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The map label for this gene is pcaK [H]

Identifier: 189352837

GI number: 189352837

Start: 960015

End: 961376

Strand: Direct

Name: pcaK [H]

Synonym: BMULJ_04071

Alternate gene names: 189352837

Gene position: 960015-961376 (Clockwise)

Preceding gene: 189352836

Following gene: 189352839

Centisome position: 38.82

GC content: 71.22

Gene sequence:

>1362_bases
ATGAATACCACGCTGTCCGTCGACGTCAGCGAATGGATCGACCGGCGTCGCGTATCGCCGTTTCAGATCGCGATCGTCGT
GCTGTGCTTTCTCATCGTCGCGATCGACGGGTTCGACACCGCGTCGATCGGATTCGTCGCGCCCGTGATTCGGGCGGAAT
GGCAACTGTCGCCCGCGCAGCTGGCGCCGGTGTTCGGCGCGGGGCTCGCCGGGCTGATGGCCGGCGCGCTGGCGTTCGGG
CCGTTCGGCGACCGGTTCGGGCGCAAGCGGCTGCTGCTCGCCTGCGTCGCATGCTTCGGCGTCGCGAGCGCCGCGTCGGC
GAGTGCGGGCGGTGTCACGGAACTGATCGCGTGGCGCTTCGTGACGGGGCTCGGGCTTGGCGGTGCAATGCCGAATGCGA
TCACGCTGACGTCCGAATACTGTCCGGCGCGACGCCGCTCGCTGCTCGTGACGACGATGTTCTGCGGCTTCACGATCGGC
TCGGCGCTCGGCGGGCTCGTCGCCGCATCGCTGATCGAACGCGACGGCTGGCGCGCGGTGCTCGTCGTCGGCGGTGTCGC
GCCGCTGCTGTTGCTGCCGGTGCTCGCATGGCGGCTGCCGGAATCGGTGCGCTATCTGGTGAACAGCGGCGCGGCGCGCG
AGCGGATCGCCGCGCTGCTGAGCCGCATCGCGCCGGATCCGCATCTCGCGCGCGCGTCGTTCGTCGCGCCGCGCGGCAAG
CCGGCGGCGTCGCCGCTCGGCCGGCTGTTCGGGCCGGATCTGCTGCGCGGTACGCTACTGCTGTGGCTCGCGTTCTTCAT
GAGTCTGCTCGTGATCTACCTGCTGTCGAGCTGGCTGCCGACGCTGCTGCGCACGACCGGCGCGACGCTGCAGACCGCCG
CGCGCGTGACCGCGATGTTTCAGATCGGCGGTACGCTCGGTGCGATCGTGCTCGGCTGGCTGATGGACCGCTTCGATCCG
CATCGCGTGCTCGCCTGCAGCTACGTGGCGGCCGGCGTATTCGTCGCGGCGATCGGCCTGTGTGCCGCGTCGCCGGCCGG
CGCGGCGCTGGCGGTGTTCGCGGCCGGTTTCTGCGTGTCCGGCTCGCAGGTGGGGGCGAATGCGCTGTCCGCGGCGTTCT
ATCCGACCGACTGCCGGACGACCGGCGTCAGCTGGGCCAACGGGATCGGGCGCGGCGGGTCGGTGGTCGGCTCGATGGCG
GGCGGCGCGATGCTCGCGGCGGGGTTGTCGTTGCCGACGGCGTTTGCCTTGGTCGCGATGCCGTGTGTAGTTGCCGGGCT
TGCTGTCCTCGTACTCGGCGCGGTGCGCGGCGGCGCGCCGAGCGAGGCCGGCGCGGAAGCGATCGCGGGTGAGAACGTGT
GA

Upstream 100 bases:

>100_bases
ATGGATGGCGCGCCGAGGACTGCCTGAAGCCGGTCGCGTAACGCGCACGACGCCCCCGCGCGCCGGCCGAGCCGCGCGCG
TTCCTGGAGGAGACATCATC

Downstream 100 bases:

>100_bases
CCGGCGCGGGGCGATTGCGAGATGGGAATGACGCGGCGGGACGTTTCGGCAGCGGTCGATGCCGGCGTCCCGCGTTATAT
CGGCGTCATGGCGCAGGGCG

Product: 4-hydroxybenzoate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MNTTLSVDVSEWIDRRRVSPFQIAIVVLCFLIVAIDGFDTASIGFVAPVIRAEWQLSPAQLAPVFGAGLAGLMAGALAFG
PFGDRFGRKRLLLACVACFGVASAASASAGGVTELIAWRFVTGLGLGGAMPNAITLTSEYCPARRRSLLVTTMFCGFTIG
SALGGLVAASLIERDGWRAVLVVGGVAPLLLLPVLAWRLPESVRYLVNSGAARERIAALLSRIAPDPHLARASFVAPRGK
PAASPLGRLFGPDLLRGTLLLWLAFFMSLLVIYLLSSWLPTLLRTTGATLQTAARVTAMFQIGGTLGAIVLGWLMDRFDP
HRVLACSYVAAGVFVAAIGLCAASPAGAALAVFAAGFCVSGSQVGANALSAAFYPTDCRTTGVSWANGIGRGGSVVGSMA
GGAMLAAGLSLPTAFALVAMPCVVAGLAVLVLGAVRGGAPSEAGAEAIAGENV

Sequences:

>Translated_453_residues
MNTTLSVDVSEWIDRRRVSPFQIAIVVLCFLIVAIDGFDTASIGFVAPVIRAEWQLSPAQLAPVFGAGLAGLMAGALAFG
PFGDRFGRKRLLLACVACFGVASAASASAGGVTELIAWRFVTGLGLGGAMPNAITLTSEYCPARRRSLLVTTMFCGFTIG
SALGGLVAASLIERDGWRAVLVVGGVAPLLLLPVLAWRLPESVRYLVNSGAARERIAALLSRIAPDPHLARASFVAPRGK
PAASPLGRLFGPDLLRGTLLLWLAFFMSLLVIYLLSSWLPTLLRTTGATLQTAARVTAMFQIGGTLGAIVLGWLMDRFDP
HRVLACSYVAAGVFVAAIGLCAASPAGAALAVFAAGFCVSGSQVGANALSAAFYPTDCRTTGVSWANGIGRGGSVVGSMA
GGAMLAAGLSLPTAFALVAMPCVVAGLAVLVLGAVRGGAPSEAGAEAIAGENV
>Mature_453_residues
MNTTLSVDVSEWIDRRRVSPFQIAIVVLCFLIVAIDGFDTASIGFVAPVIRAEWQLSPAQLAPVFGAGLAGLMAGALAFG
PFGDRFGRKRLLLACVACFGVASAASASAGGVTELIAWRFVTGLGLGGAMPNAITLTSEYCPARRRSLLVTTMFCGFTIG
SALGGLVAASLIERDGWRAVLVVGGVAPLLLLPVLAWRLPESVRYLVNSGAARERIAALLSRIAPDPHLARASFVAPRGK
PAASPLGRLFGPDLLRGTLLLWLAFFMSLLVIYLLSSWLPTLLRTTGATLQTAARVTAMFQIGGTLGAIVLGWLMDRFDP
HRVLACSYVAAGVFVAAIGLCAASPAGAALAVFAAGFCVSGSQVGANALSAAFYPTDCRTTGVSWANGIGRGGSVVGSMA
GGAMLAAGLSLPTAFALVAMPCVVAGLAVLVLGAVRGGAPSEAGAEAIAGENV

Specific function: Could Be A Transporter For 3-Phenylpropionate (Hydrocinnamic Acid). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=432, Percent_Identity=26.8518518518519, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI166064021, Length=346, Percent_Identity=27.7456647398844, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI213021148, Length=452, Percent_Identity=24.5575221238938, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI8923870, Length=189, Percent_Identity=30.1587301587302, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI296080734, Length=351, Percent_Identity=24.2165242165242, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI296080721, Length=351, Percent_Identity=24.2165242165242, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI87081723, Length=412, Percent_Identity=38.1067961165049, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI87082159, Length=393, Percent_Identity=25.6997455470738, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082231, Length=409, Percent_Identity=24.6943765281174, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788074, Length=355, Percent_Identity=25.6338028169014, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082404, Length=215, Percent_Identity=23.7209302325581, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786229, Length=167, Percent_Identity=30.5389221556886, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788068, Length=344, Percent_Identity=22.6744186046512, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=439, Percent_Identity=24.6013667425968, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922874, Length=399, Percent_Identity=22.8070175438596, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24640198, Length=461, Percent_Identity=20.3904555314534, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640196, Length=461, Percent_Identity=20.3904555314534, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640200, Length=461, Percent_Identity=20.3904555314534, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46320; Mature: 46320

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTLSVDVSEWIDRRRVSPFQIAIVVLCFLIVAIDGFDTASIGFVAPVIRAEWQLSPAQ
CCCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHH
LAPVFGAGLAGLMAGALAFGPFGDRFGRKRLLLACVACFGVASAASASAGGVTELIAWRF
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
VTGLGLGGAMPNAITLTSEYCPARRRSLLVTTMFCGFTIGSALGGLVAASLIERDGWRAV
HHHCCCCCCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LVVGGVAPLLLLPVLAWRLPESVRYLVNSGAARERIAALLSRIAPDPHLARASFVAPRGK
EEECCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCC
PAASPLGRLFGPDLLRGTLLLWLAFFMSLLVIYLLSSWLPTLLRTTGATLQTAARVTAMF
CCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QIGGTLGAIVLGWLMDRFDPHRVLACSYVAAGVFVAAIGLCAASPAGAALAVFAAGFCVS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
GSQVGANALSAAFYPTDCRTTGVSWANGIGRGGSVVGSMAGGAMLAAGLSLPTAFALVAM
CCHHCHHHHHHCCCCCCCCCCCCCHHCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHH
PCVVAGLAVLVLGAVRGGAPSEAGAEAIAGENV
HHHHHHHHHHHHHHHCCCCCCHHCHHHHCCCCC
>Mature Secondary Structure
MNTTLSVDVSEWIDRRRVSPFQIAIVVLCFLIVAIDGFDTASIGFVAPVIRAEWQLSPAQ
CCCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHH
LAPVFGAGLAGLMAGALAFGPFGDRFGRKRLLLACVACFGVASAASASAGGVTELIAWRF
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
VTGLGLGGAMPNAITLTSEYCPARRRSLLVTTMFCGFTIGSALGGLVAASLIERDGWRAV
HHHCCCCCCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LVVGGVAPLLLLPVLAWRLPESVRYLVNSGAARERIAALLSRIAPDPHLARASFVAPRGK
EEECCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCC
PAASPLGRLFGPDLLRGTLLLWLAFFMSLLVIYLLSSWLPTLLRTTGATLQTAARVTAMF
CCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QIGGTLGAIVLGWLMDRFDPHRVLACSYVAAGVFVAAIGLCAASPAGAALAVFAAGFCVS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
GSQVGANALSAAFYPTDCRTTGVSWANGIGRGGSVVGSMAGGAMLAAGLSLPTAFALVAM
CCHHCHHHHHHCCCCCCCCCCCCCHHCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHH
PCVVAGLAVLVLGAVRGGAPSEAGAEAIAGENV
HHHHHHHHHHHHHHHCCCCCCHHCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063101 [H]