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The map label for this gene is ffh [H]

Identifier: 189183745

GI number: 189183745

Start: 883099

End: 884451

Strand: Reverse

Name: ffh [H]

Synonym: OTT_0838

Alternate gene names: 189183745

Gene position: 884451-883099 (Counterclockwise)

Preceding gene: 189183746

Following gene: 189183744

Centisome position: 44.02

GC content: 31.34

Gene sequence:

>1353_bases
ATGTTTCAAACTTTAACTCAAAAACTTAGTAATATTTTCGATAAGATTAAAGGTAGTACTGCTCTATCTGAACAACAAGT
TTTAACAATAGCACGGGAAGTAAGAATTGCATTATTAGAGGCAGATGTTTCATTAGTAGTTATTAAAGATTTTATTAATA
ATGTTGTAGAAAAAGCTAAAGGGCAGGAGGTTCTTCGTTCTGTAACACCTGGCCAAATGGTTATTAAAATTATTAGCGAT
GAGATGATAAAGGTTCTTAGCAGCTCAGAAACAGAACAAGCGCTGCGTATTGAGTTTGAACCACCTGTAAACATTATGAT
GATTGGTCTACAAGGCAGCGGAAAAACCACTACAACTGCCAAATTAGCAATGAAGCTTGCTAAAAAAAATAAAAAAGTTA
TGGTTGTATCCCTAGATATTTATAGACCAGCTGCTAGAGAACAGCTCGAAACATTAGTACGAAATCATGAAACTATACTA
TCATTACCTATAGTTTCAAATGAGAATGTGTTTCAGATTATAGCACGAAGTACTAAGGAAGCTAAGCTGCTTGGTTGTGA
TGTAGTAATTTATGATACTGCAGGTCGTCTGCATATTGATGAGCCAATGTTGCAAGAACTAAGTAATATAAAAGAAATAA
TTACTCCTAAAGAAATACTTTTAGTAGTTGATTCACTTATTGGTCAAGAATCAGTCAATGTAGCTAATCAATTTAATCAA
ACATTGAATATTTCTGGCGTTGTATTAACTAAAATTGATGGTGATTCAAGAGGAGGAGCAGCATTAAGTATTAAATATGT
TACTGGCAAGCCAATAAAATTCCTTGGCACAGGAGAAAAAACTAATGATTTAGAGGAATTTCATCCAGAAAGAATTGCTT
CACGGATATTAGGTAAAGGTGATATTGTTTCTCTAGTAGAGAAAGCAGCAGAAGTAATTAGTAAAGAAGATGCAGCTAAA
TCAGTTGAAAAATTAAAAAAAGGCAGTTTTAATCTTGAGGATTACTATCAACAGCTGCAAAACATTAATAAGATGGGAGG
AATTAGCTCAATACTTAATCTTATGCCTGGAATAAATAAACTATTGCCGAAAATTGATCAAAATCCATTTGATCAAAACA
ATGTAAAGTTACAACAGGCAATAATTTTATCAATGACAAGGTATGAAAAGTTAAATCCAGATATAATTAATGGAAAACGT
AAAAAACGTATTGCAGCTGGTTCAGGAACATCAGTTCAAGAAGTCAATAAGCTATTAAAACAATTTCAAAATATTACTTC
CTTGCTTAAAAGTGGAATGAAAGGTAATAATATACTAAAAGATAAATTTAATAATTTGAAAAATTTTTTCTAA

Upstream 100 bases:

>100_bases
TCTTAATATAGATTATGTTATATATTTACATGAATAAGTAAAAATCAACAATTTCTAGCAGTAAAATATTTAACCAATTT
CATGAACTTAAGATAGAAGC

Downstream 100 bases:

>100_bases
GTTATTTGAACAAAGGTTTTAATTTAGCAACACTCAAGAGCTGCAAAATTTAAGTATATGATTGATTCTGAAAATAATAG
CGCTAATACAGAAGATTATA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MFQTLTQKLSNIFDKIKGSTALSEQQVLTIAREVRIALLEADVSLVVIKDFINNVVEKAKGQEVLRSVTPGQMVIKIISD
EMIKVLSSSETEQALRIEFEPPVNIMMIGLQGSGKTTTTAKLAMKLAKKNKKVMVVSLDIYRPAAREQLETLVRNHETIL
SLPIVSNENVFQIIARSTKEAKLLGCDVVIYDTAGRLHIDEPMLQELSNIKEIITPKEILLVVDSLIGQESVNVANQFNQ
TLNISGVVLTKIDGDSRGGAALSIKYVTGKPIKFLGTGEKTNDLEEFHPERIASRILGKGDIVSLVEKAAEVISKEDAAK
SVEKLKKGSFNLEDYYQQLQNINKMGGISSILNLMPGINKLLPKIDQNPFDQNNVKLQQAIILSMTRYEKLNPDIINGKR
KKRIAAGSGTSVQEVNKLLKQFQNITSLLKSGMKGNNILKDKFNNLKNFF

Sequences:

>Translated_450_residues
MFQTLTQKLSNIFDKIKGSTALSEQQVLTIAREVRIALLEADVSLVVIKDFINNVVEKAKGQEVLRSVTPGQMVIKIISD
EMIKVLSSSETEQALRIEFEPPVNIMMIGLQGSGKTTTTAKLAMKLAKKNKKVMVVSLDIYRPAAREQLETLVRNHETIL
SLPIVSNENVFQIIARSTKEAKLLGCDVVIYDTAGRLHIDEPMLQELSNIKEIITPKEILLVVDSLIGQESVNVANQFNQ
TLNISGVVLTKIDGDSRGGAALSIKYVTGKPIKFLGTGEKTNDLEEFHPERIASRILGKGDIVSLVEKAAEVISKEDAAK
SVEKLKKGSFNLEDYYQQLQNINKMGGISSILNLMPGINKLLPKIDQNPFDQNNVKLQQAIILSMTRYEKLNPDIINGKR
KKRIAAGSGTSVQEVNKLLKQFQNITSLLKSGMKGNNILKDKFNNLKNFF
>Mature_450_residues
MFQTLTQKLSNIFDKIKGSTALSEQQVLTIAREVRIALLEADVSLVVIKDFINNVVEKAKGQEVLRSVTPGQMVIKIISD
EMIKVLSSSETEQALRIEFEPPVNIMMIGLQGSGKTTTTAKLAMKLAKKNKKVMVVSLDIYRPAAREQLETLVRNHETIL
SLPIVSNENVFQIIARSTKEAKLLGCDVVIYDTAGRLHIDEPMLQELSNIKEIITPKEILLVVDSLIGQESVNVANQFNQ
TLNISGVVLTKIDGDSRGGAALSIKYVTGKPIKFLGTGEKTNDLEEFHPERIASRILGKGDIVSLVEKAAEVISKEDAAK
SVEKLKKGSFNLEDYYQQLQNINKMGGISSILNLMPGINKLLPKIDQNPFDQNNVKLQQAIILSMTRYEKLNPDIINGKR
KKRIAAGSGTSVQEVNKLLKQFQNITSLLKSGMKGNNILKDKFNNLKNFF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=449, Percent_Identity=30.5122494432071, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI226371618, Length=341, Percent_Identity=33.7243401759531, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI23308697, Length=320, Percent_Identity=25.9375, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI295424842, Length=320, Percent_Identity=25.9375, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI89061728, Length=142, Percent_Identity=36.6197183098592, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=48.4777517564403, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1789874, Length=270, Percent_Identity=30, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17539958, Length=438, Percent_Identity=30.8219178082192, Blast_Score=214, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI193206261, Length=289, Percent_Identity=29.0657439446367, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=406, Percent_Identity=33.2512315270936, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6320498, Length=263, Percent_Identity=25.8555133079848, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17647949, Length=447, Percent_Identity=30.4250559284116, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24641198, Length=305, Percent_Identity=27.5409836065574, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49887; Mature: 49887

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQTLTQKLSNIFDKIKGSTALSEQQVLTIAREVRIALLEADVSLVVIKDFINNVVEKAK
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHC
GQEVLRSVTPGQMVIKIISDEMIKVLSSSETEQALRIEFEPPVNIMMIGLQGSGKTTTTA
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCHHHH
KLAMKLAKKNKKVMVVSLDIYRPAAREQLETLVRNHETILSLPIVSNENVFQIIARSTKE
HHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCCC
AKLLGCDVVIYDTAGRLHIDEPMLQELSNIKEIITPKEILLVVDSLIGQESVNVANQFNQ
CEEEECEEEEEECCCCEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHCC
TLNISGVVLTKIDGDSRGGAALSIKYVTGKPIKFLGTGEKTNDLEEFHPERIASRILGKG
CEECCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCHHHHCHHHHHHHHCCCC
DIVSLVEKAAEVISKEDAAKSVEKLKKGSFNLEDYYQQLQNINKMGGISSILNLMPGINK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCHHH
LLPKIDQNPFDQNNVKLQQAIILSMTRYEKLNPDIINGKRKKRIAAGSGTSVQEVNKLLK
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCCCCCHHHHHHHHH
QFQNITSLLKSGMKGNNILKDKFNNLKNFF
HHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MFQTLTQKLSNIFDKIKGSTALSEQQVLTIAREVRIALLEADVSLVVIKDFINNVVEKAK
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHC
GQEVLRSVTPGQMVIKIISDEMIKVLSSSETEQALRIEFEPPVNIMMIGLQGSGKTTTTA
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCHHHH
KLAMKLAKKNKKVMVVSLDIYRPAAREQLETLVRNHETILSLPIVSNENVFQIIARSTKE
HHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCCC
AKLLGCDVVIYDTAGRLHIDEPMLQELSNIKEIITPKEILLVVDSLIGQESVNVANQFNQ
CEEEECEEEEEECCCCEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHCC
TLNISGVVLTKIDGDSRGGAALSIKYVTGKPIKFLGTGEKTNDLEEFHPERIASRILGKG
CEECCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCHHHHCHHHHHHHHCCCC
DIVSLVEKAAEVISKEDAAKSVEKLKKGSFNLEDYYQQLQNINKMGGISSILNLMPGINK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCHHH
LLPKIDQNPFDQNNVKLQQAIILSMTRYEKLNPDIINGKRKKRIAAGSGTSVQEVNKLLK
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCCCCCHHHHHHHHH
QFQNITSLLKSGMKGNNILKDKFNNLKNFF
HHHHHHHHHHCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]