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The map label for this gene is gmk [H]

Identifier: 189183742

GI number: 189183742

Start: 880280

End: 880945

Strand: Reverse

Name: gmk [H]

Synonym: OTT_0835

Alternate gene names: 189183742

Gene position: 880945-880280 (Counterclockwise)

Preceding gene: 189183743

Following gene: 189183741

Centisome position: 43.85

GC content: 31.08

Gene sequence:

>666_bases
ATGTTTATTAGTTTTCCAAAACCTGCTATAGCACTTATAATATCATCTCCATCTGGAGCTGGAAAATCAAGCTTAGCTCA
TGCTGTTATTCAAAATAATAGCAATATTAAATTCTCTGTTTCAATGACAACTAGAGAAAAACGTAATAATGAAATAAATG
GCAAAGACTATATCTTTGTGACAAAAGAACAATTCGAACAGGAAATTAACAACAATACACTTCTTGAATTTTCTAAAGTA
TTCAACAACTACTATGGTATTCCAAAAGCTGGAGTGTTAGAAGATCTTAGTCAAGGTCAGAGCATTATTTTTGATATCGA
TTGGCAAGGCGCTAAAACAATACGAAAGGCTCTGAAATGTTATGTCGTTAGTGTATGCATACTTCCTCCATCAATGCAAG
AGCTAGAAAATAGGTTAAAAAAACGTAATAAAGATTCTCCAGAAACTATTCGCTACCGTTTAGAACAAGCAAAAGAAGAT
ATTAAGCATTATAGCGAATATGATTATGTAATAGTAAATGACAGCTTTGATCAAGCATTACTTGCTTTGCAATCAATACT
GATAGCTGAACAGCATAAGTTAAAAAGACTGAGTTTTAAAAATGATACACTATTAAATTATGAACAATTGTTACAAAGAG
ATGCGTGTTTTAATTATAGACAATGA

Upstream 100 bases:

>100_bases
ATACAAATAATTGTAGGTATGATATGTATGATATTATTGTATTTACTTTTAAAAATTAAGTTATTGAATAATAATATAAT
TTACAATATATTAACTTACC

Downstream 100 bases:

>100_bases
AATATTGATCTTTTATTTTATTTTACATAAAATGAGGAAAATTGTATAAAAAATGTTTTAGAACCCAAATTAAATTGAGG
TACACTAAAATTATATTACA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MFISFPKPAIALIISSPSGAGKSSLAHAVIQNNSNIKFSVSMTTREKRNNEINGKDYIFVTKEQFEQEINNNTLLEFSKV
FNNYYGIPKAGVLEDLSQGQSIIFDIDWQGAKTIRKALKCYVVSVCILPPSMQELENRLKKRNKDSPETIRYRLEQAKED
IKHYSEYDYVIVNDSFDQALLALQSILIAEQHKLKRLSFKNDTLLNYEQLLQRDACFNYRQ

Sequences:

>Translated_221_residues
MFISFPKPAIALIISSPSGAGKSSLAHAVIQNNSNIKFSVSMTTREKRNNEINGKDYIFVTKEQFEQEINNNTLLEFSKV
FNNYYGIPKAGVLEDLSQGQSIIFDIDWQGAKTIRKALKCYVVSVCILPPSMQELENRLKKRNKDSPETIRYRLEQAKED
IKHYSEYDYVIVNDSFDQALLALQSILIAEQHKLKRLSFKNDTLLNYEQLLQRDACFNYRQ
>Mature_221_residues
MFISFPKPAIALIISSPSGAGKSSLAHAVIQNNSNIKFSVSMTTREKRNNEINGKDYIFVTKEQFEQEINNNTLLEFSKV
FNNYYGIPKAGVLEDLSQGQSIIFDIDWQGAKTIRKALKCYVVSVCILPPSMQELENRLKKRNKDSPETIRYRLEQAKED
IKHYSEYDYVIVNDSFDQALLALQSILIAEQHKLKRLSFKNDTLLNYEQLLQRDACFNYRQ

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=198, Percent_Identity=38.3838383838384, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI226874833, Length=198, Percent_Identity=38.3838383838384, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI4504221, Length=198, Percent_Identity=38.3838383838384, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI38570142, Length=175, Percent_Identity=30.8571428571429, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI14780902, Length=188, Percent_Identity=30.3191489361702, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI262118259, Length=176, Percent_Identity=31.25, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI262118263, Length=176, Percent_Identity=31.25, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4505237, Length=176, Percent_Identity=31.25, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI262118255, Length=175, Percent_Identity=31.4285714285714, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI21361598, Length=188, Percent_Identity=26.063829787234, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI111154074, Length=108, Percent_Identity=32.4074074074074, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=196, Percent_Identity=42.8571428571429, Blast_Score=175, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI193203132, Length=177, Percent_Identity=37.2881355932203, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17508835, Length=177, Percent_Identity=37.2881355932203, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71988041, Length=178, Percent_Identity=25.2808988764045, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71984092, Length=148, Percent_Identity=30.4054054054054, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71988048, Length=178, Percent_Identity=25.2808988764045, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=38.0434782608696, Blast_Score=124, Evalue=9e-30,
Organism=Drosophila melanogaster, GI21356141, Length=181, Percent_Identity=32.5966850828729, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI45554481, Length=189, Percent_Identity=25.3968253968254, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85724806, Length=189, Percent_Identity=25.3968253968254, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI116007136, Length=189, Percent_Identity=25.3968253968254, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24640542, Length=189, Percent_Identity=25.3968253968254, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45554489, Length=189, Percent_Identity=25.3968253968254, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161077626, Length=189, Percent_Identity=25.3968253968254, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 25499; Mature: 25499

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFISFPKPAIALIISSPSGAGKSSLAHAVIQNNSNIKFSVSMTTREKRNNEINGKDYIFV
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCHHHCCCCCCCCEEEEE
TKEQFEQEINNNTLLEFSKVFNNYYGIPKAGVLEDLSQGQSIIFDIDWQGAKTIRKALKC
EHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
YVVSVCILPPSMQELENRLKKRNKDSPETIRYRLEQAKEDIKHYSEYDYVIVNDSFDQAL
HHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHH
LALQSILIAEQHKLKRLSFKNDTLLNYEQLLQRDACFNYRQ
HHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFISFPKPAIALIISSPSGAGKSSLAHAVIQNNSNIKFSVSMTTREKRNNEINGKDYIFV
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCHHHCCCCCCCCEEEEE
TKEQFEQEINNNTLLEFSKVFNNYYGIPKAGVLEDLSQGQSIIFDIDWQGAKTIRKALKC
EHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
YVVSVCILPPSMQELENRLKKRNKDSPETIRYRLEQAKEDIKHYSEYDYVIVNDSFDQAL
HHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHH
LALQSILIAEQHKLKRLSFKNDTLLNYEQLLQRDACFNYRQ
HHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]