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The map label for this gene is nuoL2 [H]

Identifier: 189183725

GI number: 189183725

Start: 858709

End: 860181

Strand: Reverse

Name: nuoL2 [H]

Synonym: OTT_0818

Alternate gene names: 189183725

Gene position: 860181-858709 (Counterclockwise)

Preceding gene: 189183726

Following gene: 189183724

Centisome position: 42.82

GC content: 28.04

Gene sequence:

>1473_bases
ATGCTTAAAAACATTATTTTATTATACAACGACATGATATGCTATATTCCATTTACTATAATTGGTATAATAGGTATATG
GAATTTAATTATTCCATTTCTGATTCGCAAAAATTTTATTAAAGAAATATTAATGCTTGCAATATCCATATTGCATGCTA
TTAATGCAATACTATTGTATTTTAGTTATAAAGCCGGGTATGAGCACTATACTACTATTTTCAGTATCGGAGCATTTGAT
TTTAGTCTAAGATTAAGTTTATTAGGTAGTAACATACTTTTACTAATAGCAATATTGTGGCCAATATCAATTATATATAC
TATTGGTTTTTTGAAAGCTCATAGTGAGCCAAATCAGGCTAAATTTTTACTTTGCACTAATCTATGTATATTAATTAGTA
ACTATATTGTATGTTCTGCTAATTTTTTTACTATGTTGATATGTTACGAACTTTTAACCTTTGCTACAATTCCATTAATA
AGACACGTAACTTCTCATAGAACTAGCAAAGTTTTGAGTAAATATACTCAAGGATTATATTTACCATCTTTACTATTTTT
AATGCCAACTTTAGTAGTTTTGCAATATCAATATAGTACAACAGATTTTGTAGAAATTGCTAACATATTACAATCTCGTA
CTCTATTACAAGTAAGTCCTGTTATTTTGGCATTATGTATATTGTGTGGTACTGCTAAAGCAGCTATTGTCCCTTTTCAT
AGCTGGCTTCCACCTGCTATGATAGCTCCATATCCAGTAAGCGCAATTTTACATGCTGTTGCAGTTGTTAATGTTGGTAT
TTTTTGCTTGATAACTGGAATCCTCTCAGTATTAGGAAAGGAAACATGGTTATTAAATTATATACAGTATTTTATAGGAT
ATGGAATTGTATATACCAGCATAAAGGCATTATTTCAAACTAATATCAAAAGAATTTTGGCTTACTCAACTATATCTAAC
TTAGGTATAATAGCTTTAACAGCATTTATGAATAGCCATGAATCTTTACTTGCTACTATTACTCACATAATTGCTCATTC
AATAGGTAAGATTACAGTATTCTATTCTGCAGGTTGTTTATATACAATTAGTAAATGTACTAATGTTGAAGATTTAACAT
CAATGTCTTATAAAGCTCCTATAATAACATCATGCCTAACAATAGGAAGTTTATCATTAATAGGCATACCACCATTAGCA
GGCTTTTTCAGTAAACATCATATAATCCTAGAAGCAGCAAATGAACATAATTATTTAGTAATCGCTATTACAGTTTTTTC
AGGAATAACTTCATGCTTGTATTTATCAAAAATAATAAAAACTGCCTATAGCAAAATAGATAATAAATTTAATATTAACT
CTACAAATAACATTCATTCAGAACAGATGATACCTAAACATATGCTTTATAGCACGGTATCATGTGCTAGTTTAGTTGTA
TTAATTCCTATTATTAATGCTTTAATAATGTAA

Upstream 100 bases:

>100_bases
AATTTTAACTATTATCAGCTATTTGATGCTAATATTTTACAATCACTTATTAGTATACTTACAGCCGTTTTTTCTACCAA
AAATCATGTGAGTTTTATAG

Downstream 100 bases:

>100_bases
CATGATTGACAGAACTGTCAACTATCAGTATATTGCTATAATATTAGATTGATGGACGAAGATTTAAAATGCAACAATGT
TTTCTTACTTTAACTGTATT

Product: NADH dehydrogenase I chain L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MLKNIILLYNDMICYIPFTIIGIIGIWNLIIPFLIRKNFIKEILMLAISILHAINAILLYFSYKAGYEHYTTIFSIGAFD
FSLRLSLLGSNILLLIAILWPISIIYTIGFLKAHSEPNQAKFLLCTNLCILISNYIVCSANFFTMLICYELLTFATIPLI
RHVTSHRTSKVLSKYTQGLYLPSLLFLMPTLVVLQYQYSTTDFVEIANILQSRTLLQVSPVILALCILCGTAKAAIVPFH
SWLPPAMIAPYPVSAILHAVAVVNVGIFCLITGILSVLGKETWLLNYIQYFIGYGIVYTSIKALFQTNIKRILAYSTISN
LGIIALTAFMNSHESLLATITHIIAHSIGKITVFYSAGCLYTISKCTNVEDLTSMSYKAPIITSCLTIGSLSLIGIPPLA
GFFSKHHIILEAANEHNYLVIAITVFSGITSCLYLSKIIKTAYSKIDNKFNINSTNNIHSEQMIPKHMLYSTVSCASLVV
LIPIINALIM

Sequences:

>Translated_490_residues
MLKNIILLYNDMICYIPFTIIGIIGIWNLIIPFLIRKNFIKEILMLAISILHAINAILLYFSYKAGYEHYTTIFSIGAFD
FSLRLSLLGSNILLLIAILWPISIIYTIGFLKAHSEPNQAKFLLCTNLCILISNYIVCSANFFTMLICYELLTFATIPLI
RHVTSHRTSKVLSKYTQGLYLPSLLFLMPTLVVLQYQYSTTDFVEIANILQSRTLLQVSPVILALCILCGTAKAAIVPFH
SWLPPAMIAPYPVSAILHAVAVVNVGIFCLITGILSVLGKETWLLNYIQYFIGYGIVYTSIKALFQTNIKRILAYSTISN
LGIIALTAFMNSHESLLATITHIIAHSIGKITVFYSAGCLYTISKCTNVEDLTSMSYKAPIITSCLTIGSLSLIGIPPLA
GFFSKHHIILEAANEHNYLVIAITVFSGITSCLYLSKIIKTAYSKIDNKFNINSTNNIHSEQMIPKHMLYSTVSCASLVV
LIPIINALIM
>Mature_490_residues
MLKNIILLYNDMICYIPFTIIGIIGIWNLIIPFLIRKNFIKEILMLAISILHAINAILLYFSYKAGYEHYTTIFSIGAFD
FSLRLSLLGSNILLLIAILWPISIIYTIGFLKAHSEPNQAKFLLCTNLCILISNYIVCSANFFTMLICYELLTFATIPLI
RHVTSHRTSKVLSKYTQGLYLPSLLFLMPTLVVLQYQYSTTDFVEIANILQSRTLLQVSPVILALCILCGTAKAAIVPFH
SWLPPAMIAPYPVSAILHAVAVVNVGIFCLITGILSVLGKETWLLNYIQYFIGYGIVYTSIKALFQTNIKRILAYSTISN
LGIIALTAFMNSHESLLATITHIIAHSIGKITVFYSAGCLYTISKCTNVEDLTSMSYKAPIITSCLTIGSLSLIGIPPLA
GFFSKHHIILEAANEHNYLVIAITVFSGITSCLYLSKIIKTAYSKIDNKFNINSTNNIHSEQMIPKHMLYSTVSCASLVV
LIPIINALIM

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=234, Percent_Identity=34.6153846153846, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1788614, Length=426, Percent_Identity=25.8215962441315, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1788829, Length=346, Percent_Identity=25.4335260115607, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788827, Length=434, Percent_Identity=23.7327188940092, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788831, Length=355, Percent_Identity=26.4788732394366, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI145693160, Length=444, Percent_Identity=25, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI2367154, Length=189, Percent_Identity=27.5132275132275, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54471; Mature: 54471

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNIILLYNDMICYIPFTIIGIIGIWNLIIPFLIRKNFIKEILMLAISILHAINAILLY
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSYKAGYEHYTTIFSIGAFDFSLRLSLLGSNILLLIAILWPISIIYTIGFLKAHSEPNQA
HHHHCCCHHHHHHHEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KFLLCTNLCILISNYIVCSANFFTMLICYELLTFATIPLIRHVTSHRTSKVLSKYTQGLY
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LPSLLFLMPTLVVLQYQYSTTDFVEIANILQSRTLLQVSPVILALCILCGTAKAAIVPFH
HHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECH
SWLPPAMIAPYPVSAILHAVAVVNVGIFCLITGILSVLGKETWLLNYIQYFIGYGIVYTS
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
IKALFQTNIKRILAYSTISNLGIIALTAFMNSHESLLATITHIIAHSIGKITVFYSAGCL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCHH
YTISKCTNVEDLTSMSYKAPIITSCLTIGSLSLIGIPPLAGFFSKHHIILEAANEHNYLV
HHHHHCCCHHHHHHCCCCCHHHHHHHHHCCCCEECCCCHHHHHCCCEEEEEECCCCCEEE
IAITVFSGITSCLYLSKIIKTAYSKIDNKFNINSTNNIHSEQMIPKHMLYSTVSCASLVV
EEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LIPIINALIM
HHHHHHHHCC
>Mature Secondary Structure
MLKNIILLYNDMICYIPFTIIGIIGIWNLIIPFLIRKNFIKEILMLAISILHAINAILLY
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSYKAGYEHYTTIFSIGAFDFSLRLSLLGSNILLLIAILWPISIIYTIGFLKAHSEPNQA
HHHHCCCHHHHHHHEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KFLLCTNLCILISNYIVCSANFFTMLICYELLTFATIPLIRHVTSHRTSKVLSKYTQGLY
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LPSLLFLMPTLVVLQYQYSTTDFVEIANILQSRTLLQVSPVILALCILCGTAKAAIVPFH
HHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECH
SWLPPAMIAPYPVSAILHAVAVVNVGIFCLITGILSVLGKETWLLNYIQYFIGYGIVYTS
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
IKALFQTNIKRILAYSTISNLGIIALTAFMNSHESLLATITHIIAHSIGKITVFYSAGCL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCHH
YTISKCTNVEDLTSMSYKAPIITSCLTIGSLSLIGIPPLAGFFSKHHIILEAANEHNYLV
HHHHHCCCHHHHHHCCCCCHHHHHHHHHCCCCEECCCCHHHHHCCCEEEEEECCCCCEEE
IAITVFSGITSCLYLSKIIKTAYSKIDNKFNINSTNNIHSEQMIPKHMLYSTVSCASLVV
EEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LIPIINALIM
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA