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The map label for this gene is pcaR [H]

Identifier: 189353282

GI number: 189353282

Start: 1519453

End: 1520385

Strand: Reverse

Name: pcaR [H]

Synonym: BMULJ_04522

Alternate gene names: 189353282

Gene position: 1520385-1519453 (Counterclockwise)

Preceding gene: 189353283

Following gene: 189353280

Centisome position: 61.48

GC content: 69.13

Gene sequence:

>933_bases
ATGAGCGGCGTACCGAAACCGTCGGCCCGGCAGGCGCGCGCACCGCGCGACGCCGAACGCGACGATCCGCCGCCGCCCGC
AGCGGGCGACGACGAACCGGCCGCCGGCGCATCGTCGTATCTGGTGCCCGGTCTCGAACGCGGGCTGCGGATCCTCGCCG
AATTCACGGCGCGCGAGCCGGTGCTCGGTGCGCCCGAGCTGTCGAAGCGCATCGGCATTCCGCGCACGACGACGTTCCGT
CTGCTGCAGACGCTGGAGGCGCTCGGCTTTCTCGAGCGCGTGAACGGCGATCGTTATTTCCGGCTCGGCGTCGGCGTGCT
GCGGCTCGGCTTCGAGTACCTGAACTCGCTCGAGCTGACCGATCTCGGCACGCCGGTGCTCGAACGGCTGCGCGATGCGA
CGAGCCTGTCCACGCATCTGCTGATCCGCGATCAGCGCGATGTCGTGTTCGTCGCGAAAGCGCAGAGCAACGCGTCGATG
TTCGGCTCGGTGAAGGTGCATGTCGGCACGCGGCTGCCCGCGCACGCGACCGTGCATGGCCACGTGCTGATGGGCGACCT
CACGCGCGACGCGCTGCGCCAGCTCTATCCGGAAAAGCGGCTCGAGCAGTTCACGGATCGCACACCGGCCACCGTCGACG
AACTGTACGAGCGCGTGCGTCAGTACGCGCGGCTCGGCTATGCGGTCAGCGAGGCGGCGTTCGAAAGCGGGATTTCGGCG
GTCACCGCGCCGGTGCGCGATCATTCGGGCTCGATCGTCGCCGCGATCACCGCGACGGTGCCGCGCTCCGAGATCGGCGA
CGCGGCCGAGAAGGAGCGGCTCGTCGAAGCCGTGTGCGGCGCGGCCGTCGATCTGTCGCAGCGTCTGAACTATCGTCCGC
TCGACAGCGATCCGACGTTCGCGCACGCGCGTCACAAGGTCGCGATGTTCTGA

Upstream 100 bases:

>100_bases
GGATCGTGTTGATCCGGTCGGAGCGCCCATCCATAATTCTTCATCGCGGGTATCTCGTGAGCGATTCCATTTCGTCCATG
TGCAGTGAGGCAACACAACG

Downstream 100 bases:

>100_bases
CGCGCCTCATCGGCCGCCGAGGCGGTCGCCTGTCGAGCAAGAGCGGCCCGCGGGCCGCTCTTGTCGTTTCCGGGCGCCGC
GTCGGGACGCGCGGCGCGAG

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSGVPKPSARQARAPRDAERDDPPPPAAGDDEPAAGASSYLVPGLERGLRILAEFTAREPVLGAPELSKRIGIPRTTTFR
LLQTLEALGFLERVNGDRYFRLGVGVLRLGFEYLNSLELTDLGTPVLERLRDATSLSTHLLIRDQRDVVFVAKAQSNASM
FGSVKVHVGTRLPAHATVHGHVLMGDLTRDALRQLYPEKRLEQFTDRTPATVDELYERVRQYARLGYAVSEAAFESGISA
VTAPVRDHSGSIVAAITATVPRSEIGDAAEKERLVEAVCGAAVDLSQRLNYRPLDSDPTFAHARHKVAMF

Sequences:

>Translated_310_residues
MSGVPKPSARQARAPRDAERDDPPPPAAGDDEPAAGASSYLVPGLERGLRILAEFTAREPVLGAPELSKRIGIPRTTTFR
LLQTLEALGFLERVNGDRYFRLGVGVLRLGFEYLNSLELTDLGTPVLERLRDATSLSTHLLIRDQRDVVFVAKAQSNASM
FGSVKVHVGTRLPAHATVHGHVLMGDLTRDALRQLYPEKRLEQFTDRTPATVDELYERVRQYARLGYAVSEAAFESGISA
VTAPVRDHSGSIVAAITATVPRSEIGDAAEKERLVEAVCGAAVDLSQRLNYRPLDSDPTFAHARHKVAMF
>Mature_309_residues
SGVPKPSARQARAPRDAERDDPPPPAAGDDEPAAGASSYLVPGLERGLRILAEFTAREPVLGAPELSKRIGIPRTTTFRL
LQTLEALGFLERVNGDRYFRLGVGVLRLGFEYLNSLELTDLGTPVLERLRDATSLSTHLLIRDQRDVVFVAKAQSNASMF
GSVKVHVGTRLPAHATVHGHVLMGDLTRDALRQLYPEKRLEQFTDRTPATVDELYERVRQYARLGYAVSEAAFESGISAV
TAPVRDHSGSIVAAITATVPRSEIGDAAEKERLVEAVCGAAVDLSQRLNYRPLDSDPTFAHARHKVAMF

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1786468, Length=251, Percent_Identity=28.6852589641434, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786715, Length=237, Percent_Identity=26.5822784810127, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87082359, Length=254, Percent_Identity=26.3779527559055, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1788131, Length=267, Percent_Identity=25.4681647940075, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788581, Length=255, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789999, Length=252, Percent_Identity=25.3968253968254, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 33860; Mature: 33729

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGVPKPSARQARAPRDAERDDPPPPAAGDDEPAAGASSYLVPGLERGLRILAEFTAREP
CCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
VLGAPELSKRIGIPRTTTFRLLQTLEALGFLERVNGDRYFRLGVGVLRLGFEYLNSLELT
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCHH
DLGTPVLERLRDATSLSTHLLIRDQRDVVFVAKAQSNASMFGSVKVHVGTRLPAHATVHG
HCCHHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCCEEEEEEEEECCCCCCCCEEEC
HVLMGDLTRDALRQLYPEKRLEQFTDRTPATVDELYERVRQYARLGYAVSEAAFESGISA
EEEECHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
VTAPVRDHSGSIVAAITATVPRSEIGDAAEKERLVEAVCGAAVDLSQRLNYRPLDSDPTF
HCCCCCCCCCCEEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
AHARHKVAMF
HHHHHHHCCC
>Mature Secondary Structure 
SGVPKPSARQARAPRDAERDDPPPPAAGDDEPAAGASSYLVPGLERGLRILAEFTAREP
CCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
VLGAPELSKRIGIPRTTTFRLLQTLEALGFLERVNGDRYFRLGVGVLRLGFEYLNSLELT
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCHH
DLGTPVLERLRDATSLSTHLLIRDQRDVVFVAKAQSNASMFGSVKVHVGTRLPAHATVHG
HCCHHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCCEEEEEEEEECCCCCCCCEEEC
HVLMGDLTRDALRQLYPEKRLEQFTDRTPATVDELYERVRQYARLGYAVSEAAFESGISA
EEEECHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
VTAPVRDHSGSIVAAITATVPRSEIGDAAEKERLVEAVCGAAVDLSQRLNYRPLDSDPTF
HCCCCCCCCCCEEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
AHARHKVAMF
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]