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The map label for this gene is fumC [H]

Identifier: 189183757

GI number: 189183757

Start: 893470

End: 894870

Strand: Direct

Name: fumC [H]

Synonym: OTT_0850

Alternate gene names: 189183757

Gene position: 893470-894870 (Clockwise)

Preceding gene: 189183756

Following gene: 189183761

Centisome position: 44.47

GC content: 32.41

Gene sequence:

>1401_bases
ATGAAAATAAATAAAGTTAGAATTGAAAATGATTTACTAGGTAATATAGAAGTCGAAGAGCAATATTATTGGGGAGCTCA
AACACAGCGTTCAATATTAAATTTTAAAATTGGGCATGAAAAAATGCCTCTTAGGTTAATATATGCCCTTGCATTACAAA
AACAATGTTCAGCAAAAGTAAATAAAGAGCTTGGATTACTTCAGCCTAGAATAGCAGATGCTATTATTAATGCTGCTAAA
GAGATAAGTCAAGGAAAGTATGACGATAATTTCCCATTATCAGTATGGCAAACTGGCTCAGGCACTCAGACTAATATGAA
TATAAATGAAGTAATTGCTAATATTGCTAATGAAAAGCTAGGTGGCAGTAAGGGATCAAAAGATCCAGTGCATCCAAATG
ATCATGTTAATATGAGCCAATCGTCTAATGACTCTTTTCCTACTGCTATGAATGTTGCTACAGCAATAATATTAATTAAT
AATTTAATTCCTAATCTTGAAAAATTACATGTAACATTCAAAAGCAAAATCAAAGAATGGCAATCAATAGTCAAAATTGG
TAGAACTCACTTACAGGATGCTACACCATTAACTTTAGGGCAAGAATTTTCAGCATATAGTGCGCAAATTGGTTATGCTA
TTACACGTATTACATCTGTTTTAGAAAGAGTATGTCAACTTGCTCAGGGAGGAACTGCTGTAGGTACAGGTATTAATTGC
CATAAAGATTTTTCAGTAAAATTTGTCGAAAAAATCTCAAAATTAACTGGTATAAAATTTTACTCAGCGCAAAATAAATT
TGAAGCAATATCGTGTCATGATAACCTTGTAGAACTATCTGGAGTATTAAATGTATTAGCTACTAGCTTAATGAAAATCG
CTAATGATATTAGATTGCTTGGATCAGGCCCACGATGTGGATTAGGGGAAATAGTTTTACCAATAAATGAGCCTGGATCA
TCAATTATGCCAGGTAAAGTTAATCCAACTCAAGTTGAAGCACTATCAATGATTTGTGCTCAAGTTATTGGAAATCATGT
AACAATTACTATTGCTGGATCTAGTGGGCATCTTGAGCTGAATGCATTTAAACCAGTAATTATCTATAATTTATTACAAT
CAATTCAATTATTATCAGATGGAATTCTTAGCTTCAATGATCATTGTTTATCTGGTATTCAGCCTAACATAGAGAGAATA
AAAAAAACATGCGAAGATTCTTTAATGTTAGTAACAGCGCTTAATCCACATATTGGCTATGATAACGCAGCTAAAATTGC
TAAAACAGCATATCAAAATAATATTACTTTGAAAGAAGCTGCAATATCATTGGGTCTAATGACTGCTGAGGAGTTTGACT
TATATGTCAAGGTTGAGAACATGATAGGCAGCAAAGAATAA

Upstream 100 bases:

>100_bases
TGGTGAAGATTACATTAGTTATATTATTGAGCAATAAATTTTGACTTTGTGACGATTGTCTTATTACTAATTCTAAACTA
AAACTATTAAAATTAAGCAA

Downstream 100 bases:

>100_bases
TTCTAGATTATATTGCATAAAGTGTTGAAAGTATAAAAAGCAATATATAAAATAAACTAAAGTTCGATATAAAGATTACA
GCATATTTTTCCTGCTTTCT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKINKVRIENDLLGNIEVEEQYYWGAQTQRSILNFKIGHEKMPLRLIYALALQKQCSAKVNKELGLLQPRIADAIINAAK
EISQGKYDDNFPLSVWQTGSGTQTNMNINEVIANIANEKLGGSKGSKDPVHPNDHVNMSQSSNDSFPTAMNVATAIILIN
NLIPNLEKLHVTFKSKIKEWQSIVKIGRTHLQDATPLTLGQEFSAYSAQIGYAITRITSVLERVCQLAQGGTAVGTGINC
HKDFSVKFVEKISKLTGIKFYSAQNKFEAISCHDNLVELSGVLNVLATSLMKIANDIRLLGSGPRCGLGEIVLPINEPGS
SIMPGKVNPTQVEALSMICAQVIGNHVTITIAGSSGHLELNAFKPVIIYNLLQSIQLLSDGILSFNDHCLSGIQPNIERI
KKTCEDSLMLVTALNPHIGYDNAAKIAKTAYQNNITLKEAAISLGLMTAEEFDLYVKVENMIGSKE

Sequences:

>Translated_466_residues
MKINKVRIENDLLGNIEVEEQYYWGAQTQRSILNFKIGHEKMPLRLIYALALQKQCSAKVNKELGLLQPRIADAIINAAK
EISQGKYDDNFPLSVWQTGSGTQTNMNINEVIANIANEKLGGSKGSKDPVHPNDHVNMSQSSNDSFPTAMNVATAIILIN
NLIPNLEKLHVTFKSKIKEWQSIVKIGRTHLQDATPLTLGQEFSAYSAQIGYAITRITSVLERVCQLAQGGTAVGTGINC
HKDFSVKFVEKISKLTGIKFYSAQNKFEAISCHDNLVELSGVLNVLATSLMKIANDIRLLGSGPRCGLGEIVLPINEPGS
SIMPGKVNPTQVEALSMICAQVIGNHVTITIAGSSGHLELNAFKPVIIYNLLQSIQLLSDGILSFNDHCLSGIQPNIERI
KKTCEDSLMLVTALNPHIGYDNAAKIAKTAYQNNITLKEAAISLGLMTAEEFDLYVKVENMIGSKE
>Mature_466_residues
MKINKVRIENDLLGNIEVEEQYYWGAQTQRSILNFKIGHEKMPLRLIYALALQKQCSAKVNKELGLLQPRIADAIINAAK
EISQGKYDDNFPLSVWQTGSGTQTNMNINEVIANIANEKLGGSKGSKDPVHPNDHVNMSQSSNDSFPTAMNVATAIILIN
NLIPNLEKLHVTFKSKIKEWQSIVKIGRTHLQDATPLTLGQEFSAYSAQIGYAITRITSVLERVCQLAQGGTAVGTGINC
HKDFSVKFVEKISKLTGIKFYSAQNKFEAISCHDNLVELSGVLNVLATSLMKIANDIRLLGSGPRCGLGEIVLPINEPGS
SIMPGKVNPTQVEALSMICAQVIGNHVTITIAGSSGHLELNAFKPVIIYNLLQSIQLLSDGILSFNDHCLSGIQPNIERI
KKTCEDSLMLVTALNPHIGYDNAAKIAKTAYQNNITLKEAAISLGLMTAEEFDLYVKVENMIGSKE

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=464, Percent_Identity=60.7758620689655, Blast_Score=577, Evalue=1e-165,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=50.7936507936508, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1787896, Length=462, Percent_Identity=56.7099567099567, Blast_Score=526, Evalue=1e-150,
Organism=Escherichia coli, GI87082375, Length=462, Percent_Identity=40.04329004329, Blast_Score=328, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=58.963282937365, Blast_Score=571, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=59.7560975609756, Blast_Score=417, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=59.002169197397, Blast_Score=539, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24640179, Length=468, Percent_Identity=58.1196581196581, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=58.4051724137931, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=56.3714902807775, Blast_Score=543, Evalue=1e-154,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=56.1555075593952, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24583245, Length=467, Percent_Identity=50.321199143469, Blast_Score=463, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50914; Mature: 50914

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINKVRIENDLLGNIEVEEQYYWGAQTQRSILNFKIGHEKMPLRLIYALALQKQCSAKV
CCCCEEEECCCCCCCEEEECEEECCCHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHH
NKELGLLQPRIADAIINAAKEISQGKYDDNFPLSVWQTGSGTQTNMNINEVIANIANEKL
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHC
GGSKGSKDPVHPNDHVNMSQSSNDSFPTAMNVATAIILINNLIPNLEKLHVTFKSKIKEW
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QSIVKIGRTHLQDATPLTLGQEFSAYSAQIGYAITRITSVLERVCQLAQGGTAVGTGINC
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCC
HKDFSVKFVEKISKLTGIKFYSAQNKFEAISCHDNLVELSGVLNVLATSLMKIANDIRLL
CCCCCHHHHHHHHHHHCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEE
GSGPRCGLGEIVLPINEPGSSIMPGKVNPTQVEALSMICAQVIGNHVTITIAGSSGHLEL
CCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEE
NAFKPVIIYNLLQSIQLLSDGILSFNDHCLSGIQPNIERIKKTCEDSLMLVTALNPHIGY
ECCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHCCCEEEEEECCCCCCC
DNAAKIAKTAYQNNITLKEAAISLGLMTAEEFDLYVKVENMIGSKE
CHHHHHHHHHHHCCCCHHHHHHHHHEEEHHHCEEEEEEEHHCCCCC
>Mature Secondary Structure
MKINKVRIENDLLGNIEVEEQYYWGAQTQRSILNFKIGHEKMPLRLIYALALQKQCSAKV
CCCCEEEECCCCCCCEEEECEEECCCHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHH
NKELGLLQPRIADAIINAAKEISQGKYDDNFPLSVWQTGSGTQTNMNINEVIANIANEKL
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHC
GGSKGSKDPVHPNDHVNMSQSSNDSFPTAMNVATAIILINNLIPNLEKLHVTFKSKIKEW
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QSIVKIGRTHLQDATPLTLGQEFSAYSAQIGYAITRITSVLERVCQLAQGGTAVGTGINC
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCC
HKDFSVKFVEKISKLTGIKFYSAQNKFEAISCHDNLVELSGVLNVLATSLMKIANDIRLL
CCCCCHHHHHHHHHHHCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEE
GSGPRCGLGEIVLPINEPGSSIMPGKVNPTQVEALSMICAQVIGNHVTITIAGSSGHLEL
CCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEE
NAFKPVIIYNLLQSIQLLSDGILSFNDHCLSGIQPNIERIKKTCEDSLMLVTALNPHIGY
ECCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHCCCEEEEEECCCCCCC
DNAAKIAKTAYQNNITLKEAAISLGLMTAEEFDLYVKVENMIGSKE
CHHHHHHHHHHHCCCCHHHHHHHHHEEEHHHCEEEEEEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA