Click here to switch to the map view.

The map label for this gene is xsc [H]

Identifier: 189352762

GI number: 189352762

Start: 874601

End: 876418

Strand: Reverse

Name: xsc [H]

Synonym: BMULJ_03994

Alternate gene names: 189352762

Gene position: 876418-874601 (Counterclockwise)

Preceding gene: 189352763

Following gene: 189352761

Centisome position: 35.44

GC content: 66.5

Gene sequence:

>1818_bases
ATGAGCGAACACACCTCTTCCCAGCGCGCGTCGTCCAGCGGCCCGCAGGACATGACGCCGTCCGAAGCCTTCGTCGAGAC
CCTGGCCGCGAACGGCGTGACCGACATGTTCGGCATCATGGGCTCCGCGTTCATGGACGCGATGGACATCTTCGCGCCGG
CCGGCATCCGCTTGATCCCCGTCGTGCACGAACAGGGCGCCGGCCACATGGCCGACGGCTATGCGCGCGTGTCGGGCCGC
CACGGCGTCGTGATCGGCCAGAACGGCCCCGGCATCAGCAACTGCGTCACCGCCATCGCGGCCGCGTACTGGGCGCACAG
CCCGGTCGTGATCGTCACGCCGGAAGCCGGCACGATGGGCATCGGCCTCGGCGGCTTCCAGGAAGCGAACCAGCTGCCGA
TGTTCCAGGAATTCACGAAGTACCAGGGTCACGTCACGCACCCGGCGCGCATGGCCGAATTCACGGCGCGCTGCTTCGAC
CGCGCGCAGGCCGAGATGGGGCCGACGCAGCTCAACATTCCGCGCGACTACTTCTACGGCAAGATCAAGGTCGAAATTCC
GCAGCCGCGCAAGCTCGATCGCGGCCCCGGCGGCGAGCAAAGCCTGAACGATGCGGCCGAGCTGATCGCGCAGGCGAAGT
TCCCCGTGATCATCTCGGGCGGCGGCGTCGTGATGGCCGACGCGGTCGAGGAATGCAAGGCGCTCGCCGAACGGCTCGGC
GCGCCGGTCGTCAACAGCTACCTGCACAACGACTCGTTCCCGGCGAATCATCCGCTCTGGTGCGGCCCGCTCGGCTATCA
GGGCTCGAAGGCCGCGATGAAGCTGCTGTCGCGCGCGGACGTCGTGATCGCGCTCGGCTCGCGGCTCGGGCCCTTCGGCA
CGCTGCCGCAGCACGGGCTCGACTACTGGCCGAAGGACGCGAAGATCATCCAGATCGACGCCGATCACAAGATGCTCGGC
CTCGTGAAGAAGATCTCGGTCGGCATCTGCGGCGACGCGAAGGCCGCGGCGGTCGCGCTCACGCAGCGTCTCGCTGGCCG
CACGCTCGCATGCGATGCGACGCGCGGCGAACGCGCCGACCAGATCGCGACCGAGAAGGCCGCGTGGGAGAAGGAACTCG
ACGAATGGACGCACGAGCGCGACGCGTTCAGCCTCGACATGATCGAGGAGCAGAAGCACGAGAAGACCTTCAACGGCGGC
CAGTATCTGCATCCGCGCCAGGTGCTGCGCGAGCTCGAGAAGGCAATGCCCGAGGACGTGATGGTGTCCACCGACATCGG
CAACATCAACTCGGTCGCAAACAGCTATCTGCGCTTCAACAAGCCGCGCAGCTTCTTCGCGGCGATGAGCTGGGGCAACT
GCGGCTACGCGTTCCCGACCATCATCGGCGCGAAGGTCGCCGCGCCGCACCGCCCGGCCGTCTCGTATGCCGGTGACGGC
GCATGGGGCATGAGCCTGATGGAGACGATGACCTGCGTGCGTCACAACATTCCGGTCACGGCCGTCGTGTTCCACAACCG
CCAGTGGGGCGCGGAGAAAAAGAACCAGGTCGACTTCTACAACCGTCGCTTCGTCGCGGGCGAGCTCGACAACCAGAGCT
TCGCGGCGATCGCGCGTGCGATGGGCGCCGAAGGGATCGTCGTCGATCGTCTCGAGGACGTCGGCCCGGCCCTGAAGCGC
GCGATCGACATGCAGATGAACGAGGGCAAGACGACGATCATCGAGATCATGTGCACCCGCGAACTCGGCGATCCGTTCCG
CCGCGATGCGCTGTCGAAGCCGGTCCGCATCCTCGACAAGTACAAGGACTACGTGTAA

Upstream 100 bases:

>100_bases
ATATTCCTGAGCCGACAGCGGAATCGCTTGACCCGGCATCGCCAGAAACTAGTATCCGGAACATGATGTTCCGTTAATTG
AACAATCTCGGAGACACCCC

Downstream 100 bases:

>100_bases
CGCCGCGTCGCCGACGCATGACGCCGGCCGTGCGCGACGCGCGCGGCCGGTCCCCGGCCGGATGCCGTGCCCCGTGCGGG
CCGCCGCTTCCGGCCGTTTT

Product: sulfoacetaldehyde acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 605; Mature: 604

Protein sequence:

>605_residues
MSEHTSSQRASSSGPQDMTPSEAFVETLAANGVTDMFGIMGSAFMDAMDIFAPAGIRLIPVVHEQGAGHMADGYARVSGR
HGVVIGQNGPGISNCVTAIAAAYWAHSPVVIVTPEAGTMGIGLGGFQEANQLPMFQEFTKYQGHVTHPARMAEFTARCFD
RAQAEMGPTQLNIPRDYFYGKIKVEIPQPRKLDRGPGGEQSLNDAAELIAQAKFPVIISGGGVVMADAVEECKALAERLG
APVVNSYLHNDSFPANHPLWCGPLGYQGSKAAMKLLSRADVVIALGSRLGPFGTLPQHGLDYWPKDAKIIQIDADHKMLG
LVKKISVGICGDAKAAAVALTQRLAGRTLACDATRGERADQIATEKAAWEKELDEWTHERDAFSLDMIEEQKHEKTFNGG
QYLHPRQVLRELEKAMPEDVMVSTDIGNINSVANSYLRFNKPRSFFAAMSWGNCGYAFPTIIGAKVAAPHRPAVSYAGDG
AWGMSLMETMTCVRHNIPVTAVVFHNRQWGAEKKNQVDFYNRRFVAGELDNQSFAAIARAMGAEGIVVDRLEDVGPALKR
AIDMQMNEGKTTIIEIMCTRELGDPFRRDALSKPVRILDKYKDYV

Sequences:

>Translated_605_residues
MSEHTSSQRASSSGPQDMTPSEAFVETLAANGVTDMFGIMGSAFMDAMDIFAPAGIRLIPVVHEQGAGHMADGYARVSGR
HGVVIGQNGPGISNCVTAIAAAYWAHSPVVIVTPEAGTMGIGLGGFQEANQLPMFQEFTKYQGHVTHPARMAEFTARCFD
RAQAEMGPTQLNIPRDYFYGKIKVEIPQPRKLDRGPGGEQSLNDAAELIAQAKFPVIISGGGVVMADAVEECKALAERLG
APVVNSYLHNDSFPANHPLWCGPLGYQGSKAAMKLLSRADVVIALGSRLGPFGTLPQHGLDYWPKDAKIIQIDADHKMLG
LVKKISVGICGDAKAAAVALTQRLAGRTLACDATRGERADQIATEKAAWEKELDEWTHERDAFSLDMIEEQKHEKTFNGG
QYLHPRQVLRELEKAMPEDVMVSTDIGNINSVANSYLRFNKPRSFFAAMSWGNCGYAFPTIIGAKVAAPHRPAVSYAGDG
AWGMSLMETMTCVRHNIPVTAVVFHNRQWGAEKKNQVDFYNRRFVAGELDNQSFAAIARAMGAEGIVVDRLEDVGPALKR
AIDMQMNEGKTTIIEIMCTRELGDPFRRDALSKPVRILDKYKDYV
>Mature_604_residues
SEHTSSQRASSSGPQDMTPSEAFVETLAANGVTDMFGIMGSAFMDAMDIFAPAGIRLIPVVHEQGAGHMADGYARVSGRH
GVVIGQNGPGISNCVTAIAAAYWAHSPVVIVTPEAGTMGIGLGGFQEANQLPMFQEFTKYQGHVTHPARMAEFTARCFDR
AQAEMGPTQLNIPRDYFYGKIKVEIPQPRKLDRGPGGEQSLNDAAELIAQAKFPVIISGGGVVMADAVEECKALAERLGA
PVVNSYLHNDSFPANHPLWCGPLGYQGSKAAMKLLSRADVVIALGSRLGPFGTLPQHGLDYWPKDAKIIQIDADHKMLGL
VKKISVGICGDAKAAAVALTQRLAGRTLACDATRGERADQIATEKAAWEKELDEWTHERDAFSLDMIEEQKHEKTFNGGQ
YLHPRQVLRELEKAMPEDVMVSTDIGNINSVANSYLRFNKPRSFFAAMSWGNCGYAFPTIIGAKVAAPHRPAVSYAGDGA
WGMSLMETMTCVRHNIPVTAVVFHNRQWGAEKKNQVDFYNRRFVAGELDNQSFAAIARAMGAEGIVVDRLEDVGPALKRA
IDMQMNEGKTTIIEIMCTRELGDPFRRDALSKPVRILDKYKDYV

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=606, Percent_Identity=24.4224422442244, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI93004078, Length=594, Percent_Identity=24.0740740740741, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI87081685, Length=568, Percent_Identity=27.112676056338, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1790104, Length=559, Percent_Identity=26.4758497316637, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1786717, Length=581, Percent_Identity=25.1290877796902, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1787096, Length=587, Percent_Identity=24.5315161839864, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1788716, Length=503, Percent_Identity=25.2485089463221, Blast_Score=122, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17542570, Length=585, Percent_Identity=23.0769230769231, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17531299, Length=588, Percent_Identity=23.9795918367347, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17531301, Length=588, Percent_Identity=23.9795918367347, Blast_Score=97, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323755, Length=571, Percent_Identity=26.7950963222417, Blast_Score=193, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6320816, Length=589, Percent_Identity=22.4108658743633, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19922626, Length=498, Percent_Identity=24.2971887550201, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017820
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.3.3.15 [H]

Molecular weight: Translated: 65887; Mature: 65756

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHTSSQRASSSGPQDMTPSEAFVETLAANGVTDMFGIMGSAFMDAMDIFAPAGIRLIP
CCCCCCCHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
VVHEQGAGHMADGYARVSGRHGVVIGQNGPGISNCVTAIAAAYWAHSPVVIVTPEAGTMG
EEECCCCCCCCCCHHEECCCCCEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCEE
IGLGGFQEANQLPMFQEFTKYQGHVTHPARMAEFTARCFDRAQAEMGPTQLNIPRDYFYG
CCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCHHHEEE
KIKVEIPQPRKLDRGPGGEQSLNDAAELIAQAKFPVIISGGGVVMADAVEECKALAERLG
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCEEEHHHHHHHHHHHHHHC
APVVNSYLHNDSFPANHPLWCGPLGYQGSKAAMKLLSRADVVIALGSRLGPFGTLPQHGL
CHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCC
DYWPKDAKIIQIDADHKMLGLVKKISVGICGDAKAAAVALTQRLAGRTLACDATRGERAD
CCCCCCCEEEEEECCCHHHHHHHHHHCEECCCHHHHHHHHHHHHCCCEEEECCCCCCHHH
QIATEKAAWEKELDEWTHERDAFSLDMIEEQKHEKTFNGGQYLHPRQVLRELEKAMPEDV
HHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCE
MVSTDIGNINSVANSYLRFNKPRSFFAAMSWGNCGYAFPTIIGAKVAAPHRPAVSYAGDG
EEECCCCCHHHHHHHHHHCCCCHHHHEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
AWGMSLMETMTCVRHNIPVTAVVFHNRQWGAEKKNQVDFYNRRFVAGELDNQSFAAIARA
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHCEEEEECCCCHHHHHHHHH
MGAEGIVVDRLEDVGPALKRAIDMQMNEGKTTIIEIMCTRELGDPFRRDALSKPVRILDK
HCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECHHHCCHHHHHHHHHHHHHHHH
YKDYV
HHCCC
>Mature Secondary Structure 
SEHTSSQRASSSGPQDMTPSEAFVETLAANGVTDMFGIMGSAFMDAMDIFAPAGIRLIP
CCCCCCHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
VVHEQGAGHMADGYARVSGRHGVVIGQNGPGISNCVTAIAAAYWAHSPVVIVTPEAGTMG
EEECCCCCCCCCCHHEECCCCCEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCEE
IGLGGFQEANQLPMFQEFTKYQGHVTHPARMAEFTARCFDRAQAEMGPTQLNIPRDYFYG
CCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCHHHEEE
KIKVEIPQPRKLDRGPGGEQSLNDAAELIAQAKFPVIISGGGVVMADAVEECKALAERLG
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCEEEHHHHHHHHHHHHHHC
APVVNSYLHNDSFPANHPLWCGPLGYQGSKAAMKLLSRADVVIALGSRLGPFGTLPQHGL
CHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCC
DYWPKDAKIIQIDADHKMLGLVKKISVGICGDAKAAAVALTQRLAGRTLACDATRGERAD
CCCCCCCEEEEEECCCHHHHHHHHHHCEECCCHHHHHHHHHHHHCCCEEEECCCCCCHHH
QIATEKAAWEKELDEWTHERDAFSLDMIEEQKHEKTFNGGQYLHPRQVLRELEKAMPEDV
HHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCE
MVSTDIGNINSVANSYLRFNKPRSFFAAMSWGNCGYAFPTIIGAKVAAPHRPAVSYAGDG
EEECCCCCHHHHHHHHHHCCCCHHHHEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
AWGMSLMETMTCVRHNIPVTAVVFHNRQWGAEKKNQVDFYNRRFVAGELDNQSFAAIARA
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHCEEEEECCCCHHHHHHHHH
MGAEGIVVDRLEDVGPALKRAIDMQMNEGKTTIIEIMCTRELGDPFRRDALSKPVRILDK
HCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECHHHCCHHHHHHHHHHHHHHHH
YKDYV
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12358600 [H]