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The map label for this gene is cysG [H]

Identifier: 189353124

GI number: 189353124

Start: 1316940

End: 1317695

Strand: Direct

Name: cysG [H]

Synonym: BMULJ_04360

Alternate gene names: 189353124

Gene position: 1316940-1317695 (Clockwise)

Preceding gene: 189353117

Following gene: 189353125

Centisome position: 53.25

GC content: 72.75

Gene sequence:

>756_bases
ATGACGACTGGAAAAGTCACGCTGCTGGGCGCCGGGCCCGGCGATCTCGATCTCCTCACGCTGAAGGCCGTGAAAGCGCT
GGCGGCCGCCGACGTGCTGCTGCTCGACGATCTCGTCGACGCGCGCATCGTCGAACTCGCGCCGCATGCACGCGTCGTGC
GCGTCGGCAAACGCGGCGGCTGCCGCTCGACGCCGCAGGCGTTCATCGAGCGGCTGATGCGCCGCTACGCGCTGCGCGGC
GCGCACGTCGTGCGCGTGAAAGGCGGCGATGCATTGCTGTTCGGCCGCGCCGGCGAAGAACTCGCGACGCTGCGCGCCGC
CGCGATTCCGGTCGAGATCGTGAACGGCATCTCGTCGGGCTTCGCGGCCGCCGCGAGCCTCGGCGTGTCGCTGACGCACC
GCGAGCATTGCCAGGGCGTCACGTTCGTGACCGCGCATCGGCAGGATCACGGCGAGCCCGACTGGGCACAACTCGCGGCG
ACCGGCACGACGCTCGCGATCTATATGGGAATGAGCCGCATCGAGCGGATCGCCGCGGGCCTGCTCGCCGCATTGCCCGC
ATCGACGCCCGCCGCGGCCGTGCAGTGGGCCGGCACGCCCGCCGAACGGCGCTGGATCGGCACGCTCGGTGCGCTGGCCG
ACGGCGTCGAAGCGGCGCGGCTCGGCAGCCCCGCCGTGATTCTCGTCGGCGCGGCGATCGGCGAAGCGGGCGCGCTCGAT
GCCGATCGTGCCGCCGCCCTGTCGCGGGCCGCGTAG

Upstream 100 bases:

>100_bases
CGTGCGCGGCATCGCCGGGTGCGGCCGTCATAGCGGCTGCCGACGCTGCCGCAATGACCGCGTTGAACGACCGCCCGCCC
GGGCGGCGATGGAATACGAC

Downstream 100 bases:

>100_bases
CATGCGCGGCGTCATCCCGCCTCTCGTCGAATCCCGCGTGCGGGCTGGCTGCGGCACGCGACGGCGATACGTCGTCGCGC
GTCCGACTCGGTCCGCCATC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MTTGKVTLLGAGPGDLDLLTLKAVKALAAADVLLLDDLVDARIVELAPHARVVRVGKRGGCRSTPQAFIERLMRRYALRG
AHVVRVKGGDALLFGRAGEELATLRAAAIPVEIVNGISSGFAAAASLGVSLTHREHCQGVTFVTAHRQDHGEPDWAQLAA
TGTTLAIYMGMSRIERIAAGLLAALPASTPAAAVQWAGTPAERRWIGTLGALADGVEAARLGSPAVILVGAAIGEAGALD
ADRAAALSRAA

Sequences:

>Translated_251_residues
MTTGKVTLLGAGPGDLDLLTLKAVKALAAADVLLLDDLVDARIVELAPHARVVRVGKRGGCRSTPQAFIERLMRRYALRG
AHVVRVKGGDALLFGRAGEELATLRAAAIPVEIVNGISSGFAAAASLGVSLTHREHCQGVTFVTAHRQDHGEPDWAQLAA
TGTTLAIYMGMSRIERIAAGLLAALPASTPAAAVQWAGTPAERRWIGTLGALADGVEAARLGSPAVILVGAAIGEAGALD
ADRAAALSRAA
>Mature_250_residues
TTGKVTLLGAGPGDLDLLTLKAVKALAAADVLLLDDLVDARIVELAPHARVVRVGKRGGCRSTPQAFIERLMRRYALRGA
HVVRVKGGDALLFGRAGEELATLRAAAIPVEIVNGISSGFAAAASLGVSLTHREHCQGVTFVTAHRQDHGEPDWAQLAAT
GTTLAIYMGMSRIERIAAGLLAALPASTPAAAVQWAGTPAERRWIGTLGALADGVEAARLGSPAVILVGAAIGEAGALDA
DRAAALSRAA

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=234, Percent_Identity=42.7350427350427, Blast_Score=167, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6322922, Length=248, Percent_Identity=28.6290322580645, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 25726; Mature: 25595

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTGKVTLLGAGPGDLDLLTLKAVKALAAADVLLLDDLVDARIVELAPHARVVRVGKRGG
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
CRSTPQAFIERLMRRYALRGAHVVRVKGGDALLFGRAGEELATLRAAAIPVEIVNGISSG
CCCCHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
FAAAASLGVSLTHREHCQGVTFVTAHRQDHGEPDWAQLAATGTTLAIYMGMSRIERIAAG
HHHHHHHCCEEECHHHHCCCEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
LLAALPASTPAAAVQWAGTPAERRWIGTLGALADGVEAARLGSPAVILVGAAIGEAGALD
HHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEEECCCCCCCC
ADRAAALSRAA
HHHHHHHHCCC
>Mature Secondary Structure 
TTGKVTLLGAGPGDLDLLTLKAVKALAAADVLLLDDLVDARIVELAPHARVVRVGKRGG
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
CRSTPQAFIERLMRRYALRGAHVVRVKGGDALLFGRAGEELATLRAAAIPVEIVNGISSG
CCCCHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
FAAAASLGVSLTHREHCQGVTFVTAHRQDHGEPDWAQLAATGTTLAIYMGMSRIERIAAG
HHHHHHHCCEEECHHHHCCCEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
LLAALPASTPAAAVQWAGTPAERRWIGTLGALADGVEAARLGSPAVILVGAAIGEAGALD
HHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEEECCCCCCCC
ADRAAALSRAA
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]