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The map label for this gene is fabG [H]

Identifier: 189352953

GI number: 189352953

Start: 1108695

End: 1109489

Strand: Reverse

Name: fabG [H]

Synonym: BMULJ_04187

Alternate gene names: 189352953

Gene position: 1109489-1108695 (Counterclockwise)

Preceding gene: 189352955

Following gene: 189352948

Centisome position: 44.86

GC content: 68.05

Gene sequence:

>795_bases
ATGCACATCGATCTGAAAGGCAAGACCGCGGTCGTCACAGCTTCGACCGCCGGCATCGGACTCGCCGTCGCCGAAGGACT
CGCGCGCGCAGGCGCACGCGTCGTCGTCAACGGACGCAGCGACGCGTCGGTCCAATCGGCGATCGCCCACCTGCGCACGG
CCGCGCCCGGTGCGGATATCGACGGCGTCGCCGCCGACCTGTCCGGCGCCGCCGGCGCCGCGCGCATCGCGCAGCACACG
CCGAACGCCGACATCCTCGTCAACAACGCGGGCATCTACGGGCTGAAGCCGTTCTTCGACATCGACGATGCCGAATGGAC
GCACTACTTCGAGATGAACGTGATGTCGGGCGTGCGGCTCGCGCGGCACTATCTGAAAGGGATGCTCGAACGCGACTGGG
GCCGCGTCGTGTTCGTGTCGTCGGAGTCGGGACTGAACATTCCCGTCGACATGATTCATTACGGCTTCTCGAAGACGGCC
CAGCTGTCGATCGCGCGCGGTCTCGCGAAGCTCGCGGCCGGCACGCGCGTGACCGTCAATTCGGTGCTGCCGGGGCCGAC
GCTGTCGGAAGGCGTGCGCACGATGCTACAGGACACGGCCGACCAGACCGGCCGCAGCGTCGACGACGTCGCGGTGGACT
TCGTCCGCGAGCATCGCGCGAGTTCGATCATTCAGCGGCCAGCGACGCCCGAGGAGGTCGCGAACATGGTCGTCTACGTC
TGTTCGCCGCAGGCATCGGCGACGACGGGCGCGGCGCTGCGCGTCGACGGCGGCGTCGTCGATACGATCGCGTAG

Upstream 100 bases:

>100_bases
CATCGCTTCGCTGCCGGCGCGCGCGGTTTCGCCTAAGCTTGGAACTCCGGCCGCTGCGGCATGCGCCGGCGGCTCCGTTC
CCTCTTCTTCCGGTACGCTC

Downstream 100 bases:

>100_bases
CGCGCCGACGGCTGCCGCGCTACGCGCCGCCGTTGCGCGCCTGCAGTCGGCCGCTGCGGTCGGCGTTCATGCAGGTGTCG
AAACCGTGGTGCGTGACCGC

Product: 3-oxoacyl-[acyl-carrier protein] reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MHIDLKGKTAVVTASTAGIGLAVAEGLARAGARVVVNGRSDASVQSAIAHLRTAAPGADIDGVAADLSGAAGAARIAQHT
PNADILVNNAGIYGLKPFFDIDDAEWTHYFEMNVMSGVRLARHYLKGMLERDWGRVVFVSSESGLNIPVDMIHYGFSKTA
QLSIARGLAKLAAGTRVTVNSVLPGPTLSEGVRTMLQDTADQTGRSVDDVAVDFVREHRASSIIQRPATPEEVANMVVYV
CSPQASATTGAALRVDGGVVDTIA

Sequences:

>Translated_264_residues
MHIDLKGKTAVVTASTAGIGLAVAEGLARAGARVVVNGRSDASVQSAIAHLRTAAPGADIDGVAADLSGAAGAARIAQHT
PNADILVNNAGIYGLKPFFDIDDAEWTHYFEMNVMSGVRLARHYLKGMLERDWGRVVFVSSESGLNIPVDMIHYGFSKTA
QLSIARGLAKLAAGTRVTVNSVLPGPTLSEGVRTMLQDTADQTGRSVDDVAVDFVREHRASSIIQRPATPEEVANMVVYV
CSPQASATTGAALRVDGGVVDTIA
>Mature_264_residues
MHIDLKGKTAVVTASTAGIGLAVAEGLARAGARVVVNGRSDASVQSAIAHLRTAAPGADIDGVAADLSGAAGAARIAQHT
PNADILVNNAGIYGLKPFFDIDDAEWTHYFEMNVMSGVRLARHYLKGMLERDWGRVVFVSSESGLNIPVDMIHYGFSKTA
QLSIARGLAKLAAGTRVTVNSVLPGPTLSEGVRTMLQDTADQTGRSVDDVAVDFVREHRASSIIQRPATPEEVANMVVYV
CSPQASATTGAALRVDGGVVDTIA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=262, Percent_Identity=30.5343511450382, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI5031737, Length=264, Percent_Identity=31.4393939393939, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI33667109, Length=245, Percent_Identity=33.0612244897959, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI7705925, Length=264, Percent_Identity=26.5151515151515, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI19923817, Length=261, Percent_Identity=24.1379310344828, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI126723191, Length=186, Percent_Identity=32.258064516129, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI66933014, Length=259, Percent_Identity=25.8687258687259, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI10190746, Length=216, Percent_Identity=30.5555555555556, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=265, Percent_Identity=28.6792452830189, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787905, Length=265, Percent_Identity=29.4339622641509, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI87082100, Length=264, Percent_Identity=28.7878787878788, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790717, Length=265, Percent_Identity=26.0377358490566, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786812, Length=258, Percent_Identity=28.6821705426357, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788459, Length=258, Percent_Identity=26.7441860465116, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI2367365, Length=258, Percent_Identity=29.8449612403101, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082160, Length=273, Percent_Identity=23.4432234432234, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789208, Length=273, Percent_Identity=25.2747252747253, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI2367175, Length=258, Percent_Identity=30.6201550387597, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=263, Percent_Identity=28.1368821292776, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17560676, Length=263, Percent_Identity=29.277566539924, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=256, Percent_Identity=30.859375, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=30.5660377358491, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=29.0566037735849, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=258, Percent_Identity=28.6821705426357, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=28.7878787878788, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=28.4090909090909, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=261, Percent_Identity=27.9693486590038, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=187, Percent_Identity=28.8770053475936, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=222, Percent_Identity=26.5765765765766, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=26.2357414448669, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=192, Percent_Identity=23.9583333333333, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21355319, Length=260, Percent_Identity=29.6153846153846, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI23397609, Length=260, Percent_Identity=31.9230769230769, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357041, Length=259, Percent_Identity=30.5019305019305, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639444, Length=270, Percent_Identity=28.8888888888889, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24644337, Length=261, Percent_Identity=31.0344827586207, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28571526, Length=259, Percent_Identity=28.957528957529, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24643142, Length=258, Percent_Identity=26.7441860465116, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644339, Length=265, Percent_Identity=27.1698113207547, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27564; Mature: 27564

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIDLKGKTAVVTASTAGIGLAVAEGLARAGARVVVNGRSDASVQSAIAHLRTAAPGADI
CEEECCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCC
DGVAADLSGAAGAARIAQHTPNADILVNNAGIYGLKPFFDIDDAEWTHYFEMNVMSGVRL
CCHHHCCCCCCHHHHHHHCCCCCCEEEECCCEEECCCCCCCCCCCEEEEEEHHHHHHHHH
ARHYLKGMLERDWGRVVFVSSESGLNIPVDMIHYGFSKTAQLSIARGLAKLAAGTRVTVN
HHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEE
SVLPGPTLSEGVRTMLQDTADQTGRSVDDVAVDFVREHRASSIIQRPATPEEVANMVVYV
CCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCEEEEE
CSPQASATTGAALRVDGGVVDTIA
ECCCCCCCCCCEEEECCCEEECCC
>Mature Secondary Structure
MHIDLKGKTAVVTASTAGIGLAVAEGLARAGARVVVNGRSDASVQSAIAHLRTAAPGADI
CEEECCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCC
DGVAADLSGAAGAARIAQHTPNADILVNNAGIYGLKPFFDIDDAEWTHYFEMNVMSGVRL
CCHHHCCCCCCHHHHHHHCCCCCCEEEECCCEEECCCCCCCCCCCEEEEEEHHHHHHHHH
ARHYLKGMLERDWGRVVFVSSESGLNIPVDMIHYGFSKTAQLSIARGLAKLAAGTRVTVN
HHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEE
SVLPGPTLSEGVRTMLQDTADQTGRSVDDVAVDFVREHRASSIIQRPATPEEVANMVVYV
CCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCEEEEE
CSPQASATTGAALRVDGGVVDTIA
ECCCCCCCCCCEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]