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The map label for this gene is lrp [H]

Identifier: 189352088

GI number: 189352088

Start: 109132

End: 109632

Strand: Direct

Name: lrp [H]

Synonym: BMULJ_03305

Alternate gene names: 189352088

Gene position: 109132-109632 (Clockwise)

Preceding gene: 189352086

Following gene: 189352089

Centisome position: 4.41

GC content: 64.07

Gene sequence:

>501_bases
ATGAAATTAGAAAGGAAAGCGGCTTCGCGTGGCGAGCTCGCGCCGGCGCTCGATCGCATCGACCGCGCGATTCTTCGGCA
ATTGCAGCGGGACGCGTCGATCTCGAACGTGAACCTCGCCGCGAAGGTGAAGCTCAGCGCGCCCGCCTGCCTGCGGCGCG
TCGAGCGGCTGAAGGAAATGGGGCTGATCCGCGGGATCGTCGCGCTGCTCGATCCGAAGCCGCTCGGGGCCGGCATGCTG
GTCGTGATCGGCTTCGTGCTCGACCGCTCGACGCCCGAAGCGTTCGCCGCATTCGAGACGGCAGCGCAAAAGGTATCGGG
CTGCGTCGAATGCCATGTCGTGACGGGCGAGTTCGACTACTTCATGCTGGTGCGCACGCGCGACAACGAGAGCTTCAATC
GGCTGCACGCGGAGCAACTGCTCTATCTGCCGGGCGTGCGGCAGGTGAGGTCGTTCATGGTGCTCAAGGAGATTCTTTCG
ACGCACGCGTTGCCGGTTTAG

Upstream 100 bases:

>100_bases
GCGCGAAATGAGCTTGCGAAATAAATCGCGTCGGCCTACGTTGTCGAATGGAATCACGTCGATCCAGCAATTTCAGTTCG
TCGAAACGGAGACAGACGCA

Downstream 100 bases:

>100_bases
CAGGAGTCCTTCGGTGCGTCGGCTGCGCCGCCGGTTCGTGATGAACGGTGCACGCGTGCTGCATCGCAGCCGACCGGTCC
GGGGCTGGAAATGTGAAAAA

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MKLERKAASRGELAPALDRIDRAILRQLQRDASISNVNLAAKVKLSAPACLRRVERLKEMGLIRGIVALLDPKPLGAGML
VVIGFVLDRSTPEAFAAFETAAQKVSGCVECHVVTGEFDYFMLVRTRDNESFNRLHAEQLLYLPGVRQVRSFMVLKEILS
THALPV

Sequences:

>Translated_166_residues
MKLERKAASRGELAPALDRIDRAILRQLQRDASISNVNLAAKVKLSAPACLRRVERLKEMGLIRGIVALLDPKPLGAGML
VVIGFVLDRSTPEAFAAFETAAQKVSGCVECHVVTGEFDYFMLVRTRDNESFNRLHAEQLLYLPGVRQVRSFMVLKEILS
THALPV
>Mature_166_residues
MKLERKAASRGELAPALDRIDRAILRQLQRDASISNVNLAAKVKLSAPACLRRVERLKEMGLIRGIVALLDPKPLGAGML
VVIGFVLDRSTPEAFAAFETAAQKVSGCVECHVVTGEFDYFMLVRTRDNESFNRLHAEQLLYLPGVRQVRSFMVLKEILS
THALPV

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=148, Percent_Identity=45.2702702702703, Blast_Score=140, Evalue=4e-35,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=30.6666666666667, Blast_Score=89, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18413; Mature: 18413

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLERKAASRGELAPALDRIDRAILRQLQRDASISNVNLAAKVKLSAPACLRRVERLKEM
CCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHH
GLIRGIVALLDPKPLGAGMLVVIGFVLDRSTPEAFAAFETAAQKVSGCVECHVVTGEFDY
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCE
FMLVRTRDNESFNRLHAEQLLYLPGVRQVRSFMVLKEILSTHALPV
EEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLERKAASRGELAPALDRIDRAILRQLQRDASISNVNLAAKVKLSAPACLRRVERLKEM
CCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHH
GLIRGIVALLDPKPLGAGMLVVIGFVLDRSTPEAFAAFETAAQKVSGCVECHVVTGEFDY
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCE
FMLVRTRDNESFNRLHAEQLLYLPGVRQVRSFMVLKEILSTHALPV
EEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]