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The map label for this gene is murC [H]

Identifier: 189183854

GI number: 189183854

Start: 991196

End: 992704

Strand: Direct

Name: murC [H]

Synonym: OTT_0947

Alternate gene names: 189183854

Gene position: 991196-992704 (Clockwise)

Preceding gene: 189183853

Following gene: 189183855

Centisome position: 49.34

GC content: 30.95

Gene sequence:

>1509_bases
ATGTCAAAAAGGCATGCTTATATAAGTATTATTTGCATGACATTGTTAGCAAATCGAAGACTTAAAAGTAATTTTGGTAT
TGTGCACATTATTGGTATCGGTGGTATAGGTATGAGTGGTATCGCAGAAATAATGTACAATCTAGGTTATAAGATTAGAG
GATCAGATCTGACTAGTAATGTTAATACTGAAAGATTGAGGTTATTAGGCATTGAAGTATTACATGGACATAATGCTAAT
AATATTAATGGAGCAGGAATTGTAGTTATATCTTCTGCTATAAAACACAATAACCCTGAATATCAGGCTGCAATCTCAGC
AAAAATACCAATAATATCTAGAGCAGAGATGTTAGCTGAGCTGATGAGGTCAAAAATTGCTATAGCAATTTCAGGATCTC
ATGGCAAAACTACTACAACAGCATTGATTGCTTGCATATTTGAAGCATGTGGGTTACATCCTACAGTTATTACTGGTGGA
ATTATGAATAATAAGGCCACAAATGCTTATTTAGGTGATGGTGATTATTTCATTGCTGAAGCTGATGAATCAGATGCAAC
TTTTATTAAAATTCCTGCAACGATTGCTGTTATTACTAATATTGATGTTGAGCATTTAGATTTTTATAAAAATTTTGATA
ATTTGATTAGTGCTTTTCGTAAATTTATTATTAATTTACCATATGATGGTTTTGCAGTAGCTTGTATTGATGATATTACA
GTACAAAATTTAATAGCTAAAATTACATCTAGAAAGATTATTACTTATGGTATTGATTCTAAGAATGCACATATTCAGGC
ATTTAATATTAATACTGATAATGGTTATTCAACCTATGATGTTAGAATTAAAGCATATAATTTTCATAATGAAGTCATAA
TTACGCAAGTTACTTTACCAGCTTTAGGTAAGCATAACATTCTCAATTCACTAGCTGCAATAGCTATTGCTGTAGAGCTA
AACTTAGACTTAAATATTATTAAGGATGGATTTAAAAATTTTAAAGGTATTGCGAGGCGCTTTACAAAGATCGGAGAGTA
TAATAACATTACCGTTATTGATGACTATGCTCACCATCCTGCAGAAATTATAGCAACAATTGATATAGCAAGATGTATTG
CAGATAAGCAGCAGGGAAGGGTTATAGCTGTATTTCAACCGCATCGTTACTCTAGACTAAAACAGTTATTTTCAGAGTTT
ACTCATTGCTTTCAACGTGTAGATCAATTATATATTTCGCAAATATACGATGCTGGAGAACAAGAAACATATAACTTATC
TCATATTTCTTTAGTTAATGCTATTAAGAGTTATTATCATAGCGTATATGTTATGCCTATAAATAATTTAGATGATTTGC
CGCAAATTATTTATAGGCAAGTTAAACCATATGATATTATTCTACTAATGGGAGCTGGAGATATTACTAAATTTGCAGCA
ATATTGCCACAGCAATTACAGGAATTATTAAAGCAGCATGTCTACAGTGATATCACTACCAAAAGTTAA

Upstream 100 bases:

>100_bases
TTTCTAATTTTAGCAGCTTACTTGGTTAATATTGAGTTGTAGCTTGTGCTTAAGCAATTCTAATAAATGGAAGAAGGCTG
TATATTTTAAGAAAAATAGC

Downstream 100 bases:

>100_bases
CGGTGAATATAGAAAAAATTTTAAACTATCTCACCTGACTTGGTTTAAGGTTGGTGGAATTAGTCAAGTTTTTTATAAAC
CTAAAGATGAGCATGATCTG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MSKRHAYISIICMTLLANRRLKSNFGIVHIIGIGGIGMSGIAEIMYNLGYKIRGSDLTSNVNTERLRLLGIEVLHGHNAN
NINGAGIVVISSAIKHNNPEYQAAISAKIPIISRAEMLAELMRSKIAIAISGSHGKTTTTALIACIFEACGLHPTVITGG
IMNNKATNAYLGDGDYFIAEADESDATFIKIPATIAVITNIDVEHLDFYKNFDNLISAFRKFIINLPYDGFAVACIDDIT
VQNLIAKITSRKIITYGIDSKNAHIQAFNINTDNGYSTYDVRIKAYNFHNEVIITQVTLPALGKHNILNSLAAIAIAVEL
NLDLNIIKDGFKNFKGIARRFTKIGEYNNITVIDDYAHHPAEIIATIDIARCIADKQQGRVIAVFQPHRYSRLKQLFSEF
THCFQRVDQLYISQIYDAGEQETYNLSHISLVNAIKSYYHSVYVMPINNLDDLPQIIYRQVKPYDIILLMGAGDITKFAA
ILPQQLQELLKQHVYSDITTKS

Sequences:

>Translated_502_residues
MSKRHAYISIICMTLLANRRLKSNFGIVHIIGIGGIGMSGIAEIMYNLGYKIRGSDLTSNVNTERLRLLGIEVLHGHNAN
NINGAGIVVISSAIKHNNPEYQAAISAKIPIISRAEMLAELMRSKIAIAISGSHGKTTTTALIACIFEACGLHPTVITGG
IMNNKATNAYLGDGDYFIAEADESDATFIKIPATIAVITNIDVEHLDFYKNFDNLISAFRKFIINLPYDGFAVACIDDIT
VQNLIAKITSRKIITYGIDSKNAHIQAFNINTDNGYSTYDVRIKAYNFHNEVIITQVTLPALGKHNILNSLAAIAIAVEL
NLDLNIIKDGFKNFKGIARRFTKIGEYNNITVIDDYAHHPAEIIATIDIARCIADKQQGRVIAVFQPHRYSRLKQLFSEF
THCFQRVDQLYISQIYDAGEQETYNLSHISLVNAIKSYYHSVYVMPINNLDDLPQIIYRQVKPYDIILLMGAGDITKFAA
ILPQQLQELLKQHVYSDITTKS
>Mature_501_residues
SKRHAYISIICMTLLANRRLKSNFGIVHIIGIGGIGMSGIAEIMYNLGYKIRGSDLTSNVNTERLRLLGIEVLHGHNANN
INGAGIVVISSAIKHNNPEYQAAISAKIPIISRAEMLAELMRSKIAIAISGSHGKTTTTALIACIFEACGLHPTVITGGI
MNNKATNAYLGDGDYFIAEADESDATFIKIPATIAVITNIDVEHLDFYKNFDNLISAFRKFIINLPYDGFAVACIDDITV
QNLIAKITSRKIITYGIDSKNAHIQAFNINTDNGYSTYDVRIKAYNFHNEVIITQVTLPALGKHNILNSLAAIAIAVELN
LDLNIIKDGFKNFKGIARRFTKIGEYNNITVIDDYAHHPAEIIATIDIARCIADKQQGRVIAVFQPHRYSRLKQLFSEFT
HCFQRVDQLYISQIYDAGEQETYNLSHISLVNAIKSYYHSVYVMPINNLDDLPQIIYRQVKPYDIILLMGAGDITKFAAI
LPQQLQELLKQHVYSDITTKS

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=473, Percent_Identity=37.8435517970402, Blast_Score=272, Evalue=4e-74,
Organism=Escherichia coli, GI1790680, Length=479, Percent_Identity=26.7223382045929, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI1786274, Length=327, Percent_Identity=24.4648318042813, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 55827; Mature: 55696

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRHAYISIICMTLLANRRLKSNFGIVHIIGIGGIGMSGIAEIMYNLGYKIRGSDLTSN
CCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCC
VNTERLRLLGIEVLHGHNANNINGAGIVVISSAIKHNNPEYQAAISAKIPIISRAEMLAE
CCHHHEEEEEEEEEECCCCCCCCCCEEEEEEHHHHCCCCCEEEEEEECCCCHHHHHHHHH
LMRSKIAIAISGSHGKTTTTALIACIFEACGLHPTVITGGIMNNKATNAYLGDGDYFIAE
HHHCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEECCCCEEEEE
ADESDATFIKIPATIAVITNIDVEHLDFYKNFDNLISAFRKFIINLPYDGFAVACIDDIT
CCCCCCEEEEECEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEHHHH
VQNLIAKITSRKIITYGIDSKNAHIQAFNINTDNGYSTYDVRIKAYNFHNEVIITQVTLP
HHHHHHHHHCCEEEEEECCCCCCEEEEEEECCCCCCEEEEEEEEEEECCCEEEEEEEECC
ALGKHNILNSLAAIAIAVELNLDLNIIKDGFKNFKGIARRFTKIGEYNNITVIDDYAHHP
CCCCHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
AEIIATIDIARCIADKQQGRVIAVFQPHRYSRLKQLFSEFTHCFQRVDQLYISQIYDAGE
HHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QETYNLSHISLVNAIKSYYHSVYVMPINNLDDLPQIIYRQVKPYDIILLMGAGDITKFAA
CCCCCCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHH
ILPQQLQELLKQHVYSDITTKS
HHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SKRHAYISIICMTLLANRRLKSNFGIVHIIGIGGIGMSGIAEIMYNLGYKIRGSDLTSN
CCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCC
VNTERLRLLGIEVLHGHNANNINGAGIVVISSAIKHNNPEYQAAISAKIPIISRAEMLAE
CCHHHEEEEEEEEEECCCCCCCCCCEEEEEEHHHHCCCCCEEEEEEECCCCHHHHHHHHH
LMRSKIAIAISGSHGKTTTTALIACIFEACGLHPTVITGGIMNNKATNAYLGDGDYFIAE
HHHCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEECCCCEEEEE
ADESDATFIKIPATIAVITNIDVEHLDFYKNFDNLISAFRKFIINLPYDGFAVACIDDIT
CCCCCCEEEEECEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEHHHH
VQNLIAKITSRKIITYGIDSKNAHIQAFNINTDNGYSTYDVRIKAYNFHNEVIITQVTLP
HHHHHHHHHCCEEEEEECCCCCCEEEEEEECCCCCCEEEEEEEEEEECCCEEEEEEEECC
ALGKHNILNSLAAIAIAVELNLDLNIIKDGFKNFKGIARRFTKIGEYNNITVIDDYAHHP
CCCCHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
AEIIATIDIARCIADKQQGRVIAVFQPHRYSRLKQLFSEFTHCFQRVDQLYISQIYDAGE
HHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QETYNLSHISLVNAIKSYYHSVYVMPINNLDDLPQIIYRQVKPYDIILLMGAGDITKFAA
CCCCCCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHH
ILPQQLQELLKQHVYSDITTKS
HHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA