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The map label for this gene is nadC [H]

Identifier: 189352489

GI number: 189352489

Start: 543232

End: 544068

Strand: Direct

Name: nadC [H]

Synonym: BMULJ_03709

Alternate gene names: 189352489

Gene position: 543232-544068 (Clockwise)

Preceding gene: 189352488

Following gene: 189352490

Centisome position: 21.97

GC content: 62.13

Gene sequence:

>837_bases
ATGACCCGCGCGGCGATGACGCGCAACGTCCGCGATGCGCTCGCGGAAGATATCGGCGAGGCCGACTGGACATCGCTACT
GATCGACCCCGACGCTTCAGCTGAAGCCGTCCTGACCGTACGCGAACCCGCTCTGTTGTGCGGCAGACCGTGGTTCGACG
AAACATTCCAGCAGGTCGACCCGCGCATCACGATTGAATGGTTGGTCGGCGAAGGCGAGCGGATGCACGAAGGGCAGGCC
GTCTGCCGGATCGCTGGTCTGGCGCGCGGTATGCTCACCGCCGAGCGCACCGCGCTCAACTTCATTCAGTTGCTTTCGGG
CGTGGCCACCGAGACAAGCTTGATGACGCAGATCGTCGAAGGCACGTCTGCGCGGATTCTCGACACACGCAAAACGCTTC
CGGGATTGCGCCTCGCGCAAAAATACGCAGTTCGTGTTGGCGGCGGCGAAAACCATCGCCGAGGGCTGTACGACGGCATT
CTGATCAAGGAAAACCACATCGCGGCGGGCGGGGGCATTGCTTCGACGCTGCGCGCCACGGAAGCATTGGGTGCAGGTGT
GCCGGTGCAGGTCGAGGTGGAGACGCTCGATGAGTTAAAGGAAGCGTTGGCTGGGGGCGCTGCGGCGATTCTACTCGACA
ATTTCTCGATTGAGGCGATGCGCGAGGCTGTGCGTGTCACCGCAGGGCGCGCCGAGCTTGAAGTCTCGGGCGGTGTGACC
GAGCAGACGCTGCGAACCATTGCCGAGACCGGCGTGGACCGTATTTCGCTAGGTAAGTTGACGAAGAACGTCAGGGCGAT
TGATTTTTCACTTCGCTTCGCGGAGTTTGCCGGGTGA

Upstream 100 bases:

>100_bases
CTAATAATATTGGCGGGCGTGCCAGGTCGCCGACAGGCACGACGGCAGGCCACGGCATGCTGCTCCCTCGCTAAAAAAAT
ACGGATCTGGAATGGATGGA

Downstream 100 bases:

>100_bases
CGGGGCGGGCGCTCACGTGTGCGCCCTAAAGGGAGCCTAACCGAACTTTTGTGTGTGAGGCATAAACTGATGGCCAAGGA
GCCACGTTATGCCACGCAAA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MTRAAMTRNVRDALAEDIGEADWTSLLIDPDASAEAVLTVREPALLCGRPWFDETFQQVDPRITIEWLVGEGERMHEGQA
VCRIAGLARGMLTAERTALNFIQLLSGVATETSLMTQIVEGTSARILDTRKTLPGLRLAQKYAVRVGGGENHRRGLYDGI
LIKENHIAAGGGIASTLRATEALGAGVPVQVEVETLDELKEALAGGAAAILLDNFSIEAMREAVRVTAGRAELEVSGGVT
EQTLRTIAETGVDRISLGKLTKNVRAIDFSLRFAEFAG

Sequences:

>Translated_278_residues
MTRAAMTRNVRDALAEDIGEADWTSLLIDPDASAEAVLTVREPALLCGRPWFDETFQQVDPRITIEWLVGEGERMHEGQA
VCRIAGLARGMLTAERTALNFIQLLSGVATETSLMTQIVEGTSARILDTRKTLPGLRLAQKYAVRVGGGENHRRGLYDGI
LIKENHIAAGGGIASTLRATEALGAGVPVQVEVETLDELKEALAGGAAAILLDNFSIEAMREAVRVTAGRAELEVSGGVT
EQTLRTIAETGVDRISLGKLTKNVRAIDFSLRFAEFAG
>Mature_277_residues
TRAAMTRNVRDALAEDIGEADWTSLLIDPDASAEAVLTVREPALLCGRPWFDETFQQVDPRITIEWLVGEGERMHEGQAV
CRIAGLARGMLTAERTALNFIQLLSGVATETSLMTQIVEGTSARILDTRKTLPGLRLAQKYAVRVGGGENHRRGLYDGIL
IKENHIAAGGGIASTLRATEALGAGVPVQVEVETLDELKEALAGGAAAILLDNFSIEAMREAVRVTAGRAELEVSGGVTE
QTLRTIAETGVDRISLGKLTKNVRAIDFSLRFAEFAG

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=266, Percent_Identity=32.7067669172932, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=50, Blast_Score=232, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6321162, Length=289, Percent_Identity=32.8719723183391, Blast_Score=148, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29839; Mature: 29708

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRAAMTRNVRDALAEDIGEADWTSLLIDPDASAEAVLTVREPALLCGRPWFDETFQQVD
CCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEEECCHHHCCCCCHHHHHHHCC
PRITIEWLVGEGERMHEGQAVCRIAGLARGMLTAERTALNFIQLLSGVATETSLMTQIVE
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GTSARILDTRKTLPGLRLAQKYAVRVGGGENHRRGLYDGILIKENHIAAGGGIASTLRAT
CCCCEEEEHHHCCCCHHHHHHHEEEECCCCCCCCCCCCCEEEECCCEECCCCHHHHHHHH
EALGAGVPVQVEVETLDELKEALAGGAAAILLDNFSIEAMREAVRVTAGRAELEVSGGVT
HHHCCCCCEEEEHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCH
EQTLRTIAETGVDRISLGKLTKNVRAIDFSLRFAEFAG
HHHHHHHHHCCCCCEEHHHHHCCCEEEEEEEEHHHHCC
>Mature Secondary Structure 
TRAAMTRNVRDALAEDIGEADWTSLLIDPDASAEAVLTVREPALLCGRPWFDETFQQVD
CCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEEECCHHHCCCCCHHHHHHHCC
PRITIEWLVGEGERMHEGQAVCRIAGLARGMLTAERTALNFIQLLSGVATETSLMTQIVE
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GTSARILDTRKTLPGLRLAQKYAVRVGGGENHRRGLYDGILIKENHIAAGGGIASTLRAT
CCCCEEEEHHHCCCCHHHHHHHEEEECCCCCCCCCCCCCEEEECCCEECCCCHHHHHHHH
EALGAGVPVQVEVETLDELKEALAGGAAAILLDNFSIEAMREAVRVTAGRAELEVSGGVT
HHHCCCCCEEEEHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCH
EQTLRTIAETGVDRISLGKLTKNVRAIDFSLRFAEFAG
HHHHHHHHHCCCCCEEHHHHHCCCEEEEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]