERGGARGGSIVNVSSQAALVGLPAHLSYCASKAAM
DAITRVLCIELGPHGIRVNSVNPTVTLTPMAQFAWSDPAKSAPMLAAIPLGRFAQPDEVVAPVLFLLSGAASMISGVSLA
IDGGYTAR

Sequences:

>Translated_248_residues
MNMQFDFSGARVLVTGASSGIGRACAVALAQAGAQVVAAARDMAALETLAGETGCDTVRLDVGGDEQAIDAVLARYAAFD
GLVNCAGVASLESALDVGAASFDRVMTVNARGAALVARAVARGMIERGGARGGSIVNVSSQAALVGLPAHLSYCASKAAM
DAITRVLCIELGPHGIRVNSVNPTVTLTPMAQFAWSDPAKSAPMLAAIPLGRFAQPDEVVAPVLFLLSGAASMISGVSLA
IDGGYTAR
>Mature_248_residues
MNMQFDFSGARVLVTGASSGIGRACAVALAQAGAQVVAAARDMAALETLAGETGCDTVRLDVGGDEQAIDAVLARYAAFD
GLVNCAGVASLESALDVGAASFDRVMTVNARGAALVARAVARGMIERGGARGGSIVNVSSQAALVGLPAHLSYCASKAAM
DAITRVLCIELGPHGIRVNSVNPTVTLTPMAQFAWSDPAKSAPMLAAIPLGRFAQPDEVVAPVLFLLSGAASMISGVSLA
IDGGYTAR

Specific function: Reduces cyclopentanol to cyclopentanone. The enzyme also shows considerable activity toward cyclohexanol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=246, Percent_Identity=46.7479674796748, Blast_Score=203, Evalue=1e-52,
Organism=Homo sapiens, GI32483357, Length=247, Percent_Identity=34.0080971659919, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI15277342, Length=269, Percent_Identity=34.5724907063197, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI126723750, Length=248, Percent_Identity=30.241935483871, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI40254992, Length=241, Percent_Identity=34.0248962655602, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI4503817, Length=209, Percent_Identity=31.5789473684211, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI19923817, Length=253, Percent_Identity=28.4584980237154, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI10190704, Length=242, Percent_Identity=31.8181818181818, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI66933014, Length=245, Percent_Identity=30.6122448979592, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI7706318, Length=193, Percent_Identity=31.6062176165803, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=32.2448979591837, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI109715829, Length=244, Percent_Identity=30.7377049180328, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI59889578, Length=233, Percent_Identity=27.8969957081545, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI126723191, Length=181, Percent_Identity=34.8066298342541, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI7657478, Length=206, Percent_Identity=34.4660194174757, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI20149619, Length=189, Percent_Identity=31.7460317460317, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI33667109, Length=195, Percent_Identity=34.3589743589744, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=32.2709163346614, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=30.6772908366534, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=31.2252964426877, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1788459, Length=243, Percent_Identity=32.9218106995885, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=34.6774193548387, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786812, Length=249, Percent_Identity=32.9317269076305, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=30.6122448979592, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=35.0194552529183, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI2367365, Length=252, Percent_Identity=32.1428571428571, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787905, Length=254, Percent_Identity=31.496062992126, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787820, Length=178, Percent_Identity=30.3370786516854, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789378, Length=246, Percent_Identity=28.0487804878049, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789057, Length=188, Percent_Identity=29.2553191489362, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1786701, Length=176, Percent_Identity=30.6818181818182, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI1787526, Length=213, Percent_Identity=28.6384976525822, Blast_Score=60, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=251, Percent_Identity=47.0119521912351, Blast_Score=218, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=34.8178137651822, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71994600, Length=248, Percent_Identity=31.8548387096774, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=32.4528301886792, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=32.3308270676692, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=32.824427480916, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=31.9548872180451, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=32.5757575757576, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=32.0610687022901, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=31.0204081632653, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=32.7067669172932, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=31.9230769230769, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17555706, Length=240, Percent_Identity=31.6666666666667, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI193204405, Length=272, Percent_Identity=30.5147058823529, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17562990, Length=267, Percent_Identity=31.0861423220974, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562908, Length=264, Percent_Identity=30.3030303030303, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560676, Length=246, Percent_Identity=32.1138211382114, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=29.7709923664122, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=30.46875, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17544670, Length=266, Percent_Identity=29.6992481203008, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=30.7984790874525, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17538480, Length=271, Percent_Identity=29.520295202952, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17536651, Length=257, Percent_Identity=28.7937743190661, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17536025, Length=256, Percent_Identity=28.90625, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538182, Length=246, Percent_Identity=31.7073170731707, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=268, Percent_Identity=30.5970149253731, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=265, Percent_Identity=28.6792452830189, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=268, Percent_Identity=29.8507462686567, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17561272, Length=235, Percent_Identity=27.6595744680851, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17507613, Length=262, Percent_Identity=28.2442748091603, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32563809, Length=262, Percent_Identity=28.2442748091603, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=194, Percent_Identity=26.2886597938144, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17558628, Length=196, Percent_Identity=28.0612244897959, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=255, Percent_Identity=27.4509803921569, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322067, Length=179, Percent_Identity=31.2849162011173, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24643142, Length=246, Percent_Identity=42.6829268292683, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI23397609, Length=247, Percent_Identity=38.4615384615385, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21357041, Length=256, Percent_Identity=35.546875, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28571526, Length=254, Percent_Identity=35.0393700787402, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=35.2713178294574, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=33.8775510204082, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24644337, Length=175, Percent_Identity=37.7142857142857, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355319, Length=253, Percent_Identity=28.0632411067194, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356301, Length=208, Percent_Identity=31.25, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24580925, Length=192, Percent_Identity=30.2083333333333, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737361, Length=249, Percent_Identity=31.7269076305221, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21358495, Length=194, Percent_Identity=31.4432989690722, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.163 [H]

Molecular weight: Translated: 24964; Mature: 24964

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMQFDFSGARVLVTGASSGIGRACAVALAQAGAQVVAAARDMAALETLAGETGCDTVRL
CCCEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
DVGGDEQAIDAVLARYAAFDGLVNCAGVASLESALDVGAASFDRVMTVNARGAALVARAV
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHH
ARGMIERGGARGGSIVNVSSQAALVGLPAHLSYCASKAAMDAITRVLCIELGPHGIRVNS
HHHHHHHCCCCCCCEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEC
VNPTVTLTPMAQFAWSDPAKSAPMLAAIPLGRFAQPDEVVAPVLFLLSGAASMISGVSLA
CCCEEEEEEHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCHHHHHCCCEEE
IDGGYTAR
ECCCCCCC
>Mature Secondary Structure
MNMQFDFSGARVLVTGASSGIGRACAVALAQAGAQVVAAARDMAALETLAGETGCDTVRL
CCCEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
DVGGDEQAIDAVLARYAAFDGLVNCAGVASLESALDVGAASFDRVMTVNARGAALVARAV
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHH
ARGMIERGGARGGSIVNVSSQAALVGLPAHLSYCASKAAMDAITRVLCIELGPHGIRVNS
HHHHHHHCCCCCCCEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEC
VNPTVTLTPMAQFAWSDPAKSAPMLAAIPLGRFAQPDEVVAPVLFLLSGAASMISGVSLA
CCCEEEEEEHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCHHHHHCCCEEE
IDGGYTAR
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12406764 [H]