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The map label for this gene is ilvA [H]

Identifier: 189353092

GI number: 189353092

Start: 1274999

End: 1275979

Strand: Direct

Name: ilvA [H]

Synonym: BMULJ_04328

Alternate gene names: 189353092

Gene position: 1274999-1275979 (Clockwise)

Preceding gene: 189353091

Following gene: 189353093

Centisome position: 51.55

GC content: 68.2

Gene sequence:

>981_bases
ATGAACTCATTGCCCCTCCCCAGCTTCGACGACGTTGCCGCCGCGGCGGCGAGAATCGCCGGCCACGCGCACCGCACGCC
CGTGATGACGTCGCGCACGGTCGACGACGCGCTCGGCGCGCAGGTGTTCTTCAAGTGCGAGAACCTGCAGCGCATGGGTG
CGTTCAAGTTTCGCGGCGCATTCAACGCGCTGTCGCGTTTCGATGCGGAACAGCGCCGCCGCGGCGTCGTTGCGTTTTCG
TCGGGCAATCATGCGCAGGCGATCGCGCTGTCCGCGCGCATGCTCGGGATTCCGGCGACGATCGTGATGCCGCAGGATGC
GCCTGCCGCGAAGATCGCCGCGACGCGCGGCTACGGCGGCACCGTCGTCACGTACGACCGCTACACCGAGGATCGCGAGC
AGATCGGCCGCGAACTTGCGGAACGGGACGGGCTCACGCTGATTCCGCCGTACGATCATCCGGACGTGATCGCCGGTCAG
GGCACCGCGGCCATGGAGCTGTTCGACGAAGTCGGCCCGCTCGACGCGGTATTCACGCCGCTCGGCGGCGGCGGGCTGCT
GTCGGGCACCGCGCTCGCGACGCGCGCGCTGTCGCCGAACGCGCGGCTGTACGGCGTCGAGCCGGAAGCCGGCAACGACG
GCCAGCAATCGTTCCGTTCGGGCGCGATCGTCCACATCGATACGCCGCGCACGATCGCCGACGGCGCGCAGACGCAGCAT
CTCGGCAACATCACGTTCCCGATCATCCGCCGCGACGTCGACGACATCCTCACCGCGACCGACGACGAGCTCGTCGACTG
CATGCGCTTGTTCGCGGCGCGTATGAAGATTGTCGTCGAGCCGACCGGCTGTCTGTCGTTCGCCGGCGCGCGGCGCATGA
AGGACGAACTGAAGGGCAAGCGCGTCGGCATCGTGATCAGCGGCGGAAACGTCGATCTCGACGCGTTCAGCGCATTGCTC
GCGAGCCGGCCGCAAAGCTGA

Upstream 100 bases:

>100_bases
GGCGTGTCGCGCGCGACGGTGTACAACGATGCGAAATGATGCGCGGGCGCGGCATGCCGCCGCGCCCGGCTGTTGACGGA
CTCTTTCACTCGAGCGACTC

Downstream 100 bases:

>100_bases
GCGAAGCGGCAACGCATCCTTCACGTCGCGTTAAGTTTCGCGACCTAGACTGACGAGGTCATCCCCGCAGTCCGTCGTGA
AGGAGTTGCCATGAACACGC

Product: serine/threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MNSLPLPSFDDVAAAAARIAGHAHRTPVMTSRTVDDALGAQVFFKCENLQRMGAFKFRGAFNALSRFDAEQRRRGVVAFS
SGNHAQAIALSARMLGIPATIVMPQDAPAAKIAATRGYGGTVVTYDRYTEDREQIGRELAERDGLTLIPPYDHPDVIAGQ
GTAAMELFDEVGPLDAVFTPLGGGGLLSGTALATRALSPNARLYGVEPEAGNDGQQSFRSGAIVHIDTPRTIADGAQTQH
LGNITFPIIRRDVDDILTATDDELVDCMRLFAARMKIVVEPTGCLSFAGARRMKDELKGKRVGIVISGGNVDLDAFSALL
ASRPQS

Sequences:

>Translated_326_residues
MNSLPLPSFDDVAAAAARIAGHAHRTPVMTSRTVDDALGAQVFFKCENLQRMGAFKFRGAFNALSRFDAEQRRRGVVAFS
SGNHAQAIALSARMLGIPATIVMPQDAPAAKIAATRGYGGTVVTYDRYTEDREQIGRELAERDGLTLIPPYDHPDVIAGQ
GTAAMELFDEVGPLDAVFTPLGGGGLLSGTALATRALSPNARLYGVEPEAGNDGQQSFRSGAIVHIDTPRTIADGAQTQH
LGNITFPIIRRDVDDILTATDDELVDCMRLFAARMKIVVEPTGCLSFAGARRMKDELKGKRVGIVISGGNVDLDAFSALL
ASRPQS
>Mature_326_residues
MNSLPLPSFDDVAAAAARIAGHAHRTPVMTSRTVDDALGAQVFFKCENLQRMGAFKFRGAFNALSRFDAEQRRRGVVAFS
SGNHAQAIALSARMLGIPATIVMPQDAPAAKIAATRGYGGTVVTYDRYTEDREQIGRELAERDGLTLIPPYDHPDVIAGQ
GTAAMELFDEVGPLDAVFTPLGGGGLLSGTALATRALSPNARLYGVEPEAGNDGQQSFRSGAIVHIDTPRTIADGAQTQH
LGNITFPIIRRDVDDILTATDDELVDCMRLFAARMKIVVEPTGCLSFAGARRMKDELKGKRVGIVISGGNVDLDAFSALL
ASRPQS

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=328, Percent_Identity=40.5487804878049, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI19923959, Length=145, Percent_Identity=36.551724137931, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI33469958, Length=144, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1789505, Length=319, Percent_Identity=38.5579937304075, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1790207, Length=295, Percent_Identity=34.9152542372881, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17508781, Length=311, Percent_Identity=35.048231511254, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71991565, Length=306, Percent_Identity=34.3137254901961, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17537387, Length=305, Percent_Identity=32.4590163934426, Blast_Score=137, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322631, Length=318, Percent_Identity=66.6666666666667, Blast_Score=433, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6320930, Length=301, Percent_Identity=35.2159468438538, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319788, Length=263, Percent_Identity=24.7148288973384, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355833, Length=314, Percent_Identity=35.3503184713376, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24645328, Length=219, Percent_Identity=31.0502283105023, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 34740; Mature: 34740

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSLPLPSFDDVAAAAARIAGHAHRTPVMTSRTVDDALGAQVFFKCENLQRMGAFKFRGA
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCEEEEEEHHHHHHCCHHHHHH
FNALSRFDAEQRRRGVVAFSSGNHAQAIALSARMLGIPATIVMPQDAPAAKIAATRGYGG
HHHHHHCCHHHHHCCEEEECCCCCCEEEEEHHHHCCCCEEEEECCCCCCHHEEEECCCCC
TVVTYDRYTEDREQIGRELAERDGLTLIPPYDHPDVIAGQGTAAMELFDEVGPLDAVFTP
EEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCCCEECCCHHHHHHHHHHCCCHHHHCC
LGGGGLLSGTALATRALSPNARLYGVEPEAGNDGQQSFRSGAIVHIDTPRTIADGAQTQH
CCCCCCCCCHHHHHHCCCCCCEEEEECCCCCCCHHHHHHCCCEEEECCCCHHHCCCCHHH
LGNITFPIIRRDVDDILTATDDELVDCMRLFAARMKIVVEPTGCLSFAGARRMKDELKGK
CCCCCHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHCCC
RVGIVISGGNVDLDAFSALLASRPQS
EEEEEEECCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MNSLPLPSFDDVAAAAARIAGHAHRTPVMTSRTVDDALGAQVFFKCENLQRMGAFKFRGA
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCEEEEEEHHHHHHCCHHHHHH
FNALSRFDAEQRRRGVVAFSSGNHAQAIALSARMLGIPATIVMPQDAPAAKIAATRGYGG
HHHHHHCCHHHHHCCEEEECCCCCCEEEEEHHHHCCCCEEEEECCCCCCHHEEEECCCCC
TVVTYDRYTEDREQIGRELAERDGLTLIPPYDHPDVIAGQGTAAMELFDEVGPLDAVFTP
EEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCCCEECCCHHHHHHHHHHCCCHHHHCC
LGGGGLLSGTALATRALSPNARLYGVEPEAGNDGQQSFRSGAIVHIDTPRTIADGAQTQH
CCCCCCCCCHHHHHHCCCCCCEEEEECCCCCCCHHHHHHCCCEEEECCCCHHHCCCCHHH
LGNITFPIIRRDVDDILTATDDELVDCMRLFAARMKIVVEPTGCLSFAGARRMKDELKGK
CCCCCHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHCCC
RVGIVISGGNVDLDAFSALLASRPQS
EEEEEEECCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]