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The map label for this gene is ach1 [H]

Identifier: 189352812

GI number: 189352812

Start: 932472

End: 933986

Strand: Direct

Name: ach1 [H]

Synonym: BMULJ_04044

Alternate gene names: 189352812

Gene position: 932472-933986 (Clockwise)

Preceding gene: 189352803

Following gene: 189352814

Centisome position: 37.7

GC content: 66.8

Gene sequence:

>1515_bases
ATGACTTCATCACGCATCCTCGCTCCCGCGCTGCGTTCGCTCGTCCGCACTGCCGACCAGGCCGCCGCGCTGATCCGTCC
CGGCATGACCGTCGCGATGAGCGGCTTCACCGGCTCGGGCTACCCGAAGGCCGTGCCGGCCGCGCTCGCCGCCCATATCG
AGGCCGCCCATGCGCGCGGCGAAGACTTCCGGATCAACGTGCTGACGGGCGCCTCGACCGCACCCGAACTCGACGGCGCG
CTCGCGCGCACGAACGGCATCTCGATGCGGCTGCCGTACCAGTCCGACCCGACGCTACGCGACAAGATCAACGGCGGCGA
AGTCGACTATCAGGACATTCACCTGAGCCACGTCGCGCAGTACGCATGGTTCGGACTGTTCGGCGAGCTGGATGTCGCGA
TCGTCGAAGTCGCCGGCATCCGCGAGGACGGGCTGCTGATTCCGTCGGCGTCGGTCGGCAACAACAAGACGTGGCTCGAG
CAGGCGAAGCACGTGATTCTCGAGGTCAACGCACGTCAGCCGCTCGGCCTCGACGGGATGCACGACATCTATTACGGCAC
CGCATTGCCGCCGAACCGCAAGCCGATCCCGCTGACGAAAAGCGACGACCGCATCGGCGAGCCGTATCTGCGCTGCCCGG
CCGAGAAGATCGTCGCGATCGTCGAGACCGACGCGCCGGACCGCAGCAACGCGTTCTCCGCGCCGGACGACACGTCGAAG
CAGATCGCGACGCGCCTGATCGACTTCCTGCGCCACGAAGTGAAGCGCGGCCGGCTGCCCGCGAATCTGCTGCCGTTGCA
GTCGGGCGTCGGCAACATCACGAACGCGGTGCTCGCCGAACTGAGCTCGGCCGGCTTTTCCGATCTGACCGCGTACACGG
AAGTGATCCAGGACGGCATGCTCGACCTGCTCGCCGACGGCACGCTGCGTTTCGCATCGGCGACCGCGCTGTCGCTGAGC
CCGCCCGCCGTGCAGCGCTTCGCCGACCAGATCGCGATGTTCCGCGAGAAGATCCTGCTGCGCCCGCAGGAGATCAGCAA
CCATCCGGAGCTCGTGCGCCGGCTCGGCTGCATCGCGATGAACGGCATGATCGAGGCCGACATCTACGGCAACGTGAACT
CGACGCACGTGATGGGCACGAAGATCCAGAACGGCATTGGCGGCTCGGGCGACTTCGCGCGCAACGGCTATCTGTCGTGC
TTCATGTCGGCGAGCACCGCGAAGGGCGGCGCGATTTCGCGGATCGTGCCGATGGCAAGCCATGTCGACCATACCGAGCA
CGACGTCGCGGTGGTCGTCACCGAGCAGGGGCTCGCCGACCTGCGTGGGCTCTCGCCGAAGCAGCGCGCACGCAAGATCA
TCGCGACCTGCGCGCATCCGGATTACCGGCCGATGCTCGAGGACTATTTCGAGCGCGCGTCGCACGAGAGCTTCGGCAAG
CACACGCCGCATCTGCTCGCCGAAGCGCTGTCGTGGCACGAGCGCTTCGTGCGTACCGGCACGATGAAGGTCTGA

Upstream 100 bases:

>100_bases
GGTGCCGGCCGCCCAACGCGGCCCCAAGGGCTTCACGTCGCTCAGGAGACACCCCCCCGCGACGTCAACGACAGACCGAA
ACGCGTCAGAAATCCCACTC

Downstream 100 bases:

>100_bases
CCGGAGGTCGGCCGGAAGGCCTGATCGCGCCGCACCGGCGCGCACGCGGCGTTAGTCCATCGCCGCGTGCGCGACGTCGA
CGTCCGCGCCCTTGCGCGGC

Product: acetyl-CoA hydrolase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MTSSRILAPALRSLVRTADQAAALIRPGMTVAMSGFTGSGYPKAVPAALAAHIEAAHARGEDFRINVLTGASTAPELDGA
LARTNGISMRLPYQSDPTLRDKINGGEVDYQDIHLSHVAQYAWFGLFGELDVAIVEVAGIREDGLLIPSASVGNNKTWLE
QAKHVILEVNARQPLGLDGMHDIYYGTALPPNRKPIPLTKSDDRIGEPYLRCPAEKIVAIVETDAPDRSNAFSAPDDTSK
QIATRLIDFLRHEVKRGRLPANLLPLQSGVGNITNAVLAELSSAGFSDLTAYTEVIQDGMLDLLADGTLRFASATALSLS
PPAVQRFADQIAMFREKILLRPQEISNHPELVRRLGCIAMNGMIEADIYGNVNSTHVMGTKIQNGIGGSGDFARNGYLSC
FMSASTAKGGAISRIVPMASHVDHTEHDVAVVVTEQGLADLRGLSPKQRARKIIATCAHPDYRPMLEDYFERASHESFGK
HTPHLLAEALSWHERFVRTGTMKV

Sequences:

>Translated_504_residues
MTSSRILAPALRSLVRTADQAAALIRPGMTVAMSGFTGSGYPKAVPAALAAHIEAAHARGEDFRINVLTGASTAPELDGA
LARTNGISMRLPYQSDPTLRDKINGGEVDYQDIHLSHVAQYAWFGLFGELDVAIVEVAGIREDGLLIPSASVGNNKTWLE
QAKHVILEVNARQPLGLDGMHDIYYGTALPPNRKPIPLTKSDDRIGEPYLRCPAEKIVAIVETDAPDRSNAFSAPDDTSK
QIATRLIDFLRHEVKRGRLPANLLPLQSGVGNITNAVLAELSSAGFSDLTAYTEVIQDGMLDLLADGTLRFASATALSLS
PPAVQRFADQIAMFREKILLRPQEISNHPELVRRLGCIAMNGMIEADIYGNVNSTHVMGTKIQNGIGGSGDFARNGYLSC
FMSASTAKGGAISRIVPMASHVDHTEHDVAVVVTEQGLADLRGLSPKQRARKIIATCAHPDYRPMLEDYFERASHESFGK
HTPHLLAEALSWHERFVRTGTMKV
>Mature_503_residues
TSSRILAPALRSLVRTADQAAALIRPGMTVAMSGFTGSGYPKAVPAALAAHIEAAHARGEDFRINVLTGASTAPELDGAL
ARTNGISMRLPYQSDPTLRDKINGGEVDYQDIHLSHVAQYAWFGLFGELDVAIVEVAGIREDGLLIPSASVGNNKTWLEQ
AKHVILEVNARQPLGLDGMHDIYYGTALPPNRKPIPLTKSDDRIGEPYLRCPAEKIVAIVETDAPDRSNAFSAPDDTSKQ
IATRLIDFLRHEVKRGRLPANLLPLQSGVGNITNAVLAELSSAGFSDLTAYTEVIQDGMLDLLADGTLRFASATALSLSP
PAVQRFADQIAMFREKILLRPQEISNHPELVRRLGCIAMNGMIEADIYGNVNSTHVMGTKIQNGIGGSGDFARNGYLSCF
MSASTAKGGAISRIVPMASHVDHTEHDVAVVVTEQGLADLRGLSPKQRARKIIATCAHPDYRPMLEDYFERASHESFGKH
TPHLLAEALSWHERFVRTGTMKV

Specific function: Forms succinyl-CoA from succinate and acetyl-CoA [H]

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=487, Percent_Identity=45.7905544147844, Blast_Score=430, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17538151, Length=469, Percent_Identity=24.7334754797441, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319456, Length=525, Percent_Identity=44.3809523809524, Blast_Score=414, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702
- InterPro:   IPR006472
- InterPro:   IPR017821 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro; PF04223 CitF [H]

EC number: NA

Molecular weight: Translated: 54554; Mature: 54423

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSRILAPALRSLVRTADQAAALIRPGMTVAMSGFTGSGYPKAVPAALAAHIEAAHARG
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
EDFRINVLTGASTAPELDGALARTNGISMRLPYQSDPTLRDKINGGEVDYQDIHLSHVAQ
CCEEEEEEECCCCCCCCCCHHHHCCCCEEECCCCCCCCHHHCCCCCCCCHHHHHHHHHHH
YAWFGLFGELDVAIVEVAGIREDGLLIPSASVGNNKTWLEQAKHVILEVNARQPLGLDGM
HHHHHHHCCCCEEEEEEECCCCCCEEECCCCCCCCHHHHHHHCEEEEEECCCCCCCCCCC
HDIYYGTALPPNRKPIPLTKSDDRIGEPYLRCPAEKIVAIVETDAPDRSNAFSAPDDTSK
HHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHEEEEEECCCCCCCCCCCCCCCHHH
QIATRLIDFLRHEVKRGRLPANLLPLQSGVGNITNAVLAELSSAGFSDLTAYTEVIQDGM
HHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LDLLADGTLRFASATALSLSPPAVQRFADQIAMFREKILLRPQEISNHPELVRRLGCIAM
HHHHHCCCEEECCEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHH
NGMIEADIYGNVNSTHVMGTKIQNGIGGSGDFARNGYLSCFMSASTAKGGAISRIVPMAS
CCEEEEEEECCCCCCEEECCHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHH
HVDHTEHDVAVVVTEQGLADLRGLSPKQRARKIIATCAHPDYRPMLEDYFERASHESFGK
HCCCCCCCEEEEEECCCHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHCCC
HTPHLLAEALSWHERFVRTGTMKV
CCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TSSRILAPALRSLVRTADQAAALIRPGMTVAMSGFTGSGYPKAVPAALAAHIEAAHARG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
EDFRINVLTGASTAPELDGALARTNGISMRLPYQSDPTLRDKINGGEVDYQDIHLSHVAQ
CCEEEEEEECCCCCCCCCCHHHHCCCCEEECCCCCCCCHHHCCCCCCCCHHHHHHHHHHH
YAWFGLFGELDVAIVEVAGIREDGLLIPSASVGNNKTWLEQAKHVILEVNARQPLGLDGM
HHHHHHHCCCCEEEEEEECCCCCCEEECCCCCCCCHHHHHHHCEEEEEECCCCCCCCCCC
HDIYYGTALPPNRKPIPLTKSDDRIGEPYLRCPAEKIVAIVETDAPDRSNAFSAPDDTSK
HHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHEEEEEECCCCCCCCCCCCCCCHHH
QIATRLIDFLRHEVKRGRLPANLLPLQSGVGNITNAVLAELSSAGFSDLTAYTEVIQDGM
HHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LDLLADGTLRFASATALSLSPPAVQRFADQIAMFREKILLRPQEISNHPELVRRLGCIAM
HHHHHCCCEEECCEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHH
NGMIEADIYGNVNSTHVMGTKIQNGIGGSGDFARNGYLSCFMSASTAKGGAISRIVPMAS
CCEEEEEEECCCCCCEEECCHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHH
HVDHTEHDVAVVVTEQGLADLRGLSPKQRARKIIATCAHPDYRPMLEDYFERASHESFGK
HCCCCCCCEEEEEECCCHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHCCC
HTPHLLAEALSWHERFVRTGTMKV
CCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]