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The map label for this gene is glmS [H]

Identifier: 189352792

GI number: 189352792

Start: 906072

End: 907895

Strand: Reverse

Name: glmS [H]

Synonym: BMULJ_04024

Alternate gene names: 189352792

Gene position: 907895-906072 (Counterclockwise)

Preceding gene: 189352793

Following gene: 189352791

Centisome position: 36.71

GC content: 67.93

Gene sequence:

>1824_bases
ATGTGCGGAATCGTCGGAGCAAGCGGCCTGAACAATCAGGTGCCGCAATTGGTCAATGCCCTCAGCCGGCTCGAGTATCG
CGGCTACGACTCATGCGGGATCGCGGTGCTGCGCGACGGGCGCCTGCGCAGCGAGCGCACGCTGCGGCGCGTCGCCGACC
TGCAGGATCGCGTGCTGACGCTCGGGCTCGAGGCGCAGACCTGTATCGCCCACACGCGCTGGGCGACGCACGGCGCGCCG
TCGGAGAAAAACGCGCATCCGATCGTGTCGCGCGACACGATCGCGGTCGTGCATAACGGCATCATCGAAAACCACGACAC
GCTGCGCGCGGAGCTGCGTCAACGCGGCTACGAATTCCGCGGCGAGACCGATACCGAGGTGATCGCGCATCTCGTGCACA
GCCTCTATCGCGGCGACCTGTTCGACGCGGTGCGGCGCGCGGTCAAGCGGCTGCACGGCGCGTACGCAATCGCCGTACTG
AGCGCGCACGAACCGCAGCGGCTCGTCGCCGCCCGCGCGGGCTCGCCGCTCGTGATCGGCATCGGCGCGACGCAGAACTA
TCTGGCATCGGACTGCGCGGCGCTCGGCGAGCTGACCGACCGCTTCGTCTATCTCGAAGACGGCGACGTCGCGCTGATCA
CGCCGGACCGTATCGACGTCGTCGATGCGCTTGGCGAAGAAGCGCGCCGCCCGCTGTGCGAAGTGCGCGCGCGCGACAGC
GATGCCGCGCTCGGCCCGTACCAGCACTTCATGCAGAAGGAGATCTTCGAGCAGCCGAAGGCGATCGAGAACACGCTCGA
AGGGATCGAGGAAATCTCGCCCGCCCTCTTCGATGCGCACGCGGACACGCGTGCGCTGCTGTCGAAGGTGAAAAGCGTGC
TGCTGCTCGGCTGCGGCACCAGCTATTACGCGGGGCTCACCGCGAAATACTGGCTCGAGTCGATCGCCGGCGTGCCCGCG
CAGGTCGAGATCGCGAGCGAATACCGCTATCGCGACGCGGTCGCCGATCCGCGCACGCTCGTCGTCGGCATTTCGCAGTC
GGGCGAGACGGCCGACACGATCGGCGCGCTCGAACGCGCGCGCACGACGGGCCAGGATCTGTCGATGGCGATCTGCAACG
TCGCGACGAGCACGATCGCGCGCAACTCGCCGCTGCGCTTTTTGACGCGCGCCGGCGCGGAGCTCGGCGTCGCGTCGACG
AAGGCGTTCACGACGCAGCTCGTCGCGCTGTACCTGCTGACGCTCACGCTCGCCCAGATGCGCGGCCGGCTCGATCCGGA
ACAGGCGGCGCAACGACTGCGCGAGCTGCATGCGCTGCCCGCACGCATCGGCCACGCGCTCGCGCTCGAGACGCAAATCA
TGGGCTGGGCCGATAAATTCGCGAAAAGCGAGAACGCGCTGTTCCTCGGGCGCGGGATTCATTACCCGATCGCGATGGAA
GGCGCGCTGAAGCTGAAGGAAGTGTCGTACATCCACGCGGAAGGCTACCCGGCCGGCGAGCTCAAGCATGGCCCGCTCGC
GCTCGTCACGAGCGCGATGCCGGTCGTCACGATCGCGCCGGACGACCGGTTGTTCCAGAAGCTCAAGTCGAACATGGCCG
AGGTGCGCGCGCGCGGCGGGCGGCTGTACGTGCTCGCCGGCGATCAGCTCGAACTCGAGGCCGACCGCGACACGCACCTG
ATCCGCGTGCGCGAATCGGGCGATGCGCTCTCGCCGATCGTCAACGTGATCCCGTTGCAGCTGCTCGCGTATCACGTCGG
CTGCGCGCGCGGCGCGGACGTCGACAAGCCGCGCAACCTCGCGAAATCGGTGACGGTCGAATGA

Upstream 100 bases:

>100_bases
CAATGCATGACACGTCTTCCGCGCGGTGCGACCTGGTCGGGACGCCGTCCCGACGCGCCGCGCAGGCAAGCCGGAACCAT
CTTCTGGACGAGGTGAAAAC

Downstream 100 bases:

>100_bases
CGGCGCCGCGCGTCGCCCCCTCGGCCGGCGCGCGGCCGGGCGCCGGCCGTCGCGCCGCGGCATGGATCGCCGCGTCGATC
GTCTGCAGCGCATGCTGCGT

Product: glucosamine-fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MCGIVGASGLNNQVPQLVNALSRLEYRGYDSCGIAVLRDGRLRSERTLRRVADLQDRVLTLGLEAQTCIAHTRWATHGAP
SEKNAHPIVSRDTIAVVHNGIIENHDTLRAELRQRGYEFRGETDTEVIAHLVHSLYRGDLFDAVRRAVKRLHGAYAIAVL
SAHEPQRLVAARAGSPLVIGIGATQNYLASDCAALGELTDRFVYLEDGDVALITPDRIDVVDALGEEARRPLCEVRARDS
DAALGPYQHFMQKEIFEQPKAIENTLEGIEEISPALFDAHADTRALLSKVKSVLLLGCGTSYYAGLTAKYWLESIAGVPA
QVEIASEYRYRDAVADPRTLVVGISQSGETADTIGALERARTTGQDLSMAICNVATSTIARNSPLRFLTRAGAELGVAST
KAFTTQLVALYLLTLTLAQMRGRLDPEQAAQRLRELHALPARIGHALALETQIMGWADKFAKSENALFLGRGIHYPIAME
GALKLKEVSYIHAEGYPAGELKHGPLALVTSAMPVVTIAPDDRLFQKLKSNMAEVRARGGRLYVLAGDQLELEADRDTHL
IRVRESGDALSPIVNVIPLQLLAYHVGCARGADVDKPRNLAKSVTVE

Sequences:

>Translated_607_residues
MCGIVGASGLNNQVPQLVNALSRLEYRGYDSCGIAVLRDGRLRSERTLRRVADLQDRVLTLGLEAQTCIAHTRWATHGAP
SEKNAHPIVSRDTIAVVHNGIIENHDTLRAELRQRGYEFRGETDTEVIAHLVHSLYRGDLFDAVRRAVKRLHGAYAIAVL
SAHEPQRLVAARAGSPLVIGIGATQNYLASDCAALGELTDRFVYLEDGDVALITPDRIDVVDALGEEARRPLCEVRARDS
DAALGPYQHFMQKEIFEQPKAIENTLEGIEEISPALFDAHADTRALLSKVKSVLLLGCGTSYYAGLTAKYWLESIAGVPA
QVEIASEYRYRDAVADPRTLVVGISQSGETADTIGALERARTTGQDLSMAICNVATSTIARNSPLRFLTRAGAELGVAST
KAFTTQLVALYLLTLTLAQMRGRLDPEQAAQRLRELHALPARIGHALALETQIMGWADKFAKSENALFLGRGIHYPIAME
GALKLKEVSYIHAEGYPAGELKHGPLALVTSAMPVVTIAPDDRLFQKLKSNMAEVRARGGRLYVLAGDQLELEADRDTHL
IRVRESGDALSPIVNVIPLQLLAYHVGCARGADVDKPRNLAKSVTVE
>Mature_607_residues
MCGIVGASGLNNQVPQLVNALSRLEYRGYDSCGIAVLRDGRLRSERTLRRVADLQDRVLTLGLEAQTCIAHTRWATHGAP
SEKNAHPIVSRDTIAVVHNGIIENHDTLRAELRQRGYEFRGETDTEVIAHLVHSLYRGDLFDAVRRAVKRLHGAYAIAVL
SAHEPQRLVAARAGSPLVIGIGATQNYLASDCAALGELTDRFVYLEDGDVALITPDRIDVVDALGEEARRPLCEVRARDS
DAALGPYQHFMQKEIFEQPKAIENTLEGIEEISPALFDAHADTRALLSKVKSVLLLGCGTSYYAGLTAKYWLESIAGVPA
QVEIASEYRYRDAVADPRTLVVGISQSGETADTIGALERARTTGQDLSMAICNVATSTIARNSPLRFLTRAGAELGVAST
KAFTTQLVALYLLTLTLAQMRGRLDPEQAAQRLRELHALPARIGHALALETQIMGWADKFAKSENALFLGRGIHYPIAME
GALKLKEVSYIHAEGYPAGELKHGPLALVTSAMPVVTIAPDDRLFQKLKSNMAEVRARGGRLYVLAGDQLELEADRDTHL
IRVRESGDALSPIVNVIPLQLLAYHVGCARGADVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=693, Percent_Identity=35.6421356421356, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=35.131195335277, Blast_Score=385, Evalue=1e-107,
Organism=Escherichia coli, GI1790167, Length=611, Percent_Identity=50.5728314238953, Blast_Score=582, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI17539970, Length=431, Percent_Identity=37.122969837587, Blast_Score=269, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=37.037037037037, Blast_Score=261, Evalue=9e-70,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=37.037037037037, Blast_Score=261, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6322745, Length=456, Percent_Identity=35.0877192982456, Blast_Score=261, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6323731, Length=435, Percent_Identity=30.3448275862069, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6323730, Length=208, Percent_Identity=35.5769230769231, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21357745, Length=687, Percent_Identity=35.8078602620087, Blast_Score=384, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66101; Mature: 66101

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGASGLNNQVPQLVNALSRLEYRGYDSCGIAVLRDGRLRSERTLRRVADLQDRVLT
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHEE
LGLEAQTCIAHTRWATHGAPSEKNAHPIVSRDTIAVVHNGIIENHDTLRAELRQRGYEFR
ECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCHHCCHHHHHHHHHHCCCCCC
GETDTEVIAHLVHSLYRGDLFDAVRRAVKRLHGAYAIAVLSAHEPQRLVAARAGSPLVIG
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHCCCCCEEEE
IGATQNYLASDCAALGELTDRFVYLEDGDVALITPDRIDVVDALGEEARRPLCEVRARDS
ECCCHHHHHHHHHHHHHHHHCEEEEECCCEEEECCCHHHHHHHHHHHHCCCHHHHHCCCC
DAALGPYQHFMQKEIFEQPKAIENTLEGIEEISPALFDAHADTRALLSKVKSVLLLGCGT
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHEECCCC
SYYAGLTAKYWLESIAGVPAQVEIASEYRYRDAVADPRTLVVGISQSGETADTIGALERA
HHHHCCHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHH
RTTGQDLSMAICNVATSTIARNSPLRFLTRAGAELGVASTKAFTTQLVALYLLTLTLAQM
HCCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RGRLDPEQAAQRLRELHALPARIGHALALETQIMGWADKFAKSENALFLGRGIHYPIAME
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEC
GALKLKEVSYIHAEGYPAGELKHGPLALVTSAMPVVTIAPDDRLFQKLKSNMAEVRARGG
CCEEHHHEEEEECCCCCCCCCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHCCC
RLYVLAGDQLELEADRDTHLIRVRESGDALSPIVNVIPLQLLAYHVGCARGADVDKPRNL
EEEEEECCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AKSVTVE
HHHCCCC
>Mature Secondary Structure
MCGIVGASGLNNQVPQLVNALSRLEYRGYDSCGIAVLRDGRLRSERTLRRVADLQDRVLT
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHEE
LGLEAQTCIAHTRWATHGAPSEKNAHPIVSRDTIAVVHNGIIENHDTLRAELRQRGYEFR
ECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCHHCCHHHHHHHHHHCCCCCC
GETDTEVIAHLVHSLYRGDLFDAVRRAVKRLHGAYAIAVLSAHEPQRLVAARAGSPLVIG
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHCCCCCEEEE
IGATQNYLASDCAALGELTDRFVYLEDGDVALITPDRIDVVDALGEEARRPLCEVRARDS
ECCCHHHHHHHHHHHHHHHHCEEEEECCCEEEECCCHHHHHHHHHHHHCCCHHHHHCCCC
DAALGPYQHFMQKEIFEQPKAIENTLEGIEEISPALFDAHADTRALLSKVKSVLLLGCGT
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHEECCCC
SYYAGLTAKYWLESIAGVPAQVEIASEYRYRDAVADPRTLVVGISQSGETADTIGALERA
HHHHCCHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHH
RTTGQDLSMAICNVATSTIARNSPLRFLTRAGAELGVASTKAFTTQLVALYLLTLTLAQM
HCCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RGRLDPEQAAQRLRELHALPARIGHALALETQIMGWADKFAKSENALFLGRGIHYPIAME
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEC
GALKLKEVSYIHAEGYPAGELKHGPLALVTSAMPVVTIAPDDRLFQKLKSNMAEVRARGG
CCEEHHHEEEEECCCCCCCCCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHCCC
RLYVLAGDQLELEADRDTHLIRVRESGDALSPIVNVIPLQLLAYHVGCARGADVDKPRNL
EEEEEECCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AKSVTVE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]