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The map label for this gene is trpA [H]

Identifier: 189352660

GI number: 189352660

Start: 749697

End: 750512

Strand: Direct

Name: trpA [H]

Synonym: BMULJ_03891

Alternate gene names: 189352660

Gene position: 749697-750512 (Clockwise)

Preceding gene: 189352659

Following gene: 189352661

Centisome position: 30.31

GC content: 68.87

Gene sequence:

>816_bases
ATGTCGCGTATTCAGCAGACCTTCGCCGCACTCGCCCAGCAGGGCCGAAAGGGCCTGATCCCGTTCATCACGGCCGGCGA
CCCGGATCCCGCGAAAACGGTCGAATTCATGCACGCGCTCGCCGCCGGCGGCGCGGACGTCATCGAGCTCGGCGTGCCGT
TCTCGGACCCGATGGCCGACGGCCCCGTGATCCAGCGCTCGTCGGAACGCGCGCTCGCGCGCGGCGTCACGCTCAAGCAC
GTGCTCGCCGACGTCAAGCGCTTTCGCGAGACCAATCAGACGACGCCCGTCGTGCTGATGGGCTATGCGAACCCCATCGA
GCGGCACGGCGTCGACGCGTTCGCGGCCGATGCGCGCGCGGCGGGCGTCGACGGCGTGCTCGTCGTCGACTATCCGCCCG
AAGAAGCGGCCGTATTCGCCGAGAAAATGCGTGCAGCCGGCATCGACCCGATCTTCTTGCTCGCGCCGACGTCGACCGAC
GCGCGCATCGCGGAAGTGGGCAAGATCGCGAGCGGCTACGTGTACTACGTGTCGCTGAAGGGCGTGACCGGCGCCGGAAA
TCTGGATGTTTCGAGCATTGCGGGTAAAATCCCGGCCATCAAGTCGCGCGTGCCGGTTCCGGTGGGCGTCGGCTTCGGCA
TCCGCGACGCCGAAACGGCACGTGCGGTGGCCGAGGTGTCGGACGCCGTCGTGATCGGCAGCCGCCTCGTTCAGCTGCTC
GAAAGCGCTGCGCCGGAAGGCGCCGTCGCCGCGCTGCAGGCCTTCATTGCCGAGCTGCGCGCCGCGCTGGACGGCGCGGC
GAACACGGCGCGATAA

Upstream 100 bases:

>100_bases
GTGTGCATGACGCACGCCGCCGCATCGCCGGTCGCACACTTTGCACGGACCCGGCCGGGGCGCTGACGCGCCGCGTCCGG
ATCGACACAGGAAAATTGCC

Downstream 100 bases:

>100_bases
CCACAACACAGCAAGCGGAGCGGGCCGCACGGCCCGTCCCGCCACGGAACAGGAAACCATACGATGAGCTGGCTCGACAA
ACTGTTGCCGCCGAAGATCA

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MSRIQQTFAALAQQGRKGLIPFITAGDPDPAKTVEFMHALAAGGADVIELGVPFSDPMADGPVIQRSSERALARGVTLKH
VLADVKRFRETNQTTPVVLMGYANPIERHGVDAFAADARAAGVDGVLVVDYPPEEAAVFAEKMRAAGIDPIFLLAPTSTD
ARIAEVGKIASGYVYYVSLKGVTGAGNLDVSSIAGKIPAIKSRVPVPVGVGFGIRDAETARAVAEVSDAVVIGSRLVQLL
ESAAPEGAVAALQAFIAELRAALDGAANTAR

Sequences:

>Translated_271_residues
MSRIQQTFAALAQQGRKGLIPFITAGDPDPAKTVEFMHALAAGGADVIELGVPFSDPMADGPVIQRSSERALARGVTLKH
VLADVKRFRETNQTTPVVLMGYANPIERHGVDAFAADARAAGVDGVLVVDYPPEEAAVFAEKMRAAGIDPIFLLAPTSTD
ARIAEVGKIASGYVYYVSLKGVTGAGNLDVSSIAGKIPAIKSRVPVPVGVGFGIRDAETARAVAEVSDAVVIGSRLVQLL
ESAAPEGAVAALQAFIAELRAALDGAANTAR
>Mature_270_residues
SRIQQTFAALAQQGRKGLIPFITAGDPDPAKTVEFMHALAAGGADVIELGVPFSDPMADGPVIQRSSERALARGVTLKHV
LADVKRFRETNQTTPVVLMGYANPIERHGVDAFAADARAAGVDGVLVVDYPPEEAAVFAEKMRAAGIDPIFLLAPTSTDA
RIAEVGKIASGYVYYVSLKGVTGAGNLDVSSIAGKIPAIKSRVPVPVGVGFGIRDAETARAVAEVSDAVVIGSRLVQLLE
SAAPEGAVAALQAFIAELRAALDGAANTAR

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=265, Percent_Identity=35.4716981132075, Blast_Score=160, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6321412, Length=250, Percent_Identity=42.8, Blast_Score=188, Evalue=8e-49,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 28055; Mature: 27924

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIQQTFAALAQQGRKGLIPFITAGDPDPAKTVEFMHALAAGGADVIELGVPFSDPMAD
CCHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCC
GPVIQRSSERALARGVTLKHVLADVKRFRETNQTTPVVLMGYANPIERHGVDAFAADARA
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHCCCCHHHHCHHH
AGVDGVLVVDYPPEEAAVFAEKMRAAGIDPIFLLAPTSTDARIAEVGKIASGYVYYVSLK
CCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEEEEE
GVTGAGNLDVSSIAGKIPAIKSRVPVPVGVGFGIRDAETARAVAEVSDAVVIGSRLVQLL
CCCCCCCCCHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ESAAPEGAVAALQAFIAELRAALDGAANTAR
HHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SRIQQTFAALAQQGRKGLIPFITAGDPDPAKTVEFMHALAAGGADVIELGVPFSDPMAD
CHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCC
GPVIQRSSERALARGVTLKHVLADVKRFRETNQTTPVVLMGYANPIERHGVDAFAADARA
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHCCCCHHHHCHHH
AGVDGVLVVDYPPEEAAVFAEKMRAAGIDPIFLLAPTSTDARIAEVGKIASGYVYYVSLK
CCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEEEEE
GVTGAGNLDVSSIAGKIPAIKSRVPVPVGVGFGIRDAETARAVAEVSDAVVIGSRLVQLL
CCCCCCCCCHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ESAAPEGAVAALQAFIAELRAALDGAANTAR
HHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA