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The map label for this gene is pcaK [H]

Identifier: 189352021

GI number: 189352021

Start: 39168

End: 40526

Strand: Direct

Name: pcaK [H]

Synonym: BMULJ_03238

Alternate gene names: 189352021

Gene position: 39168-40526 (Clockwise)

Preceding gene: 189352020

Following gene: 189352024

Centisome position: 1.58

GC content: 67.18

Gene sequence:

>1359_bases
GTGAATCGCACCGCGGTGGTCGACGTCCAGACCTTCATCAACGAGCAGCCGTTCGGCGGCTTTCAGTGGCTCGTGTTTCT
CATGTGTTTCGTGATCGTCCTGCTCGACGGATTCGATACGGCCGCGATCGGCTTTATCGCGCCGTCGCTGCTCGGCGAAT
GGAATCTCACCAAGCCCGATCTCGCACCGGTGCTGAGCGCCGCGCTGTTCGGCCTCGCCTGCGGCGCGCTCGTGTCGGGC
CCGCTGTCGGATCGGCTCGGGCGACGCGTGCTGCTGCTCGGCTCGGTGTTCCTGTTCGGCATCGCGTGCCTCGTGTCCGC
GTTCTCGACGACGATCGGGCATCTGACCGTGCTGCGCTTCGTGACCGGCGTCGGGCTCGGCGCCGCGATGCCGAATGCGG
TCACGATGATGGGCGAGTTCTGCCCGGACAAGCGCCGCGCGACCGTGATCAACCTGATGTTCTGCGGCTTTCCGCTCGGT
GCGGCATTCGGCGGGTTTCTCGCCGCGTGGATGATTCCGCATTTCGGCTGGCGCAGCGTGCTGGTGCTCGGCGGCGTGAC
GCCGCTGCTGCTCGGCGTGCTGCTGCTGTTGAAGATGCCGGAATCGGTGCGCTTCATGGTCGCGCACGGCCATCCGGTCG
ACCGGATCCGCGCGACGCTCGCGCGCATCTCGCGCGATGCGCTGAACGCGAGCGCGTTCGCGATGACCGAGTCGGCGCCG
CAGACCGGCGGCAAGGGGCTCGGCGTCGTGCTGTCGCGCTCCTACGTGATCGGCTCGGTGATGCTGTGGGCCGCGTACTT
CATGGGGCTCGTGATCTTCTACGCGTCGATCAACTGGATGCCGATTCTGCTGAAGGATGCGGGCCTCACGCCGAAGAGCG
CGACGCTGATTTCCGCGCTGTTCCCGCTCGGCGGCGTTGGCGCAGTGCTGTGCGGTGTGCTGATGGATCGCTTCAACGCG
AACCGCGTGATCGCCGTCTGCTATGCGCTGACGGCCGTTAGCGTCTATGCGATCGGGCAGGCGGCCGGCAACGTCGGGCT
GCTCGTGCTGGTCGTGTTCGTCGCCGGCGTGCTGATGAACACCGCGCAATCGTCGATGCCCGCGCTGGCGGCTGCGTTTT
ATCCGACCGAAGGGCGCGGCACCGGTGTCGCGTGGATGCTCGGCGTCGGACGCTTCGGCGGGATTGCTGGGTCGTTTCTG
GTTGCGGAACTGACGCGCCGGCATTTCTCGTTCGCCGGCGTGTTCGCGACGATCGCGGTGGCCGGGCTGCTTGCCTGCGT
CGCGCTGCTGATCAAGCAGATCGCGCGGCCGCATCGGACGACGCCGTCGACCGGCACGATCGAGCCGATCGGGCACTGA

Upstream 100 bases:

>100_bases
AAGGAATGGCCCGGCGCCCGCCGGGCCGCCGACAATCCGGCGTCGCGGCACGCAGCGCATCGAGCGCCTGCCGAGCCCGA
CATCGACAAGGAGACAGACA

Downstream 100 bases:

>100_bases
GCGGGGCCAGGCTCGGCGTGCCGGCGTTCGGGCGGCGCGCCGGGCTCGGCCAGTGGGTTGGTCGTGGGTCGCGGCTCGCC
CCTCGCGGCTCGCGGCTCGC

Product: 4-hydroxybenzoate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MNRTAVVDVQTFINEQPFGGFQWLVFLMCFVIVLLDGFDTAAIGFIAPSLLGEWNLTKPDLAPVLSAALFGLACGALVSG
PLSDRLGRRVLLLGSVFLFGIACLVSAFSTTIGHLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLG
AAFGGFLAAWMIPHFGWRSVLVLGGVTPLLLGVLLLLKMPESVRFMVAHGHPVDRIRATLARISRDALNASAFAMTESAP
QTGGKGLGVVLSRSYVIGSVMLWAAYFMGLVIFYASINWMPILLKDAGLTPKSATLISALFPLGGVGAVLCGVLMDRFNA
NRVIAVCYALTAVSVYAIGQAAGNVGLLVLVVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFL
VAELTRRHFSFAGVFATIAVAGLLACVALLIKQIARPHRTTPSTGTIEPIGH

Sequences:

>Translated_452_residues
MNRTAVVDVQTFINEQPFGGFQWLVFLMCFVIVLLDGFDTAAIGFIAPSLLGEWNLTKPDLAPVLSAALFGLACGALVSG
PLSDRLGRRVLLLGSVFLFGIACLVSAFSTTIGHLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLG
AAFGGFLAAWMIPHFGWRSVLVLGGVTPLLLGVLLLLKMPESVRFMVAHGHPVDRIRATLARISRDALNASAFAMTESAP
QTGGKGLGVVLSRSYVIGSVMLWAAYFMGLVIFYASINWMPILLKDAGLTPKSATLISALFPLGGVGAVLCGVLMDRFNA
NRVIAVCYALTAVSVYAIGQAAGNVGLLVLVVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFL
VAELTRRHFSFAGVFATIAVAGLLACVALLIKQIARPHRTTPSTGTIEPIGH
>Mature_452_residues
MNRTAVVDVQTFINEQPFGGFQWLVFLMCFVIVLLDGFDTAAIGFIAPSLLGEWNLTKPDLAPVLSAALFGLACGALVSG
PLSDRLGRRVLLLGSVFLFGIACLVSAFSTTIGHLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLG
AAFGGFLAAWMIPHFGWRSVLVLGGVTPLLLGVLLLLKMPESVRFMVAHGHPVDRIRATLARISRDALNASAFAMTESAP
QTGGKGLGVVLSRSYVIGSVMLWAAYFMGLVIFYASINWMPILLKDAGLTPKSATLISALFPLGGVGAVLCGVLMDRFNA
NRVIAVCYALTAVSVYAIGQAAGNVGLLVLVVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFL
VAELTRRHFSFAGVFATIAVAGLLACVALLIKQIARPHRTTPSTGTIEPIGH

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=429, Percent_Identity=25.1748251748252, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI7662270, Length=213, Percent_Identity=25.3521126760563, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI216548223, Length=213, Percent_Identity=26.2910798122066, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI213021148, Length=270, Percent_Identity=25.5555555555556, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI166064021, Length=221, Percent_Identity=28.5067873303167, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI73695465, Length=213, Percent_Identity=27.2300469483568, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI87081723, Length=419, Percent_Identity=32.9355608591885, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI87082231, Length=441, Percent_Identity=24.9433106575964, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788074, Length=381, Percent_Identity=26.509186351706, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789207, Length=280, Percent_Identity=27.8571428571429, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786229, Length=209, Percent_Identity=26.3157894736842, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87082159, Length=390, Percent_Identity=24.3589743589744, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788068, Length=439, Percent_Identity=24.1457858769932, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789312, Length=215, Percent_Identity=30.2325581395349, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082320, Length=173, Percent_Identity=26.0115606936416, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=450, Percent_Identity=25.7777777777778, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71980584, Length=358, Percent_Identity=22.0670391061453, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI19922874, Length=276, Percent_Identity=28.2608695652174, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24640198, Length=210, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24640196, Length=210, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24640200, Length=210, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI161077756, Length=478, Percent_Identity=23.0125523012552, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47489; Mature: 47489

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTAVVDVQTFINEQPFGGFQWLVFLMCFVIVLLDGFDTAAIGFIAPSLLGEWNLTKPD
CCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCH
LAPVLSAALFGLACGALVSGPLSDRLGRRVLLLGSVFLFGIACLVSAFSTTIGHLTVLRF
HHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSV
HHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHH
LVLGGVTPLLLGVLLLLKMPESVRFMVAHGHPVDRIRATLARISRDALNASAFAMTESAP
HHHCCHHHHHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHHHHHHCHHHHHEECCCC
QTGGKGLGVVLSRSYVIGSVMLWAAYFMGLVIFYASINWMPILLKDAGLTPKSATLISAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
FPLGGVGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAAGNVGLLVLVVFVAGVLMN
HCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
TAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFSFAGVFATIAV
HHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLLACVALLIKQIARPHRTTPSTGTIEPIGH
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNRTAVVDVQTFINEQPFGGFQWLVFLMCFVIVLLDGFDTAAIGFIAPSLLGEWNLTKPD
CCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCH
LAPVLSAALFGLACGALVSGPLSDRLGRRVLLLGSVFLFGIACLVSAFSTTIGHLTVLRF
HHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSV
HHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHH
LVLGGVTPLLLGVLLLLKMPESVRFMVAHGHPVDRIRATLARISRDALNASAFAMTESAP
HHHCCHHHHHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHHHHHHCHHHHHEECCCC
QTGGKGLGVVLSRSYVIGSVMLWAAYFMGLVIFYASINWMPILLKDAGLTPKSATLISAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
FPLGGVGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAAGNVGLLVLVVFVAGVLMN
HCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
TAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFSFAGVFATIAV
HHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLLACVALLIKQIARPHRTTPSTGTIEPIGH
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]