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The map label for this gene is glyA [H]

Identifier: 189184287

GI number: 189184287

Start: 1406479

End: 1407759

Strand: Direct

Name: glyA [H]

Synonym: OTT_1380

Alternate gene names: 189184287

Gene position: 1406479-1407759 (Clockwise)

Preceding gene: 189184286

Following gene: 189184291

Centisome position: 70.01

GC content: 31.62

Gene sequence:

>1281_bases
ATGTGTAAAGAAATATATGATTTAATTGCTAAAGAATTATATAGACAGCAATCGACAATAGAATTAATAGCATCAGAGAA
TTTTACTAGTAAAGCAGTCATGCTAGCTCAAGGTTCTATTCTTACAAATAAATATGCAGAAGGATATATCAATAAAAGAT
ATTATGGTGGCTGTGAATTTATTGATGAAGTAGAAAGCCTTGCTATTGATAAAGTAAAAAAACTTTTTAAGTGCAACTAT
GCGAATGTACAACCACATTCTGGCTCTCAAGCTAATCAAGCAGTATTTTTAGCTTTGTTAAAGCCTGGTGATACAATTTT
AGCTATGGATTTAAATAGCGGTGGTCATTTAACCCATGGCGCTAAACCTAATCTTTCTGGTAAATTTTTTAATGCAGTTC
ATTACTGTGTTAACAAAGATAGTTATTTAATTGACTATAATGAAGTTGAAATGCTAGCTCAGCAGCATAAACCAAAACTT
ATAATTGTCGGTTATTCAGCTTATTCAAGAAAGATAAACTTTGCAACATTTAAAGAAATAGCAGATAAAGTAGGAGCCTA
TCTTTTAGCAGATATTGCGCATATTGCTGGCTTAGTAGCTACAGAGTATCATTCTAGTCCTATACCATATGCTCATGTTG
TAACTAGCACTACTCATAAGACTTTAAGAGGACCAAGAGGTGGCTTGATTCTAACTAATGATGAATCAATAAGTAAAAAA
ATTAATTCTGCTGTATTTCCAGGTATGCAGGGCGGTCCATTAATGCATGTCATTGCTGCTAAAGCAATTGCTTTTTCTGA
AGCCTTAATGCCTCAATATAAAGAATATATTAATCAAGTAATGTTAAATGCGAAGGTACTAGCTAAGTTACTACAAGACA
GAGGTTATAATATTTTAACAGGTGGAACAGATAATCATATGCTGCTAGTAGATTTAAGAGGAAAGAATATCACAGGACAA
GAAGCTGAATATTTACTAGATGCAGCTGGCATTACTTGTAATAAACAAGTAATGCCTTTTGATACTACTTCTCCAACCAT
TACATCTGGTATTAGATTAGGAACTCCAGCTTGTACTACTAGAGGATTTAAAGAAAATGATTTTATTACTGTAGGAAAAT
ATATTGCCGATATTTTAGACAATATTGCAATAATTAAGTCCGCAAAAAAAAATGAAGATATAACTATTACTGAAATTGAA
AATAGCTTGGATAGTGTTATTACTCACACAAAACAACATGTGCAAGAATTATGTAATAGTTTTCCAATTTATACTAACTA
G

Upstream 100 bases:

>100_bases
TACTATTAAAGATACTGATTATAGTGATGATTGTAGCGATGATGAAAGTAATAACAATAACAGCTAAAACTTGTTTATAA
GATAAAATTGGAGGTTGTAA

Downstream 100 bases:

>100_bases
ATAGTGCTAACAAACAACTAACTTAAATAACATCAAGATCAATAAAAACAAAGGAAGAAAAAGTAAGCTTAGTCAGGTGT
AATAAGGAAATGTTGCTATA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MCKEIYDLIAKELYRQQSTIELIASENFTSKAVMLAQGSILTNKYAEGYINKRYYGGCEFIDEVESLAIDKVKKLFKCNY
ANVQPHSGSQANQAVFLALLKPGDTILAMDLNSGGHLTHGAKPNLSGKFFNAVHYCVNKDSYLIDYNEVEMLAQQHKPKL
IIVGYSAYSRKINFATFKEIADKVGAYLLADIAHIAGLVATEYHSSPIPYAHVVTSTTHKTLRGPRGGLILTNDESISKK
INSAVFPGMQGGPLMHVIAAKAIAFSEALMPQYKEYINQVMLNAKVLAKLLQDRGYNILTGGTDNHMLLVDLRGKNITGQ
EAEYLLDAAGITCNKQVMPFDTTSPTITSGIRLGTPACTTRGFKENDFITVGKYIADILDNIAIIKSAKKNEDITITEIE
NSLDSVITHTKQHVQELCNSFPIYTN

Sequences:

>Translated_426_residues
MCKEIYDLIAKELYRQQSTIELIASENFTSKAVMLAQGSILTNKYAEGYINKRYYGGCEFIDEVESLAIDKVKKLFKCNY
ANVQPHSGSQANQAVFLALLKPGDTILAMDLNSGGHLTHGAKPNLSGKFFNAVHYCVNKDSYLIDYNEVEMLAQQHKPKL
IIVGYSAYSRKINFATFKEIADKVGAYLLADIAHIAGLVATEYHSSPIPYAHVVTSTTHKTLRGPRGGLILTNDESISKK
INSAVFPGMQGGPLMHVIAAKAIAFSEALMPQYKEYINQVMLNAKVLAKLLQDRGYNILTGGTDNHMLLVDLRGKNITGQ
EAEYLLDAAGITCNKQVMPFDTTSPTITSGIRLGTPACTTRGFKENDFITVGKYIADILDNIAIIKSAKKNEDITITEIE
NSLDSVITHTKQHVQELCNSFPIYTN
>Mature_426_residues
MCKEIYDLIAKELYRQQSTIELIASENFTSKAVMLAQGSILTNKYAEGYINKRYYGGCEFIDEVESLAIDKVKKLFKCNY
ANVQPHSGSQANQAVFLALLKPGDTILAMDLNSGGHLTHGAKPNLSGKFFNAVHYCVNKDSYLIDYNEVEMLAQQHKPKL
IIVGYSAYSRKINFATFKEIADKVGAYLLADIAHIAGLVATEYHSSPIPYAHVVTSTTHKTLRGPRGGLILTNDESISKK
INSAVFPGMQGGPLMHVIAAKAIAFSEALMPQYKEYINQVMLNAKVLAKLLQDRGYNILTGGTDNHMLLVDLRGKNITGQ
EAEYLLDAAGITCNKQVMPFDTTSPTITSGIRLGTPACTTRGFKENDFITVGKYIADILDNIAIIKSAKKNEDITITEIE
NSLDSVITHTKQHVQELCNSFPIYTN

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=446, Percent_Identity=43.4977578475336, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI261862352, Length=446, Percent_Identity=43.4977578475336, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI261862350, Length=446, Percent_Identity=43.4977578475336, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI261862348, Length=446, Percent_Identity=43.4977578475336, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI261862346, Length=446, Percent_Identity=42.3766816143498, Blast_Score=341, Evalue=6e-94,
Organism=Homo sapiens, GI22547186, Length=451, Percent_Identity=44.3458980044346, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI22547189, Length=434, Percent_Identity=41.9354838709677, Blast_Score=298, Evalue=7e-81,
Organism=Escherichia coli, GI1788902, Length=424, Percent_Identity=53.7735849056604, Blast_Score=444, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI25144732, Length=449, Percent_Identity=44.7661469933185, Blast_Score=357, Evalue=5e-99,
Organism=Caenorhabditis elegans, GI25144729, Length=449, Percent_Identity=44.7661469933185, Blast_Score=357, Evalue=7e-99,
Organism=Saccharomyces cerevisiae, GI6319739, Length=395, Percent_Identity=44.3037974683544, Blast_Score=338, Evalue=9e-94,
Organism=Saccharomyces cerevisiae, GI6323087, Length=446, Percent_Identity=39.237668161435, Blast_Score=315, Evalue=7e-87,
Organism=Drosophila melanogaster, GI24640005, Length=446, Percent_Identity=43.9461883408072, Blast_Score=359, Evalue=2e-99,
Organism=Drosophila melanogaster, GI221329721, Length=446, Percent_Identity=43.9461883408072, Blast_Score=358, Evalue=3e-99,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 46948; Mature: 46948

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCKEIYDLIAKELYRQQSTIELIASENFTSKAVMLAQGSILTNKYAEGYINKRYYGGCEF
CCHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCHHH
IDEVESLAIDKVKKLFKCNYANVQPHSGSQANQAVFLALLKPGDTILAMDLNSGGHLTHG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCC
AKPNLSGKFFNAVHYCVNKDSYLIDYNEVEMLAQQHKPKLIIVGYSAYSRKINFATFKEI
CCCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCEEEEEEHHHCCCCCHHHHHHH
ADKVGAYLLADIAHIAGLVATEYHSSPIPYAHVVTSTTHKTLRGPRGGLILTNDESISKK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCCCCEEEECCHHHHHH
INSAVFPGMQGGPLMHVIAAKAIAFSEALMPQYKEYINQVMLNAKVLAKLLQDRGYNILT
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
GGTDNHMLLVDLRGKNITGQEAEYLLDAAGITCNKQVMPFDTTSPTITSGIRLGTPACTT
CCCCCCEEEEEECCCCCCCCHHHHHHHHCCCEECCEECCCCCCCCCHHCCEEECCCHHHC
RGFKENDFITVGKYIADILDNIAIIKSAKKNEDITITEIENSLDSVITHTKQHVQELCNS
CCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHC
FPIYTN
CCCCCC
>Mature Secondary Structure
MCKEIYDLIAKELYRQQSTIELIASENFTSKAVMLAQGSILTNKYAEGYINKRYYGGCEF
CCHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCHHH
IDEVESLAIDKVKKLFKCNYANVQPHSGSQANQAVFLALLKPGDTILAMDLNSGGHLTHG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCC
AKPNLSGKFFNAVHYCVNKDSYLIDYNEVEMLAQQHKPKLIIVGYSAYSRKINFATFKEI
CCCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCEEEEEEHHHCCCCCHHHHHHH
ADKVGAYLLADIAHIAGLVATEYHSSPIPYAHVVTSTTHKTLRGPRGGLILTNDESISKK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCCCCEEEECCHHHHHH
INSAVFPGMQGGPLMHVIAAKAIAFSEALMPQYKEYINQVMLNAKVLAKLLQDRGYNILT
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
GGTDNHMLLVDLRGKNITGQEAEYLLDAAGITCNKQVMPFDTTSPTITSGIRLGTPACTT
CCCCCCEEEEEECCCCCCCCHHHHHHHHCCCEECCEECCCCCCCCCHHCCEEECCCHHHC
RGFKENDFITVGKYIADILDNIAIIKSAKKNEDITITEIENSLDSVITHTKQHVQELCNS
CCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHC
FPIYTN
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA