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The map label for this gene is mmlH [H]

Identifier: 189352585

GI number: 189352585

Start: 659980

End: 661260

Strand: Direct

Name: mmlH [H]

Synonym: BMULJ_03816

Alternate gene names: 189352585

Gene position: 659980-661260 (Clockwise)

Preceding gene: 189352584

Following gene: 189352586

Centisome position: 26.69

GC content: 64.64

Gene sequence:

>1281_bases
ATGAAGACGAGTGCAACGGCAGCGACGCACGACACGGCGTCTGCCGCCGCGGATAAAGGGTTCGCGCGCATTTCCGGTAT
GGAGTGGCGTTCGCTGTCGCTCGCGGGGCTCGGCTGGACATTCGAGAGCTACGACTCGTTCCTGCTTTCGCTGTTGCTGC
CGACGCTTGCGCTGCAGTTCGGGCTGAGCAAGGCGCAGCTCGGCATGTTCACGAGCGTGACGGCGGCCGGACAGATCGCC
GGCGGCATTCTGTTCGGCTTCGTATCGGACCGGATAGGGCGCGTGCGCACCGCGCTGCTCTGCATCGGCATCTATTCGTT
GTTCTCGGGCTTGATCGCGTTCGCACCCGATTCGCACTGGTTCGCGGCGCTGCGCTTTCTCGGCGCGCTTGGCATGGGCG
GAACCTGGACGGCCGGCGCGGCGCTGATCGCGGAAACCTGGCACCCGAGCCGGCGAGGCAAGGGCGGTGCGCTGATGCAG
ATGGGCTTGCCGATCGGCGCGATTCTGGCGATCGCGATCTCGGGCATCGTCGGTGCCGCGCATGGCGGATTGGCCGGTGA
CGGCTGGCGCCTGCTGTTCCTGATCGGCGCGTCGCCGTTCTTCATTCTGTTCTGGGTCGCGCGCAAGACGCCGGAATCGC
CGATCTGGCTCGAACGCAAGCATGCCAGGTCGTCCGTCCGCCAAGCCGACGCGGCCGCGCACGAGAAGCTCAACGTGCGC
GGCCTGCTCACTGCCTTCTGTTTCATCTTCTTTCTGCAGTACCTCTACTGGGGTGTATTCACATGGACGCCGACCTTTCT
GGTCACGGTGAAGCATCTCGACTTCGTGCATAGCCTGAAGTTCGTGCTGGCGCTGCAGTTCGGCGCGATCACAGGGTTTC
TGCTGTTCTCGGCATGGGTCGATCGGATCGGTCGTCGTCCGATGTTCCTGGCGTACCTGCTCGTCGGTGCAATCGCCGTC
GGCGTGTACATCGTGTCGGCGAATGCGTTGCTGCTGATGATCGCGATTTTTCTGACCGGCTTCAGCGTGAACGGCATCTT
CGCGGGTGCCGGTCCGTTCCTCGCGGAGATCATCGGCAACACGGCGTCGCGCGGATTCTTCATGGGGCTCGCATACAACG
GCGGCCGTCTCGGCGGCTTCATCGCGCCGTTGATCATCGGTGCGCTGGCGTCGACCTCGGGCGGCTTCGTGCTCGGACTG
GCGACGACGATCGTCGCGTTCATCGCCGCGGCTGCAGTCGTGCTGTTCGCGCCCGAAACGCGCGGCAAGGCGCTGTCATG
A

Upstream 100 bases:

>100_bases
TCAAACGACTCGCGTCCGCAATGTCGGCCGATGAAAAGACCGCGCTGTTCAGCCGGACAGCGGCATCGACGTATCGCATC
GCGATTCCGGGAGACAAGCC

Downstream 100 bases:

>100_bases
ACGTGGCAACGCAAGCGGGATGGGTGAGCAGGCTGTTTCCCGCGCTGTCGGAGGCATCGTTGCGGCGCTATCTGAGCGGG
CAAGTCGCGTCGGTGCTCGG

Product: permease of the major facilitator superfamily

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKTSATAATHDTASAAADKGFARISGMEWRSLSLAGLGWTFESYDSFLLSLLLPTLALQFGLSKAQLGMFTSVTAAGQIA
GGILFGFVSDRIGRVRTALLCIGIYSLFSGLIAFAPDSHWFAALRFLGALGMGGTWTAGAALIAETWHPSRRGKGGALMQ
MGLPIGAILAIAISGIVGAAHGGLAGDGWRLLFLIGASPFFILFWVARKTPESPIWLERKHARSSVRQADAAAHEKLNVR
GLLTAFCFIFFLQYLYWGVFTWTPTFLVTVKHLDFVHSLKFVLALQFGAITGFLLFSAWVDRIGRRPMFLAYLLVGAIAV
GVYIVSANALLLMIAIFLTGFSVNGIFAGAGPFLAEIIGNTASRGFFMGLAYNGGRLGGFIAPLIIGALASTSGGFVLGL
ATTIVAFIAAAAVVLFAPETRGKALS

Sequences:

>Translated_426_residues
MKTSATAATHDTASAAADKGFARISGMEWRSLSLAGLGWTFESYDSFLLSLLLPTLALQFGLSKAQLGMFTSVTAAGQIA
GGILFGFVSDRIGRVRTALLCIGIYSLFSGLIAFAPDSHWFAALRFLGALGMGGTWTAGAALIAETWHPSRRGKGGALMQ
MGLPIGAILAIAISGIVGAAHGGLAGDGWRLLFLIGASPFFILFWVARKTPESPIWLERKHARSSVRQADAAAHEKLNVR
GLLTAFCFIFFLQYLYWGVFTWTPTFLVTVKHLDFVHSLKFVLALQFGAITGFLLFSAWVDRIGRRPMFLAYLLVGAIAV
GVYIVSANALLLMIAIFLTGFSVNGIFAGAGPFLAEIIGNTASRGFFMGLAYNGGRLGGFIAPLIIGALASTSGGFVLGL
ATTIVAFIAAAAVVLFAPETRGKALS
>Mature_426_residues
MKTSATAATHDTASAAADKGFARISGMEWRSLSLAGLGWTFESYDSFLLSLLLPTLALQFGLSKAQLGMFTSVTAAGQIA
GGILFGFVSDRIGRVRTALLCIGIYSLFSGLIAFAPDSHWFAALRFLGALGMGGTWTAGAALIAETWHPSRRGKGGALMQ
MGLPIGAILAIAISGIVGAAHGGLAGDGWRLLFLIGASPFFILFWVARKTPESPIWLERKHARSSVRQADAAAHEKLNVR
GLLTAFCFIFFLQYLYWGVFTWTPTFLVTVKHLDFVHSLKFVLALQFGAITGFLLFSAWVDRIGRRPMFLAYLLVGAIAV
GVYIVSANALLLMIAIFLTGFSVNGIFAGAGPFLAEIIGNTASRGFFMGLAYNGGRLGGFIAPLIIGALASTSGGFVLGL
ATTIVAFIAAAAVVLFAPETRGKALS

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=472, Percent_Identity=23.728813559322, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI166064021, Length=458, Percent_Identity=24.6724890829694, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI87082404, Length=398, Percent_Identity=26.6331658291457, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87082231, Length=423, Percent_Identity=26.7139479905437, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87081723, Length=363, Percent_Identity=29.4765840220386, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788074, Length=368, Percent_Identity=25, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790550, Length=304, Percent_Identity=23.6842105263158, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45037; Mature: 45037

Theoretical pI: Translated: 10.66; Mature: 10.66

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTSATAATHDTASAAADKGFARISGMEWRSLSLAGLGWTFESYDSFLLSLLLPTLALQF
CCCCCCCCCCCHHHHHHHCCHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
GLSKAQLGMFTSVTAAGQIAGGILFGFVSDRIGRVRTALLCIGIYSLFSGLIAFAPDSHW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
FAALRFLGALGMGGTWTAGAALIAETWHPSRRGKGGALMQMGLPIGAILAIAISGIVGAA
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHC
HGGLAGDGWRLLFLIGASPFFILFWVARKTPESPIWLERKHARSSVRQADAAAHEKLNVR
CCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCHH
GLLTAFCFIFFLQYLYWGVFTWTPTFLVTVKHLDFVHSLKFVLALQFGAITGFLLFSAWV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRIGRRPMFLAYLLVGAIAVGVYIVSANALLLMIAIFLTGFSVNGIFAGAGPFLAEIIGN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHCC
TASRGFFMGLAYNGGRLGGFIAPLIIGALASTSGGFVLGLATTIVAFIAAAAVVLFAPET
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
RGKALS
CCCCCC
>Mature Secondary Structure
MKTSATAATHDTASAAADKGFARISGMEWRSLSLAGLGWTFESYDSFLLSLLLPTLALQF
CCCCCCCCCCCHHHHHHHCCHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
GLSKAQLGMFTSVTAAGQIAGGILFGFVSDRIGRVRTALLCIGIYSLFSGLIAFAPDSHW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
FAALRFLGALGMGGTWTAGAALIAETWHPSRRGKGGALMQMGLPIGAILAIAISGIVGAA
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHC
HGGLAGDGWRLLFLIGASPFFILFWVARKTPESPIWLERKHARSSVRQADAAAHEKLNVR
CCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCHH
GLLTAFCFIFFLQYLYWGVFTWTPTFLVTVKHLDFVHSLKFVLALQFGAITGFLLFSAWV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRIGRRPMFLAYLLVGAIAVGVYIVSANALLLMIAIFLTGFSVNGIFAGAGPFLAEIIGN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHCC
TASRGFFMGLAYNGGRLGGFIAPLIIGALASTSGGFVLGLATTIVAFIAAAAVVLFAPET
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
RGKALS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]