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The map label for this gene is cynR [H]

Identifier: 189352106

GI number: 189352106

Start: 128637

End: 129557

Strand: Direct

Name: cynR [H]

Synonym: BMULJ_03324

Alternate gene names: 189352106

Gene position: 128637-129557 (Clockwise)

Preceding gene: 189352105

Following gene: 189352108

Centisome position: 5.2

GC content: 67.32

Gene sequence:

>921_bases
ATGTTCTCGAATACCACCGATCTCGATCTCCGGCTCATCCGGGTCTTTCTGGCCGTCGTCGACGCGCGCGGCATCACGGC
GGCCGAGGCCTCGCTCGGCGTGCGCCAGTCGACCATCAGTACGCAGCTGTCCGCGCTGGAAGCGCGCGTCGGCTTCAAGC
TATGCGATCGCGGGCGCGGCGGCTTTCGGCTCACGTCGAAAGGCGAGCGCTTCGCGGCGACGGCGCGCACGCTCGTCGCC
GCGACGTCCGAATTCGTCGCGCGCGTGCGCGACATCGATCGCAAGCTCGTCGGCACGCTGTCGATCGGCTTGATCGGCCA
GGCGCCGCTCGTCGAGAACGCGCGTCTTGCCGAAGCGATCGGCGCGTTCCGCAAGCGCGACCAGGCCGTCACGTTCTCGA
TGAAGGTCGCGTCGCCGCAGGAGCTCGAGGAAAGCCTCGTGAACAACCAGCTCGATCTCGCGATCGGCTATTTCTGGCAT
CGCGTGCCGGGGCTCGTCTATACGCCGCTGTTTACCGAGCAGCAGGTGATCTACTGCGGGCGCGGGCATCCGCTGTTTCA
TGCATCGCGCGCGGTGACGGCCGACGATCTGCAGGCGCACGACTGGGTGTGGCGCACCTATCCGGTGCCGGAGGAACAGT
GTCCGCTGCCCGAACGTCGCGTGACGGCGAGCGCGGACAGCATCGAGGCCGCGACGATCCTGATCCTGTCGGGCGGCCAT
CTCGGCTATCTGCCCGCGCACTACGCGGAGCCGTTCGAGCAGCGCGGGCTCGTGAAGGCCGTCGGACGCGCGACGTTCAG
CTTCGACGTGCCGATGCATCTCGCGATGAAGCGCAGCACGTCGGAGAAGCCGATCGTCGACGCGTTCTGCGACGATCTGC
TGCGTGCATTCGACATCAAGGCCGTCGCGCTCGCCGCGTGA

Upstream 100 bases:

>100_bases
CATCAAGGCGATGGGCTTCCCGATGTAACGAACAGGCGCGGCGGCGCGCGGCCGTTCTCATGGCAACGCATGCGTGCTCT
CTCTGTAAGCAGGCTCCAGC

Downstream 100 bases:

>100_bases
CGGCCTGACGGCCGCGTTCATGCGTCGATGCGCTCGACCTTGCCGACGAGCAGCCCGTACGACAGGCTGCCGGCGAGCGC
CATCGCCGCGATGTAGGTGA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MFSNTTDLDLRLIRVFLAVVDARGITAAEASLGVRQSTISTQLSALEARVGFKLCDRGRGGFRLTSKGERFAATARTLVA
ATSEFVARVRDIDRKLVGTLSIGLIGQAPLVENARLAEAIGAFRKRDQAVTFSMKVASPQELEESLVNNQLDLAIGYFWH
RVPGLVYTPLFTEQQVIYCGRGHPLFHASRAVTADDLQAHDWVWRTYPVPEEQCPLPERRVTASADSIEAATILILSGGH
LGYLPAHYAEPFEQRGLVKAVGRATFSFDVPMHLAMKRSTSEKPIVDAFCDDLLRAFDIKAVALAA

Sequences:

>Translated_306_residues
MFSNTTDLDLRLIRVFLAVVDARGITAAEASLGVRQSTISTQLSALEARVGFKLCDRGRGGFRLTSKGERFAATARTLVA
ATSEFVARVRDIDRKLVGTLSIGLIGQAPLVENARLAEAIGAFRKRDQAVTFSMKVASPQELEESLVNNQLDLAIGYFWH
RVPGLVYTPLFTEQQVIYCGRGHPLFHASRAVTADDLQAHDWVWRTYPVPEEQCPLPERRVTASADSIEAATILILSGGH
LGYLPAHYAEPFEQRGLVKAVGRATFSFDVPMHLAMKRSTSEKPIVDAFCDDLLRAFDIKAVALAA
>Mature_306_residues
MFSNTTDLDLRLIRVFLAVVDARGITAAEASLGVRQSTISTQLSALEARVGFKLCDRGRGGFRLTSKGERFAATARTLVA
ATSEFVARVRDIDRKLVGTLSIGLIGQAPLVENARLAEAIGAFRKRDQAVTFSMKVASPQELEESLVNNQLDLAIGYFWH
RVPGLVYTPLFTEQQVIYCGRGHPLFHASRAVTADDLQAHDWVWRTYPVPEEQCPLPERRVTASADSIEAATILILSGGH
LGYLPAHYAEPFEQRGLVKAVGRATFSFDVPMHLAMKRSTSEKPIVDAFCDDLLRAFDIKAVALAA

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=178, Percent_Identity=29.2134831460674, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788887, Length=207, Percent_Identity=30.4347826086957, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789204, Length=199, Percent_Identity=28.1407035175879, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787879, Length=149, Percent_Identity=26.1744966442953, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33572; Mature: 33572

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSNTTDLDLRLIRVFLAVVDARGITAAEASLGVRQSTISTQLSALEARVGFKLCDRGRG
CCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GFRLTSKGERFAATARTLVAATSEFVARVRDIDRKLVGTLSIGLIGQAPLVENARLAEAI
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
GAFRKRDQAVTFSMKVASPQELEESLVNNQLDLAIGYFWHRVPGLVYTPLFTEQQVIYCG
HHHHHCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEECCCCCCCEEEEEC
RGHPLFHASRAVTADDLQAHDWVWRTYPVPEEQCPLPERRVTASADSIEAATILILSGGH
CCCCCEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHEECCCCCCCEEEEEEEECCC
LGYLPAHYAEPFEQRGLVKAVGRATFSFDVPMHLAMKRSTSEKPIVDAFCDDLLRAFDIK
CCCCCCHHCCCHHHCCHHHHHHCCEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
AVALAA
EEEECC
>Mature Secondary Structure
MFSNTTDLDLRLIRVFLAVVDARGITAAEASLGVRQSTISTQLSALEARVGFKLCDRGRG
CCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GFRLTSKGERFAATARTLVAATSEFVARVRDIDRKLVGTLSIGLIGQAPLVENARLAEAI
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
GAFRKRDQAVTFSMKVASPQELEESLVNNQLDLAIGYFWHRVPGLVYTPLFTEQQVIYCG
HHHHHCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEECCCCCCCEEEEEC
RGHPLFHASRAVTADDLQAHDWVWRTYPVPEEQCPLPERRVTASADSIEAATILILSGGH
CCCCCEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHEECCCCCCCEEEEEEEECCC
LGYLPAHYAEPFEQRGLVKAVGRATFSFDVPMHLAMKRSTSEKPIVDAFCDDLLRAFDIK
CCCCCCHHCCCHHHCCHHHHHHCCEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
AVALAA
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]