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The map label for this gene is grxC [H]

Identifier: 189183802

GI number: 189183802

Start: 937912

End: 938295

Strand: Reverse

Name: grxC [H]

Synonym: OTT_0895

Alternate gene names: 189183802

Gene position: 938295-937912 (Counterclockwise)

Preceding gene: 189183803

Following gene: 189183798

Centisome position: 46.7

GC content: 25.78

Gene sequence:

>384_bases
ATGAAAAGAATTCTTATCATTGTAATACTACCTATCATTTTATCATATTTTATTATAAAAAAAACTGGTATACTAGAGTA
CATGAAAAAATCAGAGTTACAGGATGAGGATTTTATGATTTATGATGATGATAATATTTATATTTACACTAAACCGACAT
GTCCATATTGCTTAAATGCAAAATCACTTTTAAATCAAAAGTCAGTATCATTTAAAGAAATAGATATTAGTAATAATCAG
CAGCTACATGAAAAATTGAAGCAAGCTACTTCTCAAACTACTGTACCATATATATTTATATATGGCCAATTTATTGGCGG
ATATATGCAATTACAAGATCTTGATAATACTGACAAATTAGATGAGTTATTAGCACAGAAATAA

Upstream 100 bases:

>100_bases
ATATAATTAGAATCATTTGTCTTGACATAGTTTTTAACTTCCTTGTATTATTTATTTTAAAGCATAGGTTTAAAATAAAT
TCACTTAAATTTTTAATTAA

Downstream 100 bases:

>100_bases
ATTTTCTATATCACGTGTTCATACTAATCTAGTGATTATGCGTCCAATCAGATCGCTATTTCAACTGTCATTTTCATACT
TGCATGTGAAATATCCGCTT

Product: glutaredoxin 3

Products: NA

Alternate protein names: Grx3 [H]

Number of amino acids: Translated: 127; Mature: 127

Protein sequence:

>127_residues
MKRILIIVILPIILSYFIIKKTGILEYMKKSELQDEDFMIYDDDNIYIYTKPTCPYCLNAKSLLNQKSVSFKEIDISNNQ
QLHEKLKQATSQTTVPYIFIYGQFIGGYMQLQDLDNTDKLDELLAQK

Sequences:

>Translated_127_residues
MKRILIIVILPIILSYFIIKKTGILEYMKKSELQDEDFMIYDDDNIYIYTKPTCPYCLNAKSLLNQKSVSFKEIDISNNQ
QLHEKLKQATSQTTVPYIFIYGQFIGGYMQLQDLDNTDKLDELLAQK
>Mature_127_residues
MKRILIIVILPIILSYFIIKKTGILEYMKKSELQDEDFMIYDDDNIYIYTKPTCPYCLNAKSLLNQKSVSFKEIDISNNQ
QLHEKLKQATSQTTVPYIFIYGQFIGGYMQLQDLDNTDKLDELLAQK

Specific function: The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione re

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790039, Length=80, Percent_Identity=50, Blast_Score=80, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI115532750, Length=91, Percent_Identity=36.2637362637363, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011900
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 14871; Mature: 14871

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRILIIVILPIILSYFIIKKTGILEYMKKSELQDEDFMIYDDDNIYIYTKPTCPYCLNA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEECCCCCCEECH
KSLLNQKSVSFKEIDISNNQQLHEKLKQATSQTTVPYIFIYGQFIGGYMQLQDLDNTDKL
HHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEECHHCCEEEEECCCCHHHH
DELLAQK
HHHHHCC
>Mature Secondary Structure
MKRILIIVILPIILSYFIIKKTGILEYMKKSELQDEDFMIYDDDNIYIYTKPTCPYCLNA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEECCCCCCEECH
KSLLNQKSVSFKEIDISNNQQLHEKLKQATSQTTVPYIFIYGQFIGGYMQLQDLDNTDKL
HHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEECHHCCEEEEECCCCHHHH
DELLAQK
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]