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The map label for this gene is rtn [H]

Identifier: 189352046

GI number: 189352046

Start: 63858

End: 65444

Strand: Reverse

Name: rtn [H]

Synonym: BMULJ_03263

Alternate gene names: 189352046

Gene position: 65444-63858 (Counterclockwise)

Preceding gene: 189352047

Following gene: 189352045

Centisome position: 2.65

GC content: 70.13

Gene sequence:

>1587_bases
ATGCCGGCGCCGACCTCGGGCGCGAAGCCCGTTTTCCAGCGCAGTGCCGTCTGGCTGCGGCTGGCATTCTGCGCCGTCGT
CATCGCGTGCGTGCTGGTGCCCGCCGGTGCGCTCGTGCTGGCCGGGCGATATGCGCGCGACGCCGTCGCGCGGCACGAAG
GCCTAGTGGCCGGCGACATCGCCGCGTCGGTCGATCGCATCCTGAACAGCCTGCGCTCACGCCATGCCGACGTGCTCCCG
CCGCTCGTCGGCCGGCCGTGCAGGCAGATCTTCGCGCCGCTCGCGGAAGCCGAAACGCGGCTGCGCTATTTGCGTGCGAT
CGCGCTCGTCAACGGCAACCGGCTCACCTGTTCGTCCGCGCTCGGCGCGATCGATGCGCCGCTCGACGCCTACGTGCGCG
CGCCGGCAGCCACGCCGGCCGCCGACGGCACGCGCATCGCGCTGCTGTCCGAGACACCGTATCAGCGCGGCATCCCCGTG
CTCGTCGCGTTTCGCGCGACCGCGCGCGATGCCGGCGTGCTGTACCTGATCGAAGGCGACTACGTCGCCGACGCGCTCGC
GCACAGCGGCAGCTACGGCGCCGAAAGTGCGACGCTGTCGATCGCGGGCGCCGGCCGCCTCGATCATCGCGGCCGCTTCA
TCCCGGCATCGCGTGCCGTACGGCCGCGCGGCACGGCCATCGCGTCGCGCGCGTGGCCGTTCACGGTGTCGGTCGTCGCG
TCCGCGCAGTACGTGTCGCAAGTCGAGCGCCGCTATCGGCTGCTGTTCGGCACGATCGCGCTGCTCGTCGATGCGCTCGT
CGTCGCCGCCTACCTGATCGCGACCGCACCGCGCCGGCTGTTGCTGAAGGCCGTCGGCGATGCGCTGCGGCGCAACGAAT
TCCACGTCGTGTATCAGCCGATCGTCGAGATCGAAACGCGCCGGACCGTCGGCGTCGAAGCGCTGCTGCGCTGGCATCAC
CCGAAGTGGGGGGCCATCAGCCCGACCGCGTTCGTGCCGCAGGTCGAGTCGAGCGCCGTGCTGCCGCGCGTGACCGAATA
CGTGCTGCGCACGGCCGTGTCGGAGCTGACCGCGCTCGCGCCCGCGATGCCGCTGCGCATCGCGATCAACGTCGCGCCGA
AGGACCTCGAGCGCCCGCGCTTCATGTCGATCGTCGACGAGGCGATCCGGCGGCTGCCGCCCGGCTTCACGCTGGTTCTC
GAAGTGACCGAGCGCGTGCTGCTCGAGAAAAATCCGCGCACGACCGCGATGTTCGCCGCGCTGCGTGCGAAAGGCGTGAA
GTTCGCGATCGACGACTTCGGCACGCAGCACAGCAATCTCGACATGCTGTCGCGCTTCCCGTTCGACTACGTGAAGATCG
ACCGCCAGTTCGTCGCGCAGCTCGACGGCGGCAGCGCGCGCCTGATCGAGGGCATCGCGGCGGTCGCGCACCACTACGGG
CTGAAGATCGTCGCGGAAGGCGTCGAAACGGAAGAACAGCATCGCGCGCTGCATGCGGTCGGCATTCAGTATGCGCAGGG
TTATCTGTATCGGCGGCCGCAACGCGCGGAACAGCTCATGGACGGCCTCGTCTCCGCGCCGGCCTGA

Upstream 100 bases:

>100_bases
CGCCGCGTTGCCCCGGACCAGGCATGTGGCATGCTCGCGATCGGCCCATTCGACCGGTACATTTGCCACCATGCGCACAA
CAACAAAGGCGACCGCGGAG

Downstream 100 bases:

>100_bases
GCCGCGCATCGGCGCTGCCGCGCCGTGCAGCGCGGCGCAGGCGTGCGGCGTGCGGCGTGCCGCGTGCGCAGGCGCTACAA
TCCGCCGCCTGGGCATCCAT

Product: EAL domain (diguanylate phosphodiesterase) protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MPAPTSGAKPVFQRSAVWLRLAFCAVVIACVLVPAGALVLAGRYARDAVARHEGLVAGDIAASVDRILNSLRSRHADVLP
PLVGRPCRQIFAPLAEAETRLRYLRAIALVNGNRLTCSSALGAIDAPLDAYVRAPAATPAADGTRIALLSETPYQRGIPV
LVAFRATARDAGVLYLIEGDYVADALAHSGSYGAESATLSIAGAGRLDHRGRFIPASRAVRPRGTAIASRAWPFTVSVVA
SAQYVSQVERRYRLLFGTIALLVDALVVAAYLIATAPRRLLLKAVGDALRRNEFHVVYQPIVEIETRRTVGVEALLRWHH
PKWGAISPTAFVPQVESSAVLPRVTEYVLRTAVSELTALAPAMPLRIAINVAPKDLERPRFMSIVDEAIRRLPPGFTLVL
EVTERVLLEKNPRTTAMFAALRAKGVKFAIDDFGTQHSNLDMLSRFPFDYVKIDRQFVAQLDGGSARLIEGIAAVAHHYG
LKIVAEGVETEEQHRALHAVGIQYAQGYLYRRPQRAEQLMDGLVSAPA

Sequences:

>Translated_528_residues
MPAPTSGAKPVFQRSAVWLRLAFCAVVIACVLVPAGALVLAGRYARDAVARHEGLVAGDIAASVDRILNSLRSRHADVLP
PLVGRPCRQIFAPLAEAETRLRYLRAIALVNGNRLTCSSALGAIDAPLDAYVRAPAATPAADGTRIALLSETPYQRGIPV
LVAFRATARDAGVLYLIEGDYVADALAHSGSYGAESATLSIAGAGRLDHRGRFIPASRAVRPRGTAIASRAWPFTVSVVA
SAQYVSQVERRYRLLFGTIALLVDALVVAAYLIATAPRRLLLKAVGDALRRNEFHVVYQPIVEIETRRTVGVEALLRWHH
PKWGAISPTAFVPQVESSAVLPRVTEYVLRTAVSELTALAPAMPLRIAINVAPKDLERPRFMSIVDEAIRRLPPGFTLVL
EVTERVLLEKNPRTTAMFAALRAKGVKFAIDDFGTQHSNLDMLSRFPFDYVKIDRQFVAQLDGGSARLIEGIAAVAHHYG
LKIVAEGVETEEQHRALHAVGIQYAQGYLYRRPQRAEQLMDGLVSAPA
>Mature_527_residues
PAPTSGAKPVFQRSAVWLRLAFCAVVIACVLVPAGALVLAGRYARDAVARHEGLVAGDIAASVDRILNSLRSRHADVLPP
LVGRPCRQIFAPLAEAETRLRYLRAIALVNGNRLTCSSALGAIDAPLDAYVRAPAATPAADGTRIALLSETPYQRGIPVL
VAFRATARDAGVLYLIEGDYVADALAHSGSYGAESATLSIAGAGRLDHRGRFIPASRAVRPRGTAIASRAWPFTVSVVAS
AQYVSQVERRYRLLFGTIALLVDALVVAAYLIATAPRRLLLKAVGDALRRNEFHVVYQPIVEIETRRTVGVEALLRWHHP
KWGAISPTAFVPQVESSAVLPRVTEYVLRTAVSELTALAPAMPLRIAINVAPKDLERPRFMSIVDEAIRRLPPGFTLVLE
VTERVLLEKNPRTTAMFAALRAKGVKFAIDDFGTQHSNLDMLSRFPFDYVKIDRQFVAQLDGGSARLIEGIAAVAHHYGL
KIVAEGVETEEQHRALHAVGIQYAQGYLYRRPQRAEQLMDGLVSAPA

Specific function: Involved in resistance to phages N4 and lambda [H]

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 EAL domain [H]

Homologues:

Organism=Escherichia coli, GI1788502, Length=472, Percent_Identity=30.0847457627119, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI87081980, Length=502, Percent_Identity=28.8844621513944, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI1790496, Length=256, Percent_Identity=33.984375, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786507, Length=236, Percent_Identity=35.1694915254237, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI87081845, Length=336, Percent_Identity=29.7619047619048, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787055, Length=234, Percent_Identity=34.1880341880342, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI87081921, Length=251, Percent_Identity=30.6772908366534, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI226510982, Length=233, Percent_Identity=33.0472103004292, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1787541, Length=231, Percent_Identity=29.8701298701299, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI87081743, Length=229, Percent_Identity=30.5676855895196, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1788849, Length=238, Percent_Identity=29.4117647058824, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI87082096, Length=245, Percent_Identity=29.3877551020408, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1787410, Length=224, Percent_Identity=25.8928571428571, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL [H]

EC number: NA

Molecular weight: Translated: 57293; Mature: 57162

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS50883 EAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPTSGAKPVFQRSAVWLRLAFCAVVIACVLVPAGALVLAGRYARDAVARHEGLVAGDI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHCCCCHHHH
AASVDRILNSLRSRHADVLPPLVGRPCRQIFAPLAEAETRLRYLRAIALVNGNRLTCSSA
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHH
LGAIDAPLDAYVRAPAATPAADGTRIALLSETPYQRGIPVLVAFRATARDAGVLYLIEGD
CCCCCCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCEEEEEECC
YVADALAHSGSYGAESATLSIAGAGRLDHRGRFIPASRAVRPRGTAIASRAWPFTVSVVA
HHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEEHHHHH
SAQYVSQVERRYRLLFGTIALLVDALVVAAYLIATAPRRLLLKAVGDALRRNEFHVVYQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEH
IVEIETRRTVGVEALLRWHHPKWGAISPTAFVPQVESSAVLPRVTEYVLRTAVSELTALA
HHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
PAMPLRIAINVAPKDLERPRFMSIVDEAIRRLPPGFTLVLEVTERVLLEKNPRTTAMFAA
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCHHHHHHH
LRAKGVKFAIDDFGTQHSNLDMLSRFPFDYVKIDRQFVAQLDGGSARLIEGIAAVAHHYG
HHHCCCEEEHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
LKIVAEGVETEEQHRALHAVGIQYAQGYLYRRPQRAEQLMDGLVSAPA
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PAPTSGAKPVFQRSAVWLRLAFCAVVIACVLVPAGALVLAGRYARDAVARHEGLVAGDI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHCCCCHHHH
AASVDRILNSLRSRHADVLPPLVGRPCRQIFAPLAEAETRLRYLRAIALVNGNRLTCSSA
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHH
LGAIDAPLDAYVRAPAATPAADGTRIALLSETPYQRGIPVLVAFRATARDAGVLYLIEGD
CCCCCCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCEEEEEECC
YVADALAHSGSYGAESATLSIAGAGRLDHRGRFIPASRAVRPRGTAIASRAWPFTVSVVA
HHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEEHHHHH
SAQYVSQVERRYRLLFGTIALLVDALVVAAYLIATAPRRLLLKAVGDALRRNEFHVVYQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEH
IVEIETRRTVGVEALLRWHHPKWGAISPTAFVPQVESSAVLPRVTEYVLRTAVSELTALA
HHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
PAMPLRIAINVAPKDLERPRFMSIVDEAIRRLPPGFTLVLEVTERVLLEKNPRTTAMFAA
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCHHHHHHH
LRAKGVKFAIDDFGTQHSNLDMLSRFPFDYVKIDRQFVAQLDGGSARLIEGIAAVAHHYG
HHHCCCEEEHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
LKIVAEGVETEEQHRALHAVGIQYAQGYLYRRPQRAEQLMDGLVSAPA
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 9079933 [H]