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The map label for this gene is ftsI [H]

Identifier: 189353013

GI number: 189353013

Start: 1176710

End: 1179268

Strand: Direct

Name: ftsI [H]

Synonym: BMULJ_04247

Alternate gene names: 189353013

Gene position: 1176710-1179268 (Clockwise)

Preceding gene: 189353012

Following gene: 189353014

Centisome position: 47.58

GC content: 70.77

Gene sequence:

>2559_bases
GTGCGCGACCTTCTTGCCCAATGGGTTGCGCGCGCGCAACCGGCCGCGGCCGCCGCCGCCGTGCCCGTCAAGCGTATGCT
GGCCACCGGCTGGCACCATCTCCGTCATCCGACGCGCCGCGGCGTGCTGCTTGCGGCCGCCGCCGTGCCCGCACTATTCG
CGTTGTACGTGCTCGCGCTCGTGCCGTTCACGCCCGGCATCGGCGACATCCGCAAGGCGCGCGTCGATCAGCCGGCGCGC
GTGCTGTCGGCGGACGGCAAGCTGCTCGCCGAGTTCAAGCCGTCGAACCGCGAATGGGTGCCGCTCGCGCAGATCTCGCC
GCACGTGGTGGATGCGCTGATCGCGACCGAGGATCACCGGTTCTACCAGCATCACGGCCTCGACTGGCGGCGCACCGCGT
CGGCCGCACTCCACACGTTCTCCGGCGACCGGCAGGGCGGCTCGACGATCACGCAGCAGCTCGCGCGCAATCTGTATCCG
GACGAGATCGGACGCGCGCCGACGCTCACGCGCAAGCTGAAGGAGGCGATCACCGCGCTGAAGATCGAGGCCGTGTACAG
CAAGGACCAGATCCTCGAGACCTACCTGAACACGGTGCCGTTCCTCTACAACGCGTACGGCGTCGAGATGGCCGCGCGCA
CCTACTTCGACAAGTCGGCCGACGAGCTCGACGTGCTCGACAGTGCGACGCTCGTCGGCATGCTGAAAGGCAACAGCTAC
TACAACCCGGTGCTGAACCCCGAACGCGCGCTGCAGCGGCGCAATACGGTGCTCGGCCAGATGGTGAAGTACGGGAAGCT
GACGCCCGCGCAGTTCGCGCAACTGCAGCGCCGGCCGCTGCGGATCGACTTCGAGCGGCAGAAGGAGCCGCCGGGGCCGG
CGCCGCACTTTGCGCAGCAGCTGCGCAAATGGCTGATCGCGTGGGCCGACCGCAACGACTACAACATCTATTCGGACGGG
CTGATCGTTCGCACGACGATCGACGCGCGGCTGCAGCAGATGGCGACGCAGGCGCTGATCCTGCAGACGAACGAACTGCA
GCGCATCGCAAACAACGCCTGGAGCGGCCGCGACGGCTGCGGGACCGACAACGAAGTGTTCCGCGCCTTCATGCGCGAAT
CGCCCGAATACAAGGCCGCGCAGGATGCCGGCAAGGACGACGCGGCCGCGATGAAGGCGCTCGCCGCGGATCGCGGCTTC
ATGCGTGCGCTGTGCAAGGCGAAGACCGACGTGCAGGCCGGCTTCGTCGCGATCGATCCGCGCGACGGGCAGATCCGCGC
GTGGGTCGGCAGCCGCGACTTCGCGAGCGAGCCGTTCGACCATGTCGCGCAGGCGCGGCGCCAGCCGGGCTCGACGTTCA
AGGCGTTCGTGTACGGCGCTGCGTTCGAGCGCGGCATGAAGCCCGACGACACCTTCGTCGACCAGCCGGTGGAGATCCCG
CTGAAAGGCGGCGAGGTATGGCGGCCGAACGACGACGTGCCGCCGACCGGCAAGCCGATGACGCTGCGCGATGCGCTCGC
GCTGTCGCGCAACCGGATCACGGCGCAGGTGATGGAGAAGGTCGGCCCCGCGGCGGTCGCGCGGCTCGCGCGCGACATGG
GCGTGCGCGAGAGTCCGCTCGAGCGCGTGCCGTCGCTCGCGCTCGGGACGAGCCCCGTGACGCTGAAGGAGATGGTCGCG
TCGTACGCGACGATCGCGAACGACGGGTTGTACGTCGAGCCGCACATGGTGACGCGGATCGAGAACCGCAACGGCGACGT
GCTGGCCGAGTTTGCGCCGGCGCCGCCGGAACGCGCGCTCGACGCGGAAGCCGACAAGACGCTGCTCGACACGATGCGCA
ACGTCGTCACGCGCGGCACCGGCGCGAGCATCCGCACGCGCTTCGGCGTGCGCGGCGACGTGGCCGGCAAGACCGGTACG
ACGCAGGACAACGCGGACGGCTGGTTCATCCTGATGCAGCCCGCGCTCGTCGCCGGCGCGTGGGTCGGCTTCGACGACGG
CCGCGTGACGCTGCGCAGCGACTACTGGGGGCAGGGCGCGCACAGCGCGCTGCCGATCGTCGGCGATTTCTTCCAGCGTG
CGCAACGCGCGCGGCTGATCGATCCGAAGGCGACCTTCGATACGGAGCCGTCGCCGGGCTGGTTCGCGTCGGTGCGCGAG
CGCGTGACGGACCTCTTCGACACGTGGTTCAGGCCCGAGCCGAACAAGGTCGCCGTACCGGTCAAGGTCCAGCGGACGCC
GCGCAAGCCCGAGCCGGCCGAGAGCGGTACGGCGTCGAGCGAAGCGGCTGCGTCGGCCGCCGCTGCCGCGTCGGACGGCA
TCGTCGAGGAATGGGTGCCGGCGTCCGAAGTGGCGGCGTCCGCTGCCGCGCTGTCGGGTGCAGGTTCTCAGCCTCAGGCG
CAGCCGCAGCCGCCGGCTCAGCCGCCTGCGGCGCCCGCGCCGGGCGTCACGATGCCGGGCGGCGCGGGCAGCGGCAGCGC
GGCGTCGCCGGTCGCGCCTGCGGCGCCGCTGCAGCCGTCGACGCCCGGTGCGCCGGACGCCGGCGACGGCGCACAGTAA

Upstream 100 bases:

>100_bases
CCGGGCGTGCGCCGCGCGGCGGGGCGTCGCGCGAGTTTTGGTACGATGCTGCCTTTCCAGCAGATCCCCGACCCGCGTGA
ATCGCCGAAACGAGTCGTCC

Downstream 100 bases:

>100_bases
GGGCGGTCACGCCAGTCGGGCGGCCGGTGCGTCGAGCCGGTCGCTTCGCAGATTCATATCGTCTACGACGATAATCGTCA
GAAGATTCGACTGCGCGATC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 852; Mature: 852

Protein sequence:

>852_residues
MRDLLAQWVARAQPAAAAAAVPVKRMLATGWHHLRHPTRRGVLLAAAAVPALFALYVLALVPFTPGIGDIRKARVDQPAR
VLSADGKLLAEFKPSNREWVPLAQISPHVVDALIATEDHRFYQHHGLDWRRTASAALHTFSGDRQGGSTITQQLARNLYP
DEIGRAPTLTRKLKEAITALKIEAVYSKDQILETYLNTVPFLYNAYGVEMAARTYFDKSADELDVLDSATLVGMLKGNSY
YNPVLNPERALQRRNTVLGQMVKYGKLTPAQFAQLQRRPLRIDFERQKEPPGPAPHFAQQLRKWLIAWADRNDYNIYSDG
LIVRTTIDARLQQMATQALILQTNELQRIANNAWSGRDGCGTDNEVFRAFMRESPEYKAAQDAGKDDAAAMKALAADRGF
MRALCKAKTDVQAGFVAIDPRDGQIRAWVGSRDFASEPFDHVAQARRQPGSTFKAFVYGAAFERGMKPDDTFVDQPVEIP
LKGGEVWRPNDDVPPTGKPMTLRDALALSRNRITAQVMEKVGPAAVARLARDMGVRESPLERVPSLALGTSPVTLKEMVA
SYATIANDGLYVEPHMVTRIENRNGDVLAEFAPAPPERALDAEADKTLLDTMRNVVTRGTGASIRTRFGVRGDVAGKTGT
TQDNADGWFILMQPALVAGAWVGFDDGRVTLRSDYWGQGAHSALPIVGDFFQRAQRARLIDPKATFDTEPSPGWFASVRE
RVTDLFDTWFRPEPNKVAVPVKVQRTPRKPEPAESGTASSEAAASAAAAASDGIVEEWVPASEVAASAAALSGAGSQPQA
QPQPPAQPPAAPAPGVTMPGGAGSGSAASPVAPAAPLQPSTPGAPDAGDGAQ

Sequences:

>Translated_852_residues
MRDLLAQWVARAQPAAAAAAVPVKRMLATGWHHLRHPTRRGVLLAAAAVPALFALYVLALVPFTPGIGDIRKARVDQPAR
VLSADGKLLAEFKPSNREWVPLAQISPHVVDALIATEDHRFYQHHGLDWRRTASAALHTFSGDRQGGSTITQQLARNLYP
DEIGRAPTLTRKLKEAITALKIEAVYSKDQILETYLNTVPFLYNAYGVEMAARTYFDKSADELDVLDSATLVGMLKGNSY
YNPVLNPERALQRRNTVLGQMVKYGKLTPAQFAQLQRRPLRIDFERQKEPPGPAPHFAQQLRKWLIAWADRNDYNIYSDG
LIVRTTIDARLQQMATQALILQTNELQRIANNAWSGRDGCGTDNEVFRAFMRESPEYKAAQDAGKDDAAAMKALAADRGF
MRALCKAKTDVQAGFVAIDPRDGQIRAWVGSRDFASEPFDHVAQARRQPGSTFKAFVYGAAFERGMKPDDTFVDQPVEIP
LKGGEVWRPNDDVPPTGKPMTLRDALALSRNRITAQVMEKVGPAAVARLARDMGVRESPLERVPSLALGTSPVTLKEMVA
SYATIANDGLYVEPHMVTRIENRNGDVLAEFAPAPPERALDAEADKTLLDTMRNVVTRGTGASIRTRFGVRGDVAGKTGT
TQDNADGWFILMQPALVAGAWVGFDDGRVTLRSDYWGQGAHSALPIVGDFFQRAQRARLIDPKATFDTEPSPGWFASVRE
RVTDLFDTWFRPEPNKVAVPVKVQRTPRKPEPAESGTASSEAAASAAAAASDGIVEEWVPASEVAASAAALSGAGSQPQA
QPQPPAQPPAAPAPGVTMPGGAGSGSAASPVAPAAPLQPSTPGAPDAGDGAQ
>Mature_852_residues
MRDLLAQWVARAQPAAAAAAVPVKRMLATGWHHLRHPTRRGVLLAAAAVPALFALYVLALVPFTPGIGDIRKARVDQPAR
VLSADGKLLAEFKPSNREWVPLAQISPHVVDALIATEDHRFYQHHGLDWRRTASAALHTFSGDRQGGSTITQQLARNLYP
DEIGRAPTLTRKLKEAITALKIEAVYSKDQILETYLNTVPFLYNAYGVEMAARTYFDKSADELDVLDSATLVGMLKGNSY
YNPVLNPERALQRRNTVLGQMVKYGKLTPAQFAQLQRRPLRIDFERQKEPPGPAPHFAQQLRKWLIAWADRNDYNIYSDG
LIVRTTIDARLQQMATQALILQTNELQRIANNAWSGRDGCGTDNEVFRAFMRESPEYKAAQDAGKDDAAAMKALAADRGF
MRALCKAKTDVQAGFVAIDPRDGQIRAWVGSRDFASEPFDHVAQARRQPGSTFKAFVYGAAFERGMKPDDTFVDQPVEIP
LKGGEVWRPNDDVPPTGKPMTLRDALALSRNRITAQVMEKVGPAAVARLARDMGVRESPLERVPSLALGTSPVTLKEMVA
SYATIANDGLYVEPHMVTRIENRNGDVLAEFAPAPPERALDAEADKTLLDTMRNVVTRGTGASIRTRFGVRGDVAGKTGT
TQDNADGWFILMQPALVAGAWVGFDDGRVTLRSDYWGQGAHSALPIVGDFFQRAQRARLIDPKATFDTEPSPGWFASVRE
RVTDLFDTWFRPEPNKVAVPVKVQRTPRKPEPAESGTASSEAAASAAAAASDGIVEEWVPASEVAASAAALSGAGSQPQA
QPQPPAQPPAAPAPGVTMPGGAGSGSAASPVAPAAPLQPSTPGAPDAGDGAQ

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG5009

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=621, Percent_Identity=32.0450885668277, Blast_Score=274, Evalue=2e-74,
Organism=Escherichia coli, GI1786343, Length=601, Percent_Identity=30.2828618968386, Blast_Score=195, Evalue=9e-51,
Organism=Escherichia coli, GI1788867, Length=678, Percent_Identity=26.401179941003, Blast_Score=135, Evalue=2e-32,
Organism=Escherichia coli, GI1789601, Length=234, Percent_Identity=34.1880341880342, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.- [C]

Molecular weight: Translated: 92236; Mature: 92236

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDLLAQWVARAQPAAAAAAVPVKRMLATGWHHLRHPTRRGVLLAAAAVPALFALYVLAL
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHH
VPFTPGIGDIRKARVDQPARVLSADGKLLAEFKPSNREWVPLAQISPHVVDALIATEDHR
HCCCCCCCHHHHHHCCCCHHHHHCCCCEEEEECCCCCCEEEHHHCCHHHHHHHHHCCCHH
FYQHHGLDWRRTASAALHTFSGDRQGGSTITQQLARNLYPDEIGRAPTLTRKLKEAITAL
HHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHH
KIEAVYSKDQILETYLNTVPFLYNAYGVEMAARTYFDKSADELDVLDSATLVGMLKGNSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEECCCCC
YNPVLNPERALQRRNTVLGQMVKYGKLTPAQFAQLQRRPLRIDFERQKEPPGPAPHFAQQ
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEHHHCCCCCCCCHHHHHH
LRKWLIAWADRNDYNIYSDGLIVRTTIDARLQQMATQALILQTNELQRIANNAWSGRDGC
HHHHHHHHCCCCCCEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GTDNEVFRAFMRESPEYKAAQDAGKDDAAAMKALAADRGFMRALCKAKTDVQAGFVAIDP
CCCHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECC
RDGQIRAWVGSRDFASEPFDHVAQARRQPGSTFKAFVYGAAFERGMKPDDTFVDQPVEIP
CCCEEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
LKGGEVWRPNDDVPPTGKPMTLRDALALSRNRITAQVMEKVGPAAVARLARDMGVRESPL
ECCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHH
ERVPSLALGTSPVTLKEMVASYATIANDGLYVEPHMVTRIENRNGDVLAEFAPAPPERAL
HHCCCHHCCCCCCHHHHHHHHHHHHCCCCEEECCHHEEEEECCCCCEEEECCCCCCHHCC
DAEADKTLLDTMRNVVTRGTGASIRTRFGVRGDVAGKTGTTQDNADGWFILMQPALVAGA
CCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHE
WVGFDDGRVTLRSDYWGQGAHSALPIVGDFFQRAQRARLIDPKATFDTEPSPGWFASVRE
EEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
RVTDLFDTWFRPEPNKVAVPVKVQRTPRKPEPAESGTASSEAAASAAAAASDGIVEEWVP
HHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCC
ASEVAASAAALSGAGSQPQAQPQPPAQPPAAPAPGVTMPGGAGSGSAASPVAPAAPLQPS
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TPGAPDAGDGAQ
CCCCCCCCCCCC
>Mature Secondary Structure
MRDLLAQWVARAQPAAAAAAVPVKRMLATGWHHLRHPTRRGVLLAAAAVPALFALYVLAL
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHH
VPFTPGIGDIRKARVDQPARVLSADGKLLAEFKPSNREWVPLAQISPHVVDALIATEDHR
HCCCCCCCHHHHHHCCCCHHHHHCCCCEEEEECCCCCCEEEHHHCCHHHHHHHHHCCCHH
FYQHHGLDWRRTASAALHTFSGDRQGGSTITQQLARNLYPDEIGRAPTLTRKLKEAITAL
HHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHH
KIEAVYSKDQILETYLNTVPFLYNAYGVEMAARTYFDKSADELDVLDSATLVGMLKGNSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEECCCCC
YNPVLNPERALQRRNTVLGQMVKYGKLTPAQFAQLQRRPLRIDFERQKEPPGPAPHFAQQ
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEHHHCCCCCCCCHHHHHH
LRKWLIAWADRNDYNIYSDGLIVRTTIDARLQQMATQALILQTNELQRIANNAWSGRDGC
HHHHHHHHCCCCCCEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GTDNEVFRAFMRESPEYKAAQDAGKDDAAAMKALAADRGFMRALCKAKTDVQAGFVAIDP
CCCHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECC
RDGQIRAWVGSRDFASEPFDHVAQARRQPGSTFKAFVYGAAFERGMKPDDTFVDQPVEIP
CCCEEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
LKGGEVWRPNDDVPPTGKPMTLRDALALSRNRITAQVMEKVGPAAVARLARDMGVRESPL
ECCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHH
ERVPSLALGTSPVTLKEMVASYATIANDGLYVEPHMVTRIENRNGDVLAEFAPAPPERAL
HHCCCHHCCCCCCHHHHHHHHHHHHCCCCEEECCHHEEEEECCCCCEEEECCCCCCHHCC
DAEADKTLLDTMRNVVTRGTGASIRTRFGVRGDVAGKTGTTQDNADGWFILMQPALVAGA
CCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHE
WVGFDDGRVTLRSDYWGQGAHSALPIVGDFFQRAQRARLIDPKATFDTEPSPGWFASVRE
EEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
RVTDLFDTWFRPEPNKVAVPVKVQRTPRKPEPAESGTASSEAAASAAAAASDGIVEEWVP
HHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCC
ASEVAASAAALSGAGSQPQAQPQPPAQPPAAPAPGVTMPGGAGSGSAASPVAPAAPLQPS
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TPGAPDAGDGAQ
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]