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The map label for this gene is cobT [H]

Identifier: 189352759

GI number: 189352759

Start: 870895

End: 872616

Strand: Direct

Name: cobT [H]

Synonym: BMULJ_03991

Alternate gene names: 189352759

Gene position: 870895-872616 (Clockwise)

Preceding gene: 189352758

Following gene: 189352765

Centisome position: 35.21

GC content: 71.72

Gene sequence:

>1722_bases
GTGAGCGCCGAGCGCGACGCGGCGCGGCGCGCGCTCGCGCACGAGACGCTCGGCGCGGCCGCCGTGCGCGCGATGACGCG
CGACGCGACGCTGCACTACCGCGCGGGCCGCGTATGCCGCGCGCTTCGGCCGCTGCCGATCCATGCGCCGCATCTGCGCG
CGCAGGCGGCCGACGACGATCGTGCGTCGTGGCGCGGCGCGGCGGACGGCGCCGCATTGCGCATCCTCCATTCGGATCCC
GATTTGCATCGCGCGCAGCTCGGTGACGATCCGGTCGAGCGCGTGCTGTTCGAAATGCTCGAGCAGCTGCGCTGCGAATC
GCTCGCGCCGCCCGCGCTGCGCGGTGTCGTGCAGAACCTGCGGCACCGGTTCGAAGCGTGGTCGCGCACGTTCCATCTGT
CGGGGCAGGCCGACACGCATGTCGGCATCCTCGTGTACACGGTCGTGCAGATCGCATGGTCGCGGCTGTCCGGCTGGCCC
GTGCTCGACGAAACCGAAGACCTGATCGAAGCGTCGCGCGCGGCGATCGCGCCGCGGATCGGCACGCAGCTTGCCGCGCT
GCGCCGCTGCCGGCACGATCAGCGCGCATTCGCGGTGCATGCGCTCACGCTCGCGCGCCGGATCGCGGCGATGATCCGCG
ACGCACGCGCGTCGGTCGTCGATACCGATCCGAACGGCACGCGCGAGCCCGACGACGCACTGACGCAGTTCTCGTTGTGG
GTAGACTTCGACGATACGGGCGTCGACCTGCCGGCGCCCGTCGAAACGGGCGACAGCGCGGTGCTGCACGGCGGCGACGG
CGTCTATCGCGCGTATACGACGCGTTACGATCGCGAGCTGAAGCCGGCCGCGCAGATTCGCGCGGCGCTGCTGCGCGAGT
ATCGCGAACGGCTCGACGCGCAGATCGCCGCGCAGCGGCTCAACGTGCCGCGGCTCGCGCGTGTGCTGCGTGCGGCGCTG
GTCGTGCCGCAGACGGACGGCTGGTCGTTCGGCGAGGAGCACGGCCGCCTCGACGGCCGGCGGCTCGCGCAGCTGGTCAG
TTCGCCGGCCGAGCGACGGCTGTTCCGGCTCGAGCGCGTGCGGCCGCGCGCCGACTGCGCGCTGACCTTCCTGATCGATT
GTTCGGGGTCGATGAAGACGTGGATCGACGCGGTCGCGCTGACGGTCGATACGCTCGTGCGAGCCGGCGATGCCGCGGGC
CTCGCGACCGAGGTGCTCGGCTTCACGACCGGCGCCTGGAACGGCGGCCGCGTGCGGCAGGAATGGCTGGCACGCGGCAA
GCCGCGCCATCCGGGCCGCCTGAACGAGGCGTGTCATCTGGTGTTCAAGGATGCGGCGACGCGCTGGCGCCACGCGCGCA
CCGGCATCGCCGCGCTGTTCAAGGCCGACCTGTTCCGCGAAGGGATCGACGGCGAGGCGGTCGAATGGGCGTGCGCGCGA
CTGGCCGCGCGACCGGAGGCGCGCCGCATCCTCGTCGTGATTTCGGACGGCAGCCCGATGGACGGCGCGACCGCGCTCGC
GAACGATCCGTTCTATCTCGACAATCATCTGAAGCAGGTCGTCGCACGCGCGGAAGCGGCCGGCCGCGTCGAAGTGCTTG
GGCTCGGCGTCGGTCTCGATCTCGGTCCGTACTATCGCCACCGGCTCGCGATCGACCTGACGTCGGCGCCCGACATGAAG
CGGCTTGCCGAGATCGCGTGCTGGATCGGCGCACGGCGATGA

Upstream 100 bases:

>100_bases
ACGACGCGGAGCGGCCGATCGTCGCCGAGTACTACCAGCGCTGCTTCGGCGACGAGCTCGCGATCGGCGCGCGGGTCGGC
AGCGAGCCGGGAGCCGCGCG

Downstream 100 bases:

>100_bases
GCGCGCGAGCCGCGCGGCGCGCCGGGCGCGCGACACGCGAAGGGCCCGAAGGGCGACATGCAGCCGCTTACGCGCGATGC
AGCAGCGGCGGCAGCGAGGT

Product: cobalamin biosynthesis protein

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobT [H]

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MSAERDAARRALAHETLGAAAVRAMTRDATLHYRAGRVCRALRPLPIHAPHLRAQAADDDRASWRGAADGAALRILHSDP
DLHRAQLGDDPVERVLFEMLEQLRCESLAPPALRGVVQNLRHRFEAWSRTFHLSGQADTHVGILVYTVVQIAWSRLSGWP
VLDETEDLIEASRAAIAPRIGTQLAALRRCRHDQRAFAVHALTLARRIAAMIRDARASVVDTDPNGTREPDDALTQFSLW
VDFDDTGVDLPAPVETGDSAVLHGGDGVYRAYTTRYDRELKPAAQIRAALLREYRERLDAQIAAQRLNVPRLARVLRAAL
VVPQTDGWSFGEEHGRLDGRRLAQLVSSPAERRLFRLERVRPRADCALTFLIDCSGSMKTWIDAVALTVDTLVRAGDAAG
LATEVLGFTTGAWNGGRVRQEWLARGKPRHPGRLNEACHLVFKDAATRWRHARTGIAALFKADLFREGIDGEAVEWACAR
LAARPEARRILVVISDGSPMDGATALANDPFYLDNHLKQVVARAEAAGRVEVLGLGVGLDLGPYYRHRLAIDLTSAPDMK
RLAEIACWIGARR

Sequences:

>Translated_573_residues
MSAERDAARRALAHETLGAAAVRAMTRDATLHYRAGRVCRALRPLPIHAPHLRAQAADDDRASWRGAADGAALRILHSDP
DLHRAQLGDDPVERVLFEMLEQLRCESLAPPALRGVVQNLRHRFEAWSRTFHLSGQADTHVGILVYTVVQIAWSRLSGWP
VLDETEDLIEASRAAIAPRIGTQLAALRRCRHDQRAFAVHALTLARRIAAMIRDARASVVDTDPNGTREPDDALTQFSLW
VDFDDTGVDLPAPVETGDSAVLHGGDGVYRAYTTRYDRELKPAAQIRAALLREYRERLDAQIAAQRLNVPRLARVLRAAL
VVPQTDGWSFGEEHGRLDGRRLAQLVSSPAERRLFRLERVRPRADCALTFLIDCSGSMKTWIDAVALTVDTLVRAGDAAG
LATEVLGFTTGAWNGGRVRQEWLARGKPRHPGRLNEACHLVFKDAATRWRHARTGIAALFKADLFREGIDGEAVEWACAR
LAARPEARRILVVISDGSPMDGATALANDPFYLDNHLKQVVARAEAAGRVEVLGLGVGLDLGPYYRHRLAIDLTSAPDMK
RLAEIACWIGARR
>Mature_572_residues
SAERDAARRALAHETLGAAAVRAMTRDATLHYRAGRVCRALRPLPIHAPHLRAQAADDDRASWRGAADGAALRILHSDPD
LHRAQLGDDPVERVLFEMLEQLRCESLAPPALRGVVQNLRHRFEAWSRTFHLSGQADTHVGILVYTVVQIAWSRLSGWPV
LDETEDLIEASRAAIAPRIGTQLAALRRCRHDQRAFAVHALTLARRIAAMIRDARASVVDTDPNGTREPDDALTQFSLWV
DFDDTGVDLPAPVETGDSAVLHGGDGVYRAYTTRYDRELKPAAQIRAALLREYRERLDAQIAAQRLNVPRLARVLRAALV
VPQTDGWSFGEEHGRLDGRRLAQLVSSPAERRLFRLERVRPRADCALTFLIDCSGSMKTWIDAVALTVDTLVRAGDAAGL
ATEVLGFTTGAWNGGRVRQEWLARGKPRHPGRLNEACHLVFKDAATRWRHARTGIAALFKADLFREGIDGEAVEWACARL
AARPEARRILVVISDGSPMDGATALANDPFYLDNHLKQVVARAEAAGRVEVLGLGVGLDLGPYYRHRLAIDLTSAPDMKR
LAEIACWIGARR

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG4547

COG function: function code H; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 VWFA domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006538
- InterPro:   IPR002035 [H]

Pfam domain/function: PF06213 CobT [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 63257; Mature: 63126

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS50234 VWFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAERDAARRALAHETLGAAAVRAMTRDATLHYRAGRVCRALRPLPIHAPHLRAQAADDD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCCCC
RASWRGAADGAALRILHSDPDLHRAQLGDDPVERVLFEMLEQLRCESLAPPALRGVVQNL
HHHCCCCCCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RHRFEAWSRTFHLSGQADTHVGILVYTVVQIAWSRLSGWPVLDETEDLIEASRAAIAPRI
HHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHH
GTQLAALRRCRHDQRAFAVHALTLARRIAAMIRDARASVVDTDPNGTREPDDALTQFSLW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHHEEEEE
VDFDDTGVDLPAPVETGDSAVLHGGDGVYRAYTTRYDRELKPAAQIRAALLREYRERLDA
EEECCCCCCCCCCCCCCCCEEEECCCCEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
QIAAQRLNVPRLARVLRAALVVPQTDGWSFGEEHGRLDGRRLAQLVSSPAERRLFRLERV
HHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHCHHHHHHHHHHHC
RPRADCALTFLIDCSGSMKTWIDAVALTVDTLVRAGDAAGLATEVLGFTTGAWNGGRVRQ
CCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHH
EWLARGKPRHPGRLNEACHLVFKDAATRWRHARTGIAALFKADLFREGIDGEAVEWACAR
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LAARPEARRILVVISDGSPMDGATALANDPFYLDNHLKQVVARAEAAGRVEVLGLGVGLD
HHCCCCCCEEEEEEECCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCC
LGPYYRHRLAIDLTSAPDMKRLAEIACWIGARR
CCHHHHHEEEEEECCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAERDAARRALAHETLGAAAVRAMTRDATLHYRAGRVCRALRPLPIHAPHLRAQAADDD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCCCC
RASWRGAADGAALRILHSDPDLHRAQLGDDPVERVLFEMLEQLRCESLAPPALRGVVQNL
HHHCCCCCCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RHRFEAWSRTFHLSGQADTHVGILVYTVVQIAWSRLSGWPVLDETEDLIEASRAAIAPRI
HHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHH
GTQLAALRRCRHDQRAFAVHALTLARRIAAMIRDARASVVDTDPNGTREPDDALTQFSLW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHHEEEEE
VDFDDTGVDLPAPVETGDSAVLHGGDGVYRAYTTRYDRELKPAAQIRAALLREYRERLDA
EEECCCCCCCCCCCCCCCCEEEECCCCEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
QIAAQRLNVPRLARVLRAALVVPQTDGWSFGEEHGRLDGRRLAQLVSSPAERRLFRLERV
HHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHCHHHHHHHHHHHC
RPRADCALTFLIDCSGSMKTWIDAVALTVDTLVRAGDAAGLATEVLGFTTGAWNGGRVRQ
CCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHH
EWLARGKPRHPGRLNEACHLVFKDAATRWRHARTGIAALFKADLFREGIDGEAVEWACAR
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LAARPEARRILVVISDGSPMDGATALANDPFYLDNHLKQVVARAEAAGRVEVLGLGVGLD
HHCCCCCCEEEEEEECCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCC
LGPYYRHRLAIDLTSAPDMKRLAEIACWIGARR
CCHHHHHEEEEEECCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]