BacMap

Definition	Burkholderia multivorans ATCC 17616 chromosome 2, complete genome.
Accession	NC_010805
Length	2,473,162

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The map label for this gene is fabG [C]

Identifier: 189352307

GI number: 189352307

Start: 356269

End: 357018

Strand: Reverse

Name: fabG [C]

Synonym: BMULJ_03526

Alternate gene names: 189352307

Gene position: 357018-356269 (Counterclockwise)

Preceding gene: 189352308

Following gene: 189352306

Centisome position: 14.44

GC content: 69.47

Gene sequence:

>750_bases
ATGTTGCTCGAGAACCGGATCATCGTCGTGACGGGCGCGGCCTCGCCGCGCGGCATCGGCAAGGCCACCGCGCAGGCGCT
CGCCGCCCAGGGCGCGCGCATCGCTATCCTCGATTTGCGCGAGGAAGACGCGCGCGCGGCCGCCGCCGATCTCGGCAGCG
GCCATCTCGGGCTCGCCTGCGACGTGACCGACAAGGCCGCATGCGTCGCCGCGGCCCGCGCGACGCTCGAACGCTACGGC
CGCATCGACGGCCTCGTCAACAACGCCGGCATCACGCAGCCGGTGCGCACGCTCGACATCGGCGCGAAGGACTTCGACGC
GATCGTCGACGTGAACCTGCGCGGCACGCTCTACATGTCGCAGGCCGTGATTCCCGCGATGAAGGAACAGCAAGGCGGCA
GCATCGTCTGCATGTCGTCGGTGTCCGCGCAGCGCGGCGGCGGCATCTTCGGCGGCCCGCACTACAGCGCCGCGAAGGCC
GGCGTACTCGGCCTCGCGAAGGCGATGGCGCGCGAATTCGGCCCTGACCGCATCCGCGTCAACGCGATCACGCCCGGCCT
GATCCAGACCGACATCACCGGCGACAAGCTGACGCCCGACATGCGCGCCGACATCGTCAAGGGCATCCCGCTCGGGCGGC
TCGGCGACGCGGCCGACGTCGCGAATGCATGCCTGTTCCTCGTCAGCGACCTATCGACCTATCTGACCGGCATCACGCTC
GACGTAAACGGCGGCATGCTGATTCACTGA

Upstream 100 bases:

>100_bases
CACCTGAATTTTTCTCAGCAATGGTTGAGCGTTTCCGCGTTGATGGTGCCGCGTCGTCCCCCGACACTACAGGCACTCAT
CGACACCCAGGAGACAAACG

Downstream 100 bases:

>100_bases
GCGCGTCCGACGACCGTTCCCAAAACGCCCGGACACGACCGGGCGACATGGCAGGAGACACGACGATGAAATCCCGATAC
AGTGCGCCGCCGCTCGCCGG

Product: 3-oxoacyl-[acyl-carrier protein] reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MLLENRIIVVTGAASPRGIGKATAQALAAQGARIAILDLREEDARAAAADLGSGHLGLACDVTDKAACVAAARATLERYG
RIDGLVNNAGITQPVRTLDIGAKDFDAIVDVNLRGTLYMSQAVIPAMKEQQGGSIVCMSSVSAQRGGGIFGGPHYSAAKA
GVLGLAKAMAREFGPDRIRVNAITPGLIQTDITGDKLTPDMRADIVKGIPLGRLGDAADVANACLFLVSDLSTYLTGITL
DVNGGMLIH

Sequences:

>Translated_249_residues
MLLENRIIVVTGAASPRGIGKATAQALAAQGARIAILDLREEDARAAAADLGSGHLGLACDVTDKAACVAAARATLERYG
RIDGLVNNAGITQPVRTLDIGAKDFDAIVDVNLRGTLYMSQAVIPAMKEQQGGSIVCMSSVSAQRGGGIFGGPHYSAAKA
GVLGLAKAMAREFGPDRIRVNAITPGLIQTDITGDKLTPDMRADIVKGIPLGRLGDAADVANACLFLVSDLSTYLTGITL
DVNGGMLIH
>Mature_249_residues
MLLENRIIVVTGAASPRGIGKATAQALAAQGARIAILDLREEDARAAAADLGSGHLGLACDVTDKAACVAAARATLERYG
RIDGLVNNAGITQPVRTLDIGAKDFDAIVDVNLRGTLYMSQAVIPAMKEQQGGSIVCMSSVSAQRGGGIFGGPHYSAAKA
GVLGLAKAMAREFGPDRIRVNAITPGLIQTDITGDKLTPDMRADIVKGIPLGRLGDAADVANACLFLVSDLSTYLTGITL
DVNGGMLIH

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=232, Percent_Identity=39.2241379310345, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI15277342, Length=266, Percent_Identity=36.0902255639098, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI59889578, Length=227, Percent_Identity=36.1233480176211, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=28.957528957529, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=33.7301587301587, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI7705925, Length=249, Percent_Identity=34.136546184739, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI66933014, Length=226, Percent_Identity=31.4159292035398, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI5031737, Length=254, Percent_Identity=32.2834645669291, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI126723750, Length=256, Percent_Identity=32.8125, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=31.25, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI4758504, Length=256, Percent_Identity=31.25, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI33667109, Length=199, Percent_Identity=34.6733668341709, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4503301, Length=228, Percent_Identity=28.0701754385965, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4504505, Length=224, Percent_Identity=32.5892857142857, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI7706318, Length=206, Percent_Identity=31.0679611650485, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI31542939, Length=207, Percent_Identity=30.9178743961353, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI20149619, Length=207, Percent_Identity=29.951690821256, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4503817, Length=187, Percent_Identity=33.6898395721925, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI126723191, Length=188, Percent_Identity=32.9787234042553, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI83715985, Length=256, Percent_Identity=29.296875, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI150247226, Length=197, Percent_Identity=31.4720812182741, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI40254986, Length=193, Percent_Identity=33.6787564766839, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI224922801, Length=183, Percent_Identity=30.0546448087432, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI40807363, Length=195, Percent_Identity=27.6923076923077, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=41.1290322580645, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=35.6862745098039, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=34.9397590361446, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1789208, Length=248, Percent_Identity=33.8709677419355, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787905, Length=246, Percent_Identity=32.520325203252, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790717, Length=246, Percent_Identity=32.520325203252, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788459, Length=240, Percent_Identity=34.5833333333333, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=32.1428571428571, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=28.735632183908, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1786812, Length=256, Percent_Identity=29.296875, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789378, Length=254, Percent_Identity=29.5275590551181, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787526, Length=251, Percent_Identity=29.8804780876494, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788891, Length=240, Percent_Identity=28.3333333333333, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI2367365, Length=228, Percent_Identity=28.5087719298246, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787545, Length=265, Percent_Identity=30.188679245283, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1787820, Length=186, Percent_Identity=29.0322580645161, Blast_Score=74, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=42.1686746987952, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=37.6984126984127, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17560676, Length=250, Percent_Identity=30.8, Blast_Score=113, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71994600, Length=253, Percent_Identity=33.201581027668, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI115534694, Length=241, Percent_Identity=32.3651452282158, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=30.7086614173228, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=32.5396825396825, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17544670, Length=261, Percent_Identity=27.9693486590038, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17551412, Length=264, Percent_Identity=29.9242424242424, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17565030, Length=267, Percent_Identity=32.2097378277154, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17538182, Length=253, Percent_Identity=31.6205533596838, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=27.8625954198473, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=29.9242424242424, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17561272, Length=235, Percent_Identity=29.7872340425532, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562904, Length=269, Percent_Identity=28.996282527881, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17538480, Length=265, Percent_Identity=30.188679245283, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=28.4644194756554, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17536651, Length=252, Percent_Identity=27.3809523809524, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17536025, Length=252, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=257, Percent_Identity=27.2373540856031, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17568967, Length=197, Percent_Identity=29.4416243654822, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=28.6792452830189, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538486, Length=264, Percent_Identity=28.4090909090909, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=27.9245283018868, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=259, Percent_Identity=26.6409266409266, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=27.4436090225564, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=27.8625954198473, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=197, Percent_Identity=25.3807106598985, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=190, Percent_Identity=29.4736842105263, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=195, Percent_Identity=25.1282051282051, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=194, Percent_Identity=25.7731958762887, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558628, Length=196, Percent_Identity=31.6326530612245, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=25.8555133079848, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=25.9541984732824, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=214, Percent_Identity=33.6448598130841, Blast_Score=106, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324126, Length=254, Percent_Identity=29.9212598425197, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322226, Length=190, Percent_Identity=24.2105263157895, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=199, Percent_Identity=24.1206030150754, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=200, Percent_Identity=27, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24639444, Length=250, Percent_Identity=35.2, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI23397609, Length=251, Percent_Identity=34.6613545816733, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=32.8, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=34.5238095238095, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24643142, Length=247, Percent_Identity=32.7935222672065, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17737361, Length=234, Percent_Identity=32.4786324786325, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24644339, Length=257, Percent_Identity=30.7392996108949, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24644337, Length=234, Percent_Identity=32.0512820512821, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI18859837, Length=220, Percent_Identity=32.7272727272727, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24641232, Length=239, Percent_Identity=27.1966527196653, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI281364892, Length=196, Percent_Identity=31.6326530612245, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640492, Length=216, Percent_Identity=26.8518518518519, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21357673, Length=195, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24641388, Length=238, Percent_Identity=30.672268907563, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24649181, Length=200, Percent_Identity=27.5, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI116007236, Length=239, Percent_Identity=26.3598326359833, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648693, Length=234, Percent_Identity=27.3504273504274, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355889, Length=234, Percent_Identity=27.3504273504274, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358495, Length=209, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24665243, Length=192, Percent_Identity=32.2916666666667, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28571387, Length=252, Percent_Identity=26.5873015873016, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007234, Length=220, Percent_Identity=28.6363636363636, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221331218, Length=192, Percent_Identity=32.2916666666667, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221331216, Length=193, Percent_Identity=32.6424870466321, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24665247, Length=193, Percent_Identity=32.6424870466321, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25636; Mature: 25636

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLENRIIVVTGAASPRGIGKATAQALAAQGARIAILDLREEDARAAAADLGSGHLGLAC
CEECCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCEEEEE
DVTDKAACVAAARATLERYGRIDGLVNNAGITQPVRTLDIGAKDFDAIVDVNLRGTLYMS
ECCCHHHHHHHHHHHHHHHHHHCCEECCCCCCCCHHEEECCCCCCCEEEEECCCCEEEEH
QAVIPAMKEQQGGSIVCMSSVSAQRGGGIFGGPHYSAAKAGVLGLAKAMAREFGPDRIRV
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
NAITPGLIQTDITGDKLTPDMRADIVKGIPLGRLGDAADVANACLFLVSDLSTYLTGITL
EEECCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEE
DVNGGMLIH
EECCCEEEC
>Mature Secondary Structure
MLLENRIIVVTGAASPRGIGKATAQALAAQGARIAILDLREEDARAAAADLGSGHLGLAC
CEECCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCEEEEE
DVTDKAACVAAARATLERYGRIDGLVNNAGITQPVRTLDIGAKDFDAIVDVNLRGTLYMS
ECCCHHHHHHHHHHHHHHHHHHCCEECCCCCCCCHHEEECCCCCCCEEEEECCCCEEEEH
QAVIPAMKEQQGGSIVCMSSVSAQRGGGIFGGPHYSAAKAGVLGLAKAMAREFGPDRIRV
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
NAITPGLIQTDITGDKLTPDMRADIVKGIPLGRLGDAADVANACLFLVSDLSTYLTGITL
EEECCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEE
DVNGGMLIH
EECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]